Ernesto Nuñez - Academia.edu (original) (raw)

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Papers by Ernesto Nuñez

Research paper thumbnail of Efficacy and safety of an oral live attenuated human rotavirus vaccine against rotavirus gastroenteritis during the first 2 years of life in Latin American infants: a randomised, double-blind, placebo-controlled phase III study

Lancet, 2008

Background Peak incidence of rotavirus gastroenteritis is seen in infants between 6 and 24 months... more Background Peak incidence of rotavirus gastroenteritis is seen in infants between 6 and 24 months of age. We therefore aimed to assess the 2-year effi cacy and safety of an oral live attenuated human rotavirus vaccine for prevention of severe gastroenteritis in infants.

Research paper thumbnail of Effi cacy and safety of an oral live attenuated human rotavirus vaccine against rotavirus gastroenteritis during the fi rst 2 years of life in Latin American infants: a randomised, double-blind, placebo-controlled phase III study

Background Peak incidence of rotavirus gastroenteritis is seen in infants between 6 and 24 months... more Background Peak incidence of rotavirus gastroenteritis is seen in infants between 6 and 24 months of age. We therefore aimed to assess the 2-year effi cacy and safety of an oral live attenuated human rotavirus vaccine for prevention of severe gastroenteritis in infants.

Research paper thumbnail of Secondary patellar resurfacing in the treatment of patellofemoral pain after total knee arthroplasty

Knee Surgery Sports Traumatology Arthroscopy

Purpose This paper reports a prospective review of patients who, between 2004 and 2007, underwent... more Purpose This paper reports a prospective review of patients who, between 2004 and 2007, underwent secondary patellar resurfacing (SPR) due to anterior knee pain after a primary total knee arthroplasty (TKA). The aim was to evaluate the clinical outcomes obtained with the SPR and to compare them with radiological findings. Methods A total of twenty-seven consecutive patients met the inclusion criteria. There were twenty-three (85%) women and four (15%) men with a median age of 70 years. The patients were evaluated before and after the surgery with the same functional scores and radiological parameters. Bone scintigraphy was also used in the assessment, and a CT-scan was performed in order to evaluate the femoral component rotation. The median time between TKA and SPR was 18 months. Results With a median follow-up of 23 months, seventeen patients (63%) reported a clear subjective improvement after SPR, and patellofemoral scores (primary outcome measure), KSS and WOMAC (secondary outcome measures) showed a statistically significant improvement following the procedure. There were no significant changes after SPR in the Insall-Salvati ratio, the lateral patellar displacement or the lateral patellar tilt. The mean time between TKA and SPR had no statistically significant effect on outcome. The bone scintigraphy revealed increased patellar uptake in seven cases, but this was not related to subsequent improvement after SPR. Rotational computed tomography showed a median internal rotation of the femoral component of 1º. The complications observed were a patellar component loosening and an acute post-infection. Conclusion No clinical or radiological parameter was found to be related to the final outcome after SPR. There was a discrepancy between functional scale scores and the patient’s subjective satisfaction. Level of evidence Prospective case series with no comparison group, Level IV.

Research paper thumbnail of derecho probatorio

CORTE SUPREMA DE JUSTICIA: San Salvador, a las catorce horas y quince minutos del día diecisiete ... more CORTE SUPREMA DE JUSTICIA: San Salvador, a las catorce horas y quince minutos del día diecisiete de marzo de dos mil once.

Research paper thumbnail of Efficacy and safety of an oral live attenuated human rotavirus vaccine against rotavirus gastroenteritis during the first 2 years of life in Latin American infants: a randomised, double-blind, placebo-controlled phase III study

Lancet, 2008

Background Peak incidence of rotavirus gastroenteritis is seen in infants between 6 and 24 months... more Background Peak incidence of rotavirus gastroenteritis is seen in infants between 6 and 24 months of age. We therefore aimed to assess the 2-year effi cacy and safety of an oral live attenuated human rotavirus vaccine for prevention of severe gastroenteritis in infants.

Research paper thumbnail of Effi cacy and safety of an oral live attenuated human rotavirus vaccine against rotavirus gastroenteritis during the fi rst 2 years of life in Latin American infants: a randomised, double-blind, placebo-controlled phase III study

Background Peak incidence of rotavirus gastroenteritis is seen in infants between 6 and 24 months... more Background Peak incidence of rotavirus gastroenteritis is seen in infants between 6 and 24 months of age. We therefore aimed to assess the 2-year effi cacy and safety of an oral live attenuated human rotavirus vaccine for prevention of severe gastroenteritis in infants.

Research paper thumbnail of Secondary patellar resurfacing in the treatment of patellofemoral pain after total knee arthroplasty

Knee Surgery Sports Traumatology Arthroscopy

Purpose This paper reports a prospective review of patients who, between 2004 and 2007, underwent... more Purpose This paper reports a prospective review of patients who, between 2004 and 2007, underwent secondary patellar resurfacing (SPR) due to anterior knee pain after a primary total knee arthroplasty (TKA). The aim was to evaluate the clinical outcomes obtained with the SPR and to compare them with radiological findings. Methods A total of twenty-seven consecutive patients met the inclusion criteria. There were twenty-three (85%) women and four (15%) men with a median age of 70 years. The patients were evaluated before and after the surgery with the same functional scores and radiological parameters. Bone scintigraphy was also used in the assessment, and a CT-scan was performed in order to evaluate the femoral component rotation. The median time between TKA and SPR was 18 months. Results With a median follow-up of 23 months, seventeen patients (63%) reported a clear subjective improvement after SPR, and patellofemoral scores (primary outcome measure), KSS and WOMAC (secondary outcome measures) showed a statistically significant improvement following the procedure. There were no significant changes after SPR in the Insall-Salvati ratio, the lateral patellar displacement or the lateral patellar tilt. The mean time between TKA and SPR had no statistically significant effect on outcome. The bone scintigraphy revealed increased patellar uptake in seven cases, but this was not related to subsequent improvement after SPR. Rotational computed tomography showed a median internal rotation of the femoral component of 1º. The complications observed were a patellar component loosening and an acute post-infection. Conclusion No clinical or radiological parameter was found to be related to the final outcome after SPR. There was a discrepancy between functional scale scores and the patient’s subjective satisfaction. Level of evidence Prospective case series with no comparison group, Level IV.

Research paper thumbnail of derecho probatorio

CORTE SUPREMA DE JUSTICIA: San Salvador, a las catorce horas y quince minutos del día diecisiete ... more CORTE SUPREMA DE JUSTICIA: San Salvador, a las catorce horas y quince minutos del día diecisiete de marzo de dos mil once.

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