Erling Mellerup - Academia.edu (original) (raw)
Papers by Erling Mellerup
PloS one, 2015
The main objective of the study was to find combinations of genetic variants significantly associ... more The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.
PLoS ONE, 2013
Complex diseases may be associated with combinations of changes in DNA, where the single change h... more Complex diseases may be associated with combinations of changes in DNA, where the single change has little impact alone. In a previous study of patients with bipolar disorder and controls combinations of SNP genotypes were analyzed, and four large clusters of combinations were found to be significantly associated with bipolar disorder. It has now been found that these clusters may be connected to clinical data.
Genes & cancer, 2015
In the single locus strategy a number of genetic variants are analyzed, in order to find variants... more In the single locus strategy a number of genetic variants are analyzed, in order to find variants that are distributed significantly different between controls and patients. A supplementary strategy is to analyze combinations of genetic variants. A combination that is the genetic basis for a polygenic disorder will not occur in in control persons genetically unrelated to patients, so the strategy is to analyze combinations of genetic variants present exclusively in patients. In a previous study of oral cancer and leukoplakia 325 SNPs were analyzed. This study has been supplemented with an analysis of combinations of two SNP genotypes from among the 325 SNPs. Two clusters of combinations containing 95 patient specific combinations were significantly associated with oral cancer or leukoplakia. Of 373 patients with oral cancer 205 patients had a number of these 95 combinations in their genome, whereas none of 535 control persons had any of these combinations in their genome.
Neuro-Psychopharmacology, 1978
PLOS ONE, 2017
The main objective of the study was to find genetic variants that in combination are significantl... more The main objective of the study was to find genetic variants that in combination are significantly associated with bipolar disorder. In previous studies of bipolar disorder, combinations of three and four single nucleotide polymorphisms (SNP) genotypes taken from 803 SNPs were analyzed, and five clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of ten SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the five previous clusters were identified in the genomes of 266 or 44% of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.The SNP genotypes in the smaller combinations were the normal homozygote, heterozygote or variant homozygote. In the combinations containing 10 SNP genotypes almost all the genotypes were the normal homozygote. Such a finding may indicate that accumulation in the genome of combinations containing few SNP genotypes may be a risk factor for bipolar disorder when those combinations contain relatively many rare SNP genotypes, whereas combinations need to contain many SNP genotypes to be a risk factor when most of the SNP genotypes are the normal homozygote.
Computational and Structural Biotechnology Journal, 2017
In studies of polygenic disorders, scanning the genetic variants can be used to identify variant ... more In studies of polygenic disorders, scanning the genetic variants can be used to identify variant combinations. Combinations that are exclusively found in patients can be separated from those combinations occurring in control persons. Statistical analyses can be performed to determine whether the combinations that occur exclusively among patients are significantly associated with the investigated disorder. This research strategy has been applied in materials from various polygenic disorders, identifying clusters of patient-specific genetic variant combinations that are significant associated with the investigated disorders. Combinations from these clusters are found in the genomes of up to 55% of investigated patients, and are not present in the genomes of any control persons.
PLoS ONE, 2012
Complex diseases may be associated with combinations of changes in DNA, where the single change h... more Complex diseases may be associated with combinations of changes in DNA, where the single change has little impact alone. In a previous study of patients with bipolar disorder and controls combinations of SNP genotypes were analyzed, and four large clusters of combinations were found to be significantly associated with bipolar disorder. It has now been found that these clusters may be connected to clinical data.
PLoS ONE, 2011
Any given single nucleotide polymorphism (SNP) in a genome may have little or no functional impac... more Any given single nucleotide polymorphism (SNP) in a genome may have little or no functional impact. A biologically significant effect may possibly emerge only when a number of key SNP-related genotypes occur together in a single organism. Thus, in analysis of many SNPs in association studies of complex diseases, it may be useful to look at combinations of genotypes. Genes related to signal transmission, e.g., ion channel genes, may be of interest in this respect in the context of bipolar disorder. In the present study, we analysed 803 SNPs in 55 genes related to aspects of signal transmission and calculated all combinations of three genotypes from the 36803 SNP genotypes for 1355 controls and 607 patients with bipolar disorder. Four clusters of patient-specific combinations were identified. Permutation tests indicated that some of these combinations might be related to bipolar disorder. The WTCCC bipolar dataset were use for replication, 469 of the 803 SNP were present in the WTCCC dataset either directly (n = 132) or by imputation (n = 337) covering 51 of our selected genes. We found three clusters of patient-specific 36SNP combinations in the WTCCC dataset. Different SNPs were involved in the clusters in the two datasets. The present analyses of the combinations of SNP genotypes support a role for both genetic heterogeneity and interactions in the genetic architecture of bipolar disorder.
Cephalalgia, 1985
Imipramine and other tricyclic antidepressants are bound with moderate affinity at several neurot... more Imipramine and other tricyclic antidepressants are bound with moderate affinity at several neurotransmitter receptor sites. However, also specific high-affinity binding sites for imipramine have been found on neuronal platelet membranes. These high-affinity binding sites are probably located on the serotonin transport system in serotonergic neurons and platelets. Firstly, because imipramine inhibits the uptake of serotonin in neurons and platelets; secondly, because other drugs which inhibit the serotonin uptake also inhibits the imipramine binding, and the two types of inhibition are closely related; thirdly, because chemical or electrolytic destruction of serotonergic neurons is accompanied by a parallel reduction in high-affinity imipramine binding. The role of serotonin and imipramine in several theories concerning the etiology of chronic pain disorders and affective disorders emphasizes the potential importance af these binding sites for studies of affective disorders as well as for the study of new antidepressants. BIOCHEMICAL ASPECTS: A binding site or receptor can be characterized by the number ( B max) of binding sites in a specific cell type; by the affinity between the binding site and ligands specifically bound to this site (usually the affinity is expressed by the dissociation constant, KD); and finally by the physiological function of the binding site. The high-affinity 'H-imipramine binding site in neurons and platelets may be located on the serotonin transport mechanism; thus the function of the binding site may be to participate in the transport of serotonin, e.g., by binding serotonin. In that case imipramine binding should be competitively inhibited by serotonin, but this does not seem to be the case. Paroxetine , which is a much more potent and specific inhibitor of serotonin uptake than imipramine, is also bound to neuron and platelet membranes with a very high affinity. B max for paroxetine is the same as B max for imipramine in platelets ( but not in neurons) indicating that paroxetine and imipramine is bound to the same protein complex in the platelet membrane, probably the serotonin transport system. However, imipramine and paroxetine may not be bound at the same site on the serotonin transport system. Although, the two drugs show mutual inhibition with respect to binding, it is not a simple competitive inhibition, but rather an allosteric interaction. Furthermore, the temperature effect on the binding is different for the two drugs, indicating that their respective binding sites are located differently in the phospholipid membrane.finally, the molecular weights (determinated by radiation inactivation) of the polypeptide chains to which imipramine and paroxetine are being bound are different, again indicating that the two drugs are bound to two different binding sites. One of the binding sites may be directly realted to the molecular transport mechanism for serotonin, the other binding site may be a regulator which determines the affinity between the transport system and serotonin. These suggestions are purely speculative, but experiments with binding of 'Himipramine in the absence as well as in the presence of serotonin have shown that the displacement of the radioactive imipramine from the binding site is strongly modified by serotonin. Another question that is interesting from a biochemical as well as from a clinical point of view is whether the 'H-imipramine binding sites in platelets is the same as in neurons. With respect to paroxetine the binding site in platelets and neurons seems to be the same, because KD is the same for both cell types. Imipramine, on the other hand, has a much lower KD value and
Acta Pharmacologica et Toxicologica, 2009
The diurnal rhythm of oral temperature was studied in 55 lithium treated patients, 51 other psych... more The diurnal rhythm of oral temperature was studied in 55 lithium treated patients, 51 other psychiatric patients, and 58 healthy subjects. The lithium treated patients had a higher temperature than the normal controls during the 24-hour period and their temperature maximum was shifted towards an earlier time. When the lithium intake was postponed for 12 hours, temperature temporarily decreased to control values, but returned to the higher level after the lithium dose. The temperature results are discussed in relation to lithium induced changes in electrolyte metabolism.
Current developments in psychopharmacology, 1979
![Research paper thumbnail of [Winter depression and light therapy]](https://attachments.academia-assets.com/95090400/thumbnails/1.jpg)
](Nederlands tijdschrift voor geneeskunde, Jan 22, 1990
Acta Pharmacologica et Toxicologica, 2009
Psychopharmacology, 1982
For many year two Danish psychiatric hospitals having used different lithium treatment regimens. ... more For many year two Danish psychiatric hospitals having used different lithium treatment regimens. In one, slow-release tablets were given in two daily doses and, in the other conventional tablets were given in a single daily dose. In both hospitals many patients developed polyuria. Multiple regression analyses with sex, age, treatment duration, serum lithium concentration, and treatment regimen as predictor variables showed that the two treatment regimens did not affect the glomerular filtration rate or the proximal reabsorption differently, but that distal water reabsorption was significantly less affected and polyuria less pronounced in the patients given conventional tablets once daily than in those give slow-release tablets twice daily. The authors are divided among themselves as regards the implications of these findings.
Psychopharmacology, 1982
The specific high-affinity binding of 3H-imipramine to rat brain membranes was investigated. Five... more The specific high-affinity binding of 3H-imipramine to rat brain membranes was investigated. Five weeks of lithium treatment decreased the number of binding sites, but had no effect on the affinity constants. Long-term imipramine treatment had no effect on the number of binding sites but apparently decreased the affinity. The latter effect was probably due to imipramine remaining in the membrane preparation.
Psychopharmacology, 1976
LiCl was injected daily to rats in a dose of 3 mmol/kg. The rats were, in different experiments, ... more LiCl was injected daily to rats in a dose of 3 mmol/kg. The rats were, in different experiments, unoperated rats, parathyroidectomized rats and thyroparathyroidectomized rats. Serum concentrations of calcium, magnesium, and phosphate were measured 2 h after a lithium injection. Serum calcium was unaffected by lithium in unoperated and parathyroidectomized rats. In thyroparathyroidectomized rats lithium increased the serum calcium concentration. Serum magnesium was increased by lithium in all 3 groups of rats. Serum phosphate was slightly decreased by lithium in all 3 groups of rats. It is concluded that lithium increases both serum calcium and magnesium, but in the intact organism only a slight or no increase in serum calcium is seem after lithium due to physiological control mechanisms. After removal of the calcitonin producing C-cells in the thyroid gland the organism is unable to produce a fast decrease in serum calcium, and lithium is then able to increase the serum calcium concentration.
Psychiatry Research, 1982
High-affinity binding of rH-imipramine to platelet membranes from control subjects and psychiatri... more High-affinity binding of rH-imipramine to platelet membranes from control subjects and psychiatric patients was studied. Maximal binding (pmax) in depressed manic-melancholic patients was higher than in euthymic manicmelancholic patients, psychiatric controls, and normal controls.
Psychiatry Research, 1986
The thyrotropin-releasing hormone (TRH) stimulation test and the dexamethasone suppression test (... more The thyrotropin-releasing hormone (TRH) stimulation test and the dexamethasone suppression test (DST) were performed in 40 depressive patients. More endogenously depressed patients than nonendogenously depressed patients showed a blunted response to TRH. No difference was found in delta max thyroid-stimulating hormone (TSH) between patients who responded to dexamethasone administration with a normal suppression of cortisol and those who responded with nonsuppression.
Psychiatry Research, 1988
High-affinity binding of 3H-imipramine was analyzed in platelet membranes from patients with chro... more High-affinity binding of 3H-imipramine was analyzed in platelet membranes from patients with chronic psychogenic pain. The patients who in addition to the pain also showed affective symptoms such as depression and anxiety had lower binding than the pain patients without these symptoms.
Nordic Journal of Psychiatry, 1989
ABSTRACT Methodological problems in the studies of platelet imipramine binding in depressed patie... more ABSTRACT Methodological problems in the studies of platelet imipramine binding in depressed patients are discussed. It is concluded that at least some of the low values for imipramine binding reported in the literature may be artefacts. The use of tritium-labelled paroxetine instead of labelled imipramine is recommended for future studies. Studies of psychogenic pain disorders and depression indicate that the presence of pain as well as affective symptoms may be associated with decreased platelet imipramine binding. □ Depression, Imipramine binding, Platelets, Psychogenic pain.
PloS one, 2015
The main objective of the study was to find combinations of genetic variants significantly associ... more The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.
PLoS ONE, 2013
Complex diseases may be associated with combinations of changes in DNA, where the single change h... more Complex diseases may be associated with combinations of changes in DNA, where the single change has little impact alone. In a previous study of patients with bipolar disorder and controls combinations of SNP genotypes were analyzed, and four large clusters of combinations were found to be significantly associated with bipolar disorder. It has now been found that these clusters may be connected to clinical data.
Genes & cancer, 2015
In the single locus strategy a number of genetic variants are analyzed, in order to find variants... more In the single locus strategy a number of genetic variants are analyzed, in order to find variants that are distributed significantly different between controls and patients. A supplementary strategy is to analyze combinations of genetic variants. A combination that is the genetic basis for a polygenic disorder will not occur in in control persons genetically unrelated to patients, so the strategy is to analyze combinations of genetic variants present exclusively in patients. In a previous study of oral cancer and leukoplakia 325 SNPs were analyzed. This study has been supplemented with an analysis of combinations of two SNP genotypes from among the 325 SNPs. Two clusters of combinations containing 95 patient specific combinations were significantly associated with oral cancer or leukoplakia. Of 373 patients with oral cancer 205 patients had a number of these 95 combinations in their genome, whereas none of 535 control persons had any of these combinations in their genome.
Neuro-Psychopharmacology, 1978
PLOS ONE, 2017
The main objective of the study was to find genetic variants that in combination are significantl... more The main objective of the study was to find genetic variants that in combination are significantly associated with bipolar disorder. In previous studies of bipolar disorder, combinations of three and four single nucleotide polymorphisms (SNP) genotypes taken from 803 SNPs were analyzed, and five clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of ten SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the five previous clusters were identified in the genomes of 266 or 44% of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.The SNP genotypes in the smaller combinations were the normal homozygote, heterozygote or variant homozygote. In the combinations containing 10 SNP genotypes almost all the genotypes were the normal homozygote. Such a finding may indicate that accumulation in the genome of combinations containing few SNP genotypes may be a risk factor for bipolar disorder when those combinations contain relatively many rare SNP genotypes, whereas combinations need to contain many SNP genotypes to be a risk factor when most of the SNP genotypes are the normal homozygote.
Computational and Structural Biotechnology Journal, 2017
In studies of polygenic disorders, scanning the genetic variants can be used to identify variant ... more In studies of polygenic disorders, scanning the genetic variants can be used to identify variant combinations. Combinations that are exclusively found in patients can be separated from those combinations occurring in control persons. Statistical analyses can be performed to determine whether the combinations that occur exclusively among patients are significantly associated with the investigated disorder. This research strategy has been applied in materials from various polygenic disorders, identifying clusters of patient-specific genetic variant combinations that are significant associated with the investigated disorders. Combinations from these clusters are found in the genomes of up to 55% of investigated patients, and are not present in the genomes of any control persons.
PLoS ONE, 2012
Complex diseases may be associated with combinations of changes in DNA, where the single change h... more Complex diseases may be associated with combinations of changes in DNA, where the single change has little impact alone. In a previous study of patients with bipolar disorder and controls combinations of SNP genotypes were analyzed, and four large clusters of combinations were found to be significantly associated with bipolar disorder. It has now been found that these clusters may be connected to clinical data.
PLoS ONE, 2011
Any given single nucleotide polymorphism (SNP) in a genome may have little or no functional impac... more Any given single nucleotide polymorphism (SNP) in a genome may have little or no functional impact. A biologically significant effect may possibly emerge only when a number of key SNP-related genotypes occur together in a single organism. Thus, in analysis of many SNPs in association studies of complex diseases, it may be useful to look at combinations of genotypes. Genes related to signal transmission, e.g., ion channel genes, may be of interest in this respect in the context of bipolar disorder. In the present study, we analysed 803 SNPs in 55 genes related to aspects of signal transmission and calculated all combinations of three genotypes from the 36803 SNP genotypes for 1355 controls and 607 patients with bipolar disorder. Four clusters of patient-specific combinations were identified. Permutation tests indicated that some of these combinations might be related to bipolar disorder. The WTCCC bipolar dataset were use for replication, 469 of the 803 SNP were present in the WTCCC dataset either directly (n = 132) or by imputation (n = 337) covering 51 of our selected genes. We found three clusters of patient-specific 36SNP combinations in the WTCCC dataset. Different SNPs were involved in the clusters in the two datasets. The present analyses of the combinations of SNP genotypes support a role for both genetic heterogeneity and interactions in the genetic architecture of bipolar disorder.
Cephalalgia, 1985
Imipramine and other tricyclic antidepressants are bound with moderate affinity at several neurot... more Imipramine and other tricyclic antidepressants are bound with moderate affinity at several neurotransmitter receptor sites. However, also specific high-affinity binding sites for imipramine have been found on neuronal platelet membranes. These high-affinity binding sites are probably located on the serotonin transport system in serotonergic neurons and platelets. Firstly, because imipramine inhibits the uptake of serotonin in neurons and platelets; secondly, because other drugs which inhibit the serotonin uptake also inhibits the imipramine binding, and the two types of inhibition are closely related; thirdly, because chemical or electrolytic destruction of serotonergic neurons is accompanied by a parallel reduction in high-affinity imipramine binding. The role of serotonin and imipramine in several theories concerning the etiology of chronic pain disorders and affective disorders emphasizes the potential importance af these binding sites for studies of affective disorders as well as for the study of new antidepressants. BIOCHEMICAL ASPECTS: A binding site or receptor can be characterized by the number ( B max) of binding sites in a specific cell type; by the affinity between the binding site and ligands specifically bound to this site (usually the affinity is expressed by the dissociation constant, KD); and finally by the physiological function of the binding site. The high-affinity 'H-imipramine binding site in neurons and platelets may be located on the serotonin transport mechanism; thus the function of the binding site may be to participate in the transport of serotonin, e.g., by binding serotonin. In that case imipramine binding should be competitively inhibited by serotonin, but this does not seem to be the case. Paroxetine , which is a much more potent and specific inhibitor of serotonin uptake than imipramine, is also bound to neuron and platelet membranes with a very high affinity. B max for paroxetine is the same as B max for imipramine in platelets ( but not in neurons) indicating that paroxetine and imipramine is bound to the same protein complex in the platelet membrane, probably the serotonin transport system. However, imipramine and paroxetine may not be bound at the same site on the serotonin transport system. Although, the two drugs show mutual inhibition with respect to binding, it is not a simple competitive inhibition, but rather an allosteric interaction. Furthermore, the temperature effect on the binding is different for the two drugs, indicating that their respective binding sites are located differently in the phospholipid membrane.finally, the molecular weights (determinated by radiation inactivation) of the polypeptide chains to which imipramine and paroxetine are being bound are different, again indicating that the two drugs are bound to two different binding sites. One of the binding sites may be directly realted to the molecular transport mechanism for serotonin, the other binding site may be a regulator which determines the affinity between the transport system and serotonin. These suggestions are purely speculative, but experiments with binding of 'Himipramine in the absence as well as in the presence of serotonin have shown that the displacement of the radioactive imipramine from the binding site is strongly modified by serotonin. Another question that is interesting from a biochemical as well as from a clinical point of view is whether the 'H-imipramine binding sites in platelets is the same as in neurons. With respect to paroxetine the binding site in platelets and neurons seems to be the same, because KD is the same for both cell types. Imipramine, on the other hand, has a much lower KD value and
Acta Pharmacologica et Toxicologica, 2009
The diurnal rhythm of oral temperature was studied in 55 lithium treated patients, 51 other psych... more The diurnal rhythm of oral temperature was studied in 55 lithium treated patients, 51 other psychiatric patients, and 58 healthy subjects. The lithium treated patients had a higher temperature than the normal controls during the 24-hour period and their temperature maximum was shifted towards an earlier time. When the lithium intake was postponed for 12 hours, temperature temporarily decreased to control values, but returned to the higher level after the lithium dose. The temperature results are discussed in relation to lithium induced changes in electrolyte metabolism.
Current developments in psychopharmacology, 1979
Nederlands tijdschrift voor geneeskunde, Jan 22, 1990
Acta Pharmacologica et Toxicologica, 2009
Psychopharmacology, 1982
For many year two Danish psychiatric hospitals having used different lithium treatment regimens. ... more For many year two Danish psychiatric hospitals having used different lithium treatment regimens. In one, slow-release tablets were given in two daily doses and, in the other conventional tablets were given in a single daily dose. In both hospitals many patients developed polyuria. Multiple regression analyses with sex, age, treatment duration, serum lithium concentration, and treatment regimen as predictor variables showed that the two treatment regimens did not affect the glomerular filtration rate or the proximal reabsorption differently, but that distal water reabsorption was significantly less affected and polyuria less pronounced in the patients given conventional tablets once daily than in those give slow-release tablets twice daily. The authors are divided among themselves as regards the implications of these findings.
Psychopharmacology, 1982
The specific high-affinity binding of 3H-imipramine to rat brain membranes was investigated. Five... more The specific high-affinity binding of 3H-imipramine to rat brain membranes was investigated. Five weeks of lithium treatment decreased the number of binding sites, but had no effect on the affinity constants. Long-term imipramine treatment had no effect on the number of binding sites but apparently decreased the affinity. The latter effect was probably due to imipramine remaining in the membrane preparation.
Psychopharmacology, 1976
LiCl was injected daily to rats in a dose of 3 mmol/kg. The rats were, in different experiments, ... more LiCl was injected daily to rats in a dose of 3 mmol/kg. The rats were, in different experiments, unoperated rats, parathyroidectomized rats and thyroparathyroidectomized rats. Serum concentrations of calcium, magnesium, and phosphate were measured 2 h after a lithium injection. Serum calcium was unaffected by lithium in unoperated and parathyroidectomized rats. In thyroparathyroidectomized rats lithium increased the serum calcium concentration. Serum magnesium was increased by lithium in all 3 groups of rats. Serum phosphate was slightly decreased by lithium in all 3 groups of rats. It is concluded that lithium increases both serum calcium and magnesium, but in the intact organism only a slight or no increase in serum calcium is seem after lithium due to physiological control mechanisms. After removal of the calcitonin producing C-cells in the thyroid gland the organism is unable to produce a fast decrease in serum calcium, and lithium is then able to increase the serum calcium concentration.
Psychiatry Research, 1982
High-affinity binding of rH-imipramine to platelet membranes from control subjects and psychiatri... more High-affinity binding of rH-imipramine to platelet membranes from control subjects and psychiatric patients was studied. Maximal binding (pmax) in depressed manic-melancholic patients was higher than in euthymic manicmelancholic patients, psychiatric controls, and normal controls.
Psychiatry Research, 1986
The thyrotropin-releasing hormone (TRH) stimulation test and the dexamethasone suppression test (... more The thyrotropin-releasing hormone (TRH) stimulation test and the dexamethasone suppression test (DST) were performed in 40 depressive patients. More endogenously depressed patients than nonendogenously depressed patients showed a blunted response to TRH. No difference was found in delta max thyroid-stimulating hormone (TSH) between patients who responded to dexamethasone administration with a normal suppression of cortisol and those who responded with nonsuppression.
Psychiatry Research, 1988
High-affinity binding of 3H-imipramine was analyzed in platelet membranes from patients with chro... more High-affinity binding of 3H-imipramine was analyzed in platelet membranes from patients with chronic psychogenic pain. The patients who in addition to the pain also showed affective symptoms such as depression and anxiety had lower binding than the pain patients without these symptoms.
Nordic Journal of Psychiatry, 1989
ABSTRACT Methodological problems in the studies of platelet imipramine binding in depressed patie... more ABSTRACT Methodological problems in the studies of platelet imipramine binding in depressed patients are discussed. It is concluded that at least some of the low values for imipramine binding reported in the literature may be artefacts. The use of tritium-labelled paroxetine instead of labelled imipramine is recommended for future studies. Studies of psychogenic pain disorders and depression indicate that the presence of pain as well as affective symptoms may be associated with decreased platelet imipramine binding. □ Depression, Imipramine binding, Platelets, Psychogenic pain.