Erika Nieves - Academia.edu (original) (raw)
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96 DEVELOPMENT OF A MICRO PCR REACTOR FOR LAB-ON-A-CHIP DEVICES NSF Summer Undergraduate Fellowsh... more 96 DEVELOPMENT OF A MICRO PCR REACTOR FOR LAB-ON-A-CHIP DEVICES NSF Summer Undergraduate Fellowship in Sensor Technologies Erika Martinez Nieves (Art and Science Department)-University of Puerto Rico Advisor: Haim H. Bau ABSTRACT The process of ...
Frontiers in Microbiology
Bacterial infection and thrombosis are highly correlated, especially in patients with indwelling ... more Bacterial infection and thrombosis are highly correlated, especially in patients with indwelling medical devices. Coagulase-negative staphylococci, typified by Staphylococcus epidermidis, are a common cause of medical device infections owing to their biofilm forming capacity which provides protection from antibiotics and host immune response. Attention has been drawn to the interaction between S. epidermidis and host proteins, specifically fibrinogen. However, little is known regarding the impact of the transition from planktonic to biofilm forming phenotype on this interaction. Here we investigate the growth phase dependence of bacteria-fibrinogen interaction and the resulting effect on fibrin clot formation, structure, and mechanics. Flow cytometry demonstrated growth phase dependent affinity for fibrinogen. To mimic intravascular device seeding, we quantified the adhesion of S. epidermidis to a fibrinogen coated surface under continuous flow conditions in vitro. The bacterial dep...
SUNFEST
96 DEVELOPMENT OF A MICRO PCR REACTOR FOR LAB-ON-A-CHIP DEVICES NSF Summer Undergraduate Fellowsh... more 96 DEVELOPMENT OF A MICRO PCR REACTOR FOR LAB-ON-A-CHIP DEVICES NSF Summer Undergraduate Fellowship in Sensor Technologies Erika Martinez Nieves (Art and Science Department)-University of Puerto Rico Advisor: Haim H. Bau ABSTRACT The process of ...
Frontiers in Microbiology
Bacterial infection and thrombosis are highly correlated, especially in patients with indwelling ... more Bacterial infection and thrombosis are highly correlated, especially in patients with indwelling medical devices. Coagulase-negative staphylococci, typified by Staphylococcus epidermidis, are a common cause of medical device infections owing to their biofilm forming capacity which provides protection from antibiotics and host immune response. Attention has been drawn to the interaction between S. epidermidis and host proteins, specifically fibrinogen. However, little is known regarding the impact of the transition from planktonic to biofilm forming phenotype on this interaction. Here we investigate the growth phase dependence of bacteria-fibrinogen interaction and the resulting effect on fibrin clot formation, structure, and mechanics. Flow cytometry demonstrated growth phase dependent affinity for fibrinogen. To mimic intravascular device seeding, we quantified the adhesion of S. epidermidis to a fibrinogen coated surface under continuous flow conditions in vitro. The bacterial dep...