Elise Reis - Academia.edu (original) (raw)
Papers by Elise Reis
Research, Society and Development
A aterosclerose é uma doença inflamatória crônica de origem multifatorial que ocorre em resposta ... more A aterosclerose é uma doença inflamatória crônica de origem multifatorial que ocorre em resposta à agressão endotelial, acometendo principalmente a camada íntima de artérias de médio e grande calibres. O diabetes mellitus tipo 2 está associado a uma alta taxa de doença cardiovascular aterosclerótica. Esse estudo visa analisar o impacto, pelo tratamento medicamentoso do Cilostazol, que é um medicamento antiplaquetário, na redução da espessura da artéria aorta de ratos induzidos a desenvolver o diabetes por meio da administração de estreptozotocina, comparando com um grupo controle sem diabetes. O estudo mostrou que o tempo que o rato levou para desenvolver o diabetes foi de 8 semanas, os ratos do grupo que foi administrado a estreptozotocina apresentaram significativo aumento da espessura arterial aórtica, principalmente na camada intimal da artéria. Foi observada uma redução na espessura da camada intima das artérias aorta dos ratos submetidos ao tratamento com cilostazol, com expre...
Publicatio Uepg Ciencias Biologicas E Da Saude, Sep 26, 2014
Brazilian Journal of Cardiovascular Surgery
Introduction: Many publications on coronary surgery and carotid stenosis (CS) can be found, but w... more Introduction: Many publications on coronary surgery and carotid stenosis (CS) can be found, but we do not have enough information about the relationship between ischemic stroke, CS and non-coronary cardiac surgery. Objectives: To evaluate the incidence and risk factors associated with the stroke and CS ≥50% in patients undergoing non-coronary surgeries. Method: We assessed 241 patients, aged 40 years or older, between 2009 and 2016, operated in Santa Casa de Misericórdia de Ponta Grossa-PR, Brazil. We perform carotid Doppler in patients 40 years of age or older before any cardiac surgery as a routine. The incidence and possible risk factors for CS ≥50% and perioperative stroke were analyzed by univariate statistical analysis. Results: 11 patients (4.56%) presented perioperative stroke. The risk factor for stroke was CS ≥50%: OR=5.3750 (1.2909-22.3805), P=0.0208. Eighteen patients (7.46%) had CS ≥50% and their risk factors were extracardiac arteriopathy: OR=18.6607 (6.3644-54.7143), P<0.0001; COPD: OR=3.9040 (1.4491-10.5179), P=0.0071; diabetes mellitus: OR=2.9844 (1.0453-8.5204), P=0.0411; recent myocardial infarction: OR=13.8125 (1.8239-104.6052), P=0.0110; EuroSCORE II higher P=0.0056. Conclusion: The incidences of stroke and CS ≥50% were 4.56% and 7.46%, respectively. The risk factor for stroke was CS ≥50% and for CS ≥50% were extracardiac arteriopathy, COPD, diabetes mellitus, recent myocardial infarction and higher EuroSCORE II.
Brazilian journal of cardiovascular surgery
In patients with mechanical prosthetic heart valves or atrial fibrillation requiring anticoagulat... more In patients with mechanical prosthetic heart valves or atrial fibrillation requiring anticoagulation to prevent thromboembolic events, several factors influence adherence and anticoagulation complications. To evaluate the factors that interfere with the quality and complications of anticoagulation with vitamin K antagonists. A retrospective cohort study of 100 patients, in the period from 2011 to 2014, was performed. Anticoagulation conditions in the last year, regarding the presence of complications (embolisms/bleeding) and inadequate treatment were assessed: achievement of less than 8 annual prothrombin times and International Normalized Ratio outside therapeutic target in more than 40% of prothrombin times. There were 31 complications (22 minor bleeding without hospitalization and 9 major complications: 7 bleeding with hospitalization and two emboli); 70 were with International Normalized Ratio outside the target in more than 40% of the tests and 36 with insufficient number of pr...
Research, Society and Development
A aterosclerose é uma doença inflamatória crônica de origem multifatorial que ocorre em resposta ... more A aterosclerose é uma doença inflamatória crônica de origem multifatorial que ocorre em resposta à agressão endotelial, acometendo principalmente a camada íntima de artérias de médio e grande calibres. O diabetes mellitus tipo 2 está associado a uma alta taxa de doença cardiovascular aterosclerótica. Esse estudo visa analisar o impacto, pelo tratamento medicamentoso do Cilostazol, que é um medicamento antiplaquetário, na redução da espessura da artéria aorta de ratos induzidos a desenvolver o diabetes por meio da administração de estreptozotocina, comparando com um grupo controle sem diabetes. O estudo mostrou que o tempo que o rato levou para desenvolver o diabetes foi de 8 semanas, os ratos do grupo que foi administrado a estreptozotocina apresentaram significativo aumento da espessura arterial aórtica, principalmente na camada intimal da artéria. Foi observada uma redução na espessura da camada intima das artérias aorta dos ratos submetidos ao tratamento com cilostazol, com expre...
Publicatio Uepg Ciencias Biologicas E Da Saude, Sep 26, 2014
Brazilian Journal of Cardiovascular Surgery
Introduction: Many publications on coronary surgery and carotid stenosis (CS) can be found, but w... more Introduction: Many publications on coronary surgery and carotid stenosis (CS) can be found, but we do not have enough information about the relationship between ischemic stroke, CS and non-coronary cardiac surgery. Objectives: To evaluate the incidence and risk factors associated with the stroke and CS ≥50% in patients undergoing non-coronary surgeries. Method: We assessed 241 patients, aged 40 years or older, between 2009 and 2016, operated in Santa Casa de Misericórdia de Ponta Grossa-PR, Brazil. We perform carotid Doppler in patients 40 years of age or older before any cardiac surgery as a routine. The incidence and possible risk factors for CS ≥50% and perioperative stroke were analyzed by univariate statistical analysis. Results: 11 patients (4.56%) presented perioperative stroke. The risk factor for stroke was CS ≥50%: OR=5.3750 (1.2909-22.3805), P=0.0208. Eighteen patients (7.46%) had CS ≥50% and their risk factors were extracardiac arteriopathy: OR=18.6607 (6.3644-54.7143), P<0.0001; COPD: OR=3.9040 (1.4491-10.5179), P=0.0071; diabetes mellitus: OR=2.9844 (1.0453-8.5204), P=0.0411; recent myocardial infarction: OR=13.8125 (1.8239-104.6052), P=0.0110; EuroSCORE II higher P=0.0056. Conclusion: The incidences of stroke and CS ≥50% were 4.56% and 7.46%, respectively. The risk factor for stroke was CS ≥50% and for CS ≥50% were extracardiac arteriopathy, COPD, diabetes mellitus, recent myocardial infarction and higher EuroSCORE II.
Brazilian journal of cardiovascular surgery
In patients with mechanical prosthetic heart valves or atrial fibrillation requiring anticoagulat... more In patients with mechanical prosthetic heart valves or atrial fibrillation requiring anticoagulation to prevent thromboembolic events, several factors influence adherence and anticoagulation complications. To evaluate the factors that interfere with the quality and complications of anticoagulation with vitamin K antagonists. A retrospective cohort study of 100 patients, in the period from 2011 to 2014, was performed. Anticoagulation conditions in the last year, regarding the presence of complications (embolisms/bleeding) and inadequate treatment were assessed: achievement of less than 8 annual prothrombin times and International Normalized Ratio outside therapeutic target in more than 40% of prothrombin times. There were 31 complications (22 minor bleeding without hospitalization and 9 major complications: 7 bleeding with hospitalization and two emboli); 70 were with International Normalized Ratio outside the target in more than 40% of the tests and 36 with insufficient number of pr...