Emily Kakande - Academia.edu (original) (raw)
Papers by Emily Kakande
European Archives of Oto-Rhino-Laryngology, 2019
Recalcitrant chronic rhinosinusitis is a persistent inflammatory condition of the sinonasal mucos... more Recalcitrant chronic rhinosinusitis is a persistent inflammatory condition of the sinonasal mucosa despite adequate medical therapy and sinus surgery. This study aimed to demonstrate the effectiveness and safety of dilute povidone-iodine (PVP-I) sinonasal rinses as an adjunctive therapy. Prospective cohort study. Twenty-nine recalcitrant CRS patients with endoscopic evidence of ongoing inflammation and purulent discharge were prescribed 0.08% diluted PVP-I rinses. Changes to endoscopic modified Lund–Kennedy (MLK) scores at 7 weeks post-PVP-I rinsing served as the primary outcome measure. The median MLK-discharge score significantly decreased in all patients by 1.50 points post-PVP-I rinsing (p value < 0.01). The total MLK score significantly decreased in all patients by 1.50 points (p value = 0.01). Up to a 17% reduction in serum inflammatory markers was measured post-PVP-I rinsing. Sinonasal culture revealed a shift from moderate–heavy growth to lighter bacterial growth overall....
International Journal of Clinical Case Reports, 2014
is an international, open access, peer reviewed journal published online by BioPublisher. The jou... more is an international, open access, peer reviewed journal published online by BioPublisher. The journal is considering all the latest and outstanding research articles, letters and reviews in all aspects of clinical case, containing clinical medicine which advance general medical knowledge; the event in the course of observing or treating a patient; new variations in disease processes; as well as the expands the field of clinical relating to case reports. International Journal of Clinical Case Reports is committed to publishing and disseminating all the latest and outstanding research articles, letters and reviews in all areas of clinical case research, including clinical medicine, clinical events, as well as the related field.
Pathology
Vascular endothelial growth factor (VEGF) plays a critical role in tumor angiogenesis. VEGF and i... more Vascular endothelial growth factor (VEGF) plays a critical role in tumor angiogenesis. VEGF and its receptor FLT-1 signaling may contribute to cell migration of macrophages, osteoclasts and some tumor cells. However, the direct role of VEGF-Flt-1 signaling in malignant behaviors of oral squamous cell carcinoma (OSCC) is not well understood. To clarify the effects of VEGF-Flt-1 signaling in OSCC bone invasion, VEGF expression in OSCC cells and number of Flt-1+ osteoclasts at bone invasion front in 55 gingival OSCC cases were evaluated by immunohistochemistry. Twenty-four of 55 cases (43.63%) strongly expressed VEGF. The VEGF highly expressing cases were statistically correlated with the increased number of Flt-1+ osteoclasts and the more aggressive radiographic pattern of bone invasion (p < 0.001). Proliferation, migration and invasion assays were examined in HSC2 (high Flt-1 expressing) and Ho1N1 (no Flt-1 expressing) cells. Flt-1 specific ligand-placental growth factor (PlGF) in...
International Journal of Pediatric Otorhinolaryngology, 2014
Autism is a pervasive and complex developmental disorder characterized by impaired social interac... more Autism is a pervasive and complex developmental disorder characterized by impaired social interaction, atypical communication and restricted, repetitive and stereotypical patterns of behaviours, activities and interests [1]. Individuals with autism differ markedly in the number and severity of symptoms displayed [2]. Typical signs of autism include, but are not limited to; speech and language delay, regression of developmental milestones at 18-24 months of age, avoidance of eye contact, tactile defensiveness and engagement in repetitive and self-stimulating behaviours. See Table 1 in Egelhoff et al. [2] for a more comprehensive list. Approximately 80% of children with autism have some degree of cognitive impairment [3]. Autism is currently classified as a spectrum disorder, which includes autistic disorder, Asperger's disorder, Rett's disorder, childhood disintegrative disorder and pervasive developmental disorder not otherwise specified [4]. Prevalence estimates of autism spectrum disorder (ASD) are controversial. A review by
African Health Sciences, 2016
Hearing impairment is a significant disability. According to the World Health Organization (WHO),... more Hearing impairment is a significant disability. According to the World Health Organization (WHO), more than 80% of the world's approximately 120 million people with hearing impairment live in developing countries. Cochlear implant is the only therapeutic intervention for those with severe-profound sensorineural hearing loss. We are reporting an interesting case of the very first cochlear implant operation carried out in Uganda. The patient was a 23 year old male whose presenting complaint was inability to hear in the left ear for three and a half years and in the right ear for one year. He had been treated for TB(Tuberculosis) mastoiditis. After the 8 months of treatment, the otorrhea persisted and he underwent a tympanomastoidectomy on the same ear. He reported no familial history of hearing loss. On examination, ENT examination revealed a small pars flaccida retration pocket of the right tympanic membrane with cholesteatoma. The left ear had an intact tympanic membrane. Pure tone audiometry revealed profound sensorineural hearing loss in both ears(see attached PTA results), CT scan of the temporal bone showed normal inner ear anatomy bilaterally and mild sclerotic changes in both mastoid bones. He then had surgery on his right ear which included cochlear implantation. The cochlear implant (CI) was activated on the first postoperative day remotely via internet with the help of the cochlear implant team at New York University Cochlear Implant Center and the patient was immediately able to appreciate some sounds. He received a pneumococcal vaccine on the first postoperative day and was discharged the following day.
Background: A case-control was carried out to study the prevalence, the pattern and associated fa... more Background: A case-control was carried out to study the prevalence, the pattern and associated factors of hearing loss among Ugandan children with sickle cell anemia.
Methods: One hundred and thirty-two children known sickle cell and one hundred thirty aged matched non-SCA controls were recruited after medical ethics committee approval and informed consent. Two obtain information on socio-demographic characteristics, history, and examination of the participants, a structured questionnaire was administered. Pure tone audiometry (PTA) was used to assess the hearing in a sound-treated room.
Results: Twenty-two of the children had hearing impairment compared to 6 controls. Prevalence of hearing loss found among children with SCA was 17% but in the control group the prevalence found was 5%. Sensorineural hearing loss (SNHL) affected 39%, conductive (CHL) 25% and mixed (MHL) 14% among cases compared to CHL 7%, SNHL 7% and MHL 7% among the controls. The hearing loss varied from mild to moderate (95%). All sickle cell children had high-frequency hearing loss. There was a statistically significant association of hearing loss and neurologic motor deficit.
Conclusions: Sickle patients are at risk of developing hearing loss as the study demonstrated a difference in hearing threshold in children living with sickle cell anemia and the controls. High frequencies were more affected. The neurologic motor deficit was highly associated with hearing loss among patients with SCA compared to controls.
European Archives of Oto-Rhino-Laryngology, 2019
Recalcitrant chronic rhinosinusitis is a persistent inflammatory condition of the sinonasal mucos... more Recalcitrant chronic rhinosinusitis is a persistent inflammatory condition of the sinonasal mucosa despite adequate medical therapy and sinus surgery. This study aimed to demonstrate the effectiveness and safety of dilute povidone-iodine (PVP-I) sinonasal rinses as an adjunctive therapy. Prospective cohort study. Twenty-nine recalcitrant CRS patients with endoscopic evidence of ongoing inflammation and purulent discharge were prescribed 0.08% diluted PVP-I rinses. Changes to endoscopic modified Lund–Kennedy (MLK) scores at 7 weeks post-PVP-I rinsing served as the primary outcome measure. The median MLK-discharge score significantly decreased in all patients by 1.50 points post-PVP-I rinsing (p value < 0.01). The total MLK score significantly decreased in all patients by 1.50 points (p value = 0.01). Up to a 17% reduction in serum inflammatory markers was measured post-PVP-I rinsing. Sinonasal culture revealed a shift from moderate–heavy growth to lighter bacterial growth overall....
International Journal of Clinical Case Reports, 2014
is an international, open access, peer reviewed journal published online by BioPublisher. The jou... more is an international, open access, peer reviewed journal published online by BioPublisher. The journal is considering all the latest and outstanding research articles, letters and reviews in all aspects of clinical case, containing clinical medicine which advance general medical knowledge; the event in the course of observing or treating a patient; new variations in disease processes; as well as the expands the field of clinical relating to case reports. International Journal of Clinical Case Reports is committed to publishing and disseminating all the latest and outstanding research articles, letters and reviews in all areas of clinical case research, including clinical medicine, clinical events, as well as the related field.
Pathology
Vascular endothelial growth factor (VEGF) plays a critical role in tumor angiogenesis. VEGF and i... more Vascular endothelial growth factor (VEGF) plays a critical role in tumor angiogenesis. VEGF and its receptor FLT-1 signaling may contribute to cell migration of macrophages, osteoclasts and some tumor cells. However, the direct role of VEGF-Flt-1 signaling in malignant behaviors of oral squamous cell carcinoma (OSCC) is not well understood. To clarify the effects of VEGF-Flt-1 signaling in OSCC bone invasion, VEGF expression in OSCC cells and number of Flt-1+ osteoclasts at bone invasion front in 55 gingival OSCC cases were evaluated by immunohistochemistry. Twenty-four of 55 cases (43.63%) strongly expressed VEGF. The VEGF highly expressing cases were statistically correlated with the increased number of Flt-1+ osteoclasts and the more aggressive radiographic pattern of bone invasion (p < 0.001). Proliferation, migration and invasion assays were examined in HSC2 (high Flt-1 expressing) and Ho1N1 (no Flt-1 expressing) cells. Flt-1 specific ligand-placental growth factor (PlGF) in...
International Journal of Pediatric Otorhinolaryngology, 2014
Autism is a pervasive and complex developmental disorder characterized by impaired social interac... more Autism is a pervasive and complex developmental disorder characterized by impaired social interaction, atypical communication and restricted, repetitive and stereotypical patterns of behaviours, activities and interests [1]. Individuals with autism differ markedly in the number and severity of symptoms displayed [2]. Typical signs of autism include, but are not limited to; speech and language delay, regression of developmental milestones at 18-24 months of age, avoidance of eye contact, tactile defensiveness and engagement in repetitive and self-stimulating behaviours. See Table 1 in Egelhoff et al. [2] for a more comprehensive list. Approximately 80% of children with autism have some degree of cognitive impairment [3]. Autism is currently classified as a spectrum disorder, which includes autistic disorder, Asperger's disorder, Rett's disorder, childhood disintegrative disorder and pervasive developmental disorder not otherwise specified [4]. Prevalence estimates of autism spectrum disorder (ASD) are controversial. A review by
African Health Sciences, 2016
Hearing impairment is a significant disability. According to the World Health Organization (WHO),... more Hearing impairment is a significant disability. According to the World Health Organization (WHO), more than 80% of the world's approximately 120 million people with hearing impairment live in developing countries. Cochlear implant is the only therapeutic intervention for those with severe-profound sensorineural hearing loss. We are reporting an interesting case of the very first cochlear implant operation carried out in Uganda. The patient was a 23 year old male whose presenting complaint was inability to hear in the left ear for three and a half years and in the right ear for one year. He had been treated for TB(Tuberculosis) mastoiditis. After the 8 months of treatment, the otorrhea persisted and he underwent a tympanomastoidectomy on the same ear. He reported no familial history of hearing loss. On examination, ENT examination revealed a small pars flaccida retration pocket of the right tympanic membrane with cholesteatoma. The left ear had an intact tympanic membrane. Pure tone audiometry revealed profound sensorineural hearing loss in both ears(see attached PTA results), CT scan of the temporal bone showed normal inner ear anatomy bilaterally and mild sclerotic changes in both mastoid bones. He then had surgery on his right ear which included cochlear implantation. The cochlear implant (CI) was activated on the first postoperative day remotely via internet with the help of the cochlear implant team at New York University Cochlear Implant Center and the patient was immediately able to appreciate some sounds. He received a pneumococcal vaccine on the first postoperative day and was discharged the following day.
Background: A case-control was carried out to study the prevalence, the pattern and associated fa... more Background: A case-control was carried out to study the prevalence, the pattern and associated factors of hearing loss among Ugandan children with sickle cell anemia.
Methods: One hundred and thirty-two children known sickle cell and one hundred thirty aged matched non-SCA controls were recruited after medical ethics committee approval and informed consent. Two obtain information on socio-demographic characteristics, history, and examination of the participants, a structured questionnaire was administered. Pure tone audiometry (PTA) was used to assess the hearing in a sound-treated room.
Results: Twenty-two of the children had hearing impairment compared to 6 controls. Prevalence of hearing loss found among children with SCA was 17% but in the control group the prevalence found was 5%. Sensorineural hearing loss (SNHL) affected 39%, conductive (CHL) 25% and mixed (MHL) 14% among cases compared to CHL 7%, SNHL 7% and MHL 7% among the controls. The hearing loss varied from mild to moderate (95%). All sickle cell children had high-frequency hearing loss. There was a statistically significant association of hearing loss and neurologic motor deficit.
Conclusions: Sickle patients are at risk of developing hearing loss as the study demonstrated a difference in hearing threshold in children living with sickle cell anemia and the controls. High frequencies were more affected. The neurologic motor deficit was highly associated with hearing loss among patients with SCA compared to controls.