Elena Rosca - Academia.edu (original) (raw)

Elena Rosca

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Papers by Elena Rosca

Research paper thumbnail of In Silico and Experimental Studies for the Development of Novel OXAZOL-5(4H)-ONES with Pharmacological Potential

FARMACIA, 2020

New 2-(4-(4-X-phenylsulfonyl)phenyl)-4-(3-bromo/3-bromo-4-methoxy-benzylidene)oxazol-5(4H)-ones h... more New 2-(4-(4-X-phenylsulfonyl)phenyl)-4-(3-bromo/3-bromo-4-methoxy-benzylidene)oxazol-5(4H)-ones have been synthesized by reaction of some 2-(4-(4-X-phenylsulfonyl)benzamido)acetic acids derivatives with 3-bromobenzaldehyde or 3-bromo-4methoxybenzaldehyde. The structures of the newly obtained heterocycles were elucidated by IR, 1 H-NMR, 13 C-NMR, mass spectra and elemental analysis. The cytotoxicity of the new oxazolones was evaluated using Artemia salina and Daphnia magna organisms and the in vitro antimicrobial activity was assessed on Gram-positive and Gram-negative bacterial and fungal strains. Rezumat Noi 2-(4-(4-X-fenilsulfonil)fenil)-4-(3-bromo/3-bromo-4-metoxi-benziliden)-oxazol-5(4H)-one au fost sintetizate prin reacția unor derivați ai acidului 2-(4-(4-X-fenilsulfonil)benzamido)acetic cu 3-bromobenzaldehida sau 3-bromo-4-metoxibenzaldehida. Structurile noilor heterocicluri au fost elucidate prin spectrometrie în IR, 1 H-RMN, 13 C-RMN, spectre de masă și analiză elementală. Citotoxicitatea noilor oxazolone a fost evaluată pe modele experimentale animale reprezentate de Artemia salina and Daphnia magna. Compușii au fost testați in vitro pentru activitatea lor antimicrobiană față de tulpini bacteriene Gram-pozitive și Gramnegative și fungice.

Research paper thumbnail of New 2-(4-(4-bromophenylsulfonyl)phenyl)-4-arylidene-oxazol-5(4H)-ones: analgesic activity and histopathological assessment

Romanian Journal of Morphology and Embryology, 2020

This is an open-access article distributed under the terms of a Creative Commons Attribution-NonC... more This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited. ORIGINAL PAPER New 2-(4-(4-bromophenylsulfonyl)phenyl)-4-arylideneoxazol-5(4H)-ones: analgesic activity and histopathological assessment FLORICA BĂRBUCEANU 1,2) , ELENA-VALENTINA ROŞCA 3) , THEODORA-VENERA APOSTOL 3) , OANA-CRISTINA ŞEREMET 4) , CONSTANTIN DRĂGHICI 5) , DRAGOŞ PAUL MIHAI 4) , SIMONA NEGREŞ 4) , GEORGE MIHAI NIŢULESCU 6) , ŞTEFANIA-FELICIA BĂRBUCEANU 3)

Research paper thumbnail of In Silico and Experimental Studies for the Development of Novel OXAZOL-5(4H)-ONES with Pharmacological Potential

FARMACIA, 2020

New 2-(4-(4-X-phenylsulfonyl)phenyl)-4-(3-bromo/3-bromo-4-methoxy-benzylidene)oxazol-5(4H)-ones h... more New 2-(4-(4-X-phenylsulfonyl)phenyl)-4-(3-bromo/3-bromo-4-methoxy-benzylidene)oxazol-5(4H)-ones have been synthesized by reaction of some 2-(4-(4-X-phenylsulfonyl)benzamido)acetic acids derivatives with 3-bromobenzaldehyde or 3-bromo-4methoxybenzaldehyde. The structures of the newly obtained heterocycles were elucidated by IR, 1 H-NMR, 13 C-NMR, mass spectra and elemental analysis. The cytotoxicity of the new oxazolones was evaluated using Artemia salina and Daphnia magna organisms and the in vitro antimicrobial activity was assessed on Gram-positive and Gram-negative bacterial and fungal strains. Rezumat Noi 2-(4-(4-X-fenilsulfonil)fenil)-4-(3-bromo/3-bromo-4-metoxi-benziliden)-oxazol-5(4H)-one au fost sintetizate prin reacția unor derivați ai acidului 2-(4-(4-X-fenilsulfonil)benzamido)acetic cu 3-bromobenzaldehida sau 3-bromo-4-metoxibenzaldehida. Structurile noilor heterocicluri au fost elucidate prin spectrometrie în IR, 1 H-RMN, 13 C-RMN, spectre de masă și analiză elementală. Citotoxicitatea noilor oxazolone a fost evaluată pe modele experimentale animale reprezentate de Artemia salina and Daphnia magna. Compușii au fost testați in vitro pentru activitatea lor antimicrobiană față de tulpini bacteriene Gram-pozitive și Gramnegative și fungice.

Research paper thumbnail of New 2-(4-(4-bromophenylsulfonyl)phenyl)-4-arylidene-oxazol-5(4H)-ones: analgesic activity and histopathological assessment

Romanian Journal of Morphology and Embryology, 2020

This is an open-access article distributed under the terms of a Creative Commons Attribution-NonC... more This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited. ORIGINAL PAPER New 2-(4-(4-bromophenylsulfonyl)phenyl)-4-arylideneoxazol-5(4H)-ones: analgesic activity and histopathological assessment FLORICA BĂRBUCEANU 1,2) , ELENA-VALENTINA ROŞCA 3) , THEODORA-VENERA APOSTOL 3) , OANA-CRISTINA ŞEREMET 4) , CONSTANTIN DRĂGHICI 5) , DRAGOŞ PAUL MIHAI 4) , SIMONA NEGREŞ 4) , GEORGE MIHAI NIŢULESCU 6) , ŞTEFANIA-FELICIA BĂRBUCEANU 3)

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