Enxhi Lalo - Academia.edu (original) (raw)

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Papers by Enxhi Lalo

Research paper thumbnail of Real-World Outcomes of IDH Mutant AML Patients Treated with or without IDH Inhibitors

Research paper thumbnail of Real-World Outcomes and Cardiac Implications of FLT3 Inhibitors in Acute Myeloid Leukemia

Research paper thumbnail of COVID-19 In Children: What You Should Know

Research paper thumbnail of Efficacy analysis of different FLT3 inhibitors in patients with relapsed/refractory acute myeloid leukemia and high‐risk myelodysplastic syndrome

Research paper thumbnail of Congenital Heart Disease

Research paper thumbnail of Liposomal (64)Cu-PET Imaging of Anti-VEGF Drug Effects on Liposomal Delivery to Colon Cancer Xenografts

Theranostics, 2017

Liposomes (LP) deliver drug to tumors due to enhanced permeability and retention (EPR). LP were l... more Liposomes (LP) deliver drug to tumors due to enhanced permeability and retention (EPR). LP were labeled with (64)Cu for positron emission tomography (PET) to image tumor localization. Bevacizumab (bev), a VEGF targeted antibody, may modify LP delivery by altering tumor EPR and this change can also be imaged. Objective: Assess the utility of (64)Cu-labeled LP for PET in measuring altered LP delivery early after treatment with bev. Methods: HT-29 human colorectal adenocarcinoma tumors were grown subcutaneously in SCID mice. Empty LP MM-DX-929 (Merrimack Pharmaceuticals, Inc. Cambridge, MA) were labeled with (64)CuCl2 chelated with 4-DEAP-ATSC. Tumor-bearing mice received ~200-300 μCi of (64)Cu-MM-DX-929 and imaged with microPET. All mice were scanned before and after the treatment period, in which half of the mice received bev for one week. Scans were compared for changes in LP accumulation during this time. Initially, tissues were collected after the second PET for biodistribution me...

Research paper thumbnail of Liposomal (64)Cu-PET Imaging of Anti-VEGF Drug Effects on Liposomal Delivery to Colon Cancer Xenografts

Theranostics, 2017

Liposomes (LP) deliver drug to tumors due to enhanced permeability and retention (EPR). LP were l... more Liposomes (LP) deliver drug to tumors due to enhanced permeability and retention (EPR). LP were labeled with (64)Cu for positron emission tomography (PET) to image tumor localization. Bevacizumab (bev), a VEGF targeted antibody, may modify LP delivery by altering tumor EPR and this change can also be imaged. Objective: Assess the utility of (64)Cu-labeled LP for PET in measuring altered LP delivery early after treatment with bev. Methods: HT-29 human colorectal adenocarcinoma tumors were grown subcutaneously in SCID mice. Empty LP MM-DX-929 (Merrimack Pharmaceuticals, Inc. Cambridge, MA) were labeled with (64)CuCl2 chelated with 4-DEAP-ATSC. Tumor-bearing mice received ~200-300 μCi of (64)Cu-MM-DX-929 and imaged with microPET. All mice were scanned before and after the treatment period, in which half of the mice received bev for one week. Scans were compared for changes in LP accumulation during this time. Initially, tissues were collected after the second PET for biodistribution me...

Research paper thumbnail of Real-World Outcomes of IDH Mutant AML Patients Treated with or without IDH Inhibitors

Research paper thumbnail of Real-World Outcomes and Cardiac Implications of FLT3 Inhibitors in Acute Myeloid Leukemia

Research paper thumbnail of COVID-19 In Children: What You Should Know

Research paper thumbnail of Efficacy analysis of different FLT3 inhibitors in patients with relapsed/refractory acute myeloid leukemia and high‐risk myelodysplastic syndrome

Research paper thumbnail of Congenital Heart Disease

Research paper thumbnail of Liposomal (64)Cu-PET Imaging of Anti-VEGF Drug Effects on Liposomal Delivery to Colon Cancer Xenografts

Theranostics, 2017

Liposomes (LP) deliver drug to tumors due to enhanced permeability and retention (EPR). LP were l... more Liposomes (LP) deliver drug to tumors due to enhanced permeability and retention (EPR). LP were labeled with (64)Cu for positron emission tomography (PET) to image tumor localization. Bevacizumab (bev), a VEGF targeted antibody, may modify LP delivery by altering tumor EPR and this change can also be imaged. Objective: Assess the utility of (64)Cu-labeled LP for PET in measuring altered LP delivery early after treatment with bev. Methods: HT-29 human colorectal adenocarcinoma tumors were grown subcutaneously in SCID mice. Empty LP MM-DX-929 (Merrimack Pharmaceuticals, Inc. Cambridge, MA) were labeled with (64)CuCl2 chelated with 4-DEAP-ATSC. Tumor-bearing mice received ~200-300 μCi of (64)Cu-MM-DX-929 and imaged with microPET. All mice were scanned before and after the treatment period, in which half of the mice received bev for one week. Scans were compared for changes in LP accumulation during this time. Initially, tissues were collected after the second PET for biodistribution me...

Research paper thumbnail of Liposomal (64)Cu-PET Imaging of Anti-VEGF Drug Effects on Liposomal Delivery to Colon Cancer Xenografts

Theranostics, 2017

Liposomes (LP) deliver drug to tumors due to enhanced permeability and retention (EPR). LP were l... more Liposomes (LP) deliver drug to tumors due to enhanced permeability and retention (EPR). LP were labeled with (64)Cu for positron emission tomography (PET) to image tumor localization. Bevacizumab (bev), a VEGF targeted antibody, may modify LP delivery by altering tumor EPR and this change can also be imaged. Objective: Assess the utility of (64)Cu-labeled LP for PET in measuring altered LP delivery early after treatment with bev. Methods: HT-29 human colorectal adenocarcinoma tumors were grown subcutaneously in SCID mice. Empty LP MM-DX-929 (Merrimack Pharmaceuticals, Inc. Cambridge, MA) were labeled with (64)CuCl2 chelated with 4-DEAP-ATSC. Tumor-bearing mice received ~200-300 μCi of (64)Cu-MM-DX-929 and imaged with microPET. All mice were scanned before and after the treatment period, in which half of the mice received bev for one week. Scans were compared for changes in LP accumulation during this time. Initially, tissues were collected after the second PET for biodistribution me...

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