Eloy Castro - Academia.edu (original) (raw)

Papers by Eloy Castro

Research paper thumbnail of Synthesis, characterization, cytotoxic activity, and cellular accumulation of dinuclear platinum complexes derived from N, N′-di-(2-aminoethyl)-1,3-diamino-2-propanol, aryl substituted N-benzyl-1,4-butanediamines, and N-benzyl-1,6-hexanediamines

Journal of Inorganic Biochemistry, 2003

Synthesis, characterization, cytotoxic activity and crystal structures of tri-and di-organotin(IV... more Synthesis, characterization, cytotoxic activity and crystal structures of tri-and di-organotin(IV) complexes constructed from the b-{[(E)-1-(2hydroxyaryl)alkylidene]amino}propionate and b-{[(2Z)-(3-hydroxy-1methyl-2-butenylidene)]amino}propionate skeletons Abstract Reactions of potassium b-{[(E)-1-(2-hydroxyaryl)alkylidene]amino}propionates (L 1 HK-L 3 HK) and potassium b-{[(2Z)-(3-hydroxy-1-methyl-2-butenylidene)]amino}propionate (L 4 HK) with R These complexes have been characterized by 1 H, 13 C, 119 Sn NMR, ESI-MS, IR and 119m Sn Mö ssbauer spectroscopic techniques in combination with elemental analyses. The crystal structures of 1, 4, 5 and 6 were determined. In the solid state, compound 1 is a one-dimensional polymer built from SnPh 3 moieties bridged by single carboxylate ligands, but two alternating modes of bridging are present along the polymeric chain. Compound 4 is also a one-dimensional polymer built from SnBu 3 moieties bridged by the two carboxylate O-atoms of a single ligand, but only one mode of bridging is present. Di-n-butyltin compounds 5 and 6 are centrosymmetric tetranuclear bis(dicarboxylatotetrabutyldistannoxane) complexes containing a planar Sn 4 O 2 core in which two l 3 -oxo O-atoms connect an Sn 2 O 2 ring to two exocyclic Sn-atoms. The four carboxylate ligands display two different modes of coordination where both modes involve bridging of two Sn-atoms. The solution structures were predicted by 119 Sn NMR spectroscopy. The in vitro cytotoxic activity of compound 5 against WIDR, M19 MEL, A498, IGROV, H226, MCF7 and EVSA-T human tumor cell lines is reported.

Research paper thumbnail of Synthesis, characterization, cytotoxic activity, and cellular accumulation of dinuclear platinum complexes derived from N, N′-di-(2-aminoethyl)-1,3-diamino-2-propanol, aryl substituted N-benzyl-1,4-butanediamines, and N-benzyl-1,6-hexanediamines

Journal of Inorganic Biochemistry, 2003

Synthesis, characterization, cytotoxic activity and crystal structures of tri-and di-organotin(IV... more Synthesis, characterization, cytotoxic activity and crystal structures of tri-and di-organotin(IV) complexes constructed from the b-{[(E)-1-(2hydroxyaryl)alkylidene]amino}propionate and b-{[(2Z)-(3-hydroxy-1methyl-2-butenylidene)]amino}propionate skeletons Abstract Reactions of potassium b-{[(E)-1-(2-hydroxyaryl)alkylidene]amino}propionates (L 1 HK-L 3 HK) and potassium b-{[(2Z)-(3-hydroxy-1-methyl-2-butenylidene)]amino}propionate (L 4 HK) with R These complexes have been characterized by 1 H, 13 C, 119 Sn NMR, ESI-MS, IR and 119m Sn Mö ssbauer spectroscopic techniques in combination with elemental analyses. The crystal structures of 1, 4, 5 and 6 were determined. In the solid state, compound 1 is a one-dimensional polymer built from SnPh 3 moieties bridged by single carboxylate ligands, but two alternating modes of bridging are present along the polymeric chain. Compound 4 is also a one-dimensional polymer built from SnBu 3 moieties bridged by the two carboxylate O-atoms of a single ligand, but only one mode of bridging is present. Di-n-butyltin compounds 5 and 6 are centrosymmetric tetranuclear bis(dicarboxylatotetrabutyldistannoxane) complexes containing a planar Sn 4 O 2 core in which two l 3 -oxo O-atoms connect an Sn 2 O 2 ring to two exocyclic Sn-atoms. The four carboxylate ligands display two different modes of coordination where both modes involve bridging of two Sn-atoms. The solution structures were predicted by 119 Sn NMR spectroscopy. The in vitro cytotoxic activity of compound 5 against WIDR, M19 MEL, A498, IGROV, H226, MCF7 and EVSA-T human tumor cell lines is reported.