Eric Seibel - Academia.edu (original) (raw)
Papers by Eric Seibel
Ultrathin, flexible endoscopes are being developed for imaging cancer in previously inaccessible ... more Ultrathin, flexible endoscopes are being developed for imaging cancer in previously inaccessible regions of the body, allowing image-guided biopsy and laser diagnostics/therapeutics. Cancer diagnosis at high sensitivity/specificity is achieved with optical tomography microscopes.
Journal of Dynamic Systems Measurement and Control-transactions of The Asme, Jun 5, 2017
Proceedings of SPIE, Mar 3, 2014
Journal of Sound and Vibration, Apr 1, 2011
IEEE Transactions on Medical Imaging, Aug 1, 2019
Diagnostics, Aug 23, 2022
arXiv (Cornell University), Dec 21, 2022
Optics Letters, Jun 20, 2011
Ventilator-associated pneumonia (VAP) is pneumonia that occurs >48hrs after initiation of mech... more Ventilator-associated pneumonia (VAP) is pneumonia that occurs >48hrs after initiation of mechanical ventilation and is a significant cause of morbidity and mortality in patients that are hospitalized in intensive care units (ICU). The risk of developing VAP increases during use, and a diagnosis of VAP has been associated with a substantial cost. There are up to hundreds of thousands of cases in the US per year, costing the healthcare system billions annually. Patients who suffer from VAP frequently require longer ICU stays, higher exposure to antibiotics, and more hospital care at the risk of increased mortality. The SARS-CoV-2 pandemic has further increased the use of antibiotics among patients with COVID19, an indicator of increased VAP prevalence. Before 2020, strides were made to reduce the incidence of VAP through hygienic protocols known as ‘VAP bundles.’ Despite the improvements, VAP continues to be a large problem, with the inoculation of pathogens within the endotracheal tube (ETT) itself. ETTs with built-in subglottic suction devices (SSDETT) allow the removal of subglottic secretions, but this has been adopted heterogeneously. We propose novel optical device designs to be used in combination with SSD-ETTs to reduce colonization and biofilm formation on the inner lumen of ETTs and reduce the incidence of VAP and improve patient care.
Stroke, Feb 1, 2019
Our understanding and management of carotid artery disease has largely relied on angiography, US ... more Our understanding and management of carotid artery disease has largely relied on angiography, US and MR. However, existing modalities cannot accurately identify the spectrum of thrombogenic lesions on the vascular surface or reliably detect structural markers of instability. Thus, the natural history of the different histopathological hallmarks of advanced or complicated plaques is unknown, and many patients with culprit substenotic plaques are misdiagnosed with cryptogenic stroke. An intraluminal approach to directly inspect the endovascular surfaces at unprecedented resolutions would enable detailed structural analysis of carotid plaques and the identification of the root cause of carotid-related strokes. A scanning fiber angioscope (SFA), a high-definition 1.2-mm forward-viewing camera that generates videos by spirally scanning low-power laser beams, was developed for clinical use and employed to analyze the endovascular surfaces of ex vivo human carotid arteries (n=95) and endarterectomized plaques (n=20). Specimens were then imaged with US and micro-CT, and all vascular diagnostic tests obtained in the patients undergoing carotid revascularization were accessed. Imaging findings in the vascular surfaces were then validated by histomorphological analysis of >300 lesions, and an angioscopic classifier for atherosclerosis was generated. Full-color videos at 30Hz and at a resolution >200,000 pixels were generated from the entire endovascular circumference in all specimens with depth-of-focus larger than 5cm in saline solution. The ability to analyze the surface anatomy with unparalleled detail allowed the identification of early, intermediate, advanced and complex atherosclerotic lesions, including ulceration of fibrotic cap, excavation of the necrotic core leading to pseudolumens, intimal flaps, exposed necrotic core to the lumen, erosions, recent and remote intimal hemorrhages, luminal thrombus, eruptive calcified nodules and calcified intimal sheaths and plates. SFA offers a direct view of the endoluminal surfaces with unparalleled resolution and has the potential to revolutionize research, diagnosis, prognosis and image-guided therapy in carotid atherosclerosis.
Inherited mutations in BRCA1 and BRCA2 cause a 20-50% lifetime risk of ovarian, fallopian tubel, ... more Inherited mutations in BRCA1 and BRCA2 cause a 20-50% lifetime risk of ovarian, fallopian tubel, or peritoneal carcinoma. Clinical recommendations for these high-risk women include the prophylactic removal of the ovaries and fallopian tubes by age 40 after child-bearing. Recent findings suggest that many presumed ovarian or peritoneal carcinomas arise in fallopian tube epithelium. Although survival rate is >90% when ovarian cancer is detected early (Stage_I), 70% of women have advanced disease (Stage_III/IV) at presentation when survival is less than 30%. Over the years, effective early detection of ovarian cancer has remained elusive, possibly because screening techniques have mistakenly focused on the ovary as the origin of ovarian carcinoma. Unlike ovaries, the fallopian tubes are amenable to direct visual imaging without invasive surgery, using access through the uterine cervix. To develop future screening protocols, we investigated using our 1.2-mm diameter, forward-viewing, scanning fiber endoscope (SFE) to image luminal surfaces of the fallopian tube before laparoscopic surgical removal. Three anesthetized human subjects participated in our protocol development which eventually led to 70-80% of the length of fallopian tubes being imaged in scanning reflectance, using red (632nm), green (532nm), and blue (442nm) laser light. A hysteroscope with saline uterine distention was used to locate the tubal ostia. To facilitate passage of the SFE through the interstitial portion of the fallopian tube, an introducer catheter was inserted 1-cm through each ostia. During insertion, saline was flushed to reduce friction and provide clearer viewing. This is likely the first high-resolution intraluminal visualization of fallopian tubes Citation Format: Elizabeth M. Swisher, C. David Melville, Richard S. Johnston, Kathy Agnew, Seine Chiang, Eric J. Seibel. In vivo laser-based imaging of the human fallopian tube for future cancer detection. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr B36.
ABSTRACT Active steering at the distal tip can reduce stress on the flexible ureteroscope (FU) sh... more ABSTRACT Active steering at the distal tip can reduce stress on the flexible ureteroscope (FU) shaft by eliminating the internal angulation wires while also minimizing tissue trauma. A multi-segmented SMA wire actuator has been designed to produce smooth graded motion of the ultrathin scanning fiber endoscope (SFE). A steerable SFE distal tip (1-axis) is demonstrated using a three-step graded bending motion with a multi-tapped shape memory alloy (SMA) wire, power transistor switches, and binary parallel communication. The experimental bending radius and angle of the fabricated active tip (2-mm OD) is measured as 45-mm and 50°, respectively. Using nominal 4% strain of a 125-μm SMA wire, the experimental values are compared to the model predictions using a multi-link planar manipulator. A guidewire with eyes and active tip bending mechanism constitutes the new SFE, which is expected to reduce the procedural time and complications, eliminate X-ray guidance, and provide more space for adjunctive instrumentation, along with having better performance and possibly lower cost than FU.
The Journal of Urology, Apr 1, 2011
Minimally invasive medical procedures require flexible endoscopes that are thinner than existing ... more Minimally invasive medical procedures require flexible endoscopes that are thinner than existing devices while delivering high resolution images. The scanning fiber endoscope (SFE) described meets these requirements. Prototype SFEs with a 2 mm diameter distal tip envelope and better than 10 micron resolution have been developed.
Sid's Digest Of Technical Papers, 2009
Media playback capabilities of mobile devices demand a large display in a small package. We have ... more Media playback capabilities of mobile devices demand a large display in a small package. We have developed a 1‐mm x 9‐mm scan engine, projecting full‐color images through a vibrating optical fiber tip and miniature lens system. Connected by optical fiber, the projection head and RGB light sources can be distributed across the mobile device.
Sid's Digest Of Technical Papers, 2009
Mobile pico projectors need to project on surfaces at a variety of distances, for which different... more Mobile pico projectors need to project on surfaces at a variety of distances, for which different throw angles produce optimal image size and brightness. By electronically adjusting the peak drive voltage to our 1‐mm x 9‐mm scanning fiber engine, we demonstrate rapid (resolution‐maintaining) rescaling of throw angles up to 100°.
Ultrathin, flexible endoscopes are being developed for imaging cancer in previously inaccessible ... more Ultrathin, flexible endoscopes are being developed for imaging cancer in previously inaccessible regions of the body, allowing image-guided biopsy and laser diagnostics/therapeutics. Cancer diagnosis at high sensitivity/specificity is achieved with optical tomography microscopes.
Journal of Dynamic Systems Measurement and Control-transactions of The Asme, Jun 5, 2017
Proceedings of SPIE, Mar 3, 2014
Journal of Sound and Vibration, Apr 1, 2011
IEEE Transactions on Medical Imaging, Aug 1, 2019
Diagnostics, Aug 23, 2022
arXiv (Cornell University), Dec 21, 2022
Optics Letters, Jun 20, 2011
Ventilator-associated pneumonia (VAP) is pneumonia that occurs >48hrs after initiation of mech... more Ventilator-associated pneumonia (VAP) is pneumonia that occurs >48hrs after initiation of mechanical ventilation and is a significant cause of morbidity and mortality in patients that are hospitalized in intensive care units (ICU). The risk of developing VAP increases during use, and a diagnosis of VAP has been associated with a substantial cost. There are up to hundreds of thousands of cases in the US per year, costing the healthcare system billions annually. Patients who suffer from VAP frequently require longer ICU stays, higher exposure to antibiotics, and more hospital care at the risk of increased mortality. The SARS-CoV-2 pandemic has further increased the use of antibiotics among patients with COVID19, an indicator of increased VAP prevalence. Before 2020, strides were made to reduce the incidence of VAP through hygienic protocols known as ‘VAP bundles.’ Despite the improvements, VAP continues to be a large problem, with the inoculation of pathogens within the endotracheal tube (ETT) itself. ETTs with built-in subglottic suction devices (SSDETT) allow the removal of subglottic secretions, but this has been adopted heterogeneously. We propose novel optical device designs to be used in combination with SSD-ETTs to reduce colonization and biofilm formation on the inner lumen of ETTs and reduce the incidence of VAP and improve patient care.
Stroke, Feb 1, 2019
Our understanding and management of carotid artery disease has largely relied on angiography, US ... more Our understanding and management of carotid artery disease has largely relied on angiography, US and MR. However, existing modalities cannot accurately identify the spectrum of thrombogenic lesions on the vascular surface or reliably detect structural markers of instability. Thus, the natural history of the different histopathological hallmarks of advanced or complicated plaques is unknown, and many patients with culprit substenotic plaques are misdiagnosed with cryptogenic stroke. An intraluminal approach to directly inspect the endovascular surfaces at unprecedented resolutions would enable detailed structural analysis of carotid plaques and the identification of the root cause of carotid-related strokes. A scanning fiber angioscope (SFA), a high-definition 1.2-mm forward-viewing camera that generates videos by spirally scanning low-power laser beams, was developed for clinical use and employed to analyze the endovascular surfaces of ex vivo human carotid arteries (n=95) and endarterectomized plaques (n=20). Specimens were then imaged with US and micro-CT, and all vascular diagnostic tests obtained in the patients undergoing carotid revascularization were accessed. Imaging findings in the vascular surfaces were then validated by histomorphological analysis of >300 lesions, and an angioscopic classifier for atherosclerosis was generated. Full-color videos at 30Hz and at a resolution >200,000 pixels were generated from the entire endovascular circumference in all specimens with depth-of-focus larger than 5cm in saline solution. The ability to analyze the surface anatomy with unparalleled detail allowed the identification of early, intermediate, advanced and complex atherosclerotic lesions, including ulceration of fibrotic cap, excavation of the necrotic core leading to pseudolumens, intimal flaps, exposed necrotic core to the lumen, erosions, recent and remote intimal hemorrhages, luminal thrombus, eruptive calcified nodules and calcified intimal sheaths and plates. SFA offers a direct view of the endoluminal surfaces with unparalleled resolution and has the potential to revolutionize research, diagnosis, prognosis and image-guided therapy in carotid atherosclerosis.
Inherited mutations in BRCA1 and BRCA2 cause a 20-50% lifetime risk of ovarian, fallopian tubel, ... more Inherited mutations in BRCA1 and BRCA2 cause a 20-50% lifetime risk of ovarian, fallopian tubel, or peritoneal carcinoma. Clinical recommendations for these high-risk women include the prophylactic removal of the ovaries and fallopian tubes by age 40 after child-bearing. Recent findings suggest that many presumed ovarian or peritoneal carcinomas arise in fallopian tube epithelium. Although survival rate is >90% when ovarian cancer is detected early (Stage_I), 70% of women have advanced disease (Stage_III/IV) at presentation when survival is less than 30%. Over the years, effective early detection of ovarian cancer has remained elusive, possibly because screening techniques have mistakenly focused on the ovary as the origin of ovarian carcinoma. Unlike ovaries, the fallopian tubes are amenable to direct visual imaging without invasive surgery, using access through the uterine cervix. To develop future screening protocols, we investigated using our 1.2-mm diameter, forward-viewing, scanning fiber endoscope (SFE) to image luminal surfaces of the fallopian tube before laparoscopic surgical removal. Three anesthetized human subjects participated in our protocol development which eventually led to 70-80% of the length of fallopian tubes being imaged in scanning reflectance, using red (632nm), green (532nm), and blue (442nm) laser light. A hysteroscope with saline uterine distention was used to locate the tubal ostia. To facilitate passage of the SFE through the interstitial portion of the fallopian tube, an introducer catheter was inserted 1-cm through each ostia. During insertion, saline was flushed to reduce friction and provide clearer viewing. This is likely the first high-resolution intraluminal visualization of fallopian tubes Citation Format: Elizabeth M. Swisher, C. David Melville, Richard S. Johnston, Kathy Agnew, Seine Chiang, Eric J. Seibel. In vivo laser-based imaging of the human fallopian tube for future cancer detection. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr B36.
ABSTRACT Active steering at the distal tip can reduce stress on the flexible ureteroscope (FU) sh... more ABSTRACT Active steering at the distal tip can reduce stress on the flexible ureteroscope (FU) shaft by eliminating the internal angulation wires while also minimizing tissue trauma. A multi-segmented SMA wire actuator has been designed to produce smooth graded motion of the ultrathin scanning fiber endoscope (SFE). A steerable SFE distal tip (1-axis) is demonstrated using a three-step graded bending motion with a multi-tapped shape memory alloy (SMA) wire, power transistor switches, and binary parallel communication. The experimental bending radius and angle of the fabricated active tip (2-mm OD) is measured as 45-mm and 50°, respectively. Using nominal 4% strain of a 125-μm SMA wire, the experimental values are compared to the model predictions using a multi-link planar manipulator. A guidewire with eyes and active tip bending mechanism constitutes the new SFE, which is expected to reduce the procedural time and complications, eliminate X-ray guidance, and provide more space for adjunctive instrumentation, along with having better performance and possibly lower cost than FU.
The Journal of Urology, Apr 1, 2011
Minimally invasive medical procedures require flexible endoscopes that are thinner than existing ... more Minimally invasive medical procedures require flexible endoscopes that are thinner than existing devices while delivering high resolution images. The scanning fiber endoscope (SFE) described meets these requirements. Prototype SFEs with a 2 mm diameter distal tip envelope and better than 10 micron resolution have been developed.
Sid's Digest Of Technical Papers, 2009
Media playback capabilities of mobile devices demand a large display in a small package. We have ... more Media playback capabilities of mobile devices demand a large display in a small package. We have developed a 1‐mm x 9‐mm scan engine, projecting full‐color images through a vibrating optical fiber tip and miniature lens system. Connected by optical fiber, the projection head and RGB light sources can be distributed across the mobile device.
Sid's Digest Of Technical Papers, 2009
Mobile pico projectors need to project on surfaces at a variety of distances, for which different... more Mobile pico projectors need to project on surfaces at a variety of distances, for which different throw angles produce optimal image size and brightness. By electronically adjusting the peak drive voltage to our 1‐mm x 9‐mm scanning fiber engine, we demonstrate rapid (resolution‐maintaining) rescaling of throw angles up to 100°.