Emir Karacaglar - Academia.edu (original) (raw)
Papers by Emir Karacaglar
The Eurasian Journal of Medicine
Objective: AF may create confusion about the presence of severe or unstable coronary artery disea... more Objective: AF may create confusion about the presence of severe or unstable coronary artery disease in cases with unstable symptoms. Novel scores and markers are needed to determine severe coronary artery disease in such patients. We aimed to test the newly developed CHA 2 DS 2-VASc-FSH score, developed by adding family history for coronary artery disease, hyperlipidemia, and smoking to the original CHA 2 DS 2-VASc score, in the prediction of severe CAD in patients with AF and unstable symptoms. Materials and Methods: We retrospectively analyzed 72 patients presenting to Başkent Universtiy School of Medicine Hospital between April 2011 and January 2016. The CHA 2 DS 2 VASc-FSH score was assessed for the prediction of severe CAD. Results: Seventy-two patients aged 65.7±11.2 years were enrolled. Thirty-five (48.6%) patients had severe CAD and 11 (15.3%) had unstable CAD. patients with severe coronary artery disease had a significantly greater CHA 2 DS 2 VASC-FSH score (5 (1-8) vs 3(0-7); p<0.05). The CHA 2 DS 2 VASC-FSH score independently predicted severe CAD, with a CHA 2 DS 2 VASc-FSH score of 3 or greater having a sensitivity of 77.1% and a specificity of 56.8% for severe CAD. Conclusion: Among patients with AF and unstable symptoms, the CHA 2 DS 2 VASc-FSH score independently predicts severe CAD.
Saudi Journal of Kidney Diseases and Transplantation
European Journal of Therapeutics
Objective: Breast cancer is the most common cancer in women. Trastuzumab is an effective breast c... more Objective: Breast cancer is the most common cancer in women. Trastuzumab is an effective breast cancer agent. The most significant side effect of trastuzumab is left ventricular systolic dysfunction. Selvester score calculated from 12-lead electrocardiography (ECG) has a proven accuracy in predicting left ventricular infarct area and scar volume. We aimed to determine its role in detection of left ventricular systolic dysfunction among trastuzumab-treated breast cancer patients. Methods: A total of 60 trastuzumab-treated patients were retrospectively included. The patients were grouped into two groups with trastuzumab-induced left ventricular systolic dysfunction (left ventricular ejection fraction (LVEF) <55%) (Group 1) and without (Group 2). The left ventricular systolic dysfunction group was divided into two subgroups: LVEF <50% and (Group 1a) and LVEF 50-54% (Group 1b). The Selvester score was compared between Group 1 and Group 2, and between Group 1a, Group 1b, and Group 2. The predictive role of Selvester score in trastuzumab-induced left ventricular systolic dysfunction was determined with univariate and multivariate analysis. Results: The mean age of the patients was 56.7±13.7 years. Twenty (21.1%) patients had trastuzumab-induced left ventricular systolic dysfunction. The Selvester score was similar between Group 1 and Group 2. Group 1a had a significantly greater Selvester score compared to Group 1b and Group 2 (p<0.05); however, Group 1b and Group 2 had similar Selvester scores (p>0.05). The Selvester score was significantly correlated with left ventricular systolic dysfunction in univariate analysis (r=0.189, p<0.05) but not in multivariate analysis. Conclusion: Selvester score may be useful especially for detecting severe trastuzumab-induced left ventricular systolic dysfunction.
Trends Journal of Sciences Research
Background: Coronary stents are commonly used to treat obstructive coronary artery disease. It is... more Background: Coronary stents are commonly used to treat obstructive coronary artery disease. It is currently difficult to reliably predict in-stent restenosis. The aim of this study was to examine the relationship between bare metal stent restenosis and red cell distribution width (RDW), neutrophil/lymphocyte ratio (N/L ratio). It was the first study that used a control group with a normal coronary angiogram. Methods: We enrolled patients who underwent coronary angiography between June 2012 and September 2013 in our center. We enrolled a cohort of 210 consecutive patients, of which 130 had a coronary artery stent and 80 had a normal coronary angiogram. Results: The mean age of the study group was 62 (38-86) years. The mean RDW levels of patient group with no-restenosis were significantly higher than the control group but there was no significant difference between the mean RDW levels of the restenosis group and the other subgroups (14.9 (11.7-17.6), 15.5 (10.9-20.4), 15.4 (11.7-20.1), respectively). N/L ratio was significantly higher in patients with stent restenosis 2.32(1.49-5.35) compared to the other two groups whereas there was no significant difference between the control group and non-restenosis group with respect to N/L ratio. (1.71(0.84-7.89), and 2.09(0.89-9.15), respectively). Conclusions: According to our findings, RDW was not a predictor of stent restenosis or coronary artery disease. On the other hand, our findings support the hypothesis that N/L ratio is an indicator of inflammation that plays a role in-stent restenosis.
The American Journal of Cardiology
Acta Cardiologica
Osteopontin is a component of atherosclerotic lesions, secreted by monocytes, macrophages and end... more Osteopontin is a component of atherosclerotic lesions, secreted by monocytes, macrophages and endothelial and vascular smooth muscle cells, which together are responsible for neointimal proliferation. We examined whether elevated plasma osteopontin concentration was associated with in-stent restenosis in patients with coronary artery disease. We enrolled 91 patients who underwent coronary artery stenting, and 60 control patients with normal findings on coronary angiography, between June 2012 and September 2013. For patients with stents, we measured plasma osteopontin concentration at the first follow-up coronary angiogram. For controls, plasma osteopontin concentration was measured at the time of angiography. Of the 91 patients who had undergone coronary artery stenting, 31 (34.1%) had developed in-stent restenosis and the mean time passed to control coronary angiography was 36.7 months (±SD 35.1 months). Mean plasma osteopontin concentration in this group was 2721.4 ± 1787.8 pg/ml, significantly higher than the 60 patients (65.9%) with no in-stent restenosis (1770.4 ± 1208.2 pg/ml, p = .011) and the 60 patients with a normal coronary angiogram (1572.4 ± 904.8 pg/ml, p = .002). There was no significant difference in mean osteopontin concentration between the patients with no in-stent restenosis and the control group (p = .312). Elevated plasma osteopontin concentration is associated with in-stent stenosis in patients with coronary artery disease. Further studies will be needed to establish whether osteopontin can predict in-stent restenosis and guide clinical management strategies.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2017
Liver transplant is a high-risk surgery for cardiac events. The risk of 30-day major cardiac adve... more Liver transplant is a high-risk surgery for cardiac events. The risk of 30-day major cardiac adverse events is estimated at more than 5%. In this retrospective study, we evaluated our preoperative cardiac risk assessment approach. We evaluated 58 adult patients who underwent liver transplant between May 2011 and May 2015. Preoperative cardiac risk factors and results of diagnostic tests were noted. Patients were divided into 2 groups: patients with or without hepatocellular carcinoma. Electrocardiogram, echocardiogram, and treadmill tests were performed for preoperative cardiac evaluation in all candidates for liver transplant. Results of these tests showed our preference for myocardial perfusion scintigraphy and/or coronary angiography and heart catheterization. Mean age of patients was 46.5 ± 14.5 years. The most common cardiovascular risk factor was family history of coronary artery disease (24.1%) in all patients. Diabetes mellitus (15.5%) was the most common risk factor in the ...
PLOS ONE, 2016
Background This study aimed to explore the ST segment elevation myocardial infarction (STEMI) man... more Background This study aimed to explore the ST segment elevation myocardial infarction (STEMI) management practices of emergency medicine specialists working in various healthcare institutions of seven different geographical regions of Turkey, and to examine the characteristics of STEMI presentation and patient admissions in these regions.
Acta Cardiologica Sinica, 2015
In this study, we aimed to evaluate the effects of niacin on high sensitivity C reactive protein ... more In this study, we aimed to evaluate the effects of niacin on high sensitivity C reactive protein (hs-CRP) and cholesterol levels in non-ST elevated acute coronary syndrome (NSTE-ACS) patients. In this prospective, open label study, 48 NSTE-ACS were randomized to niacin or control group. Patients continued their optimal medical therapy in the control group. In the niacin group patients were assigned to receive extended-release niacin 500 mg/day. Patients were contacted 1 month later to assess compliance and side effects. Blood samples for hs-CRP were obtained upon admittance to the coronary care unit, in the third day and in the first month of the treatment. Fasting blood samples for cholesterol levels were obtained before and 30 days after the treatment. The primary end point of the study was to evaluate changes in hs-CRP, cholesterol levels, short-term cardiovascular events, and the safety of niacin in NSTE-ACS. Baseline demographic, clinical and laboratory characteristics were sim...
Anatolian journal of cardiology, Jan 28, 2016
Atherosclerotic cardiovascular disease is a major global cause of death. The common approach in p... more Atherosclerotic cardiovascular disease is a major global cause of death. The common approach in primary prevention of cardiovascular disease is to identify patients at high risk for cardiovascular disease. This article analyzes and compares the application of 2013 American College of Cardiology/American Heart Association (ACC/AHA) guideline and the 2011 European Society of Cardiology (ESC) guideline for the management of dyslipidemias for primary prevention in Turkish population. The study included 833 patients (482 women and 351 men). Risk scores were calculated according to both guidelines and indications for statin treatment were determined according to sex and age group. Variables are presented as mean±SD or median with interquartile range for continuous data and as proportions for categorical data. Variables were analyzed by unpaired t-test, Mann-Whitney U test, chi-square or Fischer's exact test as appropriate. The ACC/AHA would suggest statin treatment in 415 patients out...
Int J Cardiol, 2010
subclassified into two as those without any negative event (n=26) on follow up and those with ren... more subclassified into two as those without any negative event (n=26) on follow up and those with renarrowing of the mitral valve area (<1.5 cm 2) or rePMBV or referral to valvular surgery (n=37) on follow up. The mean age, gender, body mass index, heart rate, NYHA class, estimated GFR, hemoglobin value, LV EF, MVA, mean mitral gradient, MPAP, Wilkins score, presence of hypertension, smoking, atrial fibrillation before PMBV and LV EF, heart rate after follow up are similar between two groups. In patients in the with event group, mitral peak gradient (21.2±4.7 vs 18.5±3.2 mmHg, p=0.009), SPAP before PMBV (54.2±14.1 mmHg vs 48.1±11.6, p=0.07), NYHA class (1.8±0.5 vs 1.4±0.5, p=0.02), peak (14.4±3.7 vs 9±2.5 mmHg, p<0.001) and mean mitral gradient (6.7±2.3 vs 4.4±1 mmHg, p<0.001), MPAP (20.1±6.8 vs 14.7±5.5 mmHg, p=0.001), SPAP (39.4±9.7 vs 31.1±4.5 mmHg, p<0.001), PVR (2.5±0.6 vs 2.1±0.6 Wood unit, p=0.015), right atrial area after follow up (17.6±5.2 vs 14.7±4.7 cm 2 , p=0.03) were higher and MVA (1.4±0.2 vs 1.8±0.1 cm 2 , p<0.001), tissue Doppler RV S velocity after follow up (11.6±3.4 vs 13.7±2.5 cm/sn, p=0.01), percent improvement in MVA acute phase (55.8±23.7% vs 80±24.1%, p<0.001) and after follow up (31.4±20.9% vs 61.9±22.9%, p<0.001) were lower than those without any negative event. Conclusions: Concerning long term follow up data of patients undergoing PMBV in a single center, it seems hemodynamics influence outcomes negatively whereas valvular characteristics do not.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2015
Hematologic parameters, such as mean platelet volume, red-cell distribution width, and neutrophil... more Hematologic parameters, such as mean platelet volume, red-cell distribution width, and neutrophil-to-lymphocyte ratio, have prognostic value in multiple cardiac conditions such as stable angina pectoris, acute coronary syndromes, and heart failure. However, no previous studies have evaluated the association between hematologic parameters and asymptomatic graft rejection after heart transplant. We evaluated the role of hematologic parameters for detecting asymptomatic graft rejection after heart transplant. We retrospectively evaluated medical records of 47 adult patients who underwent orthotopic heart transplant between February 25, 2005, and July 6, 2014, in our hospital, noting their hematologic parameters before each biopsy. Two groups were created according to biopsy results: rejection and no-rejection. We excluded 4 patients who died during the first month posttransplant owing to early complications. We evaluated 422 endomyocardial biopsy results of 43 adult patients (mean age,...
Atherosclerosis Supplements, 2008
Publication Only drogenase, total cholesterol, triglycerides, low density lipoprotein levels in s... more Publication Only drogenase, total cholesterol, triglycerides, low density lipoprotein levels in serum and lipid peroxides levels in heart homogenates were observed with a concomitant decrease in myocardial glutathione and serum high density lipoprotein levels in pathogenic control rats as compared to vehicle control rats. Furthermore, aqueous Embelia ribes extract (100 and 200 mg/kg, 30 days) treatment significantly reversed all the above mentioned parameters in dose dependant manner as compared to pathogenic control rats. The results of test drug were comparable to folic acid (100 mg/kg), a standard antihyperhomocysteinemic agent. Conclusion: Aqueous Embelia ribes extract has significant antihyperhomocysteinemic and lipid lowering potential in methionine-induced hyperhomocysteinemia in albino rats.
Atherosclerosis Supplements, 2007
Atherosclerosis Supplements, 2007
Atherosclerosis Supplements, 2008
Balkan medical journal, 2012
Left ventricular diverticulum is a rare congenital malformation consisting of a localized protrus... more Left ventricular diverticulum is a rare congenital malformation consisting of a localized protrusion of the endocardium and myocardium from the free wall of the left ventricle (LV). The prevalence of the disease is 0.26% in nonselected patients who underwent cardiac catheterization. It is believed that the etiology is an intrinsic abnormality developing during embryogenesis. It often does not cause any symptoms. We report a case of isolated left ventricular diverticulum with complaints of transient ischemic attack.
European Journal of Echocardiography, 2011
Echocardiographic measurements alone do not provide accurate non-invasive selection of annuloplas... more Echocardiographic measurements alone do not provide accurate non-invasive selection of annuloplasty band size for robotic mitral valve repair.
Sakarya Medical Journal, 2014
The Eurasian Journal of Medicine
Objective: AF may create confusion about the presence of severe or unstable coronary artery disea... more Objective: AF may create confusion about the presence of severe or unstable coronary artery disease in cases with unstable symptoms. Novel scores and markers are needed to determine severe coronary artery disease in such patients. We aimed to test the newly developed CHA 2 DS 2-VASc-FSH score, developed by adding family history for coronary artery disease, hyperlipidemia, and smoking to the original CHA 2 DS 2-VASc score, in the prediction of severe CAD in patients with AF and unstable symptoms. Materials and Methods: We retrospectively analyzed 72 patients presenting to Başkent Universtiy School of Medicine Hospital between April 2011 and January 2016. The CHA 2 DS 2 VASc-FSH score was assessed for the prediction of severe CAD. Results: Seventy-two patients aged 65.7±11.2 years were enrolled. Thirty-five (48.6%) patients had severe CAD and 11 (15.3%) had unstable CAD. patients with severe coronary artery disease had a significantly greater CHA 2 DS 2 VASC-FSH score (5 (1-8) vs 3(0-7); p<0.05). The CHA 2 DS 2 VASC-FSH score independently predicted severe CAD, with a CHA 2 DS 2 VASc-FSH score of 3 or greater having a sensitivity of 77.1% and a specificity of 56.8% for severe CAD. Conclusion: Among patients with AF and unstable symptoms, the CHA 2 DS 2 VASc-FSH score independently predicts severe CAD.
Saudi Journal of Kidney Diseases and Transplantation
European Journal of Therapeutics
Objective: Breast cancer is the most common cancer in women. Trastuzumab is an effective breast c... more Objective: Breast cancer is the most common cancer in women. Trastuzumab is an effective breast cancer agent. The most significant side effect of trastuzumab is left ventricular systolic dysfunction. Selvester score calculated from 12-lead electrocardiography (ECG) has a proven accuracy in predicting left ventricular infarct area and scar volume. We aimed to determine its role in detection of left ventricular systolic dysfunction among trastuzumab-treated breast cancer patients. Methods: A total of 60 trastuzumab-treated patients were retrospectively included. The patients were grouped into two groups with trastuzumab-induced left ventricular systolic dysfunction (left ventricular ejection fraction (LVEF) <55%) (Group 1) and without (Group 2). The left ventricular systolic dysfunction group was divided into two subgroups: LVEF <50% and (Group 1a) and LVEF 50-54% (Group 1b). The Selvester score was compared between Group 1 and Group 2, and between Group 1a, Group 1b, and Group 2. The predictive role of Selvester score in trastuzumab-induced left ventricular systolic dysfunction was determined with univariate and multivariate analysis. Results: The mean age of the patients was 56.7±13.7 years. Twenty (21.1%) patients had trastuzumab-induced left ventricular systolic dysfunction. The Selvester score was similar between Group 1 and Group 2. Group 1a had a significantly greater Selvester score compared to Group 1b and Group 2 (p<0.05); however, Group 1b and Group 2 had similar Selvester scores (p>0.05). The Selvester score was significantly correlated with left ventricular systolic dysfunction in univariate analysis (r=0.189, p<0.05) but not in multivariate analysis. Conclusion: Selvester score may be useful especially for detecting severe trastuzumab-induced left ventricular systolic dysfunction.
Trends Journal of Sciences Research
Background: Coronary stents are commonly used to treat obstructive coronary artery disease. It is... more Background: Coronary stents are commonly used to treat obstructive coronary artery disease. It is currently difficult to reliably predict in-stent restenosis. The aim of this study was to examine the relationship between bare metal stent restenosis and red cell distribution width (RDW), neutrophil/lymphocyte ratio (N/L ratio). It was the first study that used a control group with a normal coronary angiogram. Methods: We enrolled patients who underwent coronary angiography between June 2012 and September 2013 in our center. We enrolled a cohort of 210 consecutive patients, of which 130 had a coronary artery stent and 80 had a normal coronary angiogram. Results: The mean age of the study group was 62 (38-86) years. The mean RDW levels of patient group with no-restenosis were significantly higher than the control group but there was no significant difference between the mean RDW levels of the restenosis group and the other subgroups (14.9 (11.7-17.6), 15.5 (10.9-20.4), 15.4 (11.7-20.1), respectively). N/L ratio was significantly higher in patients with stent restenosis 2.32(1.49-5.35) compared to the other two groups whereas there was no significant difference between the control group and non-restenosis group with respect to N/L ratio. (1.71(0.84-7.89), and 2.09(0.89-9.15), respectively). Conclusions: According to our findings, RDW was not a predictor of stent restenosis or coronary artery disease. On the other hand, our findings support the hypothesis that N/L ratio is an indicator of inflammation that plays a role in-stent restenosis.
The American Journal of Cardiology
Acta Cardiologica
Osteopontin is a component of atherosclerotic lesions, secreted by monocytes, macrophages and end... more Osteopontin is a component of atherosclerotic lesions, secreted by monocytes, macrophages and endothelial and vascular smooth muscle cells, which together are responsible for neointimal proliferation. We examined whether elevated plasma osteopontin concentration was associated with in-stent restenosis in patients with coronary artery disease. We enrolled 91 patients who underwent coronary artery stenting, and 60 control patients with normal findings on coronary angiography, between June 2012 and September 2013. For patients with stents, we measured plasma osteopontin concentration at the first follow-up coronary angiogram. For controls, plasma osteopontin concentration was measured at the time of angiography. Of the 91 patients who had undergone coronary artery stenting, 31 (34.1%) had developed in-stent restenosis and the mean time passed to control coronary angiography was 36.7 months (±SD 35.1 months). Mean plasma osteopontin concentration in this group was 2721.4 ± 1787.8 pg/ml, significantly higher than the 60 patients (65.9%) with no in-stent restenosis (1770.4 ± 1208.2 pg/ml, p = .011) and the 60 patients with a normal coronary angiogram (1572.4 ± 904.8 pg/ml, p = .002). There was no significant difference in mean osteopontin concentration between the patients with no in-stent restenosis and the control group (p = .312). Elevated plasma osteopontin concentration is associated with in-stent stenosis in patients with coronary artery disease. Further studies will be needed to establish whether osteopontin can predict in-stent restenosis and guide clinical management strategies.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2017
Liver transplant is a high-risk surgery for cardiac events. The risk of 30-day major cardiac adve... more Liver transplant is a high-risk surgery for cardiac events. The risk of 30-day major cardiac adverse events is estimated at more than 5%. In this retrospective study, we evaluated our preoperative cardiac risk assessment approach. We evaluated 58 adult patients who underwent liver transplant between May 2011 and May 2015. Preoperative cardiac risk factors and results of diagnostic tests were noted. Patients were divided into 2 groups: patients with or without hepatocellular carcinoma. Electrocardiogram, echocardiogram, and treadmill tests were performed for preoperative cardiac evaluation in all candidates for liver transplant. Results of these tests showed our preference for myocardial perfusion scintigraphy and/or coronary angiography and heart catheterization. Mean age of patients was 46.5 ± 14.5 years. The most common cardiovascular risk factor was family history of coronary artery disease (24.1%) in all patients. Diabetes mellitus (15.5%) was the most common risk factor in the ...
PLOS ONE, 2016
Background This study aimed to explore the ST segment elevation myocardial infarction (STEMI) man... more Background This study aimed to explore the ST segment elevation myocardial infarction (STEMI) management practices of emergency medicine specialists working in various healthcare institutions of seven different geographical regions of Turkey, and to examine the characteristics of STEMI presentation and patient admissions in these regions.
Acta Cardiologica Sinica, 2015
In this study, we aimed to evaluate the effects of niacin on high sensitivity C reactive protein ... more In this study, we aimed to evaluate the effects of niacin on high sensitivity C reactive protein (hs-CRP) and cholesterol levels in non-ST elevated acute coronary syndrome (NSTE-ACS) patients. In this prospective, open label study, 48 NSTE-ACS were randomized to niacin or control group. Patients continued their optimal medical therapy in the control group. In the niacin group patients were assigned to receive extended-release niacin 500 mg/day. Patients were contacted 1 month later to assess compliance and side effects. Blood samples for hs-CRP were obtained upon admittance to the coronary care unit, in the third day and in the first month of the treatment. Fasting blood samples for cholesterol levels were obtained before and 30 days after the treatment. The primary end point of the study was to evaluate changes in hs-CRP, cholesterol levels, short-term cardiovascular events, and the safety of niacin in NSTE-ACS. Baseline demographic, clinical and laboratory characteristics were sim...
Anatolian journal of cardiology, Jan 28, 2016
Atherosclerotic cardiovascular disease is a major global cause of death. The common approach in p... more Atherosclerotic cardiovascular disease is a major global cause of death. The common approach in primary prevention of cardiovascular disease is to identify patients at high risk for cardiovascular disease. This article analyzes and compares the application of 2013 American College of Cardiology/American Heart Association (ACC/AHA) guideline and the 2011 European Society of Cardiology (ESC) guideline for the management of dyslipidemias for primary prevention in Turkish population. The study included 833 patients (482 women and 351 men). Risk scores were calculated according to both guidelines and indications for statin treatment were determined according to sex and age group. Variables are presented as mean±SD or median with interquartile range for continuous data and as proportions for categorical data. Variables were analyzed by unpaired t-test, Mann-Whitney U test, chi-square or Fischer's exact test as appropriate. The ACC/AHA would suggest statin treatment in 415 patients out...
Int J Cardiol, 2010
subclassified into two as those without any negative event (n=26) on follow up and those with ren... more subclassified into two as those without any negative event (n=26) on follow up and those with renarrowing of the mitral valve area (<1.5 cm 2) or rePMBV or referral to valvular surgery (n=37) on follow up. The mean age, gender, body mass index, heart rate, NYHA class, estimated GFR, hemoglobin value, LV EF, MVA, mean mitral gradient, MPAP, Wilkins score, presence of hypertension, smoking, atrial fibrillation before PMBV and LV EF, heart rate after follow up are similar between two groups. In patients in the with event group, mitral peak gradient (21.2±4.7 vs 18.5±3.2 mmHg, p=0.009), SPAP before PMBV (54.2±14.1 mmHg vs 48.1±11.6, p=0.07), NYHA class (1.8±0.5 vs 1.4±0.5, p=0.02), peak (14.4±3.7 vs 9±2.5 mmHg, p<0.001) and mean mitral gradient (6.7±2.3 vs 4.4±1 mmHg, p<0.001), MPAP (20.1±6.8 vs 14.7±5.5 mmHg, p=0.001), SPAP (39.4±9.7 vs 31.1±4.5 mmHg, p<0.001), PVR (2.5±0.6 vs 2.1±0.6 Wood unit, p=0.015), right atrial area after follow up (17.6±5.2 vs 14.7±4.7 cm 2 , p=0.03) were higher and MVA (1.4±0.2 vs 1.8±0.1 cm 2 , p<0.001), tissue Doppler RV S velocity after follow up (11.6±3.4 vs 13.7±2.5 cm/sn, p=0.01), percent improvement in MVA acute phase (55.8±23.7% vs 80±24.1%, p<0.001) and after follow up (31.4±20.9% vs 61.9±22.9%, p<0.001) were lower than those without any negative event. Conclusions: Concerning long term follow up data of patients undergoing PMBV in a single center, it seems hemodynamics influence outcomes negatively whereas valvular characteristics do not.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2015
Hematologic parameters, such as mean platelet volume, red-cell distribution width, and neutrophil... more Hematologic parameters, such as mean platelet volume, red-cell distribution width, and neutrophil-to-lymphocyte ratio, have prognostic value in multiple cardiac conditions such as stable angina pectoris, acute coronary syndromes, and heart failure. However, no previous studies have evaluated the association between hematologic parameters and asymptomatic graft rejection after heart transplant. We evaluated the role of hematologic parameters for detecting asymptomatic graft rejection after heart transplant. We retrospectively evaluated medical records of 47 adult patients who underwent orthotopic heart transplant between February 25, 2005, and July 6, 2014, in our hospital, noting their hematologic parameters before each biopsy. Two groups were created according to biopsy results: rejection and no-rejection. We excluded 4 patients who died during the first month posttransplant owing to early complications. We evaluated 422 endomyocardial biopsy results of 43 adult patients (mean age,...
Atherosclerosis Supplements, 2008
Publication Only drogenase, total cholesterol, triglycerides, low density lipoprotein levels in s... more Publication Only drogenase, total cholesterol, triglycerides, low density lipoprotein levels in serum and lipid peroxides levels in heart homogenates were observed with a concomitant decrease in myocardial glutathione and serum high density lipoprotein levels in pathogenic control rats as compared to vehicle control rats. Furthermore, aqueous Embelia ribes extract (100 and 200 mg/kg, 30 days) treatment significantly reversed all the above mentioned parameters in dose dependant manner as compared to pathogenic control rats. The results of test drug were comparable to folic acid (100 mg/kg), a standard antihyperhomocysteinemic agent. Conclusion: Aqueous Embelia ribes extract has significant antihyperhomocysteinemic and lipid lowering potential in methionine-induced hyperhomocysteinemia in albino rats.
Atherosclerosis Supplements, 2007
Atherosclerosis Supplements, 2007
Atherosclerosis Supplements, 2008
Balkan medical journal, 2012
Left ventricular diverticulum is a rare congenital malformation consisting of a localized protrus... more Left ventricular diverticulum is a rare congenital malformation consisting of a localized protrusion of the endocardium and myocardium from the free wall of the left ventricle (LV). The prevalence of the disease is 0.26% in nonselected patients who underwent cardiac catheterization. It is believed that the etiology is an intrinsic abnormality developing during embryogenesis. It often does not cause any symptoms. We report a case of isolated left ventricular diverticulum with complaints of transient ischemic attack.
European Journal of Echocardiography, 2011
Echocardiographic measurements alone do not provide accurate non-invasive selection of annuloplas... more Echocardiographic measurements alone do not provide accurate non-invasive selection of annuloplasty band size for robotic mitral valve repair.
Sakarya Medical Journal, 2014