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Research paper thumbnail of The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila

BMC Developmental Biology, 2008

Background: Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a... more Background: Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a critical receptor-binding domain. Thus it is unclear whether it is able to interact with Notch in vivo. Unlike mammals, Drosophila have a single Notch receptor allowing a simple in vivo assay for mammalian Dlk1 function.

Research paper thumbnail of The atypical mammalian ligand Delta-like1 (Dlk1) can regulate Notch signalling in Drosophila

BMC Developmental Biology, 2008

Background: Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a... more Background: Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a critical receptor-binding domain. Thus it is unclear whether it is able to interact with Notch in vivo. Unlike mammals, Drosophila have a single Notch receptor allowing a simple in vivo assay for mammalian Dlk1 function.

Research paper thumbnail of The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila

Background: Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a... more Background: Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a critical receptor-binding domain. Thus it is unclear whether it is able to interact with Notch in vivo. Unlike mammals, Drosophila have a single Notch receptor allowing a simple in vivo assay for mammalian Dlk1 function.

Research paper thumbnail of The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila

BMC Developmental Biology, 2008

Background: Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a... more Background: Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a critical receptor-binding domain. Thus it is unclear whether it is able to interact with Notch in vivo. Unlike mammals, Drosophila have a single Notch receptor allowing a simple in vivo assay for mammalian Dlk1 function.

Research paper thumbnail of The atypical mammalian ligand Delta-like1 (Dlk1) can regulate Notch signalling in Drosophila

BMC Developmental Biology, 2008

Background: Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a... more Background: Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a critical receptor-binding domain. Thus it is unclear whether it is able to interact with Notch in vivo. Unlike mammals, Drosophila have a single Notch receptor allowing a simple in vivo assay for mammalian Dlk1 function.

Research paper thumbnail of The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila

Background: Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a... more Background: Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a critical receptor-binding domain. Thus it is unclear whether it is able to interact with Notch in vivo. Unlike mammals, Drosophila have a single Notch receptor allowing a simple in vivo assay for mammalian Dlk1 function.

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