Erika Morelli - Academia.edu (original) (raw)

Papers by Erika Morelli

Research paper thumbnail of Predictors of Treatment Failure in HIV-Positive Children Receiving Combination Antiretroviral Therapy: Cohort Data From Mozambique and Uganda

Journal of the Pediatric Infectious Diseases Society, 2014

Background. Delays detecting treatment failure and switching to second-line combination antiretro... more Background. Delays detecting treatment failure and switching to second-line combination antiretroviral therapy (cART) are often observed in human immunodeficiency virus (HIV)-infected children of low-middleincome countries (LMIC).

Research paper thumbnail of Non-AIDS definings malignancies among human immunodeficiency virus-positive subjects: Epidemiology and outcome after two decades of HAART era

World journal of virology, Jan 12, 2015

Highly active antiretroviral therapy (HAART) for human immunodeficiency virus (HIV) infection has... more Highly active antiretroviral therapy (HAART) for human immunodeficiency virus (HIV) infection has been widely available in industrialized countries since 1996; its widespread use determined a dramatic decline in acquired immunodeficiency syndrome (AIDS)-related mortality, and consequently, a significant decrease of AIDS-defining cancers. However the increased mean age of HIV-infected patients, prolonged exposure to environmental and lifestyle cancer risk factors, and coinfection with oncogenic viruses contributed to the emergence of other malignancies that are considered non-AIDS-defining cancers (NADCs) as a relevant fraction of morbidity and mortality among HIV-infected people twenty years after HAART introduction. The role of immunosuppression in the pathogenesis of NADCs is not well defined, and future researches should investigate the etiology of NADCs. In the last years there is a growing evidence that intensive chemotherapy regimens and radiotherapy could be safely administra...

Research paper thumbnail of Current and Future Antiretroviral Treatment Options in Paediatric HIV Infection

Clinical Drug Investigation, 2008

Research paper thumbnail of Predictors of Treatment Failure in HIV-Positive Children Receiving Combination Antiretroviral Therapy: Cohort Data From Mozambique and Uganda

Journal of the Pediatric Infectious Diseases Society, 2014

Background. Delays detecting treatment failure and switching to second-line combination antiretro... more Background. Delays detecting treatment failure and switching to second-line combination antiretroviral therapy (cART) are often observed in human immunodeficiency virus (HIV)-infected children of low-middleincome countries (LMIC).

Research paper thumbnail of Sustained remission of a primary nodal Merkel cell carcinoma in an HIV-positive patient

Research paper thumbnail of Sustained Remission of a Primary Nodal Merkel Cell Carcinoma in an HIV-Positive Patient

Research paper thumbnail of Linezolid in the treatment of brain abscess due to Peptostreptococcus

Scandinavian Journal of Infectious Diseases, 2006

Brain abscesses can be caused by bacteria, fungi, and parasites. Among bacteria, anaerobic organi... more Brain abscesses can be caused by bacteria, fungi, and parasites. Among bacteria, anaerobic organisms include the Bacteroides species group, Fusobacterium, Peptostreptococcus, and Propionibacterium. In these cases, a 4-week course of parenteral penicillin/cefalosporin and metronidazole is the standard of treatment. We describe a case of brain abscess secondary to anaerobic infection with Peptostreptococcus, which was successfully treated with parenteral and oral linezolid after failure of standard therapy.

Research paper thumbnail of Current and future antiretroviral treatment options in paediatric HIV infection

Clinical drug investigation, 2008

Because of a lack of prevention policies or problems in implementing prevention of mother-to-chil... more Because of a lack of prevention policies or problems in implementing prevention of mother-to-child transmission (P-MTCT), most of the 1500 daily new HIV infections in children aged<15 years are caused by MTCT. Fifteen percent of all HIV-infected individuals are children, but the vast majority lack access to highly active antiretroviral therapy (HAART), which can drastically reduce morbidity and mortality. There are 22 antiretroviral drugs currently approved by the US FDA for use in the treatment of HIV-infected adults and adolescents, but only 12 of these drugs are approved for use in children. Antiretroviral drugs belong to four major classes: nucleoside and nucleotide analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors and fusion inhibitors. According to international guidelines developed by organizations including WHO, the Paediatric European Network for Treatment of AIDS (PENTA) and the US National I...

Research paper thumbnail of Viral load detection using dried blood spots in a cohort of HIV-1-infected children in Uganda: correlations with clinical and immunological criteria for treatment failure

Journal of Clinical Microbiology, 2014

Correlations between clinical/immunological treatment failure and viral load (VL) detected by dri... more Correlations between clinical/immunological treatment failure and viral load (VL) detected by dried blood spot (DBS) sampling were explored in HIV-1-infected children in Uganda. Of 104 children on combined antiretroviral treatment (cART), 12.5% experienced clinical and/or immunological failure, while 28.8%, 44.2%, and 26.9% had VLs of <1,000, 1,000 to 5,000, and >5,000 copies/ml, respectively. Clinical/immunological failure poorly predicted virological failure.

Research paper thumbnail of Predictors of Treatment Failure in HIV-Positive Children Receiving Combination Antiretroviral Therapy: Cohort Data From Mozambique and Uganda

Journal of the Pediatric Infectious Diseases Society, 2014

Background. Delays detecting treatment failure and switching to second-line combination antiretro... more Background. Delays detecting treatment failure and switching to second-line combination antiretroviral therapy (cART) are often observed in human immunodeficiency virus (HIV)-infected children of low-middleincome countries (LMIC).

Research paper thumbnail of Non-AIDS definings malignancies among human immunodeficiency virus-positive subjects: Epidemiology and outcome after two decades of HAART era

World journal of virology, Jan 12, 2015

Highly active antiretroviral therapy (HAART) for human immunodeficiency virus (HIV) infection has... more Highly active antiretroviral therapy (HAART) for human immunodeficiency virus (HIV) infection has been widely available in industrialized countries since 1996; its widespread use determined a dramatic decline in acquired immunodeficiency syndrome (AIDS)-related mortality, and consequently, a significant decrease of AIDS-defining cancers. However the increased mean age of HIV-infected patients, prolonged exposure to environmental and lifestyle cancer risk factors, and coinfection with oncogenic viruses contributed to the emergence of other malignancies that are considered non-AIDS-defining cancers (NADCs) as a relevant fraction of morbidity and mortality among HIV-infected people twenty years after HAART introduction. The role of immunosuppression in the pathogenesis of NADCs is not well defined, and future researches should investigate the etiology of NADCs. In the last years there is a growing evidence that intensive chemotherapy regimens and radiotherapy could be safely administra...

Research paper thumbnail of Current and Future Antiretroviral Treatment Options in Paediatric HIV Infection

Clinical Drug Investigation, 2008

Research paper thumbnail of Predictors of Treatment Failure in HIV-Positive Children Receiving Combination Antiretroviral Therapy: Cohort Data From Mozambique and Uganda

Journal of the Pediatric Infectious Diseases Society, 2014

Background. Delays detecting treatment failure and switching to second-line combination antiretro... more Background. Delays detecting treatment failure and switching to second-line combination antiretroviral therapy (cART) are often observed in human immunodeficiency virus (HIV)-infected children of low-middleincome countries (LMIC).

Research paper thumbnail of Sustained remission of a primary nodal Merkel cell carcinoma in an HIV-positive patient

Research paper thumbnail of Sustained Remission of a Primary Nodal Merkel Cell Carcinoma in an HIV-Positive Patient

Research paper thumbnail of Linezolid in the treatment of brain abscess due to Peptostreptococcus

Scandinavian Journal of Infectious Diseases, 2006

Brain abscesses can be caused by bacteria, fungi, and parasites. Among bacteria, anaerobic organi... more Brain abscesses can be caused by bacteria, fungi, and parasites. Among bacteria, anaerobic organisms include the Bacteroides species group, Fusobacterium, Peptostreptococcus, and Propionibacterium. In these cases, a 4-week course of parenteral penicillin/cefalosporin and metronidazole is the standard of treatment. We describe a case of brain abscess secondary to anaerobic infection with Peptostreptococcus, which was successfully treated with parenteral and oral linezolid after failure of standard therapy.

Research paper thumbnail of Current and future antiretroviral treatment options in paediatric HIV infection

Clinical drug investigation, 2008

Because of a lack of prevention policies or problems in implementing prevention of mother-to-chil... more Because of a lack of prevention policies or problems in implementing prevention of mother-to-child transmission (P-MTCT), most of the 1500 daily new HIV infections in children aged<15 years are caused by MTCT. Fifteen percent of all HIV-infected individuals are children, but the vast majority lack access to highly active antiretroviral therapy (HAART), which can drastically reduce morbidity and mortality. There are 22 antiretroviral drugs currently approved by the US FDA for use in the treatment of HIV-infected adults and adolescents, but only 12 of these drugs are approved for use in children. Antiretroviral drugs belong to four major classes: nucleoside and nucleotide analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors and fusion inhibitors. According to international guidelines developed by organizations including WHO, the Paediatric European Network for Treatment of AIDS (PENTA) and the US National I...

Research paper thumbnail of Viral load detection using dried blood spots in a cohort of HIV-1-infected children in Uganda: correlations with clinical and immunological criteria for treatment failure

Journal of Clinical Microbiology, 2014

Correlations between clinical/immunological treatment failure and viral load (VL) detected by dri... more Correlations between clinical/immunological treatment failure and viral load (VL) detected by dried blood spot (DBS) sampling were explored in HIV-1-infected children in Uganda. Of 104 children on combined antiretroviral treatment (cART), 12.5% experienced clinical and/or immunological failure, while 28.8%, 44.2%, and 26.9% had VLs of <1,000, 1,000 to 5,000, and >5,000 copies/ml, respectively. Clinical/immunological failure poorly predicted virological failure.