Eloy Rodriguez Diaz - Academia.edu (original) (raw)

Papers by Eloy Rodriguez Diaz

Actas Dermo-Sifiliográficas, 2021

Journal of the American Academy of Dermatology, 2003

Background: Annular lichenoid dermatitis of youth (ALDY) is an uncommon disease clinically remini... more Background: Annular lichenoid dermatitis of youth (ALDY) is an uncommon disease clinically reminiscent of morphea, annular erythema or mycosis fungoides. Objective: To describe the histological and clinical features of a small series of patients with ALDY and to review the literature. Patients: We describe the clinical and histological features of six patients (age range 7-79 years) with asymptomatic erythematous macules and patches with a red-brownish border and central hypopigmentation, mostly distributed on the groin and flanks. Histologically, all cases showed lichenoid dermatitis limited to the tips of rete ridges, with many intraepidermal CD8+ and some CD4+ T cells. T cell receptor rearrangement was absent in all cases. A total of 44 patients with a consistent clinical and histological picture have been described. The disease is sensitive to topical and/or systemic corticosteroids. Conclusions: ALDY is a unique lichenoid dermatitis for whose diagnosis a clinical-pathological correlation is essential. The disease typically affects young patients, more rarely adults and elderly.

The typical rash of Still disease is an asymptomatic, salmon-coloured, macular, or maculopapular ... more The typical rash of Still disease is an asymptomatic, salmon-coloured, macular, or maculopapular eruption that appears along with the fever spikes and fades when the body temperature drops. Although not included in the diagnostic criteria, there are other frequent, persistent, pruritic and polymorphic skin manifestations of Still disease that have distinctive clinical features and specific histological findings. Among these atypical persistent pruritic eruptions (PPEs), periorbital erythema and linear flagellate papules and plaques can resemble the cutaneous manifestations of dermatomyositis (DM). The presence of these lesions in adult-onset Still disease has been associated with worse prognosis and higher mortality rates, perhaps due to the development of a secondary macrophage activation syndrome (MAS). We report two cases of Still disease with persistent atypical DM-like eruption, one in a paediatric patient (a very underreported finding) and the other in an adult. Both cases developed a secondary MAS.

Dermatology online journal, 2020

Lipedematous scalp is an uncommon entity of unknown etiology, rarely described in the pediatric a... more Lipedematous scalp is an uncommon entity of unknown etiology, rarely described in the pediatric age. It is characterized by boggy thickening of the scalp predominantly located at the vertex and occiput, which acquires a cotton-like consistency. This condition is palpable rather than visible. It is a casual finding because it is usually asymptomatic, although it may involve alopecia, pruritus, or dysesthesia. We report a 10-year-old girl with lipedematous scalp without alopecia. Sonographic and MRI findings confirmed the diagnosis of lipidematous scalp. El lipedema de cuero cabelludo o cuero cabelludo lipedematoso es una entidad infrecuente y de etiología desconocida, rara vez descrita en la edad pediátrica. Se caracteriza por un engrosamiento difuso y de tacto esponjoso del tejido celular subcutáneo localizado principalmente en vértex y occipucio. Suele ser un hallazgo casual dado que habitualmente cursa de forma asintomática, aunque puede asociar alopecia, prurito o disestesias. P...

Indian Journal of Dermatology, 2021

Archivos Argentinos de Pediatria, 2019

Presentación de casos clínicos RESUMEN La morfea profunda solitaria es una forma infrecuente de m... more Presentación de casos clínicos RESUMEN La morfea profunda solitaria es una forma infrecuente de morfea localizada en la infancia. Se caracteriza clínicamente por la presencia de un área indurada, mal delimitada y asintomática, de localización paraespinal, que no tiende a la progresión ni se asocia con manifestaciones sistémicas. Histológicamente, muestra un engrosamiento e hialinización de las fibras de colágeno dérmico, junto con infiltrados de predominio linfohistiocitario en la dermis reticular y la hipodermis. Se presenta a una paciente de 7 años con una lesión solitaria en la región dorsal media izquierda, cuyos hallazgos clínicos, ecográficos e histológicos fueron compatibles con el diagnóstico de una morfea profunda solitaria.

British Journal of Dermatology, 2004

British Journal of Dermatology, 1974

Clinical and Experimental Dermatology, 2021

Mixed vascular naevus (MVN) is characterized by the co‐occurrence of telangiectatic capillary mal... more Mixed vascular naevus (MVN) is characterized by the co‐occurrence of telangiectatic capillary malformation and naevus anaemicus, which can appear as a pure cutaneous phenotype or be combined with systemic manifestations such as brain malformations, neurological abnormalities and musculoskeletal disorders. Recently, GNA11 and GNAQ somatic mutations have been reported in some patients with isolated and syndromic MVN. We report three children with MVN syndrome with generalized cutaneous manifestations and a number of systemic associations not reported to date, including ophthalmological anomalies, musculoskeletal abnormalities such as Sprengel deformity and posterior vertebral fusion anomalies, and septal heart defects. We also confirm a somatic mutation of GNA11 in both telangiectatic naevus and naevus anaemicus in two of our patients and discuss a possible common pathogenic mechanism underlying the different manifestations of the syndrome. Currently, there are no guidelines for the evaluation of patients with MVN syndrome, but according to the different known aspects of the disease, a complete clinical examination should be made, and complementary laboratory and imaging tests should be considered.

Actas Dermo-Sifiliográficas, 2019

El pioderma gangrenoso es una enfermedad inflamatoria cutánea, rápidamente evolutiva y potencialm... more El pioderma gangrenoso es una enfermedad inflamatoria cutánea, rápidamente evolutiva y potencialmente grave que se caracteriza por el desarrollo de úlceras dolorosas. Puede aparecer en ausencia de un desencadenante subyacente o asociarse a ciertas enfermedades sistémicas, siendo las más habituales las enfermedades inflamatorias intestinales y los trastornos hematológicos 1-8. El diagnóstico definitivo de esta entidad puede suponer todo un reto, ya que no existen datos clínicos, de laboratorio, ni histopatológicos específicos, por lo que este debe basarse en la exclusión de otras causas de ulceración cutánea 1,4-6. Presentamos el caso de un paciente que comenzó con una lesión ulcerosa abdominal clínicamente compatible con un pioderma gangrenoso pero cuyo estudio histopatológico imitaba a un carcinoma epidermoide cutáneo (tabla 1).

Actas Dermo-Sifiliográficas, 2018

Resumen Las ampollas secundarias al tratamiento con PUVA son un efecto secundario de la fotoquimi... more Resumen Las ampollas secundarias al tratamiento con PUVA son un efecto secundario de la fotoquimioterapia poco descrito en la literatura científica. Se caracteriza por la aparición espontánea de ampollas asintomáticas localizadas fundamentalmente en los miembros inferiores, que se resuelven sin necesidad de tratamiento. El diagnóstico diferencial debe plantearse con una reacción fototóxica, con la pseudoporfiria y con el penfigoide ampolloso inducido por PUVA. Presentamos 5 casos de ampollas secundarias a la terapia PUVA, con el objetivo de dar a conocer las características clínicas e histológicas de dicha entidad. Su correcto diagnóstico evitará la interrupción del tratamiento, así como la realización de procedimientos diagnósticos y terapéuticos innecesarios.

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2019

191 © 2019 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd. |... more 191 © 2019 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd. | JDDG | 1610-0379/2019/1702 der altersbedingt verminderten zellvermittelten Immunität zur Läsion führten [ 10 ] . Zusammenfassend beschreiben wir einen äußerst seltenen Fall der Tuberculosis cutis colliquativa mit tuberkulöser Daktylitis des kleinen Fingers. Bei Patienten, die sich mit chronischen und auf Standardtherapie nicht ansprechenden Läsionen vorstellen, sollte eine Hauttuberkulose erwogen werden, auch an selten befallenen Körperstellen.

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2018

A 74-year-old immunocompetent Spanish man was referred for evaluation of a three-year history of ... more A 74-year-old immunocompetent Spanish man was referred for evaluation of a three-year history of slightly painful acral lesions. The patient's medical history included hypertension, dyslipidemia and ischemic heart disease. On physical examination, he had multiple well-defined, purple-red, congestive and non-infiltrated macules on his palms, soles, and toes (Figure 1a-d). The cutaneous temperature was normal and distal pulses were present. He had no other constitutional symptoms and no organomegaly or lymphadenopathy was found. Histopathology of the left palm revealed anastomosing, dilated vascular spaces lined with a flattened layer of endothelial cells (Figure 2a). No atypia or mitosis was observed. These vascular spaces occupied the complete thickness of the dermis, and dissected the collagen bundles. No hemosiderin deposits were identified. Immunohistochemistry showed that tumor proliferation was positive for endothelial markers CD31 and CD34 and the lymphatic marker D2-40 (Figure 2b, c). The nuclei of endothelial cells were stained strongly by the anti-human herpesvirus 8 (HHV-8) latent nuclear antigen-1

European journal of dermatology : EJD, Oct 8, 2017