Emre Engin - Academia.edu (original) (raw)

Papers by Emre Engin

Abdomino-pelvic adhesions arise from infection, endometriosis, or peritoneal injury during surger... more Abdomino-pelvic adhesions arise from infection, endometriosis, or peritoneal injury during surgery, and represent a significant source of morbidity in women of reproductive age. Monocyte chemotactic protein-1 (MCP-1) plays a role in the chemotaxis of mononuclear cells and fibroblasts in a murine wound repair model. To evaluate the role of MCP-1 in intraperitoneal adhesion formation, we investigated peritoneal fluid MCP-1 levels of women undergoing laparoscopy. Patients without endometriosis were divided into two groups: normal fertile women undergoing bilateral tubal ligation without intraperitoneal adhesions (n ⍧ 14) and women with pelvic adhesions (n ⍧ 8). Patients with endometriosis were arranged into two groups: women with (n ⍧ 17) and without (n ⍧ 17) adhesions. Peritoneal fluid MCP-1 levels were quantified using an enzyme-linked immunosorbent assay (ELISA). Peritoneal biopsy samples were immunostained for the detection of MCP-1 protein and macrophages, and were also processed for the presence of MCP-1 mRNA expression. Among women without endometriosis, the median peritoneal fluid MCP-1 level was 144 pg/ml (range 54-261) in women without adhesions and was 336 pg/ml (range 130-2494) in women with adhesions (P ⍧ 0.01). There was a significant correlation between adhesion scores and MCP-1 levels (r ⍧ 0.50; P ⍧ 0.018). Among women with endometriosis, peritoneal fluid MCP-1 levels significantly correlated with the stage of the disease. The presence or absence of adhesions did not significantly affect the peritoneal fluid MCP-1 levels in this group of women. In summary, we have found that women with adhesions have elevated peritoneal fluid MCP-1 levels. However, we were not able to show an incremental effect of adhesions on peritoneal fluid MCP-1 levels of patients with endometriosis. Thus, we conclude that factors besides the intraperitoneal adhesions contribute to the elevated peritoneal fluid MCP-1 levels in patients with endometriosis.

Alzheimers & Dementia, 2006

AD specific lesions) from the same subjects and with hippocampus of non demented controls. Moreov... more AD specific lesions) from the same subjects and with hippocampus of non demented controls. Moreover, all the mutations (even the homoplasmic ones) found in hippocampus of AD patients were mainly present in mtDNA genes codifying for complex I and IV subunits of the respiratory chain, that are known to be more damaged in AD. Finally the T146C (previously described) and the A1871G (not known in literature) mutations have been found only in some AD patients but not in controls, suggesting a possible AD specificity.

Tohoku Journal of Experimental Medicine, 2007

Vitamin D 3 is known to be involved in neuroprotection and exert its neuroprotective effects by m... more Vitamin D 3 is known to be involved in neuroprotection and exert its neuroprotective effects by modulating neuronal calcium homeostasis and production of neurotrophins. The single nucleotide polymorphisms (SNP) in vitamin D receptor (VDR) gene which can influence the affinity of vitamin D 3 to its receptor may be related to neurodegenerative diseases and neuronal damage by altering the vitamin D-mediated pathways. In this study, our aim was to determine whether there is an association between VDR gene and lateonset Alzheimer's disease (AD) in order to see if vitamin D contributes to AD or not. One hundred and four cases of dementia of Alzheimer type and 109 age-matched controls were genotyped according to ApaI (a: + restriction site and A: no restriction site) and TaqI (t: + restriction site and T: no restriction site) sites in intron 8 and exon 9 of the ligand-binding site of VDR gene. When the controls and patients were compared for their ApaI genotypes, the frequency of the patients with Aa genotype was significantly higher than the frequency of the healthy individuals with the same genotype ( p = 0.008, χ 2 = 9.577, OR = 2.30). Thus, the "Aa" genotype may increase the risk of developing AD 2.3 times when compared with the "AA" genotype. On the other hand, the "AT" haplotype was significantly higher in controls ( p = 0.006) indicating a protective role of the "AT" haplotype in AD. Consequently, this study provides evidence for a possible link between AD and vitamin D. vitamin D; VDR; Alzheimer's disease; SNP; haplotype

Neurobiology of Aging, 2004

significant differential expression between AD hippocampus and controls, and between APOE 4/4 and... more significant differential expression between AD hippocampus and controls, and between APOE 4/4 and 3/3 AD samples, but not between B&B stage IV and V AD tissues. After initial filtering 1541 genes remained for analysis. After stringent filtering analysis 71 differentially expressed genes remained of which 59 have been validated. Cytoskeletal genes represent one class of genes showing significant differential expression. For the comparison of B&B stages IV and V within AD samples, 48 genes demonstrated significant differential expression by p-values, but were excluded after FDR correction, implying that gene expression does not significantly change between B&B stages IV and V. The APOE genotype of AD patients did have an effect on gene expression with 99 genes showing significant expression differences by p-value and 27 genes after FDR correction between APOE 4/4 and APOE 3/3 AD samples. Condusious: Significant differences in gene expression between AD and controls have been identified. These data will be integrated with our ongoing genetic mapping studies (genomic convergence) to identify high priority candidate genes for AD genetic risk.

Human Reproduction, 1998

The peritoneal environment in endometriosis is known to have growth-promoting effects on endometr... more The peritoneal environment in endometriosis is known to have growth-promoting effects on endometrial cells. To investigate whether follicular fluid, a contributor to the peritoneal fluid, stimulates endometrial cell proliferation, we incubated endometrial stromal cells in culture with various dilutions of follicular fluid obtained from women with or without endometriosis undergoing oocyte retrieval for in-vitro fertilization. Cell proliferation assays were performed using follicular fluid from 28 women (without endometriosis, n ⍧ 13; with endometriosis, n ⍧ 15) in eight different endometrial stromal cell culture set-ups. Cell proliferation was assessed by a colorimetric method. Maximum cell proliferation was detected when endometrial cells were incubated with 50% dilution of follicular fluid for 48 h. Follicular fluid from women with endometriosis induced significantly higher cell proliferation than follicular fluid from women without endometriosis (P < 0.05). Our findings indicate that follicular fluid contents may contribute to the growth-promoting factors in the peritoneal fluid of women with endometriosis.

Dementia and Geriatric Cognitive Disorders, 2009

Background/Aims: The polymorphism (rs1800587) in the 5flanking regulatory region at -889 of the i... more Background/Aims: The polymorphism (rs1800587) in the 5flanking regulatory region at -889 of the interleukin-1 ␣ gene has been shown to be associated with inflammatory diseases and Alzheimer's disease (AD). The aim of the current study is to determine whether there is an association between the promoter region polymorphism of the interleukin-1 ␣ gene and late-onset AD in a cohort of Turkish patients. Methods: One hundred and four subjects with dementia of the Alzheimer type and 103 age-matched controls were genotyped according to the PCR with confronting two-pair primers method. Results: Although the distribution of genotypes did not significantly differ (p = 0.107), the difference between allelic frequency was nearly significant according to a 2 test (p = 0.05) when the controls and patients were compared. Conclusion: Our results showed that there is no association between the -889 C/T transition on the interleukin-1 ␣ gene and late-onset AD in the Turkish population.

Pediatric Surgery International, 2007

Inhibitors of 3-hydroxy-3methylglutarly coenzyme A, reductase, namely statins, exert pleiotropic ... more Inhibitors of 3-hydroxy-3methylglutarly coenzyme A, reductase, namely statins, exert pleiotropic actions beyond lipid-lowering effects. In ex vivo and in vitro studies, statins have antioxidative and antiinflammatory effects. Herein, we sought to determine whether treatment with fluvastatin (FV) would be beneficial in a rat model of common bile duct ligation (BDL)-induced liver injury. Female rats were subjected to a sham (n = 10) or BDL (n = 20). Obstructive jaundice was induced in rats by the ligation and division of the common bile duct. Three days after operation, rats subjected to CBDL were randomized to receive treatment with either FV (10 mg/kg) or saline every day over a 10 days experimental period. High levels of alanine aminotransferase, aspartate aminotransferase, and gamma glutamyltransferase decreased significantly (P < 0.05) in animals treated with FV with compared to saline-administrated BDL animals. Compared with sham-operated rats, CBDL rats showed significantly higher levels of total nitrite and nitrate, malondihaldehyde, tumor necrosis factor alpha, myeloperoxidase, and lower concentrations of glutathione, superoxide dismutase, and catalase in the liver tissue (P < 0.001). All of these changes were significantly attenuated (P < 0.05) by treatment with FV after CBDL. CBDL was associated with increased apoptosis and nuclear factor kappa beta expression in saline-treated rats. Treatment with FV also decreased these parameters. These data support the view that FV ameliorates hepatic inflammation, lipid peroxidation, and tissue injury in rats subjected to CDBL. FV warrants further evaluation as an adjunctive treatment to ameliorate liver injury from extrahepatic biliary obstruction.

Pediatric Nephrology, 2007

The purpose of this study was to test whether sulfasalazine has a protective action against inter... more The purpose of this study was to test whether sulfasalazine has a protective action against interstitial inflammation and the development of renal fibrosis in obstructive nephropathy. Female rats were subjected to a sham (n = 10) or unilateral ureteral obstruction (UUO, n = 30). UUO was induced in rats by ligating the left ureter. Three days after operation, rats subjected to UUO were randomized to receive tretment with either sulfasalazine (100 mg/kg) or vehicle every day for the last 7 days of the experiment. At 10 days following UUO, the obstructed kidney exhibited tubulointerstitial injury and leukocyte infiltration (mainly monocytes) that were associated with high levels of reactive oxygen species, cytokines, transforming growth factor (TGF)-β1, myeloperoxidase (MPO), and lipid peroxidation. Ten days after UUO, the obstructed kidney was also associated with increased nuclear factor kappa beta (NF-κβ) expression in saline-treated rats. Compared with sham-operated rats, UUO rat kidneys showed lower concentrations of antioxidant enzymes in the obstructed kidney tissue. All of these changes were significantly attenuated by treatment with sulfasalazine in the obstructed kidney. Sulfasalazine protected against the renal interstitial inflammation and tissue damage elicited by ureteral occlusion. Inhibition of the NF-κβ-dependent pathway and inflammatory response and oxidative stress inhibition is likely to be involved in the beneficial effects of sulfasalazine.

Alzheimers & Dementia, 2006

Background: One of the main pathological hallmarks of Alzheimer's disease (AD) is the senile plaq... more Background: One of the main pathological hallmarks of Alzheimer's disease (AD) is the senile plaques mainly consistent of insoluble deposits of the amyloid ␤ peptide (A␤). A number of other components have been identified to co-localize with senile plaques in the brains of AD patients. Recently, the novel collagenous Alzheimer amyloid plaque component (CLAC) was described. It shows a specific binding to A␤, implicating involvement of CLAC in A␤ fibrillization, proteolysis protection and A␤-mediated cytotoxicity. The gene encoding CLAC is located on chromosome band 4q24-25, in a region where we have observed increased allele sharing in Swedish AD pedigrees. Objective(s): To investigate the potential role of CLAC as a susceptibility gene for AD. Methods: Association studies in two AD populations were performed: one containing familial AD (FAD) cases, the other made up of cases from the Memory Clinic at Karolinska University Hospital. A third, population based sample set is under investigation. Results: We observed significant association in FAD cases to four single nucleotide polymorphisms (SNPs) that are in linkage disequilibrium. Furthermore, the clinic based sample confirmed the association in two of the SNPs. Conclusions: Our results add genetic evidence to the previous experimental evidence for CLAC's involvement in AD pathogenesis possibly by affecting the interaction between 〈␤ and CLAC.

It is well-known that early integration (also called data fusion) is effective when the modalitie... more It is well-known that early integration (also called data fusion) is effective when the modalities are correlated, and late integration (also called decision or opinion fusion) is optimal when modalities are uncorrelated. In this paper, we propose a new multimodal fusion strategy for open-set speaker identification using a combination of early and late integration following canonical correlation analysis (CCA) of speech and lip texture features. We also propose a method for high precision synchronization of the speech and lip features using CCA prior to the proposed fusion. Experimental results show that i) the proposed fusion strategy yields the best equal error rates (EER), which are used to quantify the performance of the fusion strategy for open-set speaker identification, and ii) precise synchronization prior to fusion improves the EER; hence, the best EER is obtained when the proposed synchronization scheme is employed together with the proposed fusion strategy. We note that the proposed fusion strategy outperforms others because the features used in the late integration are truly uncorrelated, since they are output of the CCA analysis.

Computers & Structures, 2002

This work relates to the analysis of triply coupled vibrations of thin-walled beams having nonsym... more This work relates to the analysis of triply coupled vibrations of thin-walled beams having nonsymmetrical open cross-sections. The governing differential equations for coupled bending and torsional vibrations are derived and solved exactly. A recent study on the same subject is criticized and discussed in theoretical and numerical aspects.

Abdomino-pelvic adhesions arise from infection, endometriosis, or peritoneal injury during surger... more Abdomino-pelvic adhesions arise from infection, endometriosis, or peritoneal injury during surgery, and represent a significant source of morbidity in women of reproductive age. Monocyte chemotactic protein-1 (MCP-1) plays a role in the chemotaxis of mononuclear cells and fibroblasts in a murine wound repair model. To evaluate the role of MCP-1 in intraperitoneal adhesion formation, we investigated peritoneal fluid MCP-1 levels of women undergoing laparoscopy. Patients without endometriosis were divided into two groups: normal fertile women undergoing bilateral tubal ligation without intraperitoneal adhesions (n ⍧ 14) and women with pelvic adhesions (n ⍧ 8). Patients with endometriosis were arranged into two groups: women with (n ⍧ 17) and without (n ⍧ 17) adhesions. Peritoneal fluid MCP-1 levels were quantified using an enzyme-linked immunosorbent assay (ELISA). Peritoneal biopsy samples were immunostained for the detection of MCP-1 protein and macrophages, and were also processed for the presence of MCP-1 mRNA expression. Among women without endometriosis, the median peritoneal fluid MCP-1 level was 144 pg/ml (range 54-261) in women without adhesions and was 336 pg/ml (range 130-2494) in women with adhesions (P ⍧ 0.01). There was a significant correlation between adhesion scores and MCP-1 levels (r ⍧ 0.50; P ⍧ 0.018). Among women with endometriosis, peritoneal fluid MCP-1 levels significantly correlated with the stage of the disease. The presence or absence of adhesions did not significantly affect the peritoneal fluid MCP-1 levels in this group of women. In summary, we have found that women with adhesions have elevated peritoneal fluid MCP-1 levels. However, we were not able to show an incremental effect of adhesions on peritoneal fluid MCP-1 levels of patients with endometriosis. Thus, we conclude that factors besides the intraperitoneal adhesions contribute to the elevated peritoneal fluid MCP-1 levels in patients with endometriosis.

Alzheimers & Dementia, 2006

AD specific lesions) from the same subjects and with hippocampus of non demented controls. Moreov... more AD specific lesions) from the same subjects and with hippocampus of non demented controls. Moreover, all the mutations (even the homoplasmic ones) found in hippocampus of AD patients were mainly present in mtDNA genes codifying for complex I and IV subunits of the respiratory chain, that are known to be more damaged in AD. Finally the T146C (previously described) and the A1871G (not known in literature) mutations have been found only in some AD patients but not in controls, suggesting a possible AD specificity.

Tohoku Journal of Experimental Medicine, 2007

Vitamin D 3 is known to be involved in neuroprotection and exert its neuroprotective effects by m... more Vitamin D 3 is known to be involved in neuroprotection and exert its neuroprotective effects by modulating neuronal calcium homeostasis and production of neurotrophins. The single nucleotide polymorphisms (SNP) in vitamin D receptor (VDR) gene which can influence the affinity of vitamin D 3 to its receptor may be related to neurodegenerative diseases and neuronal damage by altering the vitamin D-mediated pathways. In this study, our aim was to determine whether there is an association between VDR gene and lateonset Alzheimer's disease (AD) in order to see if vitamin D contributes to AD or not. One hundred and four cases of dementia of Alzheimer type and 109 age-matched controls were genotyped according to ApaI (a: + restriction site and A: no restriction site) and TaqI (t: + restriction site and T: no restriction site) sites in intron 8 and exon 9 of the ligand-binding site of VDR gene. When the controls and patients were compared for their ApaI genotypes, the frequency of the patients with Aa genotype was significantly higher than the frequency of the healthy individuals with the same genotype ( p = 0.008, χ 2 = 9.577, OR = 2.30). Thus, the "Aa" genotype may increase the risk of developing AD 2.3 times when compared with the "AA" genotype. On the other hand, the "AT" haplotype was significantly higher in controls ( p = 0.006) indicating a protective role of the "AT" haplotype in AD. Consequently, this study provides evidence for a possible link between AD and vitamin D. vitamin D; VDR; Alzheimer's disease; SNP; haplotype

Neurobiology of Aging, 2004

significant differential expression between AD hippocampus and controls, and between APOE 4/4 and... more significant differential expression between AD hippocampus and controls, and between APOE 4/4 and 3/3 AD samples, but not between B&B stage IV and V AD tissues. After initial filtering 1541 genes remained for analysis. After stringent filtering analysis 71 differentially expressed genes remained of which 59 have been validated. Cytoskeletal genes represent one class of genes showing significant differential expression. For the comparison of B&B stages IV and V within AD samples, 48 genes demonstrated significant differential expression by p-values, but were excluded after FDR correction, implying that gene expression does not significantly change between B&B stages IV and V. The APOE genotype of AD patients did have an effect on gene expression with 99 genes showing significant expression differences by p-value and 27 genes after FDR correction between APOE 4/4 and APOE 3/3 AD samples. Condusious: Significant differences in gene expression between AD and controls have been identified. These data will be integrated with our ongoing genetic mapping studies (genomic convergence) to identify high priority candidate genes for AD genetic risk.

Human Reproduction, 1998

The peritoneal environment in endometriosis is known to have growth-promoting effects on endometr... more The peritoneal environment in endometriosis is known to have growth-promoting effects on endometrial cells. To investigate whether follicular fluid, a contributor to the peritoneal fluid, stimulates endometrial cell proliferation, we incubated endometrial stromal cells in culture with various dilutions of follicular fluid obtained from women with or without endometriosis undergoing oocyte retrieval for in-vitro fertilization. Cell proliferation assays were performed using follicular fluid from 28 women (without endometriosis, n ⍧ 13; with endometriosis, n ⍧ 15) in eight different endometrial stromal cell culture set-ups. Cell proliferation was assessed by a colorimetric method. Maximum cell proliferation was detected when endometrial cells were incubated with 50% dilution of follicular fluid for 48 h. Follicular fluid from women with endometriosis induced significantly higher cell proliferation than follicular fluid from women without endometriosis (P < 0.05). Our findings indicate that follicular fluid contents may contribute to the growth-promoting factors in the peritoneal fluid of women with endometriosis.

Dementia and Geriatric Cognitive Disorders, 2009

Background/Aims: The polymorphism (rs1800587) in the 5flanking regulatory region at -889 of the i... more Background/Aims: The polymorphism (rs1800587) in the 5flanking regulatory region at -889 of the interleukin-1 ␣ gene has been shown to be associated with inflammatory diseases and Alzheimer's disease (AD). The aim of the current study is to determine whether there is an association between the promoter region polymorphism of the interleukin-1 ␣ gene and late-onset AD in a cohort of Turkish patients. Methods: One hundred and four subjects with dementia of the Alzheimer type and 103 age-matched controls were genotyped according to the PCR with confronting two-pair primers method. Results: Although the distribution of genotypes did not significantly differ (p = 0.107), the difference between allelic frequency was nearly significant according to a 2 test (p = 0.05) when the controls and patients were compared. Conclusion: Our results showed that there is no association between the -889 C/T transition on the interleukin-1 ␣ gene and late-onset AD in the Turkish population.

Pediatric Surgery International, 2007

Inhibitors of 3-hydroxy-3methylglutarly coenzyme A, reductase, namely statins, exert pleiotropic ... more Inhibitors of 3-hydroxy-3methylglutarly coenzyme A, reductase, namely statins, exert pleiotropic actions beyond lipid-lowering effects. In ex vivo and in vitro studies, statins have antioxidative and antiinflammatory effects. Herein, we sought to determine whether treatment with fluvastatin (FV) would be beneficial in a rat model of common bile duct ligation (BDL)-induced liver injury. Female rats were subjected to a sham (n = 10) or BDL (n = 20). Obstructive jaundice was induced in rats by the ligation and division of the common bile duct. Three days after operation, rats subjected to CBDL were randomized to receive treatment with either FV (10 mg/kg) or saline every day over a 10 days experimental period. High levels of alanine aminotransferase, aspartate aminotransferase, and gamma glutamyltransferase decreased significantly (P < 0.05) in animals treated with FV with compared to saline-administrated BDL animals. Compared with sham-operated rats, CBDL rats showed significantly higher levels of total nitrite and nitrate, malondihaldehyde, tumor necrosis factor alpha, myeloperoxidase, and lower concentrations of glutathione, superoxide dismutase, and catalase in the liver tissue (P < 0.001). All of these changes were significantly attenuated (P < 0.05) by treatment with FV after CBDL. CBDL was associated with increased apoptosis and nuclear factor kappa beta expression in saline-treated rats. Treatment with FV also decreased these parameters. These data support the view that FV ameliorates hepatic inflammation, lipid peroxidation, and tissue injury in rats subjected to CDBL. FV warrants further evaluation as an adjunctive treatment to ameliorate liver injury from extrahepatic biliary obstruction.

Pediatric Nephrology, 2007

The purpose of this study was to test whether sulfasalazine has a protective action against inter... more The purpose of this study was to test whether sulfasalazine has a protective action against interstitial inflammation and the development of renal fibrosis in obstructive nephropathy. Female rats were subjected to a sham (n = 10) or unilateral ureteral obstruction (UUO, n = 30). UUO was induced in rats by ligating the left ureter. Three days after operation, rats subjected to UUO were randomized to receive tretment with either sulfasalazine (100 mg/kg) or vehicle every day for the last 7 days of the experiment. At 10 days following UUO, the obstructed kidney exhibited tubulointerstitial injury and leukocyte infiltration (mainly monocytes) that were associated with high levels of reactive oxygen species, cytokines, transforming growth factor (TGF)-β1, myeloperoxidase (MPO), and lipid peroxidation. Ten days after UUO, the obstructed kidney was also associated with increased nuclear factor kappa beta (NF-κβ) expression in saline-treated rats. Compared with sham-operated rats, UUO rat kidneys showed lower concentrations of antioxidant enzymes in the obstructed kidney tissue. All of these changes were significantly attenuated by treatment with sulfasalazine in the obstructed kidney. Sulfasalazine protected against the renal interstitial inflammation and tissue damage elicited by ureteral occlusion. Inhibition of the NF-κβ-dependent pathway and inflammatory response and oxidative stress inhibition is likely to be involved in the beneficial effects of sulfasalazine.

Alzheimers & Dementia, 2006

Background: One of the main pathological hallmarks of Alzheimer's disease (AD) is the senile plaq... more Background: One of the main pathological hallmarks of Alzheimer's disease (AD) is the senile plaques mainly consistent of insoluble deposits of the amyloid ␤ peptide (A␤). A number of other components have been identified to co-localize with senile plaques in the brains of AD patients. Recently, the novel collagenous Alzheimer amyloid plaque component (CLAC) was described. It shows a specific binding to A␤, implicating involvement of CLAC in A␤ fibrillization, proteolysis protection and A␤-mediated cytotoxicity. The gene encoding CLAC is located on chromosome band 4q24-25, in a region where we have observed increased allele sharing in Swedish AD pedigrees. Objective(s): To investigate the potential role of CLAC as a susceptibility gene for AD. Methods: Association studies in two AD populations were performed: one containing familial AD (FAD) cases, the other made up of cases from the Memory Clinic at Karolinska University Hospital. A third, population based sample set is under investigation. Results: We observed significant association in FAD cases to four single nucleotide polymorphisms (SNPs) that are in linkage disequilibrium. Furthermore, the clinic based sample confirmed the association in two of the SNPs. Conclusions: Our results add genetic evidence to the previous experimental evidence for CLAC's involvement in AD pathogenesis possibly by affecting the interaction between 〈␤ and CLAC.

It is well-known that early integration (also called data fusion) is effective when the modalitie... more It is well-known that early integration (also called data fusion) is effective when the modalities are correlated, and late integration (also called decision or opinion fusion) is optimal when modalities are uncorrelated. In this paper, we propose a new multimodal fusion strategy for open-set speaker identification using a combination of early and late integration following canonical correlation analysis (CCA) of speech and lip texture features. We also propose a method for high precision synchronization of the speech and lip features using CCA prior to the proposed fusion. Experimental results show that i) the proposed fusion strategy yields the best equal error rates (EER), which are used to quantify the performance of the fusion strategy for open-set speaker identification, and ii) precise synchronization prior to fusion improves the EER; hence, the best EER is obtained when the proposed synchronization scheme is employed together with the proposed fusion strategy. We note that the proposed fusion strategy outperforms others because the features used in the late integration are truly uncorrelated, since they are output of the CCA analysis.

Computers & Structures, 2002

This work relates to the analysis of triply coupled vibrations of thin-walled beams having nonsym... more This work relates to the analysis of triply coupled vibrations of thin-walled beams having nonsymmetrical open cross-sections. The governing differential equations for coupled bending and torsional vibrations are derived and solved exactly. A recent study on the same subject is criticized and discussed in theoretical and numerical aspects.