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Papers by Erica Brown
Journal of Virology, 2006
All sequenced poxviruses encode orthologs of the vaccinia virus L1 and F9 proteins, which are str... more All sequenced poxviruses encode orthologs of the vaccinia virus L1 and F9 proteins, which are structurally similar and share about 20% amino acid identity. We found that F9 further resembles L1 as both proteins are membrane components of the mature virion with similar topologies and induce neutralizing antibodies. In addition, a recombinant vaccinia virus that inducibly expresses F9, like a previously described L1 mutant, had a conditional-lethal phenotype: plaque formation and replication of infectious virus were dependent on added inducer. However, only immature virus particles are made when L1 is repressed, whereas normal-looking intracellular and extracellular virions formed in the absence of F9. Except for the lack of F9, the polypeptide components of such virions were indistinguishable from those of wild-type virus. These F9-deficient virions bound to cells, but their cores did not penetrate into the cytoplasm. Furthermore, cells infected with F9-negative virions did not fuse ...
Letter to the Editor Journal of Genetic Counseling
Journal of Genetic Counseling, 2007
The article When You Care to Do Your Very Best: Genetic Counselor Experiences of Compassion Fati... more The article When You Care to Do Your Very Best: Genetic Counselor Experiences of Compassion Fatigue (June 2007, 16: 3) raises significant issues that impact on the profession of genetic counseling. As the authors state compassion fatigue is less ...
Journal of Virology, 2006
All sequenced poxviruses encode orthologs of the vaccinia virus L1 and F9 proteins, which are str... more All sequenced poxviruses encode orthologs of the vaccinia virus L1 and F9 proteins, which are structurally similar and share about 20% amino acid identity. We found that F9 further resembles L1 as both proteins are membrane components of the mature virion with similar topologies and induce neutralizing antibodies. In addition, a recombinant vaccinia virus that inducibly expresses F9, like a previously described L1 mutant, had a conditional-lethal phenotype: plaque formation and replication of infectious virus were dependent on added inducer. However, only immature virus particles are made when L1 is repressed, whereas normal-looking intracellular and extracellular virions formed in the absence of F9. Except for the lack of F9, the polypeptide components of such virions were indistinguishable from those of wild-type virus. These F9-deficient virions bound to cells, but their cores did not penetrate into the cytoplasm. Furthermore, cells infected with F9-negative virions did not fuse ...
Letter to the Editor Journal of Genetic Counseling
Journal of Genetic Counseling, 2007
The article When You Care to Do Your Very Best: Genetic Counselor Experiences of Compassion Fati... more The article When You Care to Do Your Very Best: Genetic Counselor Experiences of Compassion Fatigue (June 2007, 16: 3) raises significant issues that impact on the profession of genetic counseling. As the authors state compassion fatigue is less ...