Enrico Gherlone - Academia.edu (original) (raw)
Papers by Enrico Gherlone
Prevenzione & Assistenza Dentale, 2010
The International Journal of Periodontics Restorative Dentistry, Feb 1, 2012
The aim of this clinical study was to evaluate the 24-month clinical outcomes of immediate provis... more The aim of this clinical study was to evaluate the 24-month clinical outcomes of immediate provisionalization of dental implants placed in fresh extraction sockets using a flapless technique. Fifteen patients were included under strict inclusion and exclusion criteria. All patients required one or two teeth to be extracted for lesions with a hopeless prognosis in the maxillary monoradicular or first premolar region. Twenty implants were placed immediately after tooth extraction, and immediate provisionalization was performed. Sixteen implants had a diameter of 5 mm, and four implants had a diameter of 3.80 mm, all with a 13-mm length. After 24 months of follow-up, a cumulative survival rate of 100% was reported for all implants. Modified Bleeding Index (mBI), modified Plaque Index (mPI), probing depth (PD), marginal gingiva level (MGL), and keratinized mucosa (KM) remained stable for up to 24 months. Mean MGL at 24 months was 0.22 ± 0.15 mm; no significant changes occurred in MGL between baseline and 24 months. Mean KM remained stable from baseline to 24 months. At 24 months, a mean bone loss of 0.83 ± 0.52 mm was measured. The results of this study indicate that flapless surgery for immediately provisionalized implants placed in fresh extraction sockets provides soft tissue and marginal bone maintenance for up to 24 months of follow-up.
J Periodontol, 2010
Background: The present study considers the correlation between the meaning of keratinized mucosa... more Background: The present study considers the correlation between the meaning of keratinized mucosa (KM) and the long-term maintenance of endosseous root-form dental implants placed in fresh sockets and immediately loaded.
The Journal of Craniofacial Surgery, May 1, 2014
Purpose: Implant impressions and working models form integrated precision systems for registratio... more Purpose: Implant impressions and working models form integrated precision systems for registration and transmission of clinical data. The components of implant systems have a dimensional tolerance capable of introducing inaccuracies in the impression, thus in the prosthetic framework. This article aimed at comparing 2 repositioning impression techniques: one using impression copings (conventional technique) and the other using the final abutments as impression copings (interceptive technique). Materials and Methods: Two experimental models, one with 4 parallel implants and the other with 4 nonparallel implants, were used to make silicone impressions. Twenty impressions were made with the conventional technique, and a further 20 were made with the interceptive technique. Three-dimensional images acquired with a three-dimensional scanner were measured using a three-dimensional image analysis software, comparing models obtained from the impressions with the experimental models. Data were statistically analyzed by means of confidence intervals calculated with the mean (α = 0.05), descriptive (box plot), and bivariate analyses. Results: Statistic analysis highlighted significant differences among models obtained using both techniques: the interceptive technique generated working models with less distortion and variability. Conclusions: For internal-connection implants, the interceptive technique provided significantly more precise working models than did the conventional technique. FIGURE 4. Model alignment with a model for comparison.
Journal of Clinical Orthodontics Jco, Sep 1, 2012
Revista Internacional De Odontologia Restauradora Periodoncia, 2012
Http Dx Doi Org 10 1902 Jop 2009 090156, Sep 30, 2009
Background: Reduction of alveolar height and width after tooth extraction may provide some proble... more Background: Reduction of alveolar height and width after tooth extraction may provide some problems in implant placement, especially in the anterior maxilla for esthetic reasons. Different graft materials have been advocated to prevent bone-volume reduction. The aim of this study was to evaluate radiographic parameters of implants positioned in grafted alveoli with three different biomaterials: magnesium-enriched hydroxyapatite (MHA), calcium sulfate (CS), and heterologous porcine bone (PB).
The International Journal of Oral Maxillofacial Implants, 2012
PURPOSE: The purpose of this study was to evaluate the healing of an injectable mixture of nanopa... more PURPOSE: The purpose of this study was to evaluate the healing of an injectable mixture of nanoparticles of magnesium-enriched hydroxyapatite (mHA) in peri-implant defects.MATERIALS AND METHODS: Thirty-two dental implants were placed in 16 tibiae of eight female Large White pigs. In each animal, four implant beds (two sites each tibia) with medial three-wall intrabony defects were prepared. Via random selection, one bone defect in each tibia was filled with injectable mHA putty (n = 16, test group), whereas the other defect was not filled (n = 16, control group). Two animals were sacrificed after 2 weeks, two after 4 weeks, two after 6 weeks, and two after 8 weeks. In all, 32 block section samples were obtained for histologic and histomorphometric analyses.RESULTS: The test group exhibited statistically significantly higher values for bone-to-implant contact (BIC) and lower amounts of connective tissue (CT) over time. The test group showed a remarkable increase in vital bone values between 6 and 8 weeks after implant placement. After 8 weeks, the injectable mHA was almost completely resorbed.CONCLUSIONS: Injectable mHA putty could be a useful and suitable bone grafting material in peri-implant defects.
Journal of Clinical Orthodontics Jco, Nov 1, 2013
The International Journal of Oral Maxillofacial Implants, May 1, 2013
To report the application of an electrical mallet (magnetic mallet) in osteotome-assisted surgery... more To report the application of an electrical mallet (magnetic mallet) in osteotome-assisted surgery for sinus floor elevation with implants placed in fresh sockets and 2-year follow-up. A total of 32 patients (70 implants, 36 in the molar and 34 in the premolar regions) requiring extractions of maxillary premolars and molars were included in this prospective study. In all cases, implants were positioned immediately after tooth extraction. The implant site was prepared with osteotomes pushed by a magnetic mallet. Intraoral digital radiographic measurements were reported at 70 days and 1 and 2 years. Initial alveolar bone height and mean gained alveolar bone height were calculated for each implant over time. All implants were followed for 2 years. One of 70 implants failed 1 month after surgery. This implant was successfully replaced 6 months later. The cumulative survival rate at 2 years was 98.57%. After surgery, no membrane perforation was reported, and no patient experienced vertigo, distress, nausea, and vomiting. Radiographic results were reported at 70 days and 1 and 2 years from implant placement. The alveolar bone gain following 70 days of healing resulted in a mean value of 2.63 ± 1.01 mm and, at 2 years from implant placement, was stable at 4.08 ± 1.25 mm. Statistically significant differences (P < .05) between values at 70 days and 1 year were reported, whereas there were no statistically significant differences (P > .05) between 1 and 2 years. The electrical mallet represents a fast and accurate instrument for placing bone expanders in fresh socket implants and simultaneous sinus floor elevation to avoid patient distress.
The International journal of oral & maxillofacial implants
The purpose of this study was to evaluate the effectiveness of the platform-switching technique t... more The purpose of this study was to evaluate the effectiveness of the platform-switching technique to prevent crestal bone loss following the restoration of dental implants. This randomized prospective multicenter trial analyzed 60 partially edentulous adults recruited at 12 professional dental centers. Subjects were randomly selected to receive either platform-enlarged or control cylindric implants in three different surgical procedures: conventional nonsubmerged, submerged, and submerged with a reduced abutment. The primary outcome measure was the change in crestal bone level assessed radiographically 12 and 24 months following placement. Nonparametric analysis of variance for repeated measures (the Friedman test) was used to assess the overall significance over time of the differences among implants in changes in crestal bone levels. Comparisons among and between groups of implants were performed by the nonparametric Friedman and Wilcoxon tests, respectively. In all the analyses an alpha = .05 was considered significant. A total of 360 implants were placed (60 for each group). Three control implants failed during the 2nd year following placement. All submerged and 92% of nonsubmerged platform-enlarged implants exhibited no bone loss. Control implants with an abutment as large as the implant platform exhibited more bone loss than their platform-enlarged counterparts (P < .001) or control implants with a reduced abutment (P < .001). Submerged implants with an enlarged platform showed better crestal bone preservation than submerged control implants with a reduced abutment (P = .06). The findings of the current trial indicated that the use of implants with an enlarged platform can result in better preservation of crestal bone as compared with conventional cylindric implants when a reduced abutment is mounted.
Leukemia and Lymphoma
This randomized-controlled trial studied the efficacy of palifermin, administered as a dose durin... more This randomized-controlled trial studied the efficacy of palifermin, administered as a dose during HSCT therapy, as primary prophylaxis on paediatric patients with Acute lymphoblastic leukemia in order to reduce Oral Mucositis. Patients in the palifermin group were randomly assigned to receive Palifermin, 60 μg/kg, intravenously as a single dose 3 days before and 0, +1, and +2 post autologous HSCT infusion. The patients in the control group received only a placebo treatment. OM-related assessments were the WHO oral-toxicity scale and the patient-reported outcomes. There was a statistically significant reduction in the incidence of OM grade 3 and 4 in the palifermin group compared to the control group. There was also a reduction in the degree of severity of OM in the palifermin group (1.65 grade respect to 2.33 in the control group). Palifermin could prevent the recurrence of severe OM and improve the quality of life in patients with ALL.
American journal of dentistry, 2015
The present prospective clinical study evaluated the influence of coping design on the fracture r... more The present prospective clinical study evaluated the influence of coping design on the fracture resistance of CAD/CAM zirconia single crowns layered with dedicated ceramics. 56 subjects were provided with 90 zirconia single crowns in posterior regions. Tooth preparations were standardized and the abutment teeth were randomly distributed into three groups, according to three different coping designs (flat design, FD; porcelain-fused-to-metal-like crowns, PFM; anatomically-guided, AG). The zirconia cores were produced using a CAD/CAM software and then were hand-layered with dedicated ceramics. All crowns were cemented with a self-adhesive resin luting agent and the patients were recalled for follow-up visits after 1 month, 6 months, 1, 2 and 3 years of clinical service. The function, esthetics and marginal adaptation of the restorations were evaluated. Statistical analyses were performed to evaluate survival and success of the restorations. Success rates of 100% were reported in Group...
The International journal of oral & maxillofacial implants
The aim of this study was to compare the long-term success rates of wide-diameter implants in the... more The aim of this study was to compare the long-term success rates of wide-diameter implants in the mandibular molar region placed immediately after extraction and loaded either immediately or after a 3-month healing period. In 71 patients, 120 implants were positioned immediately after tooth extraction; 60 implants (immediate loading group) were loaded immediately and 60 were loaded after 3 months (delayed loading group). Radiographic examinations were made at baseline and at 1, 2, 3, 4, and 5 years after implant placement. After 5 years, a survival rate of 96.67% was reported for all implants (failure rate, 3.33%). Four implants were lost, two from the immediate loading group and two from the delayed loading group. There were no patient dropouts in either group. Wide-diameter implants placed in fresh extraction sockets and loaded immediately or after a delay showed no significant clinical or radiographic differences after 5 years.
Leukemia & lymphoma, 2015
This randomized-controlled trial studied the efficacy of palifermin, administered as a dose durin... more This randomized-controlled trial studied the efficacy of palifermin, administered as a dose during HSCT therapy, as primary prophylaxis on paediatric patients with Acute lymphoblastic leukemia in order to reduce Oral Mucositis. Patients in the palifermin group were randomly assigned to receive Palifermin, 60 μg/kg, intravenously as a single dose 3 days before and 0, +1, and +2 post autologous HSCT infusion. The patients in the control group received only a placebo treatment. OM-related assessments were the WHO oral-toxicity scale and the patient-reported outcomes. There was a statistically significant reduction in the incidence of OM grade 3 and 4 in the palifermin group compared to the control group. There was also a reduction in the degree of severity of OM in the palifermin group (1.65 grade respect to 2.33 in the control group). Palifermin could prevent the recurrence of severe OM and improve the quality of life in patients with ALL.
Clinical Implant Dentistry and Related Research, 2015
A recent study showed that implant-prosthetic rehabilitation in well-controlled HIV patients gave... more A recent study showed that implant-prosthetic rehabilitation in well-controlled HIV patients gave slightly worse results than in an healthy population, and failures were all linked to infection. The aim of this study was to examine the associations between the success of implant-prosthetic treatment and systemic CD4+ level, smoking habits, and oral hygiene. This mono-centric study included HIV patients with a stable disease and good oral hygiene requiring implant rehabilitation. Each patient received at least one dental implant. Prosthesis were delivered after 90 days in the upper jaw and 60 days in the lower jaw. Primary outcome measures were prosthetic failures, implant failures, peri-implant marginal bone level changes, and biological complications (peri-implantitis, pus, pain, paresthesia). The possible association with CD4 count, smoking habits, and oral hygiene was analyzed. Sixty-eight patients received 194 implants, and 66 patients (190 implants) were followed for 1 year. No significant associations were found between CD4+ count, oral hygiene-associated variables, and any of the outcome measures. If compared with nonsmoking/light smoking patients, patients who smoked >10 cigarettes/day suffered a statistically significant greater number of implant failures (p ≤ .005), presented a comparatively higher number of peri-implantitis (p < .001), as well as a higher frequency of pus (p ≤ .007), and reported pain (p ≤ .009). Within the limitation of the present study, placement of dental implants in HIV-positive patients with stable disease seems a reasonable treatment option, regardless of CD4+ cell count, provided that they are in a normal range. Oral hygiene variables were not influent in this group of patient following recall appointments, while HIV-positive heavy smokers (>10 cigarettes/day) demonstrated an increased risk of early implant failure, peri-implantitis, episodes of pus, and self-reported pain.
The International journal of oral & maxillofacial implants
The aim of this study was to compare, through histomorphometric analysis, the use of donor autoge... more The aim of this study was to compare, through histomorphometric analysis, the use of donor autogenous bone graft from calvarial or iliac sources for maxillary sinus lift procedures. Sixteen patients requiring maxillary sinus augmentation were included in this study. One group of 10 patients was alternatively selected to receive autologous calvarial bone particles, and another group of 6 patients received autologous iliac bone particles. Five months after surgery, bone biopsy specimens were obtained at the time of implant procedure and analyzed through histomorphometry. To compare mean values between the calvarial and iliac crest groups, the Student t test was performed. The level for statistical significance was set at P < .05. All patients completed the healing period following sinus augmentation procedure without complications. In the calvarial group, an average total bone volume (BV) of 73.4% +/- 13.1% was found. Nonvital bone constituted an average of 5.5% +/- 6.3% of the tot...
Objectives: The present in vitro study aimed at evaluating the influence of a novel nanocomposite... more Objectives: The present in vitro study aimed at evaluating the influence of a novel nanocomposite material on implant primary stability by means of periimplants scaffolds. Methods: Thirty-two titanium implants (Winsix, Biosafin) with an innovative design were modified with three-dimensional bioactive scaffolds made up of a new hybrid ceramo-polymeric material. The biomimetic nanocomposite material was designed to promote the precipitation of hydroxyapatite nanoinclusions in periimplant bone. The scaffolds were fabricated as a foamed hydrogel covering the coronal area of the implants; the material was characterized by swelling in contact with biological fluids, with a polymerization kinetic of 0.1 mm/hour. The modified implants were inserted in freshly explanted tibiae of minipigs; 16 standard implants were used as control. Then, the tibiae were kept hydrated in physiological solution and the implants removed after 1, 6, 12 and 24 hours. An electronic device was used to measure the r...
Prevenzione & Assistenza Dentale, 2010
The International Journal of Periodontics Restorative Dentistry, Feb 1, 2012
The aim of this clinical study was to evaluate the 24-month clinical outcomes of immediate provis... more The aim of this clinical study was to evaluate the 24-month clinical outcomes of immediate provisionalization of dental implants placed in fresh extraction sockets using a flapless technique. Fifteen patients were included under strict inclusion and exclusion criteria. All patients required one or two teeth to be extracted for lesions with a hopeless prognosis in the maxillary monoradicular or first premolar region. Twenty implants were placed immediately after tooth extraction, and immediate provisionalization was performed. Sixteen implants had a diameter of 5 mm, and four implants had a diameter of 3.80 mm, all with a 13-mm length. After 24 months of follow-up, a cumulative survival rate of 100% was reported for all implants. Modified Bleeding Index (mBI), modified Plaque Index (mPI), probing depth (PD), marginal gingiva level (MGL), and keratinized mucosa (KM) remained stable for up to 24 months. Mean MGL at 24 months was 0.22 ± 0.15 mm; no significant changes occurred in MGL between baseline and 24 months. Mean KM remained stable from baseline to 24 months. At 24 months, a mean bone loss of 0.83 ± 0.52 mm was measured. The results of this study indicate that flapless surgery for immediately provisionalized implants placed in fresh extraction sockets provides soft tissue and marginal bone maintenance for up to 24 months of follow-up.
J Periodontol, 2010
Background: The present study considers the correlation between the meaning of keratinized mucosa... more Background: The present study considers the correlation between the meaning of keratinized mucosa (KM) and the long-term maintenance of endosseous root-form dental implants placed in fresh sockets and immediately loaded.
The Journal of Craniofacial Surgery, May 1, 2014
Purpose: Implant impressions and working models form integrated precision systems for registratio... more Purpose: Implant impressions and working models form integrated precision systems for registration and transmission of clinical data. The components of implant systems have a dimensional tolerance capable of introducing inaccuracies in the impression, thus in the prosthetic framework. This article aimed at comparing 2 repositioning impression techniques: one using impression copings (conventional technique) and the other using the final abutments as impression copings (interceptive technique). Materials and Methods: Two experimental models, one with 4 parallel implants and the other with 4 nonparallel implants, were used to make silicone impressions. Twenty impressions were made with the conventional technique, and a further 20 were made with the interceptive technique. Three-dimensional images acquired with a three-dimensional scanner were measured using a three-dimensional image analysis software, comparing models obtained from the impressions with the experimental models. Data were statistically analyzed by means of confidence intervals calculated with the mean (α = 0.05), descriptive (box plot), and bivariate analyses. Results: Statistic analysis highlighted significant differences among models obtained using both techniques: the interceptive technique generated working models with less distortion and variability. Conclusions: For internal-connection implants, the interceptive technique provided significantly more precise working models than did the conventional technique. FIGURE 4. Model alignment with a model for comparison.
Journal of Clinical Orthodontics Jco, Sep 1, 2012
Revista Internacional De Odontologia Restauradora Periodoncia, 2012
Http Dx Doi Org 10 1902 Jop 2009 090156, Sep 30, 2009
Background: Reduction of alveolar height and width after tooth extraction may provide some proble... more Background: Reduction of alveolar height and width after tooth extraction may provide some problems in implant placement, especially in the anterior maxilla for esthetic reasons. Different graft materials have been advocated to prevent bone-volume reduction. The aim of this study was to evaluate radiographic parameters of implants positioned in grafted alveoli with three different biomaterials: magnesium-enriched hydroxyapatite (MHA), calcium sulfate (CS), and heterologous porcine bone (PB).
The International Journal of Oral Maxillofacial Implants, 2012
PURPOSE: The purpose of this study was to evaluate the healing of an injectable mixture of nanopa... more PURPOSE: The purpose of this study was to evaluate the healing of an injectable mixture of nanoparticles of magnesium-enriched hydroxyapatite (mHA) in peri-implant defects.MATERIALS AND METHODS: Thirty-two dental implants were placed in 16 tibiae of eight female Large White pigs. In each animal, four implant beds (two sites each tibia) with medial three-wall intrabony defects were prepared. Via random selection, one bone defect in each tibia was filled with injectable mHA putty (n = 16, test group), whereas the other defect was not filled (n = 16, control group). Two animals were sacrificed after 2 weeks, two after 4 weeks, two after 6 weeks, and two after 8 weeks. In all, 32 block section samples were obtained for histologic and histomorphometric analyses.RESULTS: The test group exhibited statistically significantly higher values for bone-to-implant contact (BIC) and lower amounts of connective tissue (CT) over time. The test group showed a remarkable increase in vital bone values between 6 and 8 weeks after implant placement. After 8 weeks, the injectable mHA was almost completely resorbed.CONCLUSIONS: Injectable mHA putty could be a useful and suitable bone grafting material in peri-implant defects.
Journal of Clinical Orthodontics Jco, Nov 1, 2013
The International Journal of Oral Maxillofacial Implants, May 1, 2013
To report the application of an electrical mallet (magnetic mallet) in osteotome-assisted surgery... more To report the application of an electrical mallet (magnetic mallet) in osteotome-assisted surgery for sinus floor elevation with implants placed in fresh sockets and 2-year follow-up. A total of 32 patients (70 implants, 36 in the molar and 34 in the premolar regions) requiring extractions of maxillary premolars and molars were included in this prospective study. In all cases, implants were positioned immediately after tooth extraction. The implant site was prepared with osteotomes pushed by a magnetic mallet. Intraoral digital radiographic measurements were reported at 70 days and 1 and 2 years. Initial alveolar bone height and mean gained alveolar bone height were calculated for each implant over time. All implants were followed for 2 years. One of 70 implants failed 1 month after surgery. This implant was successfully replaced 6 months later. The cumulative survival rate at 2 years was 98.57%. After surgery, no membrane perforation was reported, and no patient experienced vertigo, distress, nausea, and vomiting. Radiographic results were reported at 70 days and 1 and 2 years from implant placement. The alveolar bone gain following 70 days of healing resulted in a mean value of 2.63 ± 1.01 mm and, at 2 years from implant placement, was stable at 4.08 ± 1.25 mm. Statistically significant differences (P &amp;amp;amp;amp;amp;amp;amp;lt; .05) between values at 70 days and 1 year were reported, whereas there were no statistically significant differences (P &amp;amp;amp;amp;amp;amp;amp;gt; .05) between 1 and 2 years. The electrical mallet represents a fast and accurate instrument for placing bone expanders in fresh socket implants and simultaneous sinus floor elevation to avoid patient distress.
The International journal of oral & maxillofacial implants
The purpose of this study was to evaluate the effectiveness of the platform-switching technique t... more The purpose of this study was to evaluate the effectiveness of the platform-switching technique to prevent crestal bone loss following the restoration of dental implants. This randomized prospective multicenter trial analyzed 60 partially edentulous adults recruited at 12 professional dental centers. Subjects were randomly selected to receive either platform-enlarged or control cylindric implants in three different surgical procedures: conventional nonsubmerged, submerged, and submerged with a reduced abutment. The primary outcome measure was the change in crestal bone level assessed radiographically 12 and 24 months following placement. Nonparametric analysis of variance for repeated measures (the Friedman test) was used to assess the overall significance over time of the differences among implants in changes in crestal bone levels. Comparisons among and between groups of implants were performed by the nonparametric Friedman and Wilcoxon tests, respectively. In all the analyses an alpha = .05 was considered significant. A total of 360 implants were placed (60 for each group). Three control implants failed during the 2nd year following placement. All submerged and 92% of nonsubmerged platform-enlarged implants exhibited no bone loss. Control implants with an abutment as large as the implant platform exhibited more bone loss than their platform-enlarged counterparts (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .001) or control implants with a reduced abutment (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .001). Submerged implants with an enlarged platform showed better crestal bone preservation than submerged control implants with a reduced abutment (P = .06). The findings of the current trial indicated that the use of implants with an enlarged platform can result in better preservation of crestal bone as compared with conventional cylindric implants when a reduced abutment is mounted.
Leukemia and Lymphoma
This randomized-controlled trial studied the efficacy of palifermin, administered as a dose durin... more This randomized-controlled trial studied the efficacy of palifermin, administered as a dose during HSCT therapy, as primary prophylaxis on paediatric patients with Acute lymphoblastic leukemia in order to reduce Oral Mucositis. Patients in the palifermin group were randomly assigned to receive Palifermin, 60 μg/kg, intravenously as a single dose 3 days before and 0, +1, and +2 post autologous HSCT infusion. The patients in the control group received only a placebo treatment. OM-related assessments were the WHO oral-toxicity scale and the patient-reported outcomes. There was a statistically significant reduction in the incidence of OM grade 3 and 4 in the palifermin group compared to the control group. There was also a reduction in the degree of severity of OM in the palifermin group (1.65 grade respect to 2.33 in the control group). Palifermin could prevent the recurrence of severe OM and improve the quality of life in patients with ALL.
American journal of dentistry, 2015
The present prospective clinical study evaluated the influence of coping design on the fracture r... more The present prospective clinical study evaluated the influence of coping design on the fracture resistance of CAD/CAM zirconia single crowns layered with dedicated ceramics. 56 subjects were provided with 90 zirconia single crowns in posterior regions. Tooth preparations were standardized and the abutment teeth were randomly distributed into three groups, according to three different coping designs (flat design, FD; porcelain-fused-to-metal-like crowns, PFM; anatomically-guided, AG). The zirconia cores were produced using a CAD/CAM software and then were hand-layered with dedicated ceramics. All crowns were cemented with a self-adhesive resin luting agent and the patients were recalled for follow-up visits after 1 month, 6 months, 1, 2 and 3 years of clinical service. The function, esthetics and marginal adaptation of the restorations were evaluated. Statistical analyses were performed to evaluate survival and success of the restorations. Success rates of 100% were reported in Group...
The International journal of oral & maxillofacial implants
The aim of this study was to compare the long-term success rates of wide-diameter implants in the... more The aim of this study was to compare the long-term success rates of wide-diameter implants in the mandibular molar region placed immediately after extraction and loaded either immediately or after a 3-month healing period. In 71 patients, 120 implants were positioned immediately after tooth extraction; 60 implants (immediate loading group) were loaded immediately and 60 were loaded after 3 months (delayed loading group). Radiographic examinations were made at baseline and at 1, 2, 3, 4, and 5 years after implant placement. After 5 years, a survival rate of 96.67% was reported for all implants (failure rate, 3.33%). Four implants were lost, two from the immediate loading group and two from the delayed loading group. There were no patient dropouts in either group. Wide-diameter implants placed in fresh extraction sockets and loaded immediately or after a delay showed no significant clinical or radiographic differences after 5 years.
Leukemia & lymphoma, 2015
This randomized-controlled trial studied the efficacy of palifermin, administered as a dose durin... more This randomized-controlled trial studied the efficacy of palifermin, administered as a dose during HSCT therapy, as primary prophylaxis on paediatric patients with Acute lymphoblastic leukemia in order to reduce Oral Mucositis. Patients in the palifermin group were randomly assigned to receive Palifermin, 60 μg/kg, intravenously as a single dose 3 days before and 0, +1, and +2 post autologous HSCT infusion. The patients in the control group received only a placebo treatment. OM-related assessments were the WHO oral-toxicity scale and the patient-reported outcomes. There was a statistically significant reduction in the incidence of OM grade 3 and 4 in the palifermin group compared to the control group. There was also a reduction in the degree of severity of OM in the palifermin group (1.65 grade respect to 2.33 in the control group). Palifermin could prevent the recurrence of severe OM and improve the quality of life in patients with ALL.
Clinical Implant Dentistry and Related Research, 2015
A recent study showed that implant-prosthetic rehabilitation in well-controlled HIV patients gave... more A recent study showed that implant-prosthetic rehabilitation in well-controlled HIV patients gave slightly worse results than in an healthy population, and failures were all linked to infection. The aim of this study was to examine the associations between the success of implant-prosthetic treatment and systemic CD4+ level, smoking habits, and oral hygiene. This mono-centric study included HIV patients with a stable disease and good oral hygiene requiring implant rehabilitation. Each patient received at least one dental implant. Prosthesis were delivered after 90 days in the upper jaw and 60 days in the lower jaw. Primary outcome measures were prosthetic failures, implant failures, peri-implant marginal bone level changes, and biological complications (peri-implantitis, pus, pain, paresthesia). The possible association with CD4 count, smoking habits, and oral hygiene was analyzed. Sixty-eight patients received 194 implants, and 66 patients (190 implants) were followed for 1 year. No significant associations were found between CD4+ count, oral hygiene-associated variables, and any of the outcome measures. If compared with nonsmoking/light smoking patients, patients who smoked &amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;10 cigarettes/day suffered a statistically significant greater number of implant failures (p ≤ .005), presented a comparatively higher number of peri-implantitis (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .001), as well as a higher frequency of pus (p ≤ .007), and reported pain (p ≤ .009). Within the limitation of the present study, placement of dental implants in HIV-positive patients with stable disease seems a reasonable treatment option, regardless of CD4+ cell count, provided that they are in a normal range. Oral hygiene variables were not influent in this group of patient following recall appointments, while HIV-positive heavy smokers (&amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;10 cigarettes/day) demonstrated an increased risk of early implant failure, peri-implantitis, episodes of pus, and self-reported pain.
The International journal of oral & maxillofacial implants
The aim of this study was to compare, through histomorphometric analysis, the use of donor autoge... more The aim of this study was to compare, through histomorphometric analysis, the use of donor autogenous bone graft from calvarial or iliac sources for maxillary sinus lift procedures. Sixteen patients requiring maxillary sinus augmentation were included in this study. One group of 10 patients was alternatively selected to receive autologous calvarial bone particles, and another group of 6 patients received autologous iliac bone particles. Five months after surgery, bone biopsy specimens were obtained at the time of implant procedure and analyzed through histomorphometry. To compare mean values between the calvarial and iliac crest groups, the Student t test was performed. The level for statistical significance was set at P < .05. All patients completed the healing period following sinus augmentation procedure without complications. In the calvarial group, an average total bone volume (BV) of 73.4% +/- 13.1% was found. Nonvital bone constituted an average of 5.5% +/- 6.3% of the tot...
Objectives: The present in vitro study aimed at evaluating the influence of a novel nanocomposite... more Objectives: The present in vitro study aimed at evaluating the influence of a novel nanocomposite material on implant primary stability by means of periimplants scaffolds. Methods: Thirty-two titanium implants (Winsix, Biosafin) with an innovative design were modified with three-dimensional bioactive scaffolds made up of a new hybrid ceramo-polymeric material. The biomimetic nanocomposite material was designed to promote the precipitation of hydroxyapatite nanoinclusions in periimplant bone. The scaffolds were fabricated as a foamed hydrogel covering the coronal area of the implants; the material was characterized by swelling in contact with biological fluids, with a polymerization kinetic of 0.1 mm/hour. The modified implants were inserted in freshly explanted tibiae of minipigs; 16 standard implants were used as control. Then, the tibiae were kept hydrated in physiological solution and the implants removed after 1, 6, 12 and 24 hours. An electronic device was used to measure the r...