Emanuela Gatto - Academia.edu (original) (raw)

Papers by Emanuela Gatto

Research paper thumbnail of Engineering Bioinspired Luminescent Probes: Antimicrobial Peptides Chelating Lanthanide Ions

Peptides …, 2007

Gatto, E., Stella, L., Bocchinfuso, G., Palleschi, A., Palleschi, ME, Formaggio, F., et al. (2007... more Gatto, E., Stella, L., Bocchinfuso, G., Palleschi, A., Palleschi, ME, Formaggio, F., et al. (2007). Engineering Bioinspired Luminescent Probes: Antimicrobial Peptides Chelating Lanthanide Ions. In PRK Rolka (a cura di), Peptides 2006 (pp. 96-97). EPS.

Research paper thumbnail of A Molecular Dynamics Simulation Study on the Self-Association Propensity of Aib HOMO-Peptides of different Main-Chain Length

Research paper thumbnail of Effect of Peptide Aggregation and Membrane-water Partition on Antimicrobial Activity: A Lesson Learned from Spectroscopic Studies

Stella, L., Bocchinfuso, G., Gatto, E., Mazzuca, C., Palleschi, A., Pispisa, B., et al. (2007). E... more Stella, L., Bocchinfuso, G., Gatto, E., Mazzuca, C., Palleschi, A., Pispisa, B., et al. (2007). Effect of Peptide Aggregation and Membrane-water Partition on Antimicrobial Activity: A Lesson Learned from Spectroscopic Studies.. Paper presented at The 7th International Symposium on ...

Research paper thumbnail of From photovoltaics to antimicrobial activity: 15 years of optical spectroscopy, theoretical conformational analysis and passion on peptide foldamers

... Analysis and Passion on Peptide Foldamers Gianfranco Bocchinfuso, Emanuela Gatto, Claudia Maz... more ... Analysis and Passion on Peptide Foldamers Gianfranco Bocchinfuso, Emanuela Gatto, Claudia Mazzuca, Antonio Palleschi, Lorenzo Stella, and Mariano Venanzi Dip. ... 2008, 14, 184-191 [14] E. Gatto, M. Caruso, A. Porchetta, C. Toniolo, F. Formaggio, M. Crisma, M. Venanzi, J ...

Research paper thumbnail of CCDC 1049918: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Research paper thumbnail of Formulation matters! A spectroscopic and molecular dynamics investigation on the peptide CIGB552 as itself and in its therapeutical formulation

Journal of Peptide Science, 2021

Synthetic therapeutic peptides (STP) are intensively studied as new‐generation drugs, characteriz... more Synthetic therapeutic peptides (STP) are intensively studied as new‐generation drugs, characterized by high purity, biocompatibility, selectivity and stereochemical control. However, most of the studies are focussed on the bioactivity of STP without considering how the formulation actually used for therapy administration could alter the physico‐chemical properties of the active principle. The aggregation properties of a 20‐mer STP (Ac‐His‐Ala‐Arg‐Ile‐Lys‐D‐Pro‐Thr‐Phe‐Arg‐Arg‐D‐Leu‐Lys‐Trp‐Lys‐Tyr‐Lys‐Gly‐Lys‐Phe‐Trp‐NH2), showing antitumor activity, were investigated by optical spectroscopy and atomic force microscopy imaging, as itself (CIGB552) and in its therapeutic formulation (CIGB552TF). It has found that the therapeutic formulation deeply affects the aggregation properties of the investigated peptide and the morphology of the aggregates formed on mica by deposition of CIGB552 and CIGB552TF millimolar solutions. Molecular dynamics simulations studied the first steps of CIGB55...

Research paper thumbnail of Tuning the self-association of an Ala-Based Homo-Pentapetide with a Single, Internal Aib Residue

Research paper thumbnail of Aggregation properties of a therapeutic peptide for rheumatoid arthritis: A spectroscopic and molecular dynamics study

Research paper thumbnail of KuQuinones: a new class of quinoid compounds as photoactive species on ITO

Journal of Materials Chemistry C, 2016

KuQuinones deposited on ITO surface by Langmuir–Blodgett technique acted as photosensitizers, giv... more KuQuinones deposited on ITO surface by Langmuir–Blodgett technique acted as photosensitizers, giving interesting results due to their pentacyclic, highly conjugated structure, and a very low reduction potential.

Research paper thumbnail of A bioinspired dye sensitized solar cell based on a rhodamine-functionalized peptide immobilized on nanocrystalline TiO 2

Journal of Photochemistry and Photobiology A: Chemistry, 2017

A dodecapeptide (AMRKLPDAPGMH) functionalized with a tetramethylrhodamine (TAMRA) chromophore at ... more A dodecapeptide (AMRKLPDAPGMH) functionalized with a tetramethylrhodamine (TAMRA) chromophore at the N-terminus was immobilized on nanocrystalline TiO 2. The optical and binding properties of the peptide layer immobilized on the titania surface were characterized by UV-vis absorption, steadystate fluorescence and X-ray photoelectron spectroscopies. Circular Dichroism experiments and Molecular Mechanics calculations showed that the predominant conformation populated by the peptide scaffold brings Arg3, Lys4 and Asp7 in the correct position for linking the TiO 2 surface. Photocurrent generation experiments were therefore carried out to determine the photon-to-current conversion efficiency (IPCE) of a Grätzel-like Dye Sensitized Solar Cell (DSSC), the photoactive unit of which is formed by TAMRA-AMRKLPDAPGMH/TiO 2. The measured IPCE amounted to 0.65%, a value that is definitely low, but superior to those previously reported for similar bioinspired DSSCs. This result can be ascribed to the light-harvesting properties of the TAMRA chromophore and to the unique structural properties of the peptide spacer.

Research paper thumbnail of Are Two Better Than One? A New Approach for Multidentate Grafting of Peptides to a Gold Substrate

Zeitschrift für Physikalische Chemie, 2016

Multidentate binding of two helical hexapeptides to a gold surface was obtained by introducing in... more Multidentate binding of two helical hexapeptides to a gold surface was obtained by introducing in the peptide chain a non ribosomial amino acid, i.e. the 4-amino-1,2-dithiolane-4-carboxylic acid (Adt) residue, a C

Research paper thumbnail of Deposition of Tetraferrocenylporphyrins on ITO surface for photo-catalytic O2 activation

Dalton Trans., 2016

Tetraferrocenylporphyrins have been successfully deposited on ITO electrodes for O2 photo-catalyt... more Tetraferrocenylporphyrins have been successfully deposited on ITO electrodes for O2 photo-catalytic activation.

Research paper thumbnail of The Electrochemistry of Peptide Self-Assembled Monolayers

Handbook of Nanoelectrochemistry, 2015

Research paper thumbnail of Porphyrins as Active Components for Electrochemical and Photoelectrochemical Devices

Handbook of Porphyrin Science, 2014

Research paper thumbnail of Photocurrent Generation in a photosensitive polypeptide mimicking Elastin

Research paper thumbnail of With Applications to Chemistry, Physics, Materials Science, Engineering, Biology and Medicine Volume 33: Applications—Part II

Research paper thumbnail of Peptide self-assembled monolayers as a new tool for nanotechnology

Research paper thumbnail of Trichogin GA IV is able to bind Ca (II) and lanthanide ions

Research paper thumbnail of Structure, Dynamics and Bioactivity of Synthetic Analogues of the Antimicrobial Peptide Trichodecenin I RID E-9014-2011 RID A-7996-2010

Research paper thumbnail of Aggregation propensity of Aib homo‐peptides of different length: an insight from molecular dynamics simulations

Journal of Peptide Science, 2014

Interactions between peptides are relevant from a biomedical point of view, in particular for the... more Interactions between peptides are relevant from a biomedical point of view, in particular for the role played by their aggregates in different important pathologies, and also because peptide aggregates represent promising scaffolds for innovative materials.In the present article, the aggregation properties of the homo‐peptides formed by α‐aminoisobutyric acid (U) residues are discussed. The peptides investigated have chain lengths between six and 15 residues and comprise benzyl and naphthyl groups at the N‐ and C‐termini, respectively. Spectroscopic experiments and molecular dynamics simulations show that the shortest homo‐peptide, constituted by six U, does not exhibit any tendency to aggregate under the conditions examined. On the other hand, the homologous peptide with 15 U forms very stable and compact aggregates in 70/30(v/v) methanol/water solution. Atomic force microscopy images indicate that these aggregates promote formation of long fibrils once they are deposited on a mica...

Research paper thumbnail of Engineering Bioinspired Luminescent Probes: Antimicrobial Peptides Chelating Lanthanide Ions

Peptides …, 2007

Gatto, E., Stella, L., Bocchinfuso, G., Palleschi, A., Palleschi, ME, Formaggio, F., et al. (2007... more Gatto, E., Stella, L., Bocchinfuso, G., Palleschi, A., Palleschi, ME, Formaggio, F., et al. (2007). Engineering Bioinspired Luminescent Probes: Antimicrobial Peptides Chelating Lanthanide Ions. In PRK Rolka (a cura di), Peptides 2006 (pp. 96-97). EPS.

Research paper thumbnail of A Molecular Dynamics Simulation Study on the Self-Association Propensity of Aib HOMO-Peptides of different Main-Chain Length

Research paper thumbnail of Effect of Peptide Aggregation and Membrane-water Partition on Antimicrobial Activity: A Lesson Learned from Spectroscopic Studies

Stella, L., Bocchinfuso, G., Gatto, E., Mazzuca, C., Palleschi, A., Pispisa, B., et al. (2007). E... more Stella, L., Bocchinfuso, G., Gatto, E., Mazzuca, C., Palleschi, A., Pispisa, B., et al. (2007). Effect of Peptide Aggregation and Membrane-water Partition on Antimicrobial Activity: A Lesson Learned from Spectroscopic Studies.. Paper presented at The 7th International Symposium on ...

Research paper thumbnail of From photovoltaics to antimicrobial activity: 15 years of optical spectroscopy, theoretical conformational analysis and passion on peptide foldamers

... Analysis and Passion on Peptide Foldamers Gianfranco Bocchinfuso, Emanuela Gatto, Claudia Maz... more ... Analysis and Passion on Peptide Foldamers Gianfranco Bocchinfuso, Emanuela Gatto, Claudia Mazzuca, Antonio Palleschi, Lorenzo Stella, and Mariano Venanzi Dip. ... 2008, 14, 184-191 [14] E. Gatto, M. Caruso, A. Porchetta, C. Toniolo, F. Formaggio, M. Crisma, M. Venanzi, J ...

Research paper thumbnail of CCDC 1049918: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Research paper thumbnail of Formulation matters! A spectroscopic and molecular dynamics investigation on the peptide CIGB552 as itself and in its therapeutical formulation

Journal of Peptide Science, 2021

Synthetic therapeutic peptides (STP) are intensively studied as new‐generation drugs, characteriz... more Synthetic therapeutic peptides (STP) are intensively studied as new‐generation drugs, characterized by high purity, biocompatibility, selectivity and stereochemical control. However, most of the studies are focussed on the bioactivity of STP without considering how the formulation actually used for therapy administration could alter the physico‐chemical properties of the active principle. The aggregation properties of a 20‐mer STP (Ac‐His‐Ala‐Arg‐Ile‐Lys‐D‐Pro‐Thr‐Phe‐Arg‐Arg‐D‐Leu‐Lys‐Trp‐Lys‐Tyr‐Lys‐Gly‐Lys‐Phe‐Trp‐NH2), showing antitumor activity, were investigated by optical spectroscopy and atomic force microscopy imaging, as itself (CIGB552) and in its therapeutic formulation (CIGB552TF). It has found that the therapeutic formulation deeply affects the aggregation properties of the investigated peptide and the morphology of the aggregates formed on mica by deposition of CIGB552 and CIGB552TF millimolar solutions. Molecular dynamics simulations studied the first steps of CIGB55...

Research paper thumbnail of Tuning the self-association of an Ala-Based Homo-Pentapetide with a Single, Internal Aib Residue

Research paper thumbnail of Aggregation properties of a therapeutic peptide for rheumatoid arthritis: A spectroscopic and molecular dynamics study

Research paper thumbnail of KuQuinones: a new class of quinoid compounds as photoactive species on ITO

Journal of Materials Chemistry C, 2016

KuQuinones deposited on ITO surface by Langmuir–Blodgett technique acted as photosensitizers, giv... more KuQuinones deposited on ITO surface by Langmuir–Blodgett technique acted as photosensitizers, giving interesting results due to their pentacyclic, highly conjugated structure, and a very low reduction potential.

Research paper thumbnail of A bioinspired dye sensitized solar cell based on a rhodamine-functionalized peptide immobilized on nanocrystalline TiO 2

Journal of Photochemistry and Photobiology A: Chemistry, 2017

A dodecapeptide (AMRKLPDAPGMH) functionalized with a tetramethylrhodamine (TAMRA) chromophore at ... more A dodecapeptide (AMRKLPDAPGMH) functionalized with a tetramethylrhodamine (TAMRA) chromophore at the N-terminus was immobilized on nanocrystalline TiO 2. The optical and binding properties of the peptide layer immobilized on the titania surface were characterized by UV-vis absorption, steadystate fluorescence and X-ray photoelectron spectroscopies. Circular Dichroism experiments and Molecular Mechanics calculations showed that the predominant conformation populated by the peptide scaffold brings Arg3, Lys4 and Asp7 in the correct position for linking the TiO 2 surface. Photocurrent generation experiments were therefore carried out to determine the photon-to-current conversion efficiency (IPCE) of a Grätzel-like Dye Sensitized Solar Cell (DSSC), the photoactive unit of which is formed by TAMRA-AMRKLPDAPGMH/TiO 2. The measured IPCE amounted to 0.65%, a value that is definitely low, but superior to those previously reported for similar bioinspired DSSCs. This result can be ascribed to the light-harvesting properties of the TAMRA chromophore and to the unique structural properties of the peptide spacer.

Research paper thumbnail of Are Two Better Than One? A New Approach for Multidentate Grafting of Peptides to a Gold Substrate

Zeitschrift für Physikalische Chemie, 2016

Multidentate binding of two helical hexapeptides to a gold surface was obtained by introducing in... more Multidentate binding of two helical hexapeptides to a gold surface was obtained by introducing in the peptide chain a non ribosomial amino acid, i.e. the 4-amino-1,2-dithiolane-4-carboxylic acid (Adt) residue, a C

Research paper thumbnail of Deposition of Tetraferrocenylporphyrins on ITO surface for photo-catalytic O2 activation

Dalton Trans., 2016

Tetraferrocenylporphyrins have been successfully deposited on ITO electrodes for O2 photo-catalyt... more Tetraferrocenylporphyrins have been successfully deposited on ITO electrodes for O2 photo-catalytic activation.

Research paper thumbnail of The Electrochemistry of Peptide Self-Assembled Monolayers

Handbook of Nanoelectrochemistry, 2015

Research paper thumbnail of Porphyrins as Active Components for Electrochemical and Photoelectrochemical Devices

Handbook of Porphyrin Science, 2014

Research paper thumbnail of Photocurrent Generation in a photosensitive polypeptide mimicking Elastin

Research paper thumbnail of With Applications to Chemistry, Physics, Materials Science, Engineering, Biology and Medicine Volume 33: Applications—Part II

Research paper thumbnail of Peptide self-assembled monolayers as a new tool for nanotechnology

Research paper thumbnail of Trichogin GA IV is able to bind Ca (II) and lanthanide ions

Research paper thumbnail of Structure, Dynamics and Bioactivity of Synthetic Analogues of the Antimicrobial Peptide Trichodecenin I RID E-9014-2011 RID A-7996-2010

Research paper thumbnail of Aggregation propensity of Aib homo‐peptides of different length: an insight from molecular dynamics simulations

Journal of Peptide Science, 2014

Interactions between peptides are relevant from a biomedical point of view, in particular for the... more Interactions between peptides are relevant from a biomedical point of view, in particular for the role played by their aggregates in different important pathologies, and also because peptide aggregates represent promising scaffolds for innovative materials.In the present article, the aggregation properties of the homo‐peptides formed by α‐aminoisobutyric acid (U) residues are discussed. The peptides investigated have chain lengths between six and 15 residues and comprise benzyl and naphthyl groups at the N‐ and C‐termini, respectively. Spectroscopic experiments and molecular dynamics simulations show that the shortest homo‐peptide, constituted by six U, does not exhibit any tendency to aggregate under the conditions examined. On the other hand, the homologous peptide with 15 U forms very stable and compact aggregates in 70/30(v/v) methanol/water solution. Atomic force microscopy images indicate that these aggregates promote formation of long fibrils once they are deposited on a mica...