Emília Sato - Academia.edu (original) (raw)

Papers by Emília Sato

Inflammation, Dec 2, 2022

XXXIX Congresso Brasileiro de Reumatologia

IL-2, IL-5, TNF-a and IFN-c mRNA expression in epidermal keratinocytes of systemic lupus erythema... more IL-2, IL-5, TNF-a and IFN-c mRNA expression in epidermal keratinocytes of systemic lupus erythematosus skin lesions

Rev Bras Reumatol, Apr 1, 1994

A artrite reumatoide (AR) e uma doenca inflamatoria sistemica, cronica e progressiva, que se cara... more A artrite reumatoide (AR) e uma doenca inflamatoria sistemica, cronica e progressiva, que se caracteriza pelo acometimento articular e cuja etiopatogenia ainda nao esta bem esclarecida. Baseada em literatura publicada em lingua inglesa, esta revisao mostra recentes estudos sobre a possivel participacao de agentes infecciosos na etiologia e a atuacao de processos imunologicosna patogenese da AR. Resumidamente, agentes etiologicos ainda nao identificados, possivelmente infecciosos, em individuos geneticamente suscetiveis, poderiam levar ao desenvolvimento da AR atraves de alteracoes imunologicas humorais e celulares, com participacao de citocinas, metaloproteinases e proliferacao sinovial, responsaveis pela invasao e destruicao articular de modo irreversivel. O esclarecimento dos mecanismos etiopatogenicos e de fundamental importância para se tentar intervencoes terapeuticas mais eficazes

Lupus

Objectives To evaluate factors associated with COVID-19 severity outcomes in patients with system... more Objectives To evaluate factors associated with COVID-19 severity outcomes in patients with systemic lupus erythematosus (SLE). Methods This was a cross-sectional analysis of baseline data of a prospective, multi-stage cohort study—“The ReumaCoV Brazil”—designed to monitor patients with immune-mediated rheumatologic disease (IMRD) during the SARS-CoV-2 pandemic. SLE adult patients with COVID-19 were compared with those without COVID-19. SLE activity was evaluated by the patient global assessment (PGA) and SLE Disease Activity Index 2000 (SLEDAI-2K). Results 604 SLE patients were included, 317 (52.4%) with COVID-19 and 287 (47.6%) in the control group. SLE COVID-19 patients reported a lower frequency of social isolation and worked more frequently as health professionals. There was no difference in the mean SLEDAI-2K score between groups in the post–COVID-19 period (5.8 [8.6] vs. 4.5 [8.0]; p = 0.190). However, infected patients reported increased SLE activity according to the Patient ...

2 High mobility group box 1 levels in large 3 vessel vasculitis are not associated with 4 disease... more 2 High mobility group box 1 levels in large 3 vessel vasculitis are not associated with 4 disease activity but are influenced by age 5 6

Objective: To investigate the prevalence of IgM, IgG and IgA anti-phosphatidylserine (aPS) antibo... more Objective: To investigate the prevalence of IgM, IgG and IgA anti-phosphatidylserine (aPS) antibodies in patients with primary antiphospholipid syndrome (PAPS) and in healthy controls; to analyze sensitivity, and specificity of aPS antibodies for the diagnosis of APS and finally to assess associations between aPS antibodies with specific APS manifestations. Methods: A cross-sectional study was performed in 36 female PAPS patients and in 200 blood donors. IgM, IgG, and IgA antiphosphatidylserine (aPS) antibodies were tested in PAPS patients and controls using an in house technique and a commercial kit. PAPS patients were also tested for lupus anticoagulant (LAC), IgM and IgG anticardiolipin (aCL) antibodies, and for anti-β2 glycoprotein I (anti-β2GPI) antibodies. Results: The prevalence of IgM, IgG, and IgA aPS antibodies in PAPS patients was as follows: 10.8-16.7%, 32.4-35.7%, and 16.1%, respectively. Although a relatively low sensitivity was found for aPS antibodies in PAPS, the sp...

Revista Brasileira De Reumatologia, 2008

Sao Paulo Medical Journal, 2001

CONTEXT: The puerperal gestational cycle is accompanied by a state of physiological hypercoagulab... more CONTEXT: The puerperal gestational cycle is accompanied by a state of physiological hypercoagulability. Thromboembolic phenomena may occur at this time. OBJECTIVE: To report on a clinic case involving a patient that presented a family history of thromboembolism and developed deep vein thrombosis in a lower limb and vena cava thrombosis during the puerperal gestational cycle, displaying nephrotic syndrome as the main complication. DESIGN: Case report.

Rev Bras Reumatol, Jun 1, 1987

The Journal of rheumatology, 2002

To verify if endothelial function is impaired in pre-menopausal women with systemic lupus erythem... more To verify if endothelial function is impaired in pre-menopausal women with systemic lupus erythematosus (SLE) and whether endothelial dysfunction is related to disease duration, cumulative prednisone dose, antimalarial use, anticardiolipin antibody (aCL), hypertension, Raynaud's phenomenon, disease activity score, and vasculitis. Using high-resolution ultrasound, we measured the diameter of brachial artery at rest, during reactive hyperemia, and after glyceryl trinitrate (GTN). We compared 69 pre-menopausal female patients with SLE (mean age 29 +/- 8 years) with 35 age and sex-matched controls (mean age 29 +/- 6 years), The mean disease duration was 72 months. There was no significant difference in baseline brachial artery diameter. The flow-mediated dilation (endothelial dependent dilation) was significantly impaired in SLE patients when compared to controls (5.0 +/- 5.0% vs 12.0 +/- 6.0%, p < 0.001), even in the subgroup of patients without coronary artery disease risk fact...

Clinical and experimental rheumatology, 2016

OBJECTIVES The aim of this study was to evaluate the efficacy of atorvastatin to reduce the plasm... more OBJECTIVES The aim of this study was to evaluate the efficacy of atorvastatin to reduce the plasma levels of TNF system molecules (TNF-α, sTNFR1 and sTNFR2) and to assess their association with risk factors for accelerate atherosclerosis and clinical disease activity scores in SLE patients. METHODS In a previous study, 64 female SLE patients received 20 mg/day of atorvastatin and 24 SLE patients (non-treated group) were followed for 8 weeks. Plasma levels of TNF-α, sTNFR 1 and sTNFR 2 were measured by ELISA, at baseline and at the end of the study. RESULTS The plasma levels of sTNFR1 and sTNFR 2 showed a positive correlation with SLEDAI score. We also found a positive correlation between TNF-α and sTNFR 1 levels and SLICC score. Patients with current nephritis and patients with anti-ds-DNA antibodies presented higher sTNFR1 and sTNFR2 levels. Patients with abdominal obesity and arterial hypertension also had higher plasma levels of soluble receptors. At the end of 8 weeks, we observ...

BACKGROUND Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease and lupus nep... more BACKGROUND Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease and lupus nephritis (LN) is one of the main causes of morbidity and mortality in these patients. Kidney biopsy is considered the gold standard for its diagnosis and is useful for guiding therapy. On the other hand, clinical and laboratory manifestations may be related to some subtypes of histopathological classes. The objectives of this work were to evaluate the correlation between clinical and laboratory data and as histological classes of LN and to develop an instrument that can assist in the identification of the histological class in LN. METHODOLOGY A retrospective study based on analysis of medical records of 80 SLE patients who were underwent kidney biopsy between 2010 and 2017. Clinical data such as age, race, hypertension, edema, and laboratory abnormalities such as serum creatinine, urinary sediment, 24-hour proteinuria, anti-dsDNA and serum complement were collected at the time of the kidney biopsy and correlated with renal biopsy outcome. Statistical analysis: association between two categorical variables was verified by Fischer's exact test. Means were compared by analysis of variance (ANOVA). A decision tree was construct via chi-square automatic interaction detector (CHAID) and logistic regression was performed. p < 0.05 was considered significant.

Acta reumatologica portuguesa, 2009

Thoracic outlet syndrome (TOS) is defined as a set of symptoms caused by the compression of the b... more Thoracic outlet syndrome (TOS) is defined as a set of symptoms caused by the compression of the brachial plexus and subclavian vessels in the thoracic outlet region. Anomalies in musculoskeletal structures may be responsible for TOS, including prolonged transverse process of the seventh cervical vertebra, cervical rib, and first anomalous rib and clavicle fractures. The authors describe a case of a young woman with pain in the left forearm, accompanied by intermittent claudication, weigh loss, myalgias and ischemic lesions in the fingers, with no pulses and no measurable blood pressure in the left arm, who was initially diagnosed as Takayasu arteritis. The chest radiography showed accessory cervical ribs and the dynamic vascular image tests (Doppler ultra-sound and angiography) showed bilateral compression of the subclavian artery, confirming the diagnosis of TOS.

Systemic lupus erythematosus starting beyond the age of 50 years is considerate as a late onset d... more Systemic lupus erythematosus starting beyond the age of 50 years is considerate as a late onset disease, and constitutes a subgroup with some demographic, clinical and laboratory characteristics, in agreement with former studies. We performed a review searching on PubMed using key words present in the title. In this review articles published in the last ten years were included besides older ones included in the rheumatology textbooks. Since the decade of the 1960s there was the concept that late onset systemic lupus erythematosus had a benign course with less gender difference comparing to the young adult onset disease. More recent studies continue confi rming the lower predominance in female than male as compared to the younger onset disease. However, several more recent studies evaluating ethnically different populations showed that the late onset disease had worst prognosis than published previously, due to comorbidities frequent in this age group that can infl uence their health...

Blucher Medical Proceedings

BACKGROUND Dermatomyositis (DM) and polymyositis (PM) are idiopathic inflammatory myopathies (MII... more BACKGROUND Dermatomyositis (DM) and polymyositis (PM) are idiopathic inflammatory myopathies (MII) characterized by chronic inflammation affecting skeletal muscle and causing mainly proximal muscular weakness. Myostatin belongs to the TGF-β family capable to negatively regulate myoblasts proliferation during embryonic period, and, protein synthesis after this period, inhibiting hyperplasia and muscle hypertrophy. Conversely, follistatin is a glycoprotein, with myostatin antagonistic properties, stimulating proliferation of skeletal muscle fibers. There is no study evaluating the serum level of myostatin and follistatin in DM/PM patients. Objectives: To evaluate the serum level of myostatin and follistatin in DM/PM patients and controls.

BMC Public …, 2010

Background: Dermatomyositis (DM) and polymyositis (PM) are rare systemic autoimmune rheumatic dis... more Background: Dermatomyositis (DM) and polymyositis (PM) are rare systemic autoimmune rheumatic diseases with high fatality rates. There have been few population-based mortality studies of dermatomyositis and polymyositis in the world, and none have been conducted in Brazil. The objective of the present study was to employ multiplecause-of-death methodology in the analysis of trends in mortality related to dermatomyositis and polymyositis in the state of São Paulo, Brazil, between 1985 and 2007. Methods: We analyzed mortality data from the São Paulo State Data Analysis System, selecting all death certificates on which DM or PM was listed as a cause of death. The variables sex, age and underlying, associated or total mentions of causes of death were studied using mortality rates, proportions and historical trends. Statistical analysis were performed by chi-square and H Kruskal-Wallis tests, variance analysis and linear regression. A p value less than 0.05 was regarded as significant. Results: Over a 23-year period, there were 318 DM-related deaths and 316 PM-related deaths. Overall, DM/PM was designated as an underlying cause in 55.2% and as an associated cause in 44.8%; among 634 total deaths females accounted for 71.5%. During the study period, age-and gender-adjusted DM mortality rates did not change significantly, although PM as an underlying cause and total mentions of PM trended lower (p < 0.05). The mean ages at death were 47.76 ± 20.81 years for DM and 54.24 ± 17.94 years for PM (p = 0.0003). For DM/PM, respectively, as underlying causes, the principal associated causes of death were as follows: pneumonia (in 43.8%/ 33.5%); respiratory failure (in 34.4%/32.3%); interstitial pulmonary diseases and other pulmonary conditions (in 28.9%/17.6%); and septicemia (in 22.8%/15.9%). For DM/PM, respectively, as associated causes, the following were the principal underlying causes of death: respiratory disorders (in 28.3%/26.0%); circulatory disorders (in 17.4%/ 20.5%); neoplasms (in 16.7%/13.7%); infectious and parasitic diseases (in 11.6%/9.6%); and gastrointestinal disorders (in 8.0%/4.8%). Of the 318 DM-related deaths, 36 involved neoplasms, compared with 20 of the 316 PM-related deaths (p = 0.03). Conclusions: Our study using multiple cause of deaths found that DM/PM were identified as the underlying cause of death in only 55.2% of the deaths, indicating that both diseases were underestimated in the primary mortality statistics. We observed a predominance of deaths in women and in older individuals, as well as a trend toward stability in the mortality rates. We have confirmed that the risk of death is greater when either disease is accompanied by neoplasm, albeit to lesser degree in individuals with PM. The investigation of the underlying and associated causes of death related to DM/PM broaden the knowledge of the natural history of both diseases and could help integrate mortality data for use in the evaluation of control measures for DM/PM.

Takayasus's arteritis is a chronic granulomatous vasculitis involving the aorta and its main ... more Takayasus's arteritis is a chronic granulomatous vasculitis involving the aorta and its main branches. Monitoring disease activity and the choice for the best therapy has been major challenger faced by all physicians who treat these patients. Corticosteroids and immunosuppressive therapy have been used in daily medical practice, but results have not always been encouraging. Although there are no controlled studies evaluating the treatment of Takayasu's arteritis, observational studies have described the response to the use of corticosteroids, methotrexate, azathioprine and cyclophosphamide. The emerging of biological therapy has brought new perspective for Takayasu's patients who are refractory to conventional therapy.