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Research paper thumbnail of Shock Wave Therapy for Tendinopathies

Muscle and Tendon Injuries, 2017

Extracorporeal shock wave therapy (ESWT), originally introduced in medicine as urological lithotr... more Extracorporeal shock wave therapy (ESWT), originally introduced in medicine as urological lithotripsy, in the 1980s, has expanded its scope of application into the field of musculoskeletal medicine, mainly for the treatment of tendon and bone pathologies, not as a destructive force to disintegrate calcific deposits, but conversely to induce tissue-specific beneficial effects and regeneration. ESWT is considered where tendinopathies prove refractory to conventional management, where high risks of surgical complications are present, or where surgery failed. Combined with therapeutical exercises, it offers a revolutionary clinical treatment option for unresponsive tendinopathies. When applied by an experienced and trained operator, ESWT offers a strategic, efficacious, safe, noninvasive therapeutic intervention that is easily complied with and tolerated by patients. ESWT could revolutionize the nature and standard of tendinopathy management, elevating it from being palliative toward a more curative approach.

Research paper thumbnail of Shock wave as biological therapeutic tool: From mechanical stimulation to recovery and healing, through mechanotransduction

International Journal of Surgery, 2015

h i g h l i g h t s SW represents a revolutionary form of mechanotherapy (acustic stimulation). U... more h i g h l i g h t s SW represents a revolutionary form of mechanotherapy (acustic stimulation). Unlike urological lithotripsy (mechanical model), on living tissues, SW exert an anti-inflammatory action and pro-angiogenic and regenerative effects as well (biological model). Mechanotrasduction pathways sustain their clinical and experimental results. We present a summary of current knowledge of SW mechanisms of action, according to main recent data (mechanobiology). Better comprehension of SW mechanobiology could led to new therapeutical perspectives.

Research paper thumbnail of Effect of shock waves on macrophages: A possible role in tissue regeneration and remodeling

International Journal of Surgery, 2015

We report the effects of Shock Waves (SW) on macrophages activity in vitro. SW did not induce act... more We report the effects of Shock Waves (SW) on macrophages activity in vitro. SW did not induce activation of resting macrophages. Low energy SW dampens the induction of the pro-inflammatory profile in M1 macrophages. Low energy SW promotes the acquisition of an anti-inflammatory profile with M2 macrophages.

Research paper thumbnail of Single injection of platelet-rich plasma in a rat Achilles tendon tear model

Muscles, ligaments and tendons journal, 2011

The purpose of this study was to determine the efficacy of platelet-rich plasma (PRP) 1-injection... more The purpose of this study was to determine the efficacy of platelet-rich plasma (PRP) 1-injection during an Achilles tendon rat tear model. 80 male adult imbreded rats (Wistar Kyoto), underwent under surgical tendon rupture. 40 Animal (PRP group rats) were given a local injection with 0,25 mL of PRP, and 40 animal (control group) were given the same quantity of control solution. The rats were sacrified at 1, 2, 4 and 6 weeks (each time point, 20 rats of the each group) after surgical tear and tendon tissue was analysed by macroscopic aspect, histology, immunostaining and Real Time (RT)-PCR to evaluate tissue repair. PRP improved tendon remodelling by better coordination of the reconstructive process with earlier formation of tendon-like continuity only in the first week after surgery. However, after 2,4 and 6 weeks, Achilles tendons in the PRP group had no difference compared to the control group. Immunostaining and RT-PCR did not show any difference between PRP treated and untreate...

Research paper thumbnail of Shock Wave Therapy for Tendinopathies

Muscle and Tendon Injuries, 2017

Extracorporeal shock wave therapy (ESWT), originally introduced in medicine as urological lithotr... more Extracorporeal shock wave therapy (ESWT), originally introduced in medicine as urological lithotripsy, in the 1980s, has expanded its scope of application into the field of musculoskeletal medicine, mainly for the treatment of tendon and bone pathologies, not as a destructive force to disintegrate calcific deposits, but conversely to induce tissue-specific beneficial effects and regeneration. ESWT is considered where tendinopathies prove refractory to conventional management, where high risks of surgical complications are present, or where surgery failed. Combined with therapeutical exercises, it offers a revolutionary clinical treatment option for unresponsive tendinopathies. When applied by an experienced and trained operator, ESWT offers a strategic, efficacious, safe, noninvasive therapeutic intervention that is easily complied with and tolerated by patients. ESWT could revolutionize the nature and standard of tendinopathy management, elevating it from being palliative toward a more curative approach.

Research paper thumbnail of Shock wave as biological therapeutic tool: From mechanical stimulation to recovery and healing, through mechanotransduction

International Journal of Surgery, 2015

h i g h l i g h t s SW represents a revolutionary form of mechanotherapy (acustic stimulation). U... more h i g h l i g h t s SW represents a revolutionary form of mechanotherapy (acustic stimulation). Unlike urological lithotripsy (mechanical model), on living tissues, SW exert an anti-inflammatory action and pro-angiogenic and regenerative effects as well (biological model). Mechanotrasduction pathways sustain their clinical and experimental results. We present a summary of current knowledge of SW mechanisms of action, according to main recent data (mechanobiology). Better comprehension of SW mechanobiology could led to new therapeutical perspectives.

Research paper thumbnail of Effect of shock waves on macrophages: A possible role in tissue regeneration and remodeling

International Journal of Surgery, 2015

We report the effects of Shock Waves (SW) on macrophages activity in vitro. SW did not induce act... more We report the effects of Shock Waves (SW) on macrophages activity in vitro. SW did not induce activation of resting macrophages. Low energy SW dampens the induction of the pro-inflammatory profile in M1 macrophages. Low energy SW promotes the acquisition of an anti-inflammatory profile with M2 macrophages.

Research paper thumbnail of Single injection of platelet-rich plasma in a rat Achilles tendon tear model

Muscles, ligaments and tendons journal, 2011

The purpose of this study was to determine the efficacy of platelet-rich plasma (PRP) 1-injection... more The purpose of this study was to determine the efficacy of platelet-rich plasma (PRP) 1-injection during an Achilles tendon rat tear model. 80 male adult imbreded rats (Wistar Kyoto), underwent under surgical tendon rupture. 40 Animal (PRP group rats) were given a local injection with 0,25 mL of PRP, and 40 animal (control group) were given the same quantity of control solution. The rats were sacrified at 1, 2, 4 and 6 weeks (each time point, 20 rats of the each group) after surgical tear and tendon tissue was analysed by macroscopic aspect, histology, immunostaining and Real Time (RT)-PCR to evaluate tissue repair. PRP improved tendon remodelling by better coordination of the reconstructive process with earlier formation of tendon-like continuity only in the first week after surgery. However, after 2,4 and 6 weeks, Achilles tendons in the PRP group had no difference compared to the control group. Immunostaining and RT-PCR did not show any difference between PRP treated and untreate...