Elsmarieke van de Giessen - Profile on Academia.edu (original) (raw)
Papers by Elsmarieke van de Giessen
JS09.7.A Combination of Apparent Diffusion Coefficient and Fet Pet Compared with Standard Imaging for Quantitative Tumor Presence in Diffuse Gliomas
Neuro-Oncology, Aug 31, 2023
The effect of smoking on metabolite levels in the anterior cingulate cortex of first-episode psychosis patients – a case-control 1h-MRS study
Neuroscience Applied, Dec 31, 2022
Tau‐PET signal in Alzheimer’s disease is related to immune activation and synaptic signaling measured with CSF proteomics
Computerized decision support is an effective approach to select memory clinic patients for amyloid‐PET
Can escapees of familial AD help identify protective factors? A case report of an extremely resilient PSEN1 carrier
Alzheimer's & Dementia, Nov 30, 2023
The association between clinical, sociodemographic, familial, and environmental factors and treatment resistance in schizophrenia: A machine-learning-based approach
Schizophrenia Research, Nov 30, 2023
Genetic, vascular, and amyloid components of cerebral blood flow in a preclinical population
Journal of Cerebral Blood Flow and Metabolism, May 26, 2023
Aging-related cognitive decline can be accelerated by a combination of genetic factors, cardiovas... more Aging-related cognitive decline can be accelerated by a combination of genetic factors, cardiovascular and cerebrovascular dysfunction, and amyloid-β burden. Whereas cerebral blood flow (CBF) has been studied as a potential early biomarker of cognitive decline, its normal variability in healthy elderly is less known. In this study, we investigated the contribution of genetic, vascular, and amyloid-β components of CBF in a cognitively unimpaired (CU) population of monozygotic older twins. We included 134 participants who underwent arterial spin labeling (ASL) MRI and [18F]flutemetamol amyloid-PET imaging at baseline and after a four-year follow-up. Generalized estimating equations were used to investigate the associations of amyloid burden and white matter hyperintensities with CBF. We showed that, in CU individuals, CBF: 1) has a genetic component, as within-pair similarities in CBF values were moderate and significant (ICC > 0.40); 2) is negatively associated with cerebrovascular damage; and 3) is positively associated with the interaction between cardiovascular risk scores and early amyloid-β burden, which may reflect a vascular compensatory response of CBF to early amyloid-β accumulation. These findings encourage future studies to account for multiple interactions with CBF in disease trajectory analyses.
PET and SPECT Imaging of the Central Dopamine System in Humans
Springer eBooks, 2014
The neurotransmitter dopamine plays a role in many different functions of the human brain, rangin... more The neurotransmitter dopamine plays a role in many different functions of the human brain, ranging from psychomotor planning to cognition. This short review addresses which parts of the dopamine system can be imaged quantitatively in the living human brain using positron-emission tomography (PET) or single-photon emission computed tomography (SPECT).
Case 6: Parkinson’s Disease with Left-Sided Spasticity
Springer eBooks, Nov 11, 2021
Performance of a [18F]Flortaucipir PET Visual Read Method Across the Alzheimer Disease Continuum and in Dementia With Lewy Bodies
Neurology
Background and Objectives Recently, the US Food and Drug Administration approved the tau-binding ... more Background and Objectives Recently, the US Food and Drug Administration approved the tau-binding radiotracer [18F]flortaucipir and an accompanying visual read method to support the diagnostic process in cognitively impaired patients assessed for Alzheimer disease (AD). Studies evaluating this visual read method are limited. In this study, we evaluated the performance of the visual read method in participants along the AD continuum and dementia with Lewy bodies (DLB) by determining its reliability, accordance with semiquantitative analyses, and associations with clinically relevant variables. Methods We included participants who underwent tau-PET at Amsterdam University Medical Center. A subset underwent follow-up tau-PET. Two trained nuclear medicine physicians visually assessed all scans. Inter-reader agreement was calculated using Cohen κ. To examine the concordance of visual read tau positivity with semiquantification, we defined standardized uptake value ratio (SUVr) positivity ...
Neuromelanin MRI as biomarker for treatment resistance in first episode schizophrenia patients
ISMRM Annual Meeting
The current study assesses neuromelanin sensitive MRI (NM-MRI) as a potential biomarker for treat... more The current study assesses neuromelanin sensitive MRI (NM-MRI) as a potential biomarker for treatment resistance (TR) in first episode schizophrenia patients. NM-MRI is a novel MRI sequence, which indirectly measures dopamine synthesis. Research using positron emission tomography (PET) imaging suggest that TR patients show lower dopamine synthesis than responders. We acquired NM-MRI in 61 first episodes schizophrenia patients. Treatment response was determined during 6 months follow-up. TR patients showed significantly lower NM-MRI signal compared to responders. These findings are in line with previous PET studies and demonstrate the potential of NM-MRI as alternative and more accessible biomarker for TR.
Free‐Choice and No‐Choice High‐Fat Diets Affect Striatal Dopamine D 2/3 Receptor Availability, Caloric Intake, and Adiposity
Obesity, Aug 1, 2012
Different types of high‐fat (HF) diets are used to study diet‐induced obesity (DIO) in rodents an... more Different types of high‐fat (HF) diets are used to study diet‐induced obesity (DIO) in rodents and this has led to different phenotypes. This study assesses whether different HF diets differentially affect striatal dopamine D2/3 receptor (DRD2/3) availability, as decreased striatal DRD2/3 availability has been implicated in obesity in relation to reward deficiency for food. Thirty rats were randomized to either a free‐choice HF diet (HF‐choice), a premixed HF diet (HF‐no‐choice), or a standard chow diet for 28 days. Striatal DRD2/3 was measured using 123I‐IBZM storage phosphor imaging at day 29. DRD2/3 availability was significantly decreased in the dorsal striatum in the HF‐choice rats compared to chow rats, but not in HF‐no‐choice rats. Additionally, caloric intake of the HF‐choice rats was significantly higher than that of HF‐no‐choice rats and serum leptin and percentage abdominal fat store weight of total body weight were significantly higher in the HF‐choice rats compared to chow rats. These preliminary results suggest that the choice element in HF diets, which is possibly related to the motivational aspects of eating, leads to overconsumption and to a distinct state of obesity. These results are relevant for future studies on DIO when considering choice of diet type.
Therapeutic Advances in Psychopharmacology, 2019
Treatment resistance (TR) in psychosis is a major clinical problem. A biomarker predicting TR aga... more Treatment resistance (TR) in psychosis is a major clinical problem. A biomarker predicting TR against conventional antipsychotic drugs would be relevant, potentially reducing unnecessary delay to adequate treatment with clozapine. Dopa decarboxylase (DDC) activity in the striatum, measured with positron emission tomography, is elevated in responders, but not in treatment-resistant patients. Plasma DDC activity could be a surrogate marker for DDC brain activity, and thus a potential biomarker that could be used in daily clinical practice. Therefore, we determined plasma DDC activity in 40 male patients with recent-onset psychosis, of whom the majority had started treatment, whereby 21 turned out to be treatment responders and 19 treatment resistant during follow up. We observed no significant group differences. Furthermore, symptom severity was not associated with plasma DCC activity. We did observe a trend level difference in the distribution of plasma DDC activity across categories of medication, with subsequent post hoc analysis showing lower DDC activity in risperidone-using patients. This may suggest that risperidone could influence plasma DDC activity. Based on these results, plasma DDC activity does not appear to be a promising biomarker for TR in recent-onset psychosis patients who are already receiving antipsychotic treatment.
Striatal dopamine and nigral neuromelanin: a multimodal imaging study in schizophrenia and healthy controls
Neuroscience applied, 2023
Imaging of Genetic Variation Impacting Dopamine Transmission Parameters
Oxford University Press eBooks, Feb 1, 2016
Neurobiological aspects of obesity: dopamiNe, serotoNiN, aNd imagiNg academiscH proefscHrift ter ... more Neurobiological aspects of obesity: dopamiNe, serotoNiN, aNd imagiNg academiscH proefscHrift ter verkrijging van de graad van doctor aan de universiteit van amsterdam op gezag van de rector magnificus prof. dr. d.c. van den boom ten overstaan van een door het college voor promoties ingestelde commissie, in het openbaar te verdedigen in de agnietenkapel op woensdag 14 november 2012, te 14:00 uur door elisabeth maaike van de giessen geboren te papendrecht promotiecommissie promotores: prof. dr. J. booij prof. dr. W. van den brink co-promotores: prof. dr. f. baas dr. s.e. la fleur overige leden: prof. dr. e. derks prof. dr. b.l.f. van eck-smit prof. dr. a. Jansen prof. dr. t.J. de Vries dr. l. reneman faculteit der geneeskunde Voor Mark geNeral iNtroductioN aNd outliNe of tHesis geNeral iNtroductioN obesity obesity is a condition with an excess proportion of body fat. the most commonly used definition for obesity, as defined by the World Health organization (WHo), is a body mass index (bmi) of > 30 kg/m 2 , whereas a bmi between 25-30 kg/m 2 is defined as overweight, a bmi between 18.5-25 kg/m 2 as normal-weight, and a bmi below 18.5 kg/m 2 as underweight. in addition, the category morbid obesity has been used for people with a bmi > 40 kg/m 2. the growing obesity epidemic is a well-recognized health problem. in the united states, over 30% of the adult population is obese (1). in the Netherlands, this number has doubled from 5.3% in 1981 to 11.4% in 2011 (staline.cbs.nl). the obesity epidemic is not restricted to the Western world (2), but is also increasing in urban areas of some low-and middle-income countries (fig. 1). obesity leads to higher mortality and is a major risk factor for diabetes mellitus, cardiovascular diseases, cancers, musculoskeletal disorders, major depression and also alzheimer's disease (3;4) the cause of obesity is an energy imbalance, i.e. too much energy intake relative to energy expenditure, leading to accumulation of fat mass in the body. the rise of the availability of palatable food, usually high-caloric food rich in sugars and fat, goes hand in hand with the rise in obesity (5;6) and is considered one of the major causes. still, the question remains why some people become obese and some do not in this high-caloric environment. this is a complex problem involving amongst others genetic factors and gene-environment interactions that influence metabolic and psychological mechanisms for regulation of food intake. Elsmarieke van de Giessen Silja McIlwrick dick Veltman Wim van den Brink Jan Booij in preparation.
The substantia nigra in the pathology of schizophrenia: A review on post-mortem and molecular imaging findings
European Neuropsychopharmacology, Mar 1, 2023
Obesity an Addiction? Imaging of Neurotransmitter Systems in Obesity
Springer eBooks, 2014
The brain is important in the regulation of eating behavior and satiety signaling. There is also ... more The brain is important in the regulation of eating behavior and satiety signaling. There is also evidence that many neurotransmitters are involved in food intake regulation and eating behavior; consequently dysregulated neurotransmitter systems may be involved in the pathophysiology of obesity. This chapter presents an overview of results of neurotransmitter imaging studies in obese humans and compares the findings to the available knowledge of animal research and to the literature on addiction and eating disorders.
Blunted striatal dopamine release in cannabis dependence
Movement Disorders, Mar 15, 2022
α-Synucleinopathies form a subset of neurological disorders that include idiopathic Parkinson's d... more α-Synucleinopathies form a subset of neurological disorders that include idiopathic Parkinson's disease (PD), dementia with Lewy bodies (DLB), multiple systems atrophy (MSA), and some rare disorders, such as pure autonomic failure. 1 These disorders share unclear etiology, overlapping symptoms and pathological hallmarks. Neurological disorders are the leading cause of disability in the world, the fastest growing of which is PD surpassing even Alzheimer's disease (AD). 9 PD is also the most common type of α-synucleinopathies. The Global Burden of Disease Study in 2016 estimated that 6.1 million individuals had PD and that number is rising exponentially. 10 Aging is the greatest risk factor for PD and other α-synucleinopathies. Genetic factors also
JS09.7.A Combination of Apparent Diffusion Coefficient and Fet Pet Compared with Standard Imaging for Quantitative Tumor Presence in Diffuse Gliomas
Neuro-Oncology, Aug 31, 2023
The effect of smoking on metabolite levels in the anterior cingulate cortex of first-episode psychosis patients – a case-control 1h-MRS study
Neuroscience Applied, Dec 31, 2022
Tau‐PET signal in Alzheimer’s disease is related to immune activation and synaptic signaling measured with CSF proteomics
Computerized decision support is an effective approach to select memory clinic patients for amyloid‐PET
Can escapees of familial AD help identify protective factors? A case report of an extremely resilient PSEN1 carrier
Alzheimer's & Dementia, Nov 30, 2023
The association between clinical, sociodemographic, familial, and environmental factors and treatment resistance in schizophrenia: A machine-learning-based approach
Schizophrenia Research, Nov 30, 2023
Genetic, vascular, and amyloid components of cerebral blood flow in a preclinical population
Journal of Cerebral Blood Flow and Metabolism, May 26, 2023
Aging-related cognitive decline can be accelerated by a combination of genetic factors, cardiovas... more Aging-related cognitive decline can be accelerated by a combination of genetic factors, cardiovascular and cerebrovascular dysfunction, and amyloid-β burden. Whereas cerebral blood flow (CBF) has been studied as a potential early biomarker of cognitive decline, its normal variability in healthy elderly is less known. In this study, we investigated the contribution of genetic, vascular, and amyloid-β components of CBF in a cognitively unimpaired (CU) population of monozygotic older twins. We included 134 participants who underwent arterial spin labeling (ASL) MRI and [18F]flutemetamol amyloid-PET imaging at baseline and after a four-year follow-up. Generalized estimating equations were used to investigate the associations of amyloid burden and white matter hyperintensities with CBF. We showed that, in CU individuals, CBF: 1) has a genetic component, as within-pair similarities in CBF values were moderate and significant (ICC > 0.40); 2) is negatively associated with cerebrovascular damage; and 3) is positively associated with the interaction between cardiovascular risk scores and early amyloid-β burden, which may reflect a vascular compensatory response of CBF to early amyloid-β accumulation. These findings encourage future studies to account for multiple interactions with CBF in disease trajectory analyses.
PET and SPECT Imaging of the Central Dopamine System in Humans
Springer eBooks, 2014
The neurotransmitter dopamine plays a role in many different functions of the human brain, rangin... more The neurotransmitter dopamine plays a role in many different functions of the human brain, ranging from psychomotor planning to cognition. This short review addresses which parts of the dopamine system can be imaged quantitatively in the living human brain using positron-emission tomography (PET) or single-photon emission computed tomography (SPECT).
Case 6: Parkinson’s Disease with Left-Sided Spasticity
Springer eBooks, Nov 11, 2021
Performance of a [18F]Flortaucipir PET Visual Read Method Across the Alzheimer Disease Continuum and in Dementia With Lewy Bodies
Neurology
Background and Objectives Recently, the US Food and Drug Administration approved the tau-binding ... more Background and Objectives Recently, the US Food and Drug Administration approved the tau-binding radiotracer [18F]flortaucipir and an accompanying visual read method to support the diagnostic process in cognitively impaired patients assessed for Alzheimer disease (AD). Studies evaluating this visual read method are limited. In this study, we evaluated the performance of the visual read method in participants along the AD continuum and dementia with Lewy bodies (DLB) by determining its reliability, accordance with semiquantitative analyses, and associations with clinically relevant variables. Methods We included participants who underwent tau-PET at Amsterdam University Medical Center. A subset underwent follow-up tau-PET. Two trained nuclear medicine physicians visually assessed all scans. Inter-reader agreement was calculated using Cohen κ. To examine the concordance of visual read tau positivity with semiquantification, we defined standardized uptake value ratio (SUVr) positivity ...
Neuromelanin MRI as biomarker for treatment resistance in first episode schizophrenia patients
ISMRM Annual Meeting
The current study assesses neuromelanin sensitive MRI (NM-MRI) as a potential biomarker for treat... more The current study assesses neuromelanin sensitive MRI (NM-MRI) as a potential biomarker for treatment resistance (TR) in first episode schizophrenia patients. NM-MRI is a novel MRI sequence, which indirectly measures dopamine synthesis. Research using positron emission tomography (PET) imaging suggest that TR patients show lower dopamine synthesis than responders. We acquired NM-MRI in 61 first episodes schizophrenia patients. Treatment response was determined during 6 months follow-up. TR patients showed significantly lower NM-MRI signal compared to responders. These findings are in line with previous PET studies and demonstrate the potential of NM-MRI as alternative and more accessible biomarker for TR.
Free‐Choice and No‐Choice High‐Fat Diets Affect Striatal Dopamine D 2/3 Receptor Availability, Caloric Intake, and Adiposity
Obesity, Aug 1, 2012
Different types of high‐fat (HF) diets are used to study diet‐induced obesity (DIO) in rodents an... more Different types of high‐fat (HF) diets are used to study diet‐induced obesity (DIO) in rodents and this has led to different phenotypes. This study assesses whether different HF diets differentially affect striatal dopamine D2/3 receptor (DRD2/3) availability, as decreased striatal DRD2/3 availability has been implicated in obesity in relation to reward deficiency for food. Thirty rats were randomized to either a free‐choice HF diet (HF‐choice), a premixed HF diet (HF‐no‐choice), or a standard chow diet for 28 days. Striatal DRD2/3 was measured using 123I‐IBZM storage phosphor imaging at day 29. DRD2/3 availability was significantly decreased in the dorsal striatum in the HF‐choice rats compared to chow rats, but not in HF‐no‐choice rats. Additionally, caloric intake of the HF‐choice rats was significantly higher than that of HF‐no‐choice rats and serum leptin and percentage abdominal fat store weight of total body weight were significantly higher in the HF‐choice rats compared to chow rats. These preliminary results suggest that the choice element in HF diets, which is possibly related to the motivational aspects of eating, leads to overconsumption and to a distinct state of obesity. These results are relevant for future studies on DIO when considering choice of diet type.
Therapeutic Advances in Psychopharmacology, 2019
Treatment resistance (TR) in psychosis is a major clinical problem. A biomarker predicting TR aga... more Treatment resistance (TR) in psychosis is a major clinical problem. A biomarker predicting TR against conventional antipsychotic drugs would be relevant, potentially reducing unnecessary delay to adequate treatment with clozapine. Dopa decarboxylase (DDC) activity in the striatum, measured with positron emission tomography, is elevated in responders, but not in treatment-resistant patients. Plasma DDC activity could be a surrogate marker for DDC brain activity, and thus a potential biomarker that could be used in daily clinical practice. Therefore, we determined plasma DDC activity in 40 male patients with recent-onset psychosis, of whom the majority had started treatment, whereby 21 turned out to be treatment responders and 19 treatment resistant during follow up. We observed no significant group differences. Furthermore, symptom severity was not associated with plasma DCC activity. We did observe a trend level difference in the distribution of plasma DDC activity across categories of medication, with subsequent post hoc analysis showing lower DDC activity in risperidone-using patients. This may suggest that risperidone could influence plasma DDC activity. Based on these results, plasma DDC activity does not appear to be a promising biomarker for TR in recent-onset psychosis patients who are already receiving antipsychotic treatment.
Striatal dopamine and nigral neuromelanin: a multimodal imaging study in schizophrenia and healthy controls
Neuroscience applied, 2023
Imaging of Genetic Variation Impacting Dopamine Transmission Parameters
Oxford University Press eBooks, Feb 1, 2016
Neurobiological aspects of obesity: dopamiNe, serotoNiN, aNd imagiNg academiscH proefscHrift ter ... more Neurobiological aspects of obesity: dopamiNe, serotoNiN, aNd imagiNg academiscH proefscHrift ter verkrijging van de graad van doctor aan de universiteit van amsterdam op gezag van de rector magnificus prof. dr. d.c. van den boom ten overstaan van een door het college voor promoties ingestelde commissie, in het openbaar te verdedigen in de agnietenkapel op woensdag 14 november 2012, te 14:00 uur door elisabeth maaike van de giessen geboren te papendrecht promotiecommissie promotores: prof. dr. J. booij prof. dr. W. van den brink co-promotores: prof. dr. f. baas dr. s.e. la fleur overige leden: prof. dr. e. derks prof. dr. b.l.f. van eck-smit prof. dr. a. Jansen prof. dr. t.J. de Vries dr. l. reneman faculteit der geneeskunde Voor Mark geNeral iNtroductioN aNd outliNe of tHesis geNeral iNtroductioN obesity obesity is a condition with an excess proportion of body fat. the most commonly used definition for obesity, as defined by the World Health organization (WHo), is a body mass index (bmi) of > 30 kg/m 2 , whereas a bmi between 25-30 kg/m 2 is defined as overweight, a bmi between 18.5-25 kg/m 2 as normal-weight, and a bmi below 18.5 kg/m 2 as underweight. in addition, the category morbid obesity has been used for people with a bmi > 40 kg/m 2. the growing obesity epidemic is a well-recognized health problem. in the united states, over 30% of the adult population is obese (1). in the Netherlands, this number has doubled from 5.3% in 1981 to 11.4% in 2011 (staline.cbs.nl). the obesity epidemic is not restricted to the Western world (2), but is also increasing in urban areas of some low-and middle-income countries (fig. 1). obesity leads to higher mortality and is a major risk factor for diabetes mellitus, cardiovascular diseases, cancers, musculoskeletal disorders, major depression and also alzheimer's disease (3;4) the cause of obesity is an energy imbalance, i.e. too much energy intake relative to energy expenditure, leading to accumulation of fat mass in the body. the rise of the availability of palatable food, usually high-caloric food rich in sugars and fat, goes hand in hand with the rise in obesity (5;6) and is considered one of the major causes. still, the question remains why some people become obese and some do not in this high-caloric environment. this is a complex problem involving amongst others genetic factors and gene-environment interactions that influence metabolic and psychological mechanisms for regulation of food intake. Elsmarieke van de Giessen Silja McIlwrick dick Veltman Wim van den Brink Jan Booij in preparation.
The substantia nigra in the pathology of schizophrenia: A review on post-mortem and molecular imaging findings
European Neuropsychopharmacology, Mar 1, 2023
Obesity an Addiction? Imaging of Neurotransmitter Systems in Obesity
Springer eBooks, 2014
The brain is important in the regulation of eating behavior and satiety signaling. There is also ... more The brain is important in the regulation of eating behavior and satiety signaling. There is also evidence that many neurotransmitters are involved in food intake regulation and eating behavior; consequently dysregulated neurotransmitter systems may be involved in the pathophysiology of obesity. This chapter presents an overview of results of neurotransmitter imaging studies in obese humans and compares the findings to the available knowledge of animal research and to the literature on addiction and eating disorders.
Blunted striatal dopamine release in cannabis dependence
Movement Disorders, Mar 15, 2022
α-Synucleinopathies form a subset of neurological disorders that include idiopathic Parkinson's d... more α-Synucleinopathies form a subset of neurological disorders that include idiopathic Parkinson's disease (PD), dementia with Lewy bodies (DLB), multiple systems atrophy (MSA), and some rare disorders, such as pure autonomic failure. 1 These disorders share unclear etiology, overlapping symptoms and pathological hallmarks. Neurological disorders are the leading cause of disability in the world, the fastest growing of which is PD surpassing even Alzheimer's disease (AD). 9 PD is also the most common type of α-synucleinopathies. The Global Burden of Disease Study in 2016 estimated that 6.1 million individuals had PD and that number is rising exponentially. 10 Aging is the greatest risk factor for PD and other α-synucleinopathies. Genetic factors also