Emiliya Nosova - Academia.edu (original) (raw)
Papers by Emiliya Nosova
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
AIP Conference Proceedings, 2020
Mendeleev Communications, 2018
Chemistry of Heterocyclic Compounds, 2019
We have developed an efficient synthetic approach to potential antibacterial agents with double m... more We have developed an efficient synthetic approach to potential antibacterial agents with double mechanism of action through the combination of antibacterial fluoroquinolones with 1,3-benzothiazin-4-ones.
Mini-Reviews in Medicinal Chemistry, 2019
Tuberculosis (TB) takes the second place among the reasons for mortality from infectious diseases... more Tuberculosis (TB) takes the second place among the reasons for mortality from infectious diseases. For this reason, the problem of tuberculosis treatment requires urgent attention all over the world. Some 2-amino substituted 1,3-benzothiazin-4-ones (2-amino-1,3-BTZs) represent a promising new class of antitubercular agents. Other 1,3-benzothiazin-4-one derivatives, mostly 2-aryl and 2- (pyridin-2-yl) ones, are attractive due to their ability to suppress oxidative stress-induced cardiomyocyte apoptosis. This review covers the synthetic approaches to 2-amino- and 2-aryl(heteryl) substituted 1,3-benzothiazin-4-ones (1,3-BTZs). A brief overview of structure-activity relationships is presented.
Russian Chemical Reviews, 2019
Currently, the chemistry of organofluorine compounds is a leading and rapidly developing area of ... more Currently, the chemistry of organofluorine compounds is a leading and rapidly developing area of organic chemistry. Fluorine present in a molecule largely determines its specific chemical and biological properties. This thematic issue covers the trends of organofluorine chemistry that have been actively developed in Russia the last 15 – 20 years. The review describes nucleophilic substitution and heterocyclization reactions involving fluorinated arenes and quinones and skeletal cationoid rearrangements in the polyfluoroarene series. The transformations involving CF3-substituted carbocations and radical cations are considered. Heterocyclization and oxidative addition reactions of trifluoroacetamide derivatives and transformations of the organic moiety in polyfluorinated organoboranes and borates with retention of the carbon – boron bond are discussed. Particular attention is devoted to catalytic olefination using freons as an efficient synthetic route to fluorinated compounds. The ap...
Journal of Fluorine Chemistry, 2019
Interaction of o-fluorobenzoyl isothiocyanates with cycloalkylimines was studied Synthesis of... more Interaction of o-fluorobenzoyl isothiocyanates with cycloalkylimines was studied Synthesis of novel 5-fluoro-and 6,7,8-trifluoro-1,3-benzothiazin-4-ones was developed X-ray data for 6,7,8-trifluoro-2-(thiomorpholin-4-yl)-1,3-benzothiazin-4-one were obtained Fluorinated benzothiazinones exhibit a good level of antimycobacterial activity
Russian Journal of General Chemistry, 2014
ABSTRACT Novel Zn(II) complexes with 2-styryl-8-hydroxyquinoline were synthesized and characteriz... more ABSTRACT Novel Zn(II) complexes with 2-styryl-8-hydroxyquinoline were synthesized and characterized by H-1, F-19, and C-13 NMR spectroscopy and X-ray diffraction analysis. Photoluminescence properties of the ligands and complexes in solutions were studied. The effect of substituents in the quinoline and phenylethenyl fragments on spectral characteristics was discussed.
International Journal of Organic Chemistry, 2012
Novel 3-phenyl/pyridinyl-trans-2-(aryl/heteryl)vinyl-3H-quinazolin-4-ones 3a,b, 4a, 5a, 7a and th... more Novel 3-phenyl/pyridinyl-trans-2-(aryl/heteryl)vinyl-3H-quinazolin-4-ones 3a,b, 4a, 5a, 7a and their 6,7-difluoro derivatives 3c,d, 4b, 5b, 7b have been obtained by condensation of the correspondent 2-methylquinazolin-4-ones 1, 6 with aromatic (heterocyclic) aldehydes in the presence of ZnCl 2 (AcONa) or by the reaction of 2-methyl-3,1-benzoxazin-4ones 2 with the Shiff bases. Effects of aryl(heteryl) substituents on photophysical properties of (aryl/heteryl) quinazolinylethenes have been studied.
![Research paper thumbnail of ChemInform Abstract: Synthesis of Fluorinated 1,3,4-Oxadiazino[6,5,4-i,j]quinolines](https://attachments.academia-assets.com/100883018/thumbnails/1.jpg)
](ChemInform, 2010
(R)-l-fluoro-3-[(4-methylpheny@ulfinyl]-2-propanone (1) reacts with diazomethane tiording Q-2-(fl... more (R)-l-fluoro-3-[(4-methylpheny@ulfinyl]-2-propanone (1) reacts with diazomethane tiording Q-2-(fluoromethyl)-2-{ [(R)-(4-m&ylphenyl)sul6nyl]methyl}oxirane (2) as the main product. The influence of reaction wnditions (solvent temperature) on the chemo-and stereoselectivity has been studied. Several elaborations of 2, including reactions on the chiral auxiliary and opening of the oxirane ring by carbon nitrogen, oxygen, phosphorus and halogen nucleophiles. are described. Full structural elucidation of the products is provided.
![Research paper thumbnail of Fluoro-containing Heterocycles: VI. New Derivatives of 1,3,4-Thiadiazino[6,5,4-i,j]quinoline](https://attachments.academia-assets.com/100883029/thumbnails/1.jpg)
](A series of new tricyclic fluoroquinolones was prepared by replacing fluorine atoms in derivative... more A series of new tricyclic fluoroquinolones was prepared by replacing fluorine atoms in derivatives of 2-R-8-Y-7-oxo-9,10-difluoro-7H-1,3,4-thiadiazino[6,5,4-i,j]quinoline-6-carboxylic acids. In acids and esters containing a hydrogen atom in position 8 occurred replacement of F 10 by amine rests, and in compounds with a fluorine in position 8 was substituted either F 8 or F 10 and F 8 depending on the amine character. 1 H NMR spectrum, d, ppm, coupling constant, Hz ³ 19 F NMR spectrum, d F , ppm,
![Research paper thumbnail of Aryne approach towards 2,3-difluoro-10-(1H-1,2,3-triazol-1-yl)pyrido[1,2-a]indoles](https://attachments.academia-assets.com/100882973/thumbnails/1.jpg)
](Mendeleev Communications, 2015
ChemInform, 2005
Organic chemistry Z 0200 Cyclization of 2-Halobenzoyl Chlorides with Dinucleophiles as a Versatil... more Organic chemistry Z 0200 Cyclization of 2-Halobenzoyl Chlorides with Dinucleophiles as a Versatile Approach to Fused Heterocycles-[about 103 refs.].-(NOSOVA, E. V.;
Fluorine in Heterocyclic Chemistry Volume 2, 2014
The data on the chemistry of fluorinated quinolines available in the literature of the last 10–15... more The data on the chemistry of fluorinated quinolines available in the literature of the last 10–15 years are presented. A variety of synthetic methods exploiting cyclization and cycloaddition reactions, displacements of halogen atoms or the diaza group, as well as direct fluorinations have been considered. Novel approaches to functionalization of polyfluorinated quinolines, including nucleophilic displacement of fluorine atoms, cross-coupling reactions, and synthesis on the basis of organometallic compounds are discussed. Selected representative examples of fluoroquinolines exhibiting a remarkable biological activity or those quinolines which have already found their applications in medicine will also be discussed in the text. The bibliography – 158 references.
Russian Journal of Organic Chemistry, 2011
trans-2-Styryl-substituted 3H-, 3-phenyl-, and 3-naphthylquinazolin-4-ones and their 6,7-difluoro... more trans-2-Styryl-substituted 3H-, 3-phenyl-, and 3-naphthylquinazolin-4-ones and their 6,7-difluoro derivatives were synthesized by condensation of appropriate 2-methylquinazolin-4-ones with aromatic aldehydes or by the transformation of the heterocycle of 2-methyl-3,1-benzoxazin-4-one under the action of benzylidenephenylamines.
Russian Chemical Reviews, 2011
Methods for the synthesis of styrylazines and Methods for the synthesis of styrylazines and styry... more Methods for the synthesis of styrylazines and Methods for the synthesis of styrylazines and styrylbenzazines are considered, their photophysical and styrylbenzazines are considered, their photophysical and photochemical properties are analyzed. The review covers photochemical properties are analyzed. The review covers both published data and own works of the authors. Impor-both published data and own works of the authors. Important data on the prospects of application of arylhetaryl-tant data on the prospects of application of arylhetarylethenes as components of electroluminescence materials are ethenes as components of electroluminescence materials are discussed. The bibliography includes 124 references discussed. The bibliography includes 124 references. .
Russian Chemical Reviews, 2009
ABSTRACT Convenient methods for the synthesis of fluorine-containing quinazolines and their oxa a... more ABSTRACT Convenient methods for the synthesis of fluorine-containing quinazolines and their oxa and thia analogues are considered. Data on the prospects for using these compounds in medicine are given. Bibliography — 129 references.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
AIP Conference Proceedings, 2020
Mendeleev Communications, 2018
Chemistry of Heterocyclic Compounds, 2019
We have developed an efficient synthetic approach to potential antibacterial agents with double m... more We have developed an efficient synthetic approach to potential antibacterial agents with double mechanism of action through the combination of antibacterial fluoroquinolones with 1,3-benzothiazin-4-ones.
Mini-Reviews in Medicinal Chemistry, 2019
Tuberculosis (TB) takes the second place among the reasons for mortality from infectious diseases... more Tuberculosis (TB) takes the second place among the reasons for mortality from infectious diseases. For this reason, the problem of tuberculosis treatment requires urgent attention all over the world. Some 2-amino substituted 1,3-benzothiazin-4-ones (2-amino-1,3-BTZs) represent a promising new class of antitubercular agents. Other 1,3-benzothiazin-4-one derivatives, mostly 2-aryl and 2- (pyridin-2-yl) ones, are attractive due to their ability to suppress oxidative stress-induced cardiomyocyte apoptosis. This review covers the synthetic approaches to 2-amino- and 2-aryl(heteryl) substituted 1,3-benzothiazin-4-ones (1,3-BTZs). A brief overview of structure-activity relationships is presented.
Russian Chemical Reviews, 2019
Currently, the chemistry of organofluorine compounds is a leading and rapidly developing area of ... more Currently, the chemistry of organofluorine compounds is a leading and rapidly developing area of organic chemistry. Fluorine present in a molecule largely determines its specific chemical and biological properties. This thematic issue covers the trends of organofluorine chemistry that have been actively developed in Russia the last 15 – 20 years. The review describes nucleophilic substitution and heterocyclization reactions involving fluorinated arenes and quinones and skeletal cationoid rearrangements in the polyfluoroarene series. The transformations involving CF3-substituted carbocations and radical cations are considered. Heterocyclization and oxidative addition reactions of trifluoroacetamide derivatives and transformations of the organic moiety in polyfluorinated organoboranes and borates with retention of the carbon – boron bond are discussed. Particular attention is devoted to catalytic olefination using freons as an efficient synthetic route to fluorinated compounds. The ap...
Journal of Fluorine Chemistry, 2019
Interaction of o-fluorobenzoyl isothiocyanates with cycloalkylimines was studied Synthesis of... more Interaction of o-fluorobenzoyl isothiocyanates with cycloalkylimines was studied Synthesis of novel 5-fluoro-and 6,7,8-trifluoro-1,3-benzothiazin-4-ones was developed X-ray data for 6,7,8-trifluoro-2-(thiomorpholin-4-yl)-1,3-benzothiazin-4-one were obtained Fluorinated benzothiazinones exhibit a good level of antimycobacterial activity
Russian Journal of General Chemistry, 2014
ABSTRACT Novel Zn(II) complexes with 2-styryl-8-hydroxyquinoline were synthesized and characteriz... more ABSTRACT Novel Zn(II) complexes with 2-styryl-8-hydroxyquinoline were synthesized and characterized by H-1, F-19, and C-13 NMR spectroscopy and X-ray diffraction analysis. Photoluminescence properties of the ligands and complexes in solutions were studied. The effect of substituents in the quinoline and phenylethenyl fragments on spectral characteristics was discussed.
International Journal of Organic Chemistry, 2012
Novel 3-phenyl/pyridinyl-trans-2-(aryl/heteryl)vinyl-3H-quinazolin-4-ones 3a,b, 4a, 5a, 7a and th... more Novel 3-phenyl/pyridinyl-trans-2-(aryl/heteryl)vinyl-3H-quinazolin-4-ones 3a,b, 4a, 5a, 7a and their 6,7-difluoro derivatives 3c,d, 4b, 5b, 7b have been obtained by condensation of the correspondent 2-methylquinazolin-4-ones 1, 6 with aromatic (heterocyclic) aldehydes in the presence of ZnCl 2 (AcONa) or by the reaction of 2-methyl-3,1-benzoxazin-4ones 2 with the Shiff bases. Effects of aryl(heteryl) substituents on photophysical properties of (aryl/heteryl) quinazolinylethenes have been studied.
ChemInform, 2010
(R)-l-fluoro-3-[(4-methylpheny@ulfinyl]-2-propanone (1) reacts with diazomethane tiording Q-2-(fl... more (R)-l-fluoro-3-[(4-methylpheny@ulfinyl]-2-propanone (1) reacts with diazomethane tiording Q-2-(fluoromethyl)-2-{ [(R)-(4-m&ylphenyl)sul6nyl]methyl}oxirane (2) as the main product. The influence of reaction wnditions (solvent temperature) on the chemo-and stereoselectivity has been studied. Several elaborations of 2, including reactions on the chiral auxiliary and opening of the oxirane ring by carbon nitrogen, oxygen, phosphorus and halogen nucleophiles. are described. Full structural elucidation of the products is provided.
A series of new tricyclic fluoroquinolones was prepared by replacing fluorine atoms in derivative... more A series of new tricyclic fluoroquinolones was prepared by replacing fluorine atoms in derivatives of 2-R-8-Y-7-oxo-9,10-difluoro-7H-1,3,4-thiadiazino[6,5,4-i,j]quinoline-6-carboxylic acids. In acids and esters containing a hydrogen atom in position 8 occurred replacement of F 10 by amine rests, and in compounds with a fluorine in position 8 was substituted either F 8 or F 10 and F 8 depending on the amine character. 1 H NMR spectrum, d, ppm, coupling constant, Hz ³ 19 F NMR spectrum, d F , ppm,
Mendeleev Communications, 2015
ChemInform, 2005
Organic chemistry Z 0200 Cyclization of 2-Halobenzoyl Chlorides with Dinucleophiles as a Versatil... more Organic chemistry Z 0200 Cyclization of 2-Halobenzoyl Chlorides with Dinucleophiles as a Versatile Approach to Fused Heterocycles-[about 103 refs.].-(NOSOVA, E. V.;
Fluorine in Heterocyclic Chemistry Volume 2, 2014
The data on the chemistry of fluorinated quinolines available in the literature of the last 10–15... more The data on the chemistry of fluorinated quinolines available in the literature of the last 10–15 years are presented. A variety of synthetic methods exploiting cyclization and cycloaddition reactions, displacements of halogen atoms or the diaza group, as well as direct fluorinations have been considered. Novel approaches to functionalization of polyfluorinated quinolines, including nucleophilic displacement of fluorine atoms, cross-coupling reactions, and synthesis on the basis of organometallic compounds are discussed. Selected representative examples of fluoroquinolines exhibiting a remarkable biological activity or those quinolines which have already found their applications in medicine will also be discussed in the text. The bibliography – 158 references.
Russian Journal of Organic Chemistry, 2011
trans-2-Styryl-substituted 3H-, 3-phenyl-, and 3-naphthylquinazolin-4-ones and their 6,7-difluoro... more trans-2-Styryl-substituted 3H-, 3-phenyl-, and 3-naphthylquinazolin-4-ones and their 6,7-difluoro derivatives were synthesized by condensation of appropriate 2-methylquinazolin-4-ones with aromatic aldehydes or by the transformation of the heterocycle of 2-methyl-3,1-benzoxazin-4-one under the action of benzylidenephenylamines.
Russian Chemical Reviews, 2011
Methods for the synthesis of styrylazines and Methods for the synthesis of styrylazines and styry... more Methods for the synthesis of styrylazines and Methods for the synthesis of styrylazines and styrylbenzazines are considered, their photophysical and styrylbenzazines are considered, their photophysical and photochemical properties are analyzed. The review covers photochemical properties are analyzed. The review covers both published data and own works of the authors. Impor-both published data and own works of the authors. Important data on the prospects of application of arylhetaryl-tant data on the prospects of application of arylhetarylethenes as components of electroluminescence materials are ethenes as components of electroluminescence materials are discussed. The bibliography includes 124 references discussed. The bibliography includes 124 references. .
Russian Chemical Reviews, 2009
ABSTRACT Convenient methods for the synthesis of fluorine-containing quinazolines and their oxa a... more ABSTRACT Convenient methods for the synthesis of fluorine-containing quinazolines and their oxa and thia analogues are considered. Data on the prospects for using these compounds in medicine are given. Bibliography — 129 references.