Ayşen Erdem - Academia.edu (original) (raw)

Papers by Ayşen Erdem

The anatolian journal of cardiology, 2023

Clinical and Experimental Pharmacology and Physiology, May 19, 2017

Previous studies have shown that 2-deoxy-D-glucose (2-DG) increases gastric motility via the vagu... more Previous studies have shown that 2-deoxy-D-glucose (2-DG) increases gastric motility via the vagus nerve, but the underlying mechanism remains elusive. Since nitric oxide (NO) is involved in gastric motility, a possible interplay between 2-DG and NO can be suggested. In the present study, Wistar rats (250-350 g) of both sexes were intravenously injected with 2-DG (200 mg•kg-1), and the effects of the intravenous injection of the nitric oxide synthase (NOS) inhibitors; nitro-L-arginine methyl ester (L-NAME, 10 mg•kg-1) and N ω-nitro-L-arginine (L-NNA, 10 mg•kg-1) were investigated. Animals were anaesthetized and cannulated for intravenous drug injections while the left vagal nerve was electrically stimulated (0.1-10 Hz, 0.5 ms duration, 12 V, for 60 s), and intragastric pressure and gastric motility changes were monitored using a latex gastric balloon. 2-DG increased the mean intragastric pressure (baseline: 5.0 ± 0.4 cmH 2 O; after 2-DG: 14.4 ± 1.5 cmH 2 O; P = 0.0156) and significantly Accepted Article This article is protected by copyright. All rights reserved. increased the gastric motility index, while NOS inhibitors significantly attenuated both parameters. However, pretreatment with NOS inhibitors significantly augmented the gastric responses to peripheral electrical vagal stimulation. These results suggest that NO plays an excitatory role in gastric responsiveness to 2-DG and that this function may be effected in the central nervous system.

Naunyn-schmiedebergs Archives of Pharmacology, May 29, 2017

Testosterone, estradiol, and dihydrotestosterone are the main sex steroid hormones responsible fo... more Testosterone, estradiol, and dihydrotestosterone are the main sex steroid hormones responsible for the organization and sexual differentiation of brain structures during early development. The hypothalamo-pituitary-adrenocortical axis, adrenal cells, and gonads play a key role in the production of sex steroids and express adenosine receptors. Caffeine is a non-selective adenosine antagonist; therefore, it can modulate metabolic pathways in these tissues. Besides, the proportion of pregnant women that consume caffeine is ∼60%. That is why the relationship between maternal caffeine consumption and fetal development is important. Therefore, we aimed to investigate this modulatory effect of maternal caffeine consumption on sex steroids in the fetal and neonatal brain tissues. Pregnant rats were treated with a low (0.3 g/L) or high (0.8 g/L) dose of caffeine in their drinking water during pregnancy and lactation. The testosterone, estradiol, and dihydrotestosterone levels in the frontal cortex and hypothalamus were measured using radioimmunoassay at embryonic day 19 (E19), birth (PN0), and postnatal day 4 (PN4). The administration of low-dose caffeine increased the body weight in PN4 male and female rats and anogenital index in PN4 males. The administration of high-dose caffeine decreased the adrenal weight in E19 male rats and increased testosterone levels in the frontal cortex of E19 female rats and the hypothalamus of PN0 male rats. Maternal caffeine intake during pregnancy affects sex steroid levels in the frontal cortex and hypothalamus of the offspring. This concentration changes of the sex steroids in the brain may influence behavioral and neuroendocrine functions at some point in adult life.

Emotions embody goal-directed behavior for survival and adaptation through the perception of vari... more Emotions embody goal-directed behavior for survival and adaptation through the perception of variations in the environment. At a physiological level, emotions consist of three complementary components: Physical sensation, emotional expression and subjective experience. At the level of anatomical structures though, trying to segregate distinct components is impossible. Our emotions are resulting products of compatible and coordinated cortical and sub-cortical neural mechanisms originating from several anatomical structures. In this chapter, an overview of the three physiological components and underlying anatomical constructs will be presented.

European Journal of Anaesthesiology, May 1, 2005

European Journal of Anaesthesiology, May 1, 2005

induction to general anaesthesia (1,2). The goal of this study was to investigate the relationshi... more induction to general anaesthesia (1,2). The goal of this study was to investigate the relationship between preoperative values of HRV and hemodynamic responses to tracheal intubation. Materials and Methods: Spectral analysis of HRV was assessed in 100 patients (TOM Signaltechnik, Hashiba & Niederl OEG, Graz, Austria) before induction of general anaesthesia (preoperative), after induction (pre-intubation) and after tracheal intubation (post-intubation). Fentanyl with propofol (Group I, n ϭ 52) or with thiopental (Group II, n ϭ 48), followed with rocuronium, were given for induction. Absolute values of total power (TP), low and high frequency powers (LF and HF, respectively), and LF/HF ratio were analyzed. The highest percentage changes between pre-and post-intubation heart rates (d% HR) and mean arterial pressures (d% MAP), recorded by pulse oximetry and noninvasive measurements respectively, were correlated with the preoperative HRV (r-Pearson). Results and Discussions: Demographic, HRV and hemodynamic preoperative data showed no significant differences. The significant positive correlations between d% HR and preoperative TP (r ϭ 0.4984; p Ͻ 0.0001), LF (r ϭ 0.4946; p Ͻ 0.0001) and HF (r ϭ 0.3473; p Ͻ 0.001) but not LF/HF ratio (r ϭ 0.0250; p ϭ 0.851) were observed in all patients. The similar correlations were observed in Group I and II. We did not observe correlations between preoperative HRV values and d% MAP, probably due to different recording techniques of HR and MAP. Conclusion: Preoperative HRV may be predictable for the increased heart rate response to tracheal intubation. References:

Amino Acids, Oct 31, 2019

Doxorubicin (DOXO) may cause serious cardiotoxic effects that limit its use as an antineoplastic ... more Doxorubicin (DOXO) may cause serious cardiotoxic effects that limit its use as an antineoplastic agent. We aimed to evaluate the protective role of taurine (TAU), a beta amino acid with antioxidant activity, against DOXO-induced cardiotoxicity in a rat model. Thirty-one male Sprague-Dawley rats (300-400 g) were randomized into four groups: control (n = 7, intraperitoneal [ip] saline for 14 days), TAU (n = 8, 150 mg/kg body weight TAU ip for 14 days), DOXO (n = 8, 25 mg/kg body weight DOXO ip on 12th, 13th, and 14th days), and DOXO + TAU (n = 8, TAU for 14 days and DOXO on 12th, 13th, and 14th days). The left ventricular functions were evaluated on 15th day by echocardiography. The heart tissues were then excised for histological evaluation. In DOXO group, left ventricular ejection fraction (LVEF), fractional shortening (FS), and mitral lateral annulus (s') velocity were significantly lower, and the left ventricular end-diastolic and end-systolic diameters (LVEDD, LVESD) were significantly higher than control group (p < 0.05), indicating a significant deterioration in left ventricular functions. However, in comparison to DOXO group, LVESD, LVEDD, LVEF, FS, and s' were significantly improved in DOXO + TAU group (p < 0.05). On histological evaluation, contrary to the normal cellular structure of cardiomyocytes in control and TAU groups, DOXO group showed increased nuclear or cytoplasmic changes and infiltrative cell proliferation (p < 0.001), which were remarkably reduced in DOXO + TAU group (p < 0.001). TAU treatment has a protective effect against DOXO-induced cardiotoxicity on echocardiographical and histological evaluation. For common use of TAU to prevent DOXO-induced cardiotoxicity, our findings should be confirmed by clinical studies.

Cell and Tissue Research, Dec 23, 2022

PubMed, Jun 7, 2023

Aim: Empagliflozin (EMPA) is a sodium-glucose transporter-2 inhibitor used in the treatment of ty... more Aim: Empagliflozin (EMPA) is a sodium-glucose transporter-2 inhibitor used in the treatment of type 2 diabetes and has positive effects on cardiovascular outcomes. Amitriptyline (AMT) can be used in many clinical indications but leads to cardiotoxicity by causing QT prolongation. Our aim in this study was to determine how the effects of the concomitant use of empagliflozin and amitriptyline, which have been shown to have effects on sodium and calcium metabolism in cardiomyocytes, would cause an effect on QT and QTc intervals in clinical practice. Methods: Twenty-four male Wistar albino rats were randomised into four groups. The control group received only physiological serum (1 ml) via orogastric gavage (OG). The EMPA group received empagliflozin (10 mg/kg) via OG. The AMT group received amitriptyline (100 mg/kg) via OG. The AMT + EMPA group (n = 6) received amitriptyline (100 mg/kg) and empagliflozin (10 mg/kg). Under anaesthesia, QT and QTc intervals were measured at baseline, and in the first and second hours. Results: In the AMT group, QT intervals and QTc values were found to be statistically longer than in the control group (p ≤ 0.001). Empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. In the AMT + EMPA group, QT and QTc intervals were significantly lower compared to that in the AMT group (p < 0.01). Conclusion: In this study, we determined that empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. This effect was probably due to the opposite effects of these two agents in the intracellular calcium balance. With more clinical trials, the routine use of empagliflozin may be suggested to prevent QT and QTc prolongation in diabetic patients receiving amitriptyline.

Turkiye Klinikleri Tip Bilimleri Dergisi, 2001

Hava kirliliði insan saðlýðýný giderek artan boyutlarda tehdit eden bir sorundur. Çarpýk kentleþm... more Hava kirliliði insan saðlýðýný giderek artan boyutlarda tehdit eden bir sorundur. Çarpýk kentleþme, kalitesiz yakýt kullanýmý, kontrolsüz endüstriyel faaliyet, trafik, orman yangýnlarý vb. sorunlarý olan ülkemiz için bu konu büyük bir önem taþýmaktadýr. Havayý kirleten maddelerden biri olan SO 2 , özellikle kýþ aylarýnda yoðun bir þekilde atmosfere karýþmakta ve solunum yolu aracýlýðý ile alýnarak zararlý etkiler oluþturmaktadýr (1). Kýþ mevsiminde, özellikle

European Heart Journal, Nov 1, 2020

Journal of Clinical and Experimental Neuropsychology, Jul 19, 2017

Introduction: Emotion dysregulation (ED) has long been recognized in clinical descriptions of att... more Introduction: Emotion dysregulation (ED) has long been recognized in clinical descriptions of attention-deficit hyperactivity disorder (ADHD), but a renewed interest in ED has advanced research on the overlap between the two entities. Autonomic reactivity (AR) is a neurobiological correlate of emotion regulation; however, the association between ADHD and AR remains unclear. Our aim was to explore the clinical differences, AR, and subjective emotional responses to visual emotional stimuli in ADHD children with and without ED. Method: School-aged ADHD children with (n = 28) and without (n = 20) ED, according to the definition of deficiency in emotional self-regulation (DESR), and healthy controls (n = 22) were interviewed by using the Schedule for Affective Disorders and Schizophrenia for School Aged Children-Present and Lifetime version (K-SADS-PL) to screen frequent psychopathologies for these ages. All subjects were evaluated with Child Behavior Checklist 6-18 (CBCL), the Strengths and Difficulties Questionnaire (SDQ), the McMaster Family Assessment Device (FAD), the School-Age Temperament Inventory (SATI), and Conners' Parent Rating Scale (CPRS-48), which were completed by parents. To evaluate emotional responses, the International Affective Picture System (IAPS) and the subjective and physiological responses (electrodermal activity and heart rate reactivity) to selected pictures were examined. Results: Regarding clinically distinctive features, the ADHD+ED group differed from the ADHD-ED and the control groups in terms of having higher temperamental negative reactivity, more oppositional/conduct problems, and lower prosocial behaviors. In the AR measures, children in the ADHD+ED group rated unpleasant stimuli as more negative, but they still had lower heart rate reactivity (HRR) than the ADHD-ED and control groups; moreover, unlike the two other groups, the ADHD+ED group showed no differences in HRR between different emotional stimuli. Conclusion: The presented findings are unique in terms of their ability to clinically and physiologically differentiate between ADHD children with and without ED.

Life

Background: Doxorubicin (dox) is a chemotherapeutic agent widely used against various tumors. How... more Background: Doxorubicin (dox) is a chemotherapeutic agent widely used against various tumors. However, the clinical use of this agent is limited due to various organ toxicities. Taurine is an intracellular free β-amino acid with antioxidant properties. The present study investigated the protective mechanism of taurine on dox-induced hepatotoxicity. Methods: In total, 31 male Sprague-Dawley rats were used in the study. The control group received intraperitoneal (i.p.) 0.9% NaCl alone for 14 days; the taurine (Tau) group received i.p. taurine 150 mg/kg body weight/day for 14 days; the dox group received dox on days 12, 13, and 14 at a cumulative dose of 25 mg/kg body weight/3 days; and the tau+dox group received taurine and dox together at the same dose and through the same route. On day 15, biochemical evaluations were performed on blood samples taken from the left ventricle followed by histological examinations on liver samples. Results: Dox was found to increase liver function enzy...

European Journal of Anaesthesiology, 2005

induction to general anaesthesia (1,2). The goal of this study was to investigate the relationshi... more induction to general anaesthesia (1,2). The goal of this study was to investigate the relationship between preoperative values of HRV and hemodynamic responses to tracheal intubation. Materials and Methods: Spectral analysis of HRV was assessed in 100 patients (TOM Signaltechnik, Hashiba & Niederl OEG, Graz, Austria) before induction of general anaesthesia (preoperative), after induction (pre-intubation) and after tracheal intubation (post-intubation). Fentanyl with propofol (Group I, n ϭ 52) or with thiopental (Group II, n ϭ 48), followed with rocuronium, were given for induction. Absolute values of total power (TP), low and high frequency powers (LF and HF, respectively), and LF/HF ratio were analyzed. The highest percentage changes between pre-and post-intubation heart rates (d% HR) and mean arterial pressures (d% MAP), recorded by pulse oximetry and noninvasive measurements respectively, were correlated with the preoperative HRV (r-Pearson). Results and Discussions: Demographic, HRV and hemodynamic preoperative data showed no significant differences. The significant positive correlations between d% HR and preoperative TP (r ϭ 0.4984; p Ͻ 0.0001), LF (r ϭ 0.4946; p Ͻ 0.0001) and HF (r ϭ 0.3473; p Ͻ 0.001) but not LF/HF ratio (r ϭ 0.0250; p ϭ 0.851) were observed in all patients. The similar correlations were observed in Group I and II. We did not observe correlations between preoperative HRV values and d% MAP, probably due to different recording techniques of HR and MAP. Conclusion: Preoperative HRV may be predictable for the increased heart rate response to tracheal intubation. References:

The Anatolian Journal of Cardiology

Naunyn-Schmiedeberg's Archives of Pharmacology, 2017

Testosterone, estradiol, and dihydrotestosterone are the main sex steroid hormones responsible fo... more Testosterone, estradiol, and dihydrotestosterone are the main sex steroid hormones responsible for the organization and sexual differentiation of brain structures during early development. The hypothalamo-pituitary-adrenocortical axis, adrenal cells, and gonads play a key role in the production of sex steroids and express adenosine receptors. Caffeine is a non-selective adenosine antagonist; therefore, it can modulate metabolic pathways in these tissues. Besides, the proportion of pregnant women that consume caffeine is ∼60%. That is why the relationship between maternal caffeine consumption and fetal development is important. Therefore, we aimed to investigate this modulatory effect of maternal caffeine consumption on sex steroids in the fetal and neonatal brain tissues. Pregnant rats were treated with a low (0.3 g/L) or high (0.8 g/L) dose of caffeine in their drinking water during pregnancy and lactation. The testosterone, estradiol, and dihydrotestosterone levels in the frontal cortex and hypothalamus were measured using radioimmunoassay at embryonic day 19 (E19), birth (PN0), and postnatal day 4 (PN4). The administration of low-dose caffeine increased the body weight in PN4 male and female rats and anogenital index in PN4 males. The administration of high-dose caffeine decreased the adrenal weight in E19 male rats and increased testosterone levels in the frontal cortex of E19 female rats and the hypothalamus of PN0 male rats. Maternal caffeine intake during pregnancy affects sex steroid levels in the frontal cortex and hypothalamus of the offspring. This concentration changes of the sex steroids in the brain may influence behavioral and neuroendocrine functions at some point in adult life.

Cell and Tissue Research, Dec 23, 2022

The anatolian journal of cardiology, 2023

Clinical and Experimental Pharmacology and Physiology, May 19, 2017

Previous studies have shown that 2-deoxy-D-glucose (2-DG) increases gastric motility via the vagu... more Previous studies have shown that 2-deoxy-D-glucose (2-DG) increases gastric motility via the vagus nerve, but the underlying mechanism remains elusive. Since nitric oxide (NO) is involved in gastric motility, a possible interplay between 2-DG and NO can be suggested. In the present study, Wistar rats (250-350 g) of both sexes were intravenously injected with 2-DG (200 mg•kg-1), and the effects of the intravenous injection of the nitric oxide synthase (NOS) inhibitors; nitro-L-arginine methyl ester (L-NAME, 10 mg•kg-1) and N ω-nitro-L-arginine (L-NNA, 10 mg•kg-1) were investigated. Animals were anaesthetized and cannulated for intravenous drug injections while the left vagal nerve was electrically stimulated (0.1-10 Hz, 0.5 ms duration, 12 V, for 60 s), and intragastric pressure and gastric motility changes were monitored using a latex gastric balloon. 2-DG increased the mean intragastric pressure (baseline: 5.0 ± 0.4 cmH 2 O; after 2-DG: 14.4 ± 1.5 cmH 2 O; P = 0.0156) and significantly Accepted Article This article is protected by copyright. All rights reserved. increased the gastric motility index, while NOS inhibitors significantly attenuated both parameters. However, pretreatment with NOS inhibitors significantly augmented the gastric responses to peripheral electrical vagal stimulation. These results suggest that NO plays an excitatory role in gastric responsiveness to 2-DG and that this function may be effected in the central nervous system.

Naunyn-schmiedebergs Archives of Pharmacology, May 29, 2017

Testosterone, estradiol, and dihydrotestosterone are the main sex steroid hormones responsible fo... more Testosterone, estradiol, and dihydrotestosterone are the main sex steroid hormones responsible for the organization and sexual differentiation of brain structures during early development. The hypothalamo-pituitary-adrenocortical axis, adrenal cells, and gonads play a key role in the production of sex steroids and express adenosine receptors. Caffeine is a non-selective adenosine antagonist; therefore, it can modulate metabolic pathways in these tissues. Besides, the proportion of pregnant women that consume caffeine is ∼60%. That is why the relationship between maternal caffeine consumption and fetal development is important. Therefore, we aimed to investigate this modulatory effect of maternal caffeine consumption on sex steroids in the fetal and neonatal brain tissues. Pregnant rats were treated with a low (0.3 g/L) or high (0.8 g/L) dose of caffeine in their drinking water during pregnancy and lactation. The testosterone, estradiol, and dihydrotestosterone levels in the frontal cortex and hypothalamus were measured using radioimmunoassay at embryonic day 19 (E19), birth (PN0), and postnatal day 4 (PN4). The administration of low-dose caffeine increased the body weight in PN4 male and female rats and anogenital index in PN4 males. The administration of high-dose caffeine decreased the adrenal weight in E19 male rats and increased testosterone levels in the frontal cortex of E19 female rats and the hypothalamus of PN0 male rats. Maternal caffeine intake during pregnancy affects sex steroid levels in the frontal cortex and hypothalamus of the offspring. This concentration changes of the sex steroids in the brain may influence behavioral and neuroendocrine functions at some point in adult life.

Emotions embody goal-directed behavior for survival and adaptation through the perception of vari... more Emotions embody goal-directed behavior for survival and adaptation through the perception of variations in the environment. At a physiological level, emotions consist of three complementary components: Physical sensation, emotional expression and subjective experience. At the level of anatomical structures though, trying to segregate distinct components is impossible. Our emotions are resulting products of compatible and coordinated cortical and sub-cortical neural mechanisms originating from several anatomical structures. In this chapter, an overview of the three physiological components and underlying anatomical constructs will be presented.

European Journal of Anaesthesiology, May 1, 2005

European Journal of Anaesthesiology, May 1, 2005

induction to general anaesthesia (1,2). The goal of this study was to investigate the relationshi... more induction to general anaesthesia (1,2). The goal of this study was to investigate the relationship between preoperative values of HRV and hemodynamic responses to tracheal intubation. Materials and Methods: Spectral analysis of HRV was assessed in 100 patients (TOM Signaltechnik, Hashiba & Niederl OEG, Graz, Austria) before induction of general anaesthesia (preoperative), after induction (pre-intubation) and after tracheal intubation (post-intubation). Fentanyl with propofol (Group I, n ϭ 52) or with thiopental (Group II, n ϭ 48), followed with rocuronium, were given for induction. Absolute values of total power (TP), low and high frequency powers (LF and HF, respectively), and LF/HF ratio were analyzed. The highest percentage changes between pre-and post-intubation heart rates (d% HR) and mean arterial pressures (d% MAP), recorded by pulse oximetry and noninvasive measurements respectively, were correlated with the preoperative HRV (r-Pearson). Results and Discussions: Demographic, HRV and hemodynamic preoperative data showed no significant differences. The significant positive correlations between d% HR and preoperative TP (r ϭ 0.4984; p Ͻ 0.0001), LF (r ϭ 0.4946; p Ͻ 0.0001) and HF (r ϭ 0.3473; p Ͻ 0.001) but not LF/HF ratio (r ϭ 0.0250; p ϭ 0.851) were observed in all patients. The similar correlations were observed in Group I and II. We did not observe correlations between preoperative HRV values and d% MAP, probably due to different recording techniques of HR and MAP. Conclusion: Preoperative HRV may be predictable for the increased heart rate response to tracheal intubation. References:

Amino Acids, Oct 31, 2019

Doxorubicin (DOXO) may cause serious cardiotoxic effects that limit its use as an antineoplastic ... more Doxorubicin (DOXO) may cause serious cardiotoxic effects that limit its use as an antineoplastic agent. We aimed to evaluate the protective role of taurine (TAU), a beta amino acid with antioxidant activity, against DOXO-induced cardiotoxicity in a rat model. Thirty-one male Sprague-Dawley rats (300-400 g) were randomized into four groups: control (n = 7, intraperitoneal [ip] saline for 14 days), TAU (n = 8, 150 mg/kg body weight TAU ip for 14 days), DOXO (n = 8, 25 mg/kg body weight DOXO ip on 12th, 13th, and 14th days), and DOXO + TAU (n = 8, TAU for 14 days and DOXO on 12th, 13th, and 14th days). The left ventricular functions were evaluated on 15th day by echocardiography. The heart tissues were then excised for histological evaluation. In DOXO group, left ventricular ejection fraction (LVEF), fractional shortening (FS), and mitral lateral annulus (s') velocity were significantly lower, and the left ventricular end-diastolic and end-systolic diameters (LVEDD, LVESD) were significantly higher than control group (p < 0.05), indicating a significant deterioration in left ventricular functions. However, in comparison to DOXO group, LVESD, LVEDD, LVEF, FS, and s' were significantly improved in DOXO + TAU group (p < 0.05). On histological evaluation, contrary to the normal cellular structure of cardiomyocytes in control and TAU groups, DOXO group showed increased nuclear or cytoplasmic changes and infiltrative cell proliferation (p < 0.001), which were remarkably reduced in DOXO + TAU group (p < 0.001). TAU treatment has a protective effect against DOXO-induced cardiotoxicity on echocardiographical and histological evaluation. For common use of TAU to prevent DOXO-induced cardiotoxicity, our findings should be confirmed by clinical studies.

Cell and Tissue Research, Dec 23, 2022

PubMed, Jun 7, 2023

Aim: Empagliflozin (EMPA) is a sodium-glucose transporter-2 inhibitor used in the treatment of ty... more Aim: Empagliflozin (EMPA) is a sodium-glucose transporter-2 inhibitor used in the treatment of type 2 diabetes and has positive effects on cardiovascular outcomes. Amitriptyline (AMT) can be used in many clinical indications but leads to cardiotoxicity by causing QT prolongation. Our aim in this study was to determine how the effects of the concomitant use of empagliflozin and amitriptyline, which have been shown to have effects on sodium and calcium metabolism in cardiomyocytes, would cause an effect on QT and QTc intervals in clinical practice. Methods: Twenty-four male Wistar albino rats were randomised into four groups. The control group received only physiological serum (1 ml) via orogastric gavage (OG). The EMPA group received empagliflozin (10 mg/kg) via OG. The AMT group received amitriptyline (100 mg/kg) via OG. The AMT + EMPA group (n = 6) received amitriptyline (100 mg/kg) and empagliflozin (10 mg/kg). Under anaesthesia, QT and QTc intervals were measured at baseline, and in the first and second hours. Results: In the AMT group, QT intervals and QTc values were found to be statistically longer than in the control group (p ≤ 0.001). Empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. In the AMT + EMPA group, QT and QTc intervals were significantly lower compared to that in the AMT group (p < 0.01). Conclusion: In this study, we determined that empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. This effect was probably due to the opposite effects of these two agents in the intracellular calcium balance. With more clinical trials, the routine use of empagliflozin may be suggested to prevent QT and QTc prolongation in diabetic patients receiving amitriptyline.

Turkiye Klinikleri Tip Bilimleri Dergisi, 2001

Hava kirliliði insan saðlýðýný giderek artan boyutlarda tehdit eden bir sorundur. Çarpýk kentleþm... more Hava kirliliði insan saðlýðýný giderek artan boyutlarda tehdit eden bir sorundur. Çarpýk kentleþme, kalitesiz yakýt kullanýmý, kontrolsüz endüstriyel faaliyet, trafik, orman yangýnlarý vb. sorunlarý olan ülkemiz için bu konu büyük bir önem taþýmaktadýr. Havayý kirleten maddelerden biri olan SO 2 , özellikle kýþ aylarýnda yoðun bir þekilde atmosfere karýþmakta ve solunum yolu aracýlýðý ile alýnarak zararlý etkiler oluþturmaktadýr (1). Kýþ mevsiminde, özellikle

European Heart Journal, Nov 1, 2020

Journal of Clinical and Experimental Neuropsychology, Jul 19, 2017

Introduction: Emotion dysregulation (ED) has long been recognized in clinical descriptions of att... more Introduction: Emotion dysregulation (ED) has long been recognized in clinical descriptions of attention-deficit hyperactivity disorder (ADHD), but a renewed interest in ED has advanced research on the overlap between the two entities. Autonomic reactivity (AR) is a neurobiological correlate of emotion regulation; however, the association between ADHD and AR remains unclear. Our aim was to explore the clinical differences, AR, and subjective emotional responses to visual emotional stimuli in ADHD children with and without ED. Method: School-aged ADHD children with (n = 28) and without (n = 20) ED, according to the definition of deficiency in emotional self-regulation (DESR), and healthy controls (n = 22) were interviewed by using the Schedule for Affective Disorders and Schizophrenia for School Aged Children-Present and Lifetime version (K-SADS-PL) to screen frequent psychopathologies for these ages. All subjects were evaluated with Child Behavior Checklist 6-18 (CBCL), the Strengths and Difficulties Questionnaire (SDQ), the McMaster Family Assessment Device (FAD), the School-Age Temperament Inventory (SATI), and Conners' Parent Rating Scale (CPRS-48), which were completed by parents. To evaluate emotional responses, the International Affective Picture System (IAPS) and the subjective and physiological responses (electrodermal activity and heart rate reactivity) to selected pictures were examined. Results: Regarding clinically distinctive features, the ADHD+ED group differed from the ADHD-ED and the control groups in terms of having higher temperamental negative reactivity, more oppositional/conduct problems, and lower prosocial behaviors. In the AR measures, children in the ADHD+ED group rated unpleasant stimuli as more negative, but they still had lower heart rate reactivity (HRR) than the ADHD-ED and control groups; moreover, unlike the two other groups, the ADHD+ED group showed no differences in HRR between different emotional stimuli. Conclusion: The presented findings are unique in terms of their ability to clinically and physiologically differentiate between ADHD children with and without ED.

Life

Background: Doxorubicin (dox) is a chemotherapeutic agent widely used against various tumors. How... more Background: Doxorubicin (dox) is a chemotherapeutic agent widely used against various tumors. However, the clinical use of this agent is limited due to various organ toxicities. Taurine is an intracellular free β-amino acid with antioxidant properties. The present study investigated the protective mechanism of taurine on dox-induced hepatotoxicity. Methods: In total, 31 male Sprague-Dawley rats were used in the study. The control group received intraperitoneal (i.p.) 0.9% NaCl alone for 14 days; the taurine (Tau) group received i.p. taurine 150 mg/kg body weight/day for 14 days; the dox group received dox on days 12, 13, and 14 at a cumulative dose of 25 mg/kg body weight/3 days; and the tau+dox group received taurine and dox together at the same dose and through the same route. On day 15, biochemical evaluations were performed on blood samples taken from the left ventricle followed by histological examinations on liver samples. Results: Dox was found to increase liver function enzy...

European Journal of Anaesthesiology, 2005

induction to general anaesthesia (1,2). The goal of this study was to investigate the relationshi... more induction to general anaesthesia (1,2). The goal of this study was to investigate the relationship between preoperative values of HRV and hemodynamic responses to tracheal intubation. Materials and Methods: Spectral analysis of HRV was assessed in 100 patients (TOM Signaltechnik, Hashiba & Niederl OEG, Graz, Austria) before induction of general anaesthesia (preoperative), after induction (pre-intubation) and after tracheal intubation (post-intubation). Fentanyl with propofol (Group I, n ϭ 52) or with thiopental (Group II, n ϭ 48), followed with rocuronium, were given for induction. Absolute values of total power (TP), low and high frequency powers (LF and HF, respectively), and LF/HF ratio were analyzed. The highest percentage changes between pre-and post-intubation heart rates (d% HR) and mean arterial pressures (d% MAP), recorded by pulse oximetry and noninvasive measurements respectively, were correlated with the preoperative HRV (r-Pearson). Results and Discussions: Demographic, HRV and hemodynamic preoperative data showed no significant differences. The significant positive correlations between d% HR and preoperative TP (r ϭ 0.4984; p Ͻ 0.0001), LF (r ϭ 0.4946; p Ͻ 0.0001) and HF (r ϭ 0.3473; p Ͻ 0.001) but not LF/HF ratio (r ϭ 0.0250; p ϭ 0.851) were observed in all patients. The similar correlations were observed in Group I and II. We did not observe correlations between preoperative HRV values and d% MAP, probably due to different recording techniques of HR and MAP. Conclusion: Preoperative HRV may be predictable for the increased heart rate response to tracheal intubation. References:

The Anatolian Journal of Cardiology

Naunyn-Schmiedeberg's Archives of Pharmacology, 2017

Testosterone, estradiol, and dihydrotestosterone are the main sex steroid hormones responsible fo... more Testosterone, estradiol, and dihydrotestosterone are the main sex steroid hormones responsible for the organization and sexual differentiation of brain structures during early development. The hypothalamo-pituitary-adrenocortical axis, adrenal cells, and gonads play a key role in the production of sex steroids and express adenosine receptors. Caffeine is a non-selective adenosine antagonist; therefore, it can modulate metabolic pathways in these tissues. Besides, the proportion of pregnant women that consume caffeine is ∼60%. That is why the relationship between maternal caffeine consumption and fetal development is important. Therefore, we aimed to investigate this modulatory effect of maternal caffeine consumption on sex steroids in the fetal and neonatal brain tissues. Pregnant rats were treated with a low (0.3 g/L) or high (0.8 g/L) dose of caffeine in their drinking water during pregnancy and lactation. The testosterone, estradiol, and dihydrotestosterone levels in the frontal cortex and hypothalamus were measured using radioimmunoassay at embryonic day 19 (E19), birth (PN0), and postnatal day 4 (PN4). The administration of low-dose caffeine increased the body weight in PN4 male and female rats and anogenital index in PN4 males. The administration of high-dose caffeine decreased the adrenal weight in E19 male rats and increased testosterone levels in the frontal cortex of E19 female rats and the hypothalamus of PN0 male rats. Maternal caffeine intake during pregnancy affects sex steroid levels in the frontal cortex and hypothalamus of the offspring. This concentration changes of the sex steroids in the brain may influence behavioral and neuroendocrine functions at some point in adult life.

Cell and Tissue Research, Dec 23, 2022