Eliša Papić - Academia.edu (original) (raw)

Papers by Eliša Papić

Frontiers in Aging Neuroscience

IntroductionParkinson’s disease (PD) is neurodegenerative disease with a multifactorial etiopatho... more IntroductionParkinson’s disease (PD) is neurodegenerative disease with a multifactorial etiopathogenesis with accumulating evidence identifying microbiota as a potential factor in the earliest, prodromal phases of the disease. Previous research has already shown a significant difference between gut microbiota composition in PD patients as opposed to healthy controls, with a growing number of studies correlating gut microbiota changes with the clinical presentation of the disease in later stages, through various motor and non-motor symptoms. Our aim in this systematic review is to compose and assess current knowledge in the field and determine if the findings could influence future clinical practice as well as therapy in PD.MethodsWe have conducted a systematic review according to PRISMA guidelines through MEDLINE and Embase databases, with studies being selected for inclusion via a set inclusion and exclusion criteria.Results20 studies were included in this systematic review accordi...

npj Parkinson's Disease

Parkinson’s disease (PD) guidelines lack clear criteria for genetic evaluation. We assessed the y... more Parkinson’s disease (PD) guidelines lack clear criteria for genetic evaluation. We assessed the yield and rationale of genetic testing for PD in a routine clinical setting on a multicenter cohort of 149 early-onset and familial patients by exome sequencing and semi-quantitative multiplex ligation-dependent probe amplification of evidence-based PD-associated gene panel. We show that genetic testing for PD should be considered for both early-onset and familial patients alike, and a clinical yield of about 10% in the Caucasian population can be expected.

Mikroglija stanice predstavnice su prirođenog imunološkog sustava u središnjem živčanom sustavu (... more Mikroglija stanice predstavnice su prirođenog imunološkog sustava u središnjem živčanom sustavu (SŽS). Funkcija mikroglija stanica usko je vezana uz njihovu morfološku prezentaciju, a ona dalje o uvjetima, faktorima i medijatorima kojima su mikroglija stanice izložene. Tako su utvrđena dva osnovna fenotipa, M1 i M2, kao i prijelazni, M1/M2 miješani oblik. M1 oblik metabolički se vezuje uz proces aerobne glikolize i pojačane produkcije laktata, dok se M2, razgranati fenotip vezuje uz oksidativnu fosforilaciju i smirivanje upale. Cilj rada bio je otkriti ukoliko fetuin,aktivni sastojak u FCS-u, utječe na stanje polarizacije (M1/M2) i posljedične promjene fenotipskih i metaboličkih obilježja BV-2 stanica in-vitro. Kulture uzgajane bez FCS-a kroz 96 sati pokazale su morfološka i funkcijska obilježja M2 mirujuće, razgranate mikroglije, uključujući i pojačanu ekspresiju M2-specifičnih imunoflorescentnih markera (CD206). Otkrivanjem faktora koji pomiču M1/M2 ravnotežu u središnjem živčanom...

Movement Disorders Clinical Practice, 2021

Gaucher’s disease type 1 (GD1) is an autosomal recessive disease caused by mutations in the gluco... more Gaucher’s disease type 1 (GD1) is an autosomal recessive disease caused by mutations in the glucocerebrosidase (GBA) gene. Both homozygote and heterozygote mutation carriers in the GBA gene have an increased risk of developing Parkinson’s disease (PD). Around 4% of patients with GD1 fulfill the diagnostic criteria for PD, and nearly 21% develop some form of parkinsonian symptoms during the disease course. The neurological manifestations of the disease often progress rapidly, depending on the age of onset with the disease showing a tendency to reach an advanced stage early. Enzyme replacement therapy and substrate reduction therapy have not been shown to be effective as they do not reach the central nervous system. The clinical standard of care for treating advanced PD is deep brain stimulation. To the best of our knowledge, only two cases of DBS treatment of PD in GD1 have been reported so far, both of which demonstrate successful and sustained results.

Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti

Croatian Medical Journal, 2022

AimTo assess the effect of social isolation due to the coronavirus disease 2019 (COVID-19) pandem... more AimTo assess the effect of social isolation due to the coronavirus disease 2019 (COVID-19) pandemic on physical and mental health of Parkinson’s disease patients treated at the University Hospital Center Rijeka.MethodsThis cross-sectional telephone study involved Parkinson’s disease patients who had at least one control examination at University Hospital Center Rijeka in 2020 and were Croatian citizens. A questionnaire was used to obtain data on the socio-demographic characteristics and the severity of motor, anxiety, depression, and non-motor symptoms.ResultsThe final sample included 87 patients. Most patients reported subjective worsening of motor symptoms. Patients who lived alone had worse motor scores than those not living alone. The majority of patients reported worsening of anxiety symptoms. Significant worsening of anxiety symptoms was found in patients who lived alone, had a longer disease duration, and had avoided check-ups. Fewer patients had depression symptoms than motor and anxiety symptoms. Significantly higher Hamilton Depression Rating Scale scores were observed in patients with a longer disease duration. Significant worsening of non-motor symptoms was identified in patients who lived alone, were less educated, had a longer disease duration, and had a higher Charlson comorbidity index.ConclusionPatients who live alone, have longer disease duration, are less educated, avoid check-ups, and have more comorbidities are more vulnerable to the negative effects of social isolation.

Background: Parkinson’s disease (PD) is the second most frequent neurodegenerative disease, which... more Background: Parkinson’s disease (PD) is the second most frequent neurodegenerative disease, which creates a significant public health burden. There is a challenge for the optimization of therapies since patients not only respond differently to current treatment options but also develop different side effects to the treatment. Genetic variability in the human genome can serve as a biomarker for the metabolism, availability of drugs and stratification of patients for suitable therapies. The goal of this systematic review is to assess the current evidence for the clinical translation of pharmacogenomics in the personalization of treatment for Parkinson’s disease. Methods: We performed a systematic search of Medline database for publications covering the topic of pharmacogenomics and genotype specific mutations in Parkinson’s disease treatment, along with a manual search, and finally included a total of 116 publications in the review. Results: We analyzed 75 studies and 41 reviews publi...

Frontiers in Human Neuroscience

IntroductionParkinson’s disease (PD) patients have a significantly higher risk of developing deme... more IntroductionParkinson’s disease (PD) patients have a significantly higher risk of developing dementia in later disease stages, leading to severe impairments in quality of life and self-functioning. Questions remain on how deep brain stimulation (DBS) affects cognition, and whether we can individualize therapy and reduce the risk for adverse cognitive effects. Our aim in this systematic review is to assess the current knowledge in the field and determine if the findings could influence clinical practice.MethodsWe have conducted a systematic review according to PRISMA guidelines through MEDLINE and Embase databases, with studies being selected for inclusion via a set inclusion and exclusion criteria.ResultsSixty-seven studies were included in this systematic review according to the selected criteria. This includes 6 meta-analyses, 18 randomized controlled trials, 17 controlled clinical trials, and 26 observational studies with no control arms. The total number of PD patients encompass...

Medicina Fluminensis

Vitamin D nužan je nutrijent potreban za homeostazu kalcija i zdravlje koštanog sustava, no sve s... more Vitamin D nužan je nutrijent potreban za homeostazu kalcija i zdravlje koštanog sustava, no sve se češće potvrđuje njegova uloga u neurološkim bolestima. U središnjem živčanom sustavu prisutni su svi čimbenici metabolizma vitamina D te je djelovanje moguće parakrinim i autokrinim putem. Vitamin D utječe na razine neurotrofnih čimbenika, regulaciju imunološke funkcije te na homeostazu središnjeg živčanog sustava. Manjak vitamina D i njegova nadoknada predmet je istraživanja većine neurodegenerativnih bolesti te je manjak povezan s povećanim rizikom nastanka bolesti. Dosadašnja su istraživanja nadoknađivanja vitamina D obećavajuća, no postoji nedostatak visokokvalitetnih studija za čvrste dokaze i smjernice.