Eric Samson - Academia.edu (original) (raw)

Papers by Eric Samson

Research paper thumbnail of Association analysis between mortality and ionizing radiation exposure in French uranium workers

Research paper thumbnail of Internal dose assessment for the French cohort of uranium workers

Research paper thumbnail of Analysis of the association between ionizing radiation and mortality in uranium workers from five plants involved in the nuclear fuel production cycle in France

International Archives of Occupational and Environmental Health

The aim is to investigate associations between mortality and exposure to ionizing radiation in a ... more The aim is to investigate associations between mortality and exposure to ionizing radiation in a cohort of uranium workers with potential for internal and external radiation exposures. Workers employed for at least 6 months between 1958 and 2006 in five plants involved in the French nuclear fuel cycle were included and followed up between 1968 and 2013. Cause-specific standardized mortality ratios were calculated. Analyses of associations between individual cumulative radiation dose (both internal and external, lagged by 5-15 years) and mortality were conducted using Poisson regression. The cohort includes 4541 workers. The mean cumulative external dose was 11.12 mGy. Mean cumulative internal doses ranged, depending on modelling hypotheses, from 0.05 to 0.09 mGy (liver) and from 4.22 to 10.90 mGy (lung). At the end of the follow-up, 838 workers were deceased and 28 lost to follow-up. A healthy worker effect was observed. The risk of prostate and lung cancers mortality was significantly higher for workers exposed to cumulative external dose above 50 mGy compared to non-exposed, but these associations were based only on three cases and became non-significant, although of similar magnitude, after adjustment for smoking. Associations with internal dose showed no consistent pattern. For the first time, a study was conducted in a French cohort of uranium workers with a complete reconstruction of internal dose. Results are preliminary and must be interpreted with caution because of the limited cohort size and significant sources of uncertainty. Future steps of this study will overcome these limitations.

Research paper thumbnail of Circulatory disease in French nuclear fuel cycle workers chronically exposed to uranium: a nested case–control study

Occupational and Environmental Medicine

ObjectivesThere is growing evidence of an association between low-dose external γ-radiation and c... more ObjectivesThere is growing evidence of an association between low-dose external γ-radiation and circulatory system diseases (CSDs), yet sparse data exist about an association with chronic internal uranium exposure and the role of non-radiation risk factors. We conducted a nested case–control study of French AREVA NC Pierrelatte nuclear workers employed between 1960 and 2005 to estimate CSD risks adjusting for major CSD risk factors (smoking, blood pressure, body mass index, total cholesterol and glycaemia) and external γ-radiation dose.MethodsThe study included 102 cases of death from CSD and 416 controls individually matched on age, gender, birth cohort and socio-professional status. Information on CSD risk factors was collected from occupational medical records. Organ-specific absorbed doses were estimated using biomonitoring data, taking into account exposure regime and uranium physicochemical properties. External γ-radiation was measured by individual dosimeter badges. Analysis ...

Research paper thumbnail of First mortality analysis in the French cohort of uranium millers (F-Millers), period 1968-2013

International archives of occupational and environmental health, Jan 31, 2017

Epidemiological studies in cohorts of uranium millers can be informative to improve knowledge of ... more Epidemiological studies in cohorts of uranium millers can be informative to improve knowledge of the health effects of uranium, but are very rare. The aim of this study was to analyze, for the first time, mortality in a French cohort of uranium millers. The F-Millers cohort includes permanent contract workers employed at least 6 months at French uranium milling plants. Vital status and causes of death were obtained from national registries between 1968 and 2013, in order to perform comparisons with French national and local mortality rates by computing standardized mortality ratios (SMRs) with 95% confidence intervals (95% CI). The cohort includes 1291 workers. The average duration of follow-up is 32.1 years. At the end of follow-up, 448 workers were deceased and 13 lost to follow-up. We observed a significant deficit of mortality for all causes combined when the national reference was considered (SMR 0.81; 95% CI [0.74;0.89]), but no significant difference when the local reference ...

Research paper thumbnail of Prise en compte des autres sources d’exposition aux rayonnements ionisant (radioactivité naturelle et surveillance médicale au travail) dans les analyses du risque de mortalité par cancer dans la cohorte française des travailleurs du nucléaire

Archives des Maladies Professionnelles et de l'Environnement, 2016

La cohorte francaise des travailleurs du nucleaire permet de quantifier les risques sanitaires li... more La cohorte francaise des travailleurs du nucleaire permet de quantifier les risques sanitaires lies a une exposition professionnelle aux rayonnements ionisants (RI). Cependant, les travailleurs sont egalement exposes a la radioactivite naturelle et medicale avec des doses annuelles souvent superieures aux expositions professionnelles. Cette etude analyse l’impact de la prise en compte de doses non-professionnelles sur l’association entre le risque de mortalite par cancer et les expositions professionnelles aux RI. La cohorte francaise des travailleurs du nucleaire inclut tous les travailleurs du CEA, d’Areva et d’EDF, salaries pendant au moins un an entre 1950 et 1994 et ayant porte un dosimetre. L’exposition professionnelle annuelle aux RI des travailleurs a ete reconstituee sur l’ensemble de leur carriere. Les causes de deces ont ete obtenues aupres du CepiDc. Les scenarios d’exposition naturelle ont ete elabores sur la base des resultats des campagnes nationales de mesures du radon et du debit de dose gamma disponible a l’IRSN. Les scenarios d’exposition medicale reposent sur la reconstitution de l’historique des examens radiologiques realises dans le cadre de la medecine de travail. La regression de Poisson a ete utilisee pour quantifier l’association entre exposition professionnelle et mortalite par cancer, en ajustant sur les expositions non-professionnelles. La cohorte comprend 59 004 travailleurs suivis de 1968 a 2004. A la fin du suivi, 2552 individus etaient decedes par cancer. La dose cumulee moyenne due aux expositions professionnelles est de 18,4 mSv. La dose environnementale cumulee moyenne estimee est de l’ordre 130 mSv. L’exces de risque relatif non ajuste sur l’exposition environnementale est de 0,34 par Sv (90 % IC : –0,44–1,24) et n’est pas modifie dans le modele avec ajustement (0,34 [90 % IC : –0,44–1,23]). Les analyses prenant en compte l’exposition medicale sont en cours. Cette etude est la premiere a prendre en compte les sources de RI non professionnelles dans la cohorte francaise des travailleurs du nucleaire. Les resultats preliminaires suggerent que l’ajustement sur les doses environnementales ne modifie pas l’estimation du risque de deces par cancer lie aux expositions professionnelles. Les resultats des analyses portant sur l’exposition medicale apporteront des elements de reponse supplementaires sur les biais potentiels causes par l’omission de ces expositions lors des analyses du risque lie aux expositions professionnelles aux RI.

Research paper thumbnail of Risque de mortalit� par cancer dans deux cohortes de personnel de recherche en biologie en France

Arch Mal Prof Environ, 2007

Research paper thumbnail of Cancer and non-cancer mortality among French uranium cycle workers: the TRACY cohort

BMJ open, Jan 5, 2016

The health effects of internal contamination by radionuclides, and notably by uranium, are poorly... more The health effects of internal contamination by radionuclides, and notably by uranium, are poorly characterised. New cohorts of uranium workers are needed to better examine these effects. This paper analyses for the first time the mortality profile of the French cohort of uranium cycle workers. It considers mortality from cancer and non-cancer causes. The cohort includes workers employed at least 6 months between 1958 and 2006 in French companies involved in the production of nuclear fuel. Vital status and causes of death were collected from French national registries. Workers were followed-up from 1 January 1968 to 31 December 2008. Standardised mortality ratios (SMRs) were computed based on mortality rates for the French general population. The cohort includes 12 649 workers (88% men). The average length of follow-up is 27 years and the mean age at the end of the study is 60 years. Large mortality deficits are observed for non-cancer causes of death such as non-cancer respiratory ...

Research paper thumbnail of Mortality (1968-2008) in a French cohort of uranium enrichment workers potentially exposed to rapidly soluble uranium compounds

Occupational and environmental medicine, Jan 10, 2015

Until recently, enrichment of uranium for civil and military purposes in France was carried out b... more Until recently, enrichment of uranium for civil and military purposes in France was carried out by gaseous diffusion using rapidly soluble uranium compounds. We analysed the relationship between exposure to soluble uranium compounds and exposure to external γ-radiation and mortality in a cohort of 4688 French uranium enrichment workers who were employed between 1964 and 2006. Data on individual annual exposure to radiological and non-radiological hazards were collected for workers of the AREVA NC, CEA and Eurodif uranium enrichment plants from job-exposure matrixes and external dosimetry records, differentiating between natural, enriched and depleted uranium. Cause-specific mortality was compared with the French general population via standardised mortality ratios (SMR), and was analysed via Poisson regression using log-linear and linear excess relative risk models. Over the period of follow-up, 131 161 person-years at risk were accrued and 21% of the subjects had died. A strong hea...

Research paper thumbnail of Reconstitution des expositions professionnelles des travailleurs français du cycle de l’uranium

Revue d'Épidémiologie et de Santé Publique, 2012

Research paper thumbnail of Half-century archives of occupational medical data on French nuclear workers: a dusty warehouse or gold mine for epidemiological research?

Archives of Industrial Hygiene and Toxicology, 2014

This article discusses the availability and completeness of medical data on workers from the AREV... more This article discusses the availability and completeness of medical data on workers from the AREVA NC Pierrelatte nuclear plant and their possible use in epidemiological research on cardiovascular and metabolic disorders related to internal exposure to uranium. We created a computer database from files on 394 eligible workers included in an ongoing nested case-control study from a larger cohort of 2897 French nuclear workers. For each worker, we collected records of previous employment, job positions, job descriptions, medical visits, and blood test results from medical history. The dataset counts 9,471 medical examinations and 12,735 blood test results. For almost all of the parameters relevant for research on cardiovascular risk, data completeness and availability is over 90 %, but it varies with time and improves in the latest time period. In the absence of biobanks, collecting and computerising available good-quality occupational medicine archive data constitutes a valuable alte...

Research paper thumbnail of 0184 Mortality profile of the French cohort of uranium processing workers

Occupational and Environmental Medicine, 2014

Research paper thumbnail of Epidemiological studies of leukaemia in children and young adults around nuclear facilities: a critical review

Radiation Protection Dosimetry, 2008

Research paper thumbnail of External radiation exposure and mortality in a cohort of French nuclear workers

Occupational and Environmental Medicine, 2007

Research paper thumbnail of Estimating historic exposures at the European Gaseous Diffusion plants

International Journal of Hygiene and Environmental Health, 2013

Research paper thumbnail of Cancer mortality risk among biology research workers in France: first results of two retrospective cohorts studies

International Archives of Occupational and Environmental Health, 2008

Research paper thumbnail of Epidemiological studies of leukaemia in children and young adults around nuclear facilities: a critical review

Radiation Protection Dosimetry, 2008

Research paper thumbnail of Évaluation des expositions professionnelles des travailleurs SOCATRI : comment prendre en compte la polyvalence des emplois ?

Archives des Maladies Professionnelles et de l'Environnement, 2013

Research paper thumbnail of Risque de mortalité par cancer dans deux cohortes de personnel de recherche en biologie en France

Archives des Maladies Professionnelles et de l'Environnement, 2007

Research paper thumbnail of Cancer mortality risk among biology research workers in France: first results of two retrospective cohorts studies

International archives of …, 2008

Research paper thumbnail of Association analysis between mortality and ionizing radiation exposure in French uranium workers

Research paper thumbnail of Internal dose assessment for the French cohort of uranium workers

Research paper thumbnail of Analysis of the association between ionizing radiation and mortality in uranium workers from five plants involved in the nuclear fuel production cycle in France

International Archives of Occupational and Environmental Health

The aim is to investigate associations between mortality and exposure to ionizing radiation in a ... more The aim is to investigate associations between mortality and exposure to ionizing radiation in a cohort of uranium workers with potential for internal and external radiation exposures. Workers employed for at least 6 months between 1958 and 2006 in five plants involved in the French nuclear fuel cycle were included and followed up between 1968 and 2013. Cause-specific standardized mortality ratios were calculated. Analyses of associations between individual cumulative radiation dose (both internal and external, lagged by 5-15 years) and mortality were conducted using Poisson regression. The cohort includes 4541 workers. The mean cumulative external dose was 11.12 mGy. Mean cumulative internal doses ranged, depending on modelling hypotheses, from 0.05 to 0.09 mGy (liver) and from 4.22 to 10.90 mGy (lung). At the end of the follow-up, 838 workers were deceased and 28 lost to follow-up. A healthy worker effect was observed. The risk of prostate and lung cancers mortality was significantly higher for workers exposed to cumulative external dose above 50 mGy compared to non-exposed, but these associations were based only on three cases and became non-significant, although of similar magnitude, after adjustment for smoking. Associations with internal dose showed no consistent pattern. For the first time, a study was conducted in a French cohort of uranium workers with a complete reconstruction of internal dose. Results are preliminary and must be interpreted with caution because of the limited cohort size and significant sources of uncertainty. Future steps of this study will overcome these limitations.

Research paper thumbnail of Circulatory disease in French nuclear fuel cycle workers chronically exposed to uranium: a nested case–control study

Occupational and Environmental Medicine

ObjectivesThere is growing evidence of an association between low-dose external γ-radiation and c... more ObjectivesThere is growing evidence of an association between low-dose external γ-radiation and circulatory system diseases (CSDs), yet sparse data exist about an association with chronic internal uranium exposure and the role of non-radiation risk factors. We conducted a nested case–control study of French AREVA NC Pierrelatte nuclear workers employed between 1960 and 2005 to estimate CSD risks adjusting for major CSD risk factors (smoking, blood pressure, body mass index, total cholesterol and glycaemia) and external γ-radiation dose.MethodsThe study included 102 cases of death from CSD and 416 controls individually matched on age, gender, birth cohort and socio-professional status. Information on CSD risk factors was collected from occupational medical records. Organ-specific absorbed doses were estimated using biomonitoring data, taking into account exposure regime and uranium physicochemical properties. External γ-radiation was measured by individual dosimeter badges. Analysis ...

Research paper thumbnail of First mortality analysis in the French cohort of uranium millers (F-Millers), period 1968-2013

International archives of occupational and environmental health, Jan 31, 2017

Epidemiological studies in cohorts of uranium millers can be informative to improve knowledge of ... more Epidemiological studies in cohorts of uranium millers can be informative to improve knowledge of the health effects of uranium, but are very rare. The aim of this study was to analyze, for the first time, mortality in a French cohort of uranium millers. The F-Millers cohort includes permanent contract workers employed at least 6 months at French uranium milling plants. Vital status and causes of death were obtained from national registries between 1968 and 2013, in order to perform comparisons with French national and local mortality rates by computing standardized mortality ratios (SMRs) with 95% confidence intervals (95% CI). The cohort includes 1291 workers. The average duration of follow-up is 32.1 years. At the end of follow-up, 448 workers were deceased and 13 lost to follow-up. We observed a significant deficit of mortality for all causes combined when the national reference was considered (SMR 0.81; 95% CI [0.74;0.89]), but no significant difference when the local reference ...

Research paper thumbnail of Prise en compte des autres sources d’exposition aux rayonnements ionisant (radioactivité naturelle et surveillance médicale au travail) dans les analyses du risque de mortalité par cancer dans la cohorte française des travailleurs du nucléaire

Archives des Maladies Professionnelles et de l'Environnement, 2016

La cohorte francaise des travailleurs du nucleaire permet de quantifier les risques sanitaires li... more La cohorte francaise des travailleurs du nucleaire permet de quantifier les risques sanitaires lies a une exposition professionnelle aux rayonnements ionisants (RI). Cependant, les travailleurs sont egalement exposes a la radioactivite naturelle et medicale avec des doses annuelles souvent superieures aux expositions professionnelles. Cette etude analyse l’impact de la prise en compte de doses non-professionnelles sur l’association entre le risque de mortalite par cancer et les expositions professionnelles aux RI. La cohorte francaise des travailleurs du nucleaire inclut tous les travailleurs du CEA, d’Areva et d’EDF, salaries pendant au moins un an entre 1950 et 1994 et ayant porte un dosimetre. L’exposition professionnelle annuelle aux RI des travailleurs a ete reconstituee sur l’ensemble de leur carriere. Les causes de deces ont ete obtenues aupres du CepiDc. Les scenarios d’exposition naturelle ont ete elabores sur la base des resultats des campagnes nationales de mesures du radon et du debit de dose gamma disponible a l’IRSN. Les scenarios d’exposition medicale reposent sur la reconstitution de l’historique des examens radiologiques realises dans le cadre de la medecine de travail. La regression de Poisson a ete utilisee pour quantifier l’association entre exposition professionnelle et mortalite par cancer, en ajustant sur les expositions non-professionnelles. La cohorte comprend 59 004 travailleurs suivis de 1968 a 2004. A la fin du suivi, 2552 individus etaient decedes par cancer. La dose cumulee moyenne due aux expositions professionnelles est de 18,4 mSv. La dose environnementale cumulee moyenne estimee est de l’ordre 130 mSv. L’exces de risque relatif non ajuste sur l’exposition environnementale est de 0,34 par Sv (90 % IC : –0,44–1,24) et n’est pas modifie dans le modele avec ajustement (0,34 [90 % IC : –0,44–1,23]). Les analyses prenant en compte l’exposition medicale sont en cours. Cette etude est la premiere a prendre en compte les sources de RI non professionnelles dans la cohorte francaise des travailleurs du nucleaire. Les resultats preliminaires suggerent que l’ajustement sur les doses environnementales ne modifie pas l’estimation du risque de deces par cancer lie aux expositions professionnelles. Les resultats des analyses portant sur l’exposition medicale apporteront des elements de reponse supplementaires sur les biais potentiels causes par l’omission de ces expositions lors des analyses du risque lie aux expositions professionnelles aux RI.

Research paper thumbnail of Risque de mortalit� par cancer dans deux cohortes de personnel de recherche en biologie en France

Arch Mal Prof Environ, 2007

Research paper thumbnail of Cancer and non-cancer mortality among French uranium cycle workers: the TRACY cohort

BMJ open, Jan 5, 2016

The health effects of internal contamination by radionuclides, and notably by uranium, are poorly... more The health effects of internal contamination by radionuclides, and notably by uranium, are poorly characterised. New cohorts of uranium workers are needed to better examine these effects. This paper analyses for the first time the mortality profile of the French cohort of uranium cycle workers. It considers mortality from cancer and non-cancer causes. The cohort includes workers employed at least 6 months between 1958 and 2006 in French companies involved in the production of nuclear fuel. Vital status and causes of death were collected from French national registries. Workers were followed-up from 1 January 1968 to 31 December 2008. Standardised mortality ratios (SMRs) were computed based on mortality rates for the French general population. The cohort includes 12 649 workers (88% men). The average length of follow-up is 27 years and the mean age at the end of the study is 60 years. Large mortality deficits are observed for non-cancer causes of death such as non-cancer respiratory ...

Research paper thumbnail of Mortality (1968-2008) in a French cohort of uranium enrichment workers potentially exposed to rapidly soluble uranium compounds

Occupational and environmental medicine, Jan 10, 2015

Until recently, enrichment of uranium for civil and military purposes in France was carried out b... more Until recently, enrichment of uranium for civil and military purposes in France was carried out by gaseous diffusion using rapidly soluble uranium compounds. We analysed the relationship between exposure to soluble uranium compounds and exposure to external γ-radiation and mortality in a cohort of 4688 French uranium enrichment workers who were employed between 1964 and 2006. Data on individual annual exposure to radiological and non-radiological hazards were collected for workers of the AREVA NC, CEA and Eurodif uranium enrichment plants from job-exposure matrixes and external dosimetry records, differentiating between natural, enriched and depleted uranium. Cause-specific mortality was compared with the French general population via standardised mortality ratios (SMR), and was analysed via Poisson regression using log-linear and linear excess relative risk models. Over the period of follow-up, 131 161 person-years at risk were accrued and 21% of the subjects had died. A strong hea...

Research paper thumbnail of Reconstitution des expositions professionnelles des travailleurs français du cycle de l’uranium

Revue d'Épidémiologie et de Santé Publique, 2012

Research paper thumbnail of Half-century archives of occupational medical data on French nuclear workers: a dusty warehouse or gold mine for epidemiological research?

Archives of Industrial Hygiene and Toxicology, 2014

This article discusses the availability and completeness of medical data on workers from the AREV... more This article discusses the availability and completeness of medical data on workers from the AREVA NC Pierrelatte nuclear plant and their possible use in epidemiological research on cardiovascular and metabolic disorders related to internal exposure to uranium. We created a computer database from files on 394 eligible workers included in an ongoing nested case-control study from a larger cohort of 2897 French nuclear workers. For each worker, we collected records of previous employment, job positions, job descriptions, medical visits, and blood test results from medical history. The dataset counts 9,471 medical examinations and 12,735 blood test results. For almost all of the parameters relevant for research on cardiovascular risk, data completeness and availability is over 90 %, but it varies with time and improves in the latest time period. In the absence of biobanks, collecting and computerising available good-quality occupational medicine archive data constitutes a valuable alte...

Research paper thumbnail of 0184 Mortality profile of the French cohort of uranium processing workers

Occupational and Environmental Medicine, 2014

Research paper thumbnail of Epidemiological studies of leukaemia in children and young adults around nuclear facilities: a critical review

Radiation Protection Dosimetry, 2008

Research paper thumbnail of External radiation exposure and mortality in a cohort of French nuclear workers

Occupational and Environmental Medicine, 2007

Research paper thumbnail of Estimating historic exposures at the European Gaseous Diffusion plants

International Journal of Hygiene and Environmental Health, 2013

Research paper thumbnail of Cancer mortality risk among biology research workers in France: first results of two retrospective cohorts studies

International Archives of Occupational and Environmental Health, 2008

Research paper thumbnail of Epidemiological studies of leukaemia in children and young adults around nuclear facilities: a critical review

Radiation Protection Dosimetry, 2008

Research paper thumbnail of Évaluation des expositions professionnelles des travailleurs SOCATRI : comment prendre en compte la polyvalence des emplois ?

Archives des Maladies Professionnelles et de l'Environnement, 2013

Research paper thumbnail of Risque de mortalité par cancer dans deux cohortes de personnel de recherche en biologie en France

Archives des Maladies Professionnelles et de l'Environnement, 2007

Research paper thumbnail of Cancer mortality risk among biology research workers in France: first results of two retrospective cohorts studies

International archives of …, 2008