Enrique Aller - Academia.edu (original) (raw)
Papers by Enrique Aller
ChemInform Abstract: N-Isocyanotriphenyliminophosphorane, a Convenient Reagent for the Conversion of Acyl Chlorides into α-Diazoketones
ChemInform, 2000
ABSTRACT
Journal of the Chemical Society, Perkin Transactions 1, 1996
The reaction of methyl 2-diazophenylacetate 1 and dimethyl α-diazobenzylphosphonate 2 with variou... more The reaction of methyl 2-diazophenylacetate 1 and dimethyl α-diazobenzylphosphonate 2 with various N-H components in the presence of chiral dirhodium(II) catalysts results in N-H insertion in good yield but with little or no stereoselectivity.
Tetrahedron, 2009
One-flask preparation of bisferrocenyl-substituted urea and thiourea and trisferrocenyl-substitut... more One-flask preparation of bisferrocenyl-substituted urea and thiourea and trisferrocenyl-substituted guanidine have been achieved from the iminophosphorane derived from ferrocenemethyl azide by using aza-Wittig reactions with carbon dioxide and carbon disulfide. Electrochemical studies indicate that there is no electronic communications between the peripheral ferrocene units and only one reversible redox wave is observed, which underwent a remarkable cathodic shift (DE 1/2 ¼100-170 mV) in the presence of dihydrogenphosphate anion.
![Research paper thumbnail of Pyrido annelation reaction by a tandem aza Wittig/electrocyclic ring-closure strategy: Preparation of pyrazolo[4,3-c]- and pyrazolo[3,4-c]pyridine derivatives](https://attachments.academia-assets.com/42334187/thumbnails/1.jpg)
](Tetrahedron, 1991
Pyrazolo pyridines have continued to attract interest because of their biological activity and st... more Pyrazolo pyridines have continued to attract interest because of their biological activity and structural relationship to indoles and azaindoles and several methods have been adopted for the synthesis of this ring system and have been comprehensively reviewed'. However, the synthesis of pyrazolo[4,3-clpyridines has been achieved in only a limited number of ways, mostly involving the use either of 4-hydrazinopyridines or pyrazoles containing carboxylic acid functions at positions 4 and 5 as starting materials. The generality of these methods are impaired by the availability of the starting materials.
One-flask Conversion of N-Aryliminophosphoranesinto N 1 , N 2 , N 3 -TriarylguanidinesPromoted by TBAF
Synlett, 2003
... Pedro Molina*, Enrique Aller, Angeles Lorenzo. ... 9a Moroni M, Koksch B, Osipov SN, Cruciane... more ... Pedro Molina*, Enrique Aller, Angeles Lorenzo. ... 9a Moroni M, Koksch B, Osipov SN, Crucianelli M, Frigerio M, Bravo P, Burger K,J. Org. Chem. 2001, 66: 130. 9b Brewer M, Rich DH,Org. Lett. ... 21b Tárraga A, Molina P, Curiel D, López JL, Velasco MD,Tetrahedron 1999, 55: 14701. ...
Diastereoselectivity in the O-H Insertion Reactions of Rhodium Carbenoids Derived from Phenyldiazoacetates of Chiral Alcohols. Preparation of .alpha.-Hydroxy and .alpha.-Alkoxy Esters
The Journal of Organic Chemistry, 1995
Page 1. J. Org. Chem. 1995,60, 4449-4460 4449 Diastereoselectivity in the 0 - H Insertion Reactio... more Page 1. J. Org. Chem. 1995,60, 4449-4460 4449 Diastereoselectivity in the 0 - H Insertion Reactions of Rhodium Carbenoids Derived from Phenyldiazoacetates of Chiral Alcohols. Preparation of a-Hydroxy and a-Alkoxy Esters ...
Carbodiimide-mediated Annelation of a [1,2,4]Triazole Ring into a Heterocyclic Ring: Synthesis of [1,2,4]Triazolo[4,3-b]triazole, Imidazo[1,2-b][1,2,4]triazole and [1,2,4]Triazolo[1,5-d][1,2,4]triazine Derivatives
HETEROCYCLES, 1988
ABSTRACT
![Research paper thumbnail of Iminophosphorane-Mediated Synthesis of Fused Perimidines: Preparation of Quinazolino[3,4-a]perimidine Derivatives](https://attachments.academia-assets.com/42375247/thumbnails/1.jpg)
](Liebigs Annalen der Chemie, 1994
ABSTRACT An aza-Wittig-type reaction of iminophosphoranes 2 and 3, derived from 2-(2-azidophenyl)... more ABSTRACT An aza-Wittig-type reaction of iminophosphoranes 2 and 3, derived from 2-(2-azidophenyl)-1,2-dihydroperimidine and 2-(2-azidophenyl)perimidine, respectively, with isocyanates, carbon dioxide, carbon disulfide and acyl chlorides provides 6-substituted quinazolino[3,4-α]perimidines 4–10.
Biochemical Pharmacology, 2004
ITB (6-(p-bromophenyl)amino-7-(p-chlorophenyl)indazolo[2&... more ITB (6-(p-bromophenyl)amino-7-(p-chlorophenyl)indazolo[2',3':1,5]-1,2,4-triazolo[4,3-a]-1,3,5-benzotriazepine) is a novel inhibitor of cyclo-oxygenase-2 (COX-2) with antiinflammatory activity in animal models. In the present study, we investigated the effect of this compound on the production of catabolic or antiinflammatory mediators in osteoarthritis (OA) cartilage. In OA cartilage explants, ITB inhibited the production of prostaglandin E(2) (PGE(2)), tumour necrosis factor-alpha (TNF-alpha) and matrix metalloproteinase-13 (MMP-13) in a concentration-dependent manner, whereas nitrite was partially reduced. On the contrary, ITB increased the production of interleukin (IL)-10 and the expression of heme oxygenase-1 (HO-1). ITB inhibited the production of catabolic mediators at concentrations able to increase IL-10 and HO-1 in OA cartilage, suggesting that this compound may be useful in the prevention of cartilage degradation.
ChemInform Abstract: N-Isocyanotriphenyliminophosphorane, a Convenient Reagent for the Conversion of Acyl Chlorides into α-Diazoketones
ChemInform, 2000
ABSTRACT
Journal of the Chemical Society, Perkin Transactions 1, 1996
The reaction of methyl 2-diazophenylacetate 1 and dimethyl α-diazobenzylphosphonate 2 with variou... more The reaction of methyl 2-diazophenylacetate 1 and dimethyl α-diazobenzylphosphonate 2 with various N-H components in the presence of chiral dirhodium(II) catalysts results in N-H insertion in good yield but with little or no stereoselectivity.
Tetrahedron, 2009
One-flask preparation of bisferrocenyl-substituted urea and thiourea and trisferrocenyl-substitut... more One-flask preparation of bisferrocenyl-substituted urea and thiourea and trisferrocenyl-substituted guanidine have been achieved from the iminophosphorane derived from ferrocenemethyl azide by using aza-Wittig reactions with carbon dioxide and carbon disulfide. Electrochemical studies indicate that there is no electronic communications between the peripheral ferrocene units and only one reversible redox wave is observed, which underwent a remarkable cathodic shift (DE 1/2 ¼100-170 mV) in the presence of dihydrogenphosphate anion.
Tetrahedron, 1991
Pyrazolo pyridines have continued to attract interest because of their biological activity and st... more Pyrazolo pyridines have continued to attract interest because of their biological activity and structural relationship to indoles and azaindoles and several methods have been adopted for the synthesis of this ring system and have been comprehensively reviewed'. However, the synthesis of pyrazolo[4,3-clpyridines has been achieved in only a limited number of ways, mostly involving the use either of 4-hydrazinopyridines or pyrazoles containing carboxylic acid functions at positions 4 and 5 as starting materials. The generality of these methods are impaired by the availability of the starting materials.
One-flask Conversion of N-Aryliminophosphoranesinto N 1 , N 2 , N 3 -TriarylguanidinesPromoted by TBAF
Synlett, 2003
... Pedro Molina*, Enrique Aller, Angeles Lorenzo. ... 9a Moroni M, Koksch B, Osipov SN, Cruciane... more ... Pedro Molina*, Enrique Aller, Angeles Lorenzo. ... 9a Moroni M, Koksch B, Osipov SN, Crucianelli M, Frigerio M, Bravo P, Burger K,J. Org. Chem. 2001, 66: 130. 9b Brewer M, Rich DH,Org. Lett. ... 21b Tárraga A, Molina P, Curiel D, López JL, Velasco MD,Tetrahedron 1999, 55: 14701. ...
Diastereoselectivity in the O-H Insertion Reactions of Rhodium Carbenoids Derived from Phenyldiazoacetates of Chiral Alcohols. Preparation of .alpha.-Hydroxy and .alpha.-Alkoxy Esters
The Journal of Organic Chemistry, 1995
Page 1. J. Org. Chem. 1995,60, 4449-4460 4449 Diastereoselectivity in the 0 - H Insertion Reactio... more Page 1. J. Org. Chem. 1995,60, 4449-4460 4449 Diastereoselectivity in the 0 - H Insertion Reactions of Rhodium Carbenoids Derived from Phenyldiazoacetates of Chiral Alcohols. Preparation of a-Hydroxy and a-Alkoxy Esters ...
Carbodiimide-mediated Annelation of a [1,2,4]Triazole Ring into a Heterocyclic Ring: Synthesis of [1,2,4]Triazolo[4,3-b]triazole, Imidazo[1,2-b][1,2,4]triazole and [1,2,4]Triazolo[1,5-d][1,2,4]triazine Derivatives
HETEROCYCLES, 1988
ABSTRACT
Liebigs Annalen der Chemie, 1994
ABSTRACT An aza-Wittig-type reaction of iminophosphoranes 2 and 3, derived from 2-(2-azidophenyl)... more ABSTRACT An aza-Wittig-type reaction of iminophosphoranes 2 and 3, derived from 2-(2-azidophenyl)-1,2-dihydroperimidine and 2-(2-azidophenyl)perimidine, respectively, with isocyanates, carbon dioxide, carbon disulfide and acyl chlorides provides 6-substituted quinazolino[3,4-α]perimidines 4–10.
Biochemical Pharmacology, 2004
ITB (6-(p-bromophenyl)amino-7-(p-chlorophenyl)indazolo[2&... more ITB (6-(p-bromophenyl)amino-7-(p-chlorophenyl)indazolo[2',3':1,5]-1,2,4-triazolo[4,3-a]-1,3,5-benzotriazepine) is a novel inhibitor of cyclo-oxygenase-2 (COX-2) with antiinflammatory activity in animal models. In the present study, we investigated the effect of this compound on the production of catabolic or antiinflammatory mediators in osteoarthritis (OA) cartilage. In OA cartilage explants, ITB inhibited the production of prostaglandin E(2) (PGE(2)), tumour necrosis factor-alpha (TNF-alpha) and matrix metalloproteinase-13 (MMP-13) in a concentration-dependent manner, whereas nitrite was partially reduced. On the contrary, ITB increased the production of interleukin (IL)-10 and the expression of heme oxygenase-1 (HO-1). ITB inhibited the production of catabolic mediators at concentrations able to increase IL-10 and HO-1 in OA cartilage, suggesting that this compound may be useful in the prevention of cartilage degradation.