Eugene Cooper - Academia.edu (original) (raw)

Papers by Eugene Cooper

Journal of Pharmaceutical Sciences, 1988

D A model relating the parameters of permeability coefficient in the cornea with partition coeffi... more D A model relating the parameters of permeability coefficient in the cornea with partition coefficient and molecular weight of the penetrating species is presented. The development of the model is unique in that it includes the availability of a "pore" pathway with the corresponding kinetic data to substantiate this premise. The "pore" pathway is applied to small hydrophilic compounds and assumes that an aqueous diffusional space is available for transport of these compounds. This is in contrast to an alternate "partitioning" mechanism which is the most probable route of transport for larger or more lipophilic entities. The model is consistent with published data from this and other laboratories.

Journal of Pharmaceutical Sciences, 1985

The cutaneous penetration of acyclovir can be significantly increased from a propylene glycol bas... more The cutaneous penetration of acyclovir can be significantly increased from a propylene glycol base vehicle by adding small amounts of a polar lipid such as oleic acid. These results are consistent with those found for salicylic acid, and the large increases in acyclovir penetration could potentially lead to better topical treatment of herpes simplex.

Journal of Investigative Dermatology, 1981

This document provides information, based on the final Part B regulations implementing statutory ... more This document provides information, based on the final Part B regulations implementing statutory changes made by the Individuals with Disabilities Education Act (IDEA) of 1997, which will assist speech-language pathologists in their role in developing Individualized Education Programs (IEPs) as IEP team members and in implementing those portions of the IEP for which they are responsible. Included are issues regarding programmatic and systemic changes that must take place in order for successful partnerships to be established among speech-language pathologists, teachers, parents,

Journal of Pharmaceutical Sciences, 1988

D A model relating the parameters of permeability coefficient in the cornea with partition coeffi... more D A model relating the parameters of permeability coefficient in the cornea with partition coefficient and molecular weight of the penetrating species is presented. The development of the model is unique in that it includes the availability of a "pore" pathway with the corresponding kinetic data to substantiate this premise. The "pore" pathway is applied to small hydrophilic compounds and assumes that an aqueous diffusional space is available for transport of these compounds. This is in contrast to an alternate "partitioning" mechanism which is the most probable route of transport for larger or more lipophilic entities. The model is consistent with published data from this and other laboratories.

Journal of Pharmaceutical Sciences, 1985

The cutaneous penetration of acyclovir can be significantly increased from a propylene glycol bas... more The cutaneous penetration of acyclovir can be significantly increased from a propylene glycol base vehicle by adding small amounts of a polar lipid such as oleic acid. These results are consistent with those found for salicylic acid, and the large increases in acyclovir penetration could potentially lead to better topical treatment of herpes simplex.

Journal of Investigative Dermatology, 1981

This document provides information, based on the final Part B regulations implementing statutory ... more This document provides information, based on the final Part B regulations implementing statutory changes made by the Individuals with Disabilities Education Act (IDEA) of 1997, which will assist speech-language pathologists in their role in developing Individualized Education Programs (IEPs) as IEP team members and in implementing those portions of the IEP for which they are responsible. Included are issues regarding programmatic and systemic changes that must take place in order for successful partnerships to be established among speech-language pathologists, teachers, parents,