Erdal Benli - Academia.edu (original) (raw)
Papers by Erdal Benli
PubMed, Nov 1, 2018
Purpose: The aim of this study was to investigate the association between fragmented QRS and left... more Purpose: The aim of this study was to investigate the association between fragmented QRS and left ventricular (LV) systolic function in patients with erectile dysfunction (ED). Methods: A total of 106 patients with ED and without a history of coronary artery disease (CAD) were compared with 54 age- and gender-matched healthy controls. LV systolic function was evaluated using speckle tracking echocardiography via global longitudinal strain (GLS) and global circumferential strain (GCS). The patients with ED were compared with healthy controls. The study group was further subdivided into fQRS (+) and fQRS (-) groups and compared with each other. Results: The frequency of fQRS was significantly higher in the patients with ED (p = 0.01). The frequency of fQRS was higher in the patients with mild and moderate ED, and significantly higher in those with severe ED (p < 0.001). LV-GLS (%) was 17.46 ± 1.37 and 20.05 ± 1.42 in the fQRS (+) and fQRS (-) groups, respectively (p ≤ 0.001). LV-GCS (%) was 17.33 ± 0.81 and 18.55 ± 0.92 in the fQRS (+) and fQRS (-) groups, respectively (p ≤ 0.001). fQRS and age were independent predictors of LV-GLS. Conclusions: The frequency of fQRS was higher in the patients with ED even in the absence of overt CAD. In the patients with ED, the fQRS (+) group had significantly lower values of LV-GLS and LV-GCS. These results indicate that presence of fQRS is associated with subclinical LV dysfunction in patients with ED.
Yeni üroloji dergisi, Feb 27, 2023
Objective: The definite cause of overactive bladder (OAB), which negatively affects the quality o... more Objective: The definite cause of overactive bladder (OAB), which negatively affects the quality of life of patients, is unknown. This study aims to provide evidence for the inflammatory process in patients with OAB whose etiology has not been fully elucidated. Material and Methods: The study included 154 people with OAB diagnosis and 131 people as controls. This study was conducted retrospectively, cross-sectionally between April 2015 and April 2020. The data were recorded at the first meeting by an expert on this subject. Groups were compared in terms of CRP and ESR measured in serum. Statistical analysis used the chi-square test, independent samples t-test, Mann-Whitney U test, and Pearson and Spearman correlation analyses. P<0.05 was accepted as statistical significance. Results: There were no differences between the groups in terms of comorbid diseases. There were significant differences identified in terms of age and BMI between the groups (p<0.005). When groups are compared according to CRP levels, values were 0.28 [0.54] for the OAB group and 0.17 [0.22] mg/dl for the control group (p=0.047). The distribution according to ESR in the groups was 19 [30.5] and 12.5 [13] mm/h, respectively (p=0.004). Conclusion: This study provides new evidence to the literature showing the relationship between OAB and an inflammatory process. It was determined that CRP and ESR levels were increased in patients with OAB compared to the control group. These results show us that there is an inflammatory process at the onset of this disease. Keywords: inflammation, overactive bladder,
Journal of Clinical and Analytical Medicine, Apr 1, 2016
Böbreğin kistik lezyonları herediter ve nonherediter kistleri içeren çok geniş bir lezyon aralığı... more Böbreğin kistik lezyonları herediter ve nonherediter kistleri içeren çok geniş bir lezyon aralığına sahiptir. Bunlar böbrek kisti şeklinde tek bulgu olabileceği gibi ekstrarenal bir klinik sendromun parçası da olabilir. Bu nedenle kistik lezyonlar değişik birimleri içeren multidisipliner yaklaşımı gündeme getirmektedir. Otozomal dominant polikistik böbrek hastalığı, her iki böbrekte farklı boyut ve sayıda kistik değişiklikler şeklinde kendini gösteren sistemik ve kalıtsal bir hastalıktır. Herediter ve bazı edinsel kistik hastalıklar zemininde tümörle birlikteliği çeşitli çalışmalarda ortaya konsa da nadirdir. Burada otozomal dominant polikistik böbrek hastalığı tanısı almış, son altı aydır batında ağrısız kitle nedeniyle yapılan fizik muayene, radyolojik ve laboratuvar tetkikleri sonucu bilateral renal kitle tanısı konan ve nadir görülen, sağ renal kitleye nefron koruyucu cerrahi, sol renal kitleye aktif izlem ile takip edilen hasta güncel literatür taranarak tartışılmıştır.
Journal of Clinical and Analytical Medicine, Jul 1, 2012
Bu çalışmada E.coli ile oluşan idrar yolu enfeksiyonunda antibiyotik direncini ortaya koymak amaç... more Bu çalışmada E.coli ile oluşan idrar yolu enfeksiyonunda antibiyotik direncini ortaya koymak amaçlanmıştır. Gereç ve Yöntem: 2007-2011 yılları arasında Bingöl Devlet Hastanesine idrar yolu enfeksiyonu şüphesi başvuran 1412 hastadan gönderilen idrar kültür örnekleri retrospektif olarak analiz edildi. Yakın zamanda antibiyotik kullananlar çalışma dışı bırakıldı. Bulgular: İdrar yolu enfeksiyon şüphesi ile 1412 hastadan gönderilen idrar kültürlerinden 113'de (%8) üreme olmuştur. İdrar kültüründe üreme tespit edilen hastaların 78'de (%69) E.coli üredi. İdrar kültüründe E.coli üreyen hastaların cinsiyet dağılımı 13'i erkek (%17), 65'i kız (%83) şeklindeydi. Toplumdan kazanılmış idrar yolu enfeksiyonu saptanan çocukların yaş dağılımı ele alındığında %39'u 7 yaş ve altındaydı. E.coli için antibiyotik direnç oranları; ampisilin için %71, amoksilin-klavulonat için % 53, ko-trimoksazol için %51, sefalotin için %48, sefuroksim için %37, siprofloksasin için %30, sefepim için %25, norfloksasin için %21, gentamisin için %21, sulbactam-seforazom için %6, amikasin için %2,imipenem ve meropenem için %0 olarak bulundu. Sonuç: Çocuk yaş grubunda daha uzun yaşam beklentisi olduğundan antibiyotiklere karşı oluşan direnç oranları daha önem kazanmaktadır. Bu nedenle çocuklarda muhtemel üropatojenler ve antibiyotik duyarlıkları yakından izlenerek tedavide göz önünde bulundurulmalıdır.
Bratislava Medical Journal
BACKGROUND: There are very few studies in the literature focusing on whether dexmedetomidine exer... more BACKGROUND: There are very few studies in the literature focusing on whether dexmedetomidine exerts a protective effect on colistin nephrotoxicity. Our study aims to investigate the nephroprotective effect of dexmedetomidine in an experimental model of nephrotoxicity in rats. METHODS: The control group was administered saline (SF) intraperitoneally twice a day. The colistin group received an intraperitoneal (ip) injection of 10 mg/kg of colistin twice a day. The DX10 group received 10 mg/ kg of colistin 20 minutes after the intraperitoneal injection of 10 mcg/kg of dexmedetomidine. The DX20 group received 10 mg/kg of colistin 20 minutes after the intraperitoneal injection of 20 mcg/kg of dexmedetomidine. Applications were continued for 7 days, twice a day. All rats were sacrifi ced on the 8th day after blood and kidney tissue samples were taken. BUN, Creatine, KIM-1 and Endothelin-1 were studied in blood samples. RESULTS: There was a signifi cant difference in the median values of Urea, BUN and Creatine between the groups (p<0.001, p< 0.001, p < 0.001, respectively). There was a signifi cant difference in the median values of KIM-1 and Endothelin-1 between the groups (p = 0.009, p = 0.001, respectively). A signifi cant difference was observed between the histopathological scores of the groups (p < 0.001). CONCLUSION: Dexmedetomidine signifi cantly decreased the elevated levels of BUN, Creatinine, KIM-1, and Endothelin-1 induced by colistin. Dexmedetomidine, at both doses, histopathologically prevented apoptosis and reduced the number of necrotic cells in the kidneys. Dexmedetomidine provides renoprotective effects, therefore it is a valuable sedation agent for clinicians working in intensive care units (Tab. 2, Fig. 4, Ref. 19).
Asian Pacific Journal of Cancer Prevention, Jan 15, 2014
Background: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk.... more Background: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. The aim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients with bladder cancer. Materials and Methods: DKK-1 levels were determined in serum samples from 90 patients with bladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by using enzyme linked immune-sorbent assay (ELISA). Results: Elevated preoperative DKK-1 levels were associated with tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001). Conclusions: The results of our study demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase in the tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determination of bladder cancer and the detection of patients with a likely poor clinical outcome.
Archivio Italiano di Urologia e Andrologia
Objectives: Spermatogenesis, in which cell regeneration continues, can be affected by environment... more Objectives: Spermatogenesis, in which cell regeneration continues, can be affected by environmental, chemical, psychological factors or various diseases. There is conflicting information in the literature about the effect of isotretinoin, which is widely used in acne treatment, on testes and spermatogenesis. Therefore, we planned a rat study to evaluate the long-term efficacy of oral isotretinoin on testicular tissues and spermatogenesis. Materials and methods: The Group 1 (n = 6) 7.5 mg/kg/day and the Group 2 (n = 6) received isotretinoin at a dose of 30 mg/kg/day dissolved in sunflower oil, the Sham Group (n = 6) received only sunflower oil by gavage, and the control group (n = 6) received standard feed and water for four weeks. After the 4th week, all animals were fed with standard feed and water and followed for the next four weeks. At the end of the 8th week, all animals were sacrificed under deep anesthesia. Seminiferous tubule diameters, epithelial thickness, apoptotic index,...
Iranian Journal of Public Health
Background: Prostate cancer (PCa) is the most common cancer affecting men, apart from cutaneous c... more Background: Prostate cancer (PCa) is the most common cancer affecting men, apart from cutaneous cancers. Serum prostate specific antigen (PSA) levels are frequently used to predict prostate cancer diagnosis. However, many causes (e.g., prostatitis, benign prostate obstruction, urethral catheterization) may cause elevated PSA, in addition to PCa. We aimed to investigate the gamma glutamyl transferase (GGT) levels, a serum biomarker not affected by situations other than cancer causing elevated PSA. Methods: The study evaluated male patients with prostate biopsy due to high serum PSA levels and/or abnormal digital rectal examination (DRE) examined in Ordu University Education and Research Hospital, Ordu/Turkey urology clinic from April 2019 to April 2021. The patient group in the study included 261 men with PCa diagnosis and the control group included 245 healthy men with normal PSA levels, and no PCa and/or benign prostate obstruction (BPO). The two groups were compared in terms of se...
Annals of Medical Research
Middle Black Sea Journal of Health Science
Objective: We aimed to present our results and experience related to patients followed with Fourn... more Objective: We aimed to present our results and experience related to patients followed with Fournier’s gangrene.Methods: Patient data were retrospectively obtained from patient records. Data from 10 patients attending Ordu University Education-Research Hospital Urology clinic with diagnosis of Fournier’s gangrene from April 2017 to April 2021 were used. Cases developing after surgery, with compression wounds, and related to radiotherapy were excluded. Information like patient history, demographic features, comorbid diseases, physical examination findings and treatment outcomes were recorded. Results: The study included outcomes for 10 patients. Mean age was identified as 71.50±9.09 (51-78) years. All of our patients were male, with no female patient among our cases. Mean body weight of patients was 80.40±1.81 (78-83) kg. When patients are assessed in terms of substance use, 60% of patients smoked and 10% drank alcohol. The mean total number of medications used due to comorbid diseas...
Middle Black Sea Journal of Health Science
Objective: This study aims to examine whether our region's Prostate Cancer (PCa) screening pr... more Objective: This study aims to examine whether our region's Prostate Cancer (PCa) screening programs comply with the European Association of Urology (EAU) Guidelines. Method: This study was conducted as a retrospective, cross-sectional study between April 2014 and July 2022. Two hundred seventy patients who applied to our clinic for various reasons and were diagnosed with PCa were included in the study. Characteristics of the patients, such as age at diagnosis, comorbidities, age at first PSA examination, and PSA values, were recorded. Results: The mean age of the patients at the time of cancer diagnosis was 67.42±8.64 (43-91) years. PSA value (median±IQR) at the diagnosis was 9.58±19.43 (1.83-3437) ng/ml. When the distribution of cancer according to different decades of life was examined, there were 5 (%1.8) patients in the 40-50 age range, 44 (16.1%) in the 50-60 age range, 111 (40.7%) in the 60-70 age range, 86 (31.5%) in the 70-80 age range, and 24 (8.8%) after the age of 80....
Middle Black Sea Journal of Health Science
Objective: Via the use of an alternative promoter, a truncated c-KIT protein (tr-KIT) of 30-50 kD... more Objective: Via the use of an alternative promoter, a truncated c-KIT protein (tr-KIT) of 30-50 kDa is generated, lacking extracellular and transmembrane domains. Moreover, over-expression of tr-KIT, a stronger activator than c-KIT, appears to be specific to prostate cancer (PCa). Also, Imatinib, a tyrosine kinase inhibitor, blocks the activity of full-length c-KIT but has no effect on tr-KIT in PCa. Tr-KIT has its own nuclear factor binding site. However, the transcription factors (TFs) binding to this region specific to tr-KIT are not known yet. This study was conducted to define the most potential TFs specific for tr-KIT via in silico analysis.Methods: Tr-KIT potential TF binding sequence was uploaded into Tfsitescan database. Five TFs with the highest potential binding to this sequence were selected. Transcriptomic data of LNCaP (PCa expressing tr-KIT), PC3 (PCa not expressing tr-KIT) and RWPE-1 (normal prostate) cell lines (GSM1647378, GSE36022 and GSM738189, respectively) from ...
Türk biyokimya dergisi, 2017
The New Journal of Urology, Aug 1, 2016
Prostat biyopsisi uygulanan hastalarda serum c-reaktif protein düzeylerinin benign prostat hiperp... more Prostat biyopsisi uygulanan hastalarda serum c-reaktif protein düzeylerinin benign prostat hiperplazisi ve prostat kanseri arasında karşılaştırılması
Bozok tıp dergisi, Jun 29, 2018
PubMed, Nov 1, 2018
Purpose: The aim of this study was to investigate the association between fragmented QRS and left... more Purpose: The aim of this study was to investigate the association between fragmented QRS and left ventricular (LV) systolic function in patients with erectile dysfunction (ED). Methods: A total of 106 patients with ED and without a history of coronary artery disease (CAD) were compared with 54 age- and gender-matched healthy controls. LV systolic function was evaluated using speckle tracking echocardiography via global longitudinal strain (GLS) and global circumferential strain (GCS). The patients with ED were compared with healthy controls. The study group was further subdivided into fQRS (+) and fQRS (-) groups and compared with each other. Results: The frequency of fQRS was significantly higher in the patients with ED (p = 0.01). The frequency of fQRS was higher in the patients with mild and moderate ED, and significantly higher in those with severe ED (p < 0.001). LV-GLS (%) was 17.46 ± 1.37 and 20.05 ± 1.42 in the fQRS (+) and fQRS (-) groups, respectively (p ≤ 0.001). LV-GCS (%) was 17.33 ± 0.81 and 18.55 ± 0.92 in the fQRS (+) and fQRS (-) groups, respectively (p ≤ 0.001). fQRS and age were independent predictors of LV-GLS. Conclusions: The frequency of fQRS was higher in the patients with ED even in the absence of overt CAD. In the patients with ED, the fQRS (+) group had significantly lower values of LV-GLS and LV-GCS. These results indicate that presence of fQRS is associated with subclinical LV dysfunction in patients with ED.
Yeni üroloji dergisi, Feb 27, 2023
Objective: The definite cause of overactive bladder (OAB), which negatively affects the quality o... more Objective: The definite cause of overactive bladder (OAB), which negatively affects the quality of life of patients, is unknown. This study aims to provide evidence for the inflammatory process in patients with OAB whose etiology has not been fully elucidated. Material and Methods: The study included 154 people with OAB diagnosis and 131 people as controls. This study was conducted retrospectively, cross-sectionally between April 2015 and April 2020. The data were recorded at the first meeting by an expert on this subject. Groups were compared in terms of CRP and ESR measured in serum. Statistical analysis used the chi-square test, independent samples t-test, Mann-Whitney U test, and Pearson and Spearman correlation analyses. P<0.05 was accepted as statistical significance. Results: There were no differences between the groups in terms of comorbid diseases. There were significant differences identified in terms of age and BMI between the groups (p<0.005). When groups are compared according to CRP levels, values were 0.28 [0.54] for the OAB group and 0.17 [0.22] mg/dl for the control group (p=0.047). The distribution according to ESR in the groups was 19 [30.5] and 12.5 [13] mm/h, respectively (p=0.004). Conclusion: This study provides new evidence to the literature showing the relationship between OAB and an inflammatory process. It was determined that CRP and ESR levels were increased in patients with OAB compared to the control group. These results show us that there is an inflammatory process at the onset of this disease. Keywords: inflammation, overactive bladder,
Journal of Clinical and Analytical Medicine, Apr 1, 2016
Böbreğin kistik lezyonları herediter ve nonherediter kistleri içeren çok geniş bir lezyon aralığı... more Böbreğin kistik lezyonları herediter ve nonherediter kistleri içeren çok geniş bir lezyon aralığına sahiptir. Bunlar böbrek kisti şeklinde tek bulgu olabileceği gibi ekstrarenal bir klinik sendromun parçası da olabilir. Bu nedenle kistik lezyonlar değişik birimleri içeren multidisipliner yaklaşımı gündeme getirmektedir. Otozomal dominant polikistik böbrek hastalığı, her iki böbrekte farklı boyut ve sayıda kistik değişiklikler şeklinde kendini gösteren sistemik ve kalıtsal bir hastalıktır. Herediter ve bazı edinsel kistik hastalıklar zemininde tümörle birlikteliği çeşitli çalışmalarda ortaya konsa da nadirdir. Burada otozomal dominant polikistik böbrek hastalığı tanısı almış, son altı aydır batında ağrısız kitle nedeniyle yapılan fizik muayene, radyolojik ve laboratuvar tetkikleri sonucu bilateral renal kitle tanısı konan ve nadir görülen, sağ renal kitleye nefron koruyucu cerrahi, sol renal kitleye aktif izlem ile takip edilen hasta güncel literatür taranarak tartışılmıştır.
Journal of Clinical and Analytical Medicine, Jul 1, 2012
Bu çalışmada E.coli ile oluşan idrar yolu enfeksiyonunda antibiyotik direncini ortaya koymak amaç... more Bu çalışmada E.coli ile oluşan idrar yolu enfeksiyonunda antibiyotik direncini ortaya koymak amaçlanmıştır. Gereç ve Yöntem: 2007-2011 yılları arasında Bingöl Devlet Hastanesine idrar yolu enfeksiyonu şüphesi başvuran 1412 hastadan gönderilen idrar kültür örnekleri retrospektif olarak analiz edildi. Yakın zamanda antibiyotik kullananlar çalışma dışı bırakıldı. Bulgular: İdrar yolu enfeksiyon şüphesi ile 1412 hastadan gönderilen idrar kültürlerinden 113'de (%8) üreme olmuştur. İdrar kültüründe üreme tespit edilen hastaların 78'de (%69) E.coli üredi. İdrar kültüründe E.coli üreyen hastaların cinsiyet dağılımı 13'i erkek (%17), 65'i kız (%83) şeklindeydi. Toplumdan kazanılmış idrar yolu enfeksiyonu saptanan çocukların yaş dağılımı ele alındığında %39'u 7 yaş ve altındaydı. E.coli için antibiyotik direnç oranları; ampisilin için %71, amoksilin-klavulonat için % 53, ko-trimoksazol için %51, sefalotin için %48, sefuroksim için %37, siprofloksasin için %30, sefepim için %25, norfloksasin için %21, gentamisin için %21, sulbactam-seforazom için %6, amikasin için %2,imipenem ve meropenem için %0 olarak bulundu. Sonuç: Çocuk yaş grubunda daha uzun yaşam beklentisi olduğundan antibiyotiklere karşı oluşan direnç oranları daha önem kazanmaktadır. Bu nedenle çocuklarda muhtemel üropatojenler ve antibiyotik duyarlıkları yakından izlenerek tedavide göz önünde bulundurulmalıdır.
Bratislava Medical Journal
BACKGROUND: There are very few studies in the literature focusing on whether dexmedetomidine exer... more BACKGROUND: There are very few studies in the literature focusing on whether dexmedetomidine exerts a protective effect on colistin nephrotoxicity. Our study aims to investigate the nephroprotective effect of dexmedetomidine in an experimental model of nephrotoxicity in rats. METHODS: The control group was administered saline (SF) intraperitoneally twice a day. The colistin group received an intraperitoneal (ip) injection of 10 mg/kg of colistin twice a day. The DX10 group received 10 mg/ kg of colistin 20 minutes after the intraperitoneal injection of 10 mcg/kg of dexmedetomidine. The DX20 group received 10 mg/kg of colistin 20 minutes after the intraperitoneal injection of 20 mcg/kg of dexmedetomidine. Applications were continued for 7 days, twice a day. All rats were sacrifi ced on the 8th day after blood and kidney tissue samples were taken. BUN, Creatine, KIM-1 and Endothelin-1 were studied in blood samples. RESULTS: There was a signifi cant difference in the median values of Urea, BUN and Creatine between the groups (p<0.001, p< 0.001, p < 0.001, respectively). There was a signifi cant difference in the median values of KIM-1 and Endothelin-1 between the groups (p = 0.009, p = 0.001, respectively). A signifi cant difference was observed between the histopathological scores of the groups (p < 0.001). CONCLUSION: Dexmedetomidine signifi cantly decreased the elevated levels of BUN, Creatinine, KIM-1, and Endothelin-1 induced by colistin. Dexmedetomidine, at both doses, histopathologically prevented apoptosis and reduced the number of necrotic cells in the kidneys. Dexmedetomidine provides renoprotective effects, therefore it is a valuable sedation agent for clinicians working in intensive care units (Tab. 2, Fig. 4, Ref. 19).
Asian Pacific Journal of Cancer Prevention, Jan 15, 2014
Background: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk.... more Background: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. The aim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients with bladder cancer. Materials and Methods: DKK-1 levels were determined in serum samples from 90 patients with bladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by using enzyme linked immune-sorbent assay (ELISA). Results: Elevated preoperative DKK-1 levels were associated with tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001). Conclusions: The results of our study demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase in the tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determination of bladder cancer and the detection of patients with a likely poor clinical outcome.
Archivio Italiano di Urologia e Andrologia
Objectives: Spermatogenesis, in which cell regeneration continues, can be affected by environment... more Objectives: Spermatogenesis, in which cell regeneration continues, can be affected by environmental, chemical, psychological factors or various diseases. There is conflicting information in the literature about the effect of isotretinoin, which is widely used in acne treatment, on testes and spermatogenesis. Therefore, we planned a rat study to evaluate the long-term efficacy of oral isotretinoin on testicular tissues and spermatogenesis. Materials and methods: The Group 1 (n = 6) 7.5 mg/kg/day and the Group 2 (n = 6) received isotretinoin at a dose of 30 mg/kg/day dissolved in sunflower oil, the Sham Group (n = 6) received only sunflower oil by gavage, and the control group (n = 6) received standard feed and water for four weeks. After the 4th week, all animals were fed with standard feed and water and followed for the next four weeks. At the end of the 8th week, all animals were sacrificed under deep anesthesia. Seminiferous tubule diameters, epithelial thickness, apoptotic index,...
Iranian Journal of Public Health
Background: Prostate cancer (PCa) is the most common cancer affecting men, apart from cutaneous c... more Background: Prostate cancer (PCa) is the most common cancer affecting men, apart from cutaneous cancers. Serum prostate specific antigen (PSA) levels are frequently used to predict prostate cancer diagnosis. However, many causes (e.g., prostatitis, benign prostate obstruction, urethral catheterization) may cause elevated PSA, in addition to PCa. We aimed to investigate the gamma glutamyl transferase (GGT) levels, a serum biomarker not affected by situations other than cancer causing elevated PSA. Methods: The study evaluated male patients with prostate biopsy due to high serum PSA levels and/or abnormal digital rectal examination (DRE) examined in Ordu University Education and Research Hospital, Ordu/Turkey urology clinic from April 2019 to April 2021. The patient group in the study included 261 men with PCa diagnosis and the control group included 245 healthy men with normal PSA levels, and no PCa and/or benign prostate obstruction (BPO). The two groups were compared in terms of se...
Annals of Medical Research
Middle Black Sea Journal of Health Science
Objective: We aimed to present our results and experience related to patients followed with Fourn... more Objective: We aimed to present our results and experience related to patients followed with Fournier’s gangrene.Methods: Patient data were retrospectively obtained from patient records. Data from 10 patients attending Ordu University Education-Research Hospital Urology clinic with diagnosis of Fournier’s gangrene from April 2017 to April 2021 were used. Cases developing after surgery, with compression wounds, and related to radiotherapy were excluded. Information like patient history, demographic features, comorbid diseases, physical examination findings and treatment outcomes were recorded. Results: The study included outcomes for 10 patients. Mean age was identified as 71.50±9.09 (51-78) years. All of our patients were male, with no female patient among our cases. Mean body weight of patients was 80.40±1.81 (78-83) kg. When patients are assessed in terms of substance use, 60% of patients smoked and 10% drank alcohol. The mean total number of medications used due to comorbid diseas...
Middle Black Sea Journal of Health Science
Objective: This study aims to examine whether our region's Prostate Cancer (PCa) screening pr... more Objective: This study aims to examine whether our region's Prostate Cancer (PCa) screening programs comply with the European Association of Urology (EAU) Guidelines. Method: This study was conducted as a retrospective, cross-sectional study between April 2014 and July 2022. Two hundred seventy patients who applied to our clinic for various reasons and were diagnosed with PCa were included in the study. Characteristics of the patients, such as age at diagnosis, comorbidities, age at first PSA examination, and PSA values, were recorded. Results: The mean age of the patients at the time of cancer diagnosis was 67.42±8.64 (43-91) years. PSA value (median±IQR) at the diagnosis was 9.58±19.43 (1.83-3437) ng/ml. When the distribution of cancer according to different decades of life was examined, there were 5 (%1.8) patients in the 40-50 age range, 44 (16.1%) in the 50-60 age range, 111 (40.7%) in the 60-70 age range, 86 (31.5%) in the 70-80 age range, and 24 (8.8%) after the age of 80....
Middle Black Sea Journal of Health Science
Objective: Via the use of an alternative promoter, a truncated c-KIT protein (tr-KIT) of 30-50 kD... more Objective: Via the use of an alternative promoter, a truncated c-KIT protein (tr-KIT) of 30-50 kDa is generated, lacking extracellular and transmembrane domains. Moreover, over-expression of tr-KIT, a stronger activator than c-KIT, appears to be specific to prostate cancer (PCa). Also, Imatinib, a tyrosine kinase inhibitor, blocks the activity of full-length c-KIT but has no effect on tr-KIT in PCa. Tr-KIT has its own nuclear factor binding site. However, the transcription factors (TFs) binding to this region specific to tr-KIT are not known yet. This study was conducted to define the most potential TFs specific for tr-KIT via in silico analysis.Methods: Tr-KIT potential TF binding sequence was uploaded into Tfsitescan database. Five TFs with the highest potential binding to this sequence were selected. Transcriptomic data of LNCaP (PCa expressing tr-KIT), PC3 (PCa not expressing tr-KIT) and RWPE-1 (normal prostate) cell lines (GSM1647378, GSE36022 and GSM738189, respectively) from ...
Türk biyokimya dergisi, 2017
The New Journal of Urology, Aug 1, 2016
Prostat biyopsisi uygulanan hastalarda serum c-reaktif protein düzeylerinin benign prostat hiperp... more Prostat biyopsisi uygulanan hastalarda serum c-reaktif protein düzeylerinin benign prostat hiperplazisi ve prostat kanseri arasında karşılaştırılması
Bozok tıp dergisi, Jun 29, 2018