Emmanuelle GAILLARD - Academia.edu (original) (raw)

Papers by Emmanuelle GAILLARD

Research paper thumbnail of Tasmannia lanceolata leaf extract alleviates stretch mark appearance in a randomized, placebo‐controlled clinical trial in women and stimulates extracellular matrix synthesis in ex vivo human skin explants

Journal of Cosmetic Dermatology, 2020

Tasmannia lanceolata leaf extract alleviates stretch mark appearance in a randomized, placebocont... more Tasmannia lanceolata leaf extract alleviates stretch mark appearance in a randomized, placebocontrolled clinical trial in women and stimulates extracellular matrix synthesis in ex vivo human skin explants.

Research paper thumbnail of Polar lipids from wheat extract oil improve skin damages induced by aging: Evidence from a randomized, placebo‐controlled clinical trial in women and an ex vivo study on human skin explant

Journal of Cosmetic Dermatology, 2019

Background: Polar lipids from wheat (Triticum vulgare/aestivum) extract oil (WEO) are known to im... more Background: Polar lipids from wheat (Triticum vulgare/aestivum) extract oil (WEO) are known to improve skin hydration. Aims: These studies aimed to assess WEO benefits on the skin appearance of middle-aged women. Methods: A double-blind, randomized, placebo-controlled clinical study was carried out on 64 healthy women, aged from 45 to 60 years, to investigate antiaging effects and benefits for the skin. The study lasted 20 weeks including 12 weeks of oral supplementation with WEO or placebo and 8 weeks of follow-up. Wrinkles in the "crow's-feet" area were evaluated by the Lemperle score. Skin hydration was measured using a corneometer, while roughness and radiance were determined by clinical scoring. Collagen content was quantified in human skin explants exposed to ultraviolet (UV) irradiations and treated with WEO or vehicle control. Results: Compared to the placebo group, the Lemperle score was significantly reduced in the WEO group between W0 and W8 to reach a clinically significant 1 grade at W12. Facial hydration was significantly improved in the WEO group from W0 to W12, whereas leg hydration was significantly increased after 4 weeks and lasted throughout the supplementation period. Skin roughness and radiance were also significantly improved from W0 to W8 in the WEO group compared to placebo group. A higher collagen content was measured in the UV-irradiated skin explants treated with WEO compared to the untreated ones. Conclusion: These results confirmed the moisturizing effect of WEO and, for the first time, revealed its potential antiaging properties.

Research paper thumbnail of “Miliacin encapsulated by polar lipids stimulates cell proliferation in hair bulb and improves telogen effluvium in women”

Journal of Cosmetic Dermatology, 2019

Background: Miliacin, the main triterpenoid from millet, is known to stimulate keratinocyte metab... more Background: Miliacin, the main triterpenoid from millet, is known to stimulate keratinocyte metabolism and proliferation. Polar lipids are able to form vesicles with active compounds and to improve their bioavailability. Objectives: We aimed to demonstrate potential benefits of a solution of miliacin encapsulated within polar lipids (MePL) on telogen effluvium prevention and hair condition in women. METHODS: After preliminary cell proliferation studies, a placebo-controlled, multicentric, randomized, double-blind trial was performed on sixty-five nonmenopausal women affected by telogen effluvium, to assess the efficacy of a 12-week oral supplementation with MePL. Telogen and anagen densities were determined by phototrichogram analysis. Scalp dryness and hair brightness were clinically evaluated using a Likert scale. Results: MePL further enhanced cell proliferation in hair bulb from human scalp than miliacin alone. Compared to the placebo treatment, MePL supplementation significantly reduced telogen density after 12 weeks of treatment. An increase of anagen density was observed in both groups, although there was no significant difference between the two treatments. Scalp dryness was more decreased in the MePL group than in the placebo group. A better improvement of hair brightness was also observed after 12 weeks of supplementation with MePL. Conclusion: Twelve weeks of MePL supplementation significantly reduced the hair density in the telogen phase and, in parallel, improved scalp dryness and hair condition. These effects could be linked to MePL activity on cell proliferation in hair bulb. MePL is an original association of plant extract that could help to prevent and/or limit hair loss in women.

Research paper thumbnail of Tasmannia lanceolata leaf extract alleviates stretch mark appearance in a randomized, placebo‐controlled clinical trial in women and stimulates extracellular matrix synthesis in ex vivo human skin explants

Journal of Cosmetic Dermatology, 2020

Tasmannia lanceolata leaf extract alleviates stretch mark appearance in a randomized, placebocont... more Tasmannia lanceolata leaf extract alleviates stretch mark appearance in a randomized, placebocontrolled clinical trial in women and stimulates extracellular matrix synthesis in ex vivo human skin explants.

Research paper thumbnail of Polar lipids from wheat extract oil improve skin damages induced by aging: Evidence from a randomized, placebo‐controlled clinical trial in women and an ex vivo study on human skin explant

Journal of Cosmetic Dermatology, 2019

Background: Polar lipids from wheat (Triticum vulgare/aestivum) extract oil (WEO) are known to im... more Background: Polar lipids from wheat (Triticum vulgare/aestivum) extract oil (WEO) are known to improve skin hydration. Aims: These studies aimed to assess WEO benefits on the skin appearance of middle-aged women. Methods: A double-blind, randomized, placebo-controlled clinical study was carried out on 64 healthy women, aged from 45 to 60 years, to investigate antiaging effects and benefits for the skin. The study lasted 20 weeks including 12 weeks of oral supplementation with WEO or placebo and 8 weeks of follow-up. Wrinkles in the "crow's-feet" area were evaluated by the Lemperle score. Skin hydration was measured using a corneometer, while roughness and radiance were determined by clinical scoring. Collagen content was quantified in human skin explants exposed to ultraviolet (UV) irradiations and treated with WEO or vehicle control. Results: Compared to the placebo group, the Lemperle score was significantly reduced in the WEO group between W0 and W8 to reach a clinically significant 1 grade at W12. Facial hydration was significantly improved in the WEO group from W0 to W12, whereas leg hydration was significantly increased after 4 weeks and lasted throughout the supplementation period. Skin roughness and radiance were also significantly improved from W0 to W8 in the WEO group compared to placebo group. A higher collagen content was measured in the UV-irradiated skin explants treated with WEO compared to the untreated ones. Conclusion: These results confirmed the moisturizing effect of WEO and, for the first time, revealed its potential antiaging properties.

Research paper thumbnail of “Miliacin encapsulated by polar lipids stimulates cell proliferation in hair bulb and improves telogen effluvium in women”

Journal of Cosmetic Dermatology, 2019

Background: Miliacin, the main triterpenoid from millet, is known to stimulate keratinocyte metab... more Background: Miliacin, the main triterpenoid from millet, is known to stimulate keratinocyte metabolism and proliferation. Polar lipids are able to form vesicles with active compounds and to improve their bioavailability. Objectives: We aimed to demonstrate potential benefits of a solution of miliacin encapsulated within polar lipids (MePL) on telogen effluvium prevention and hair condition in women. METHODS: After preliminary cell proliferation studies, a placebo-controlled, multicentric, randomized, double-blind trial was performed on sixty-five nonmenopausal women affected by telogen effluvium, to assess the efficacy of a 12-week oral supplementation with MePL. Telogen and anagen densities were determined by phototrichogram analysis. Scalp dryness and hair brightness were clinically evaluated using a Likert scale. Results: MePL further enhanced cell proliferation in hair bulb from human scalp than miliacin alone. Compared to the placebo treatment, MePL supplementation significantly reduced telogen density after 12 weeks of treatment. An increase of anagen density was observed in both groups, although there was no significant difference between the two treatments. Scalp dryness was more decreased in the MePL group than in the placebo group. A better improvement of hair brightness was also observed after 12 weeks of supplementation with MePL. Conclusion: Twelve weeks of MePL supplementation significantly reduced the hair density in the telogen phase and, in parallel, improved scalp dryness and hair condition. These effects could be linked to MePL activity on cell proliferation in hair bulb. MePL is an original association of plant extract that could help to prevent and/or limit hair loss in women.