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Papers by Eugene Paransky

Research paper thumbnail of The challenges of adding natural graphite into castables

An original approach to the carbon incorporation into castable was developed in CIREP. It employs... more An original approach to the carbon incorporation into castable was developed in CIREP. It employs micropellets containing flake graphite with fillers and further enhanced by a surface treatment. The application of pellets significantly improves the rheology, compared with other sources of graphite, and subsequently allows introducing relatively high amounts of carbon into castables. The corrosion resistance of carbon containing castables with the pellets, mainly the low slag penetration, is comparable to carbon-containing brick. The thermomechanical properties, especially the hot strength, as well as the parameters characterizing the thermal shock resistance, can be significantly modified by using Si-metal as an antioxidant and the strength-enhancing additive. All of those positive effects make the pellets certainly an attractive and promising source of carbon for this type of applications.

Research paper thumbnail of Effects of Andalusite Grain Size on Microstructure and Mechanical Properties of Low Cement Alumina-Based Castables

Canadian Metallurgical Quarterly, 2003

Abstract Three high alumina-based, low cement castables each containing a 15% addition of andalus... more Abstract Three high alumina-based, low cement castables each containing a 15% addition of andalusite of different grain size were compared to a similar castable containing micro-silica (3.7%) and no andalusite. All castables were fired at 1450 °C for 12 hours. High temperature mechanical properties of the castables were measured employing a wedge splitting test (WST). While the castable with the micro-silica addition exhibited superior strength properties, both strength and work-of-fracture values at high temperature improved in castables containing ultra fine andalusite powder. Microstructural factors leading to the observed differences in properties are discussed.

Research paper thumbnail of Application of Cathodoluminescence Technique in Light Microscopy to Crystallisation Study of Mold Fluxes

Microscopy and Microanalysis, 2002

Research paper thumbnail of Role of Melatonin in Curtailing Oxidative Stress during COVID-19

Medicine and clinical science, Dec 30, 2021

Several studies carried out during the ongoing COVID-19 pandemic revealed that oxidation stress i... more Several studies carried out during the ongoing COVID-19 pandemic revealed that oxidation stress is a major factor in the disease development, particularly in its severe complications, such as ALI and ARDS. It has been hypothesized that the well-known natural hormone melatonin may play a significant role in countering oxidative stress and consequently easing the progression of COVID-19. The present review summarizes available information on the contribution of oxidation stress during the pathogenesis of COVID-19 and several other diseases, and the rationale of their possible treatment with melatonin. This research direction will further expand our knowledge about melatonin beyond its role as the regulator of the circadian rhythm, and towards its application as an efficient adjuvant treatment for various diseases, including COVID-19 infection.

Research paper thumbnail of Phase Recognition in AlN-Ti System by Energy Dispersive Spectroscopy and Electron Backscatter Diffraction

Mikrochimica Acta, 2000

The combination of energy dispersive spectroscopy (EDS) and electron backscatter diffraction (EBS... more The combination of energy dispersive spectroscopy (EDS) and electron backscatter diffraction (EBSD) techniques in scanning electron microscope was employed to characterize the reacted interface between Ti matrix and AlN particles. Due to the high localization of EDS and EBSD, representative measurements of chemical composition and reliable determination of the crystal structure were possible for each phase in the reaction zone with complex morphology. The TiN 1Àx (cubic, NaCl type), Ti 3 AlN (cubic, perovskite type) and Ti-rich Ti 3 Al (hexagonal, Ni 3 Sn type) phases were identi®ed in the reaction zone after annealing at 1100 C. EDSEBSD combination is an ef®cient tool for phase analysis at the interface in reactive multicomponent systems.

Research paper thumbnail of Low Voltage Transmission Electron Microscopy in Cell Biology

Progress in Histochemistry and Cytochemistry, 2015

Low voltage transmission electron microscopy (LVTEM) was employed to examine biological tissues w... more Low voltage transmission electron microscopy (LVTEM) was employed to examine biological tissues with accelerating voltages as low as 5kV. Tissue preparation was modified to take advantage of the low-voltage techniques. Treatments with heavy metals, such as post-fixation with osmium tetroxide, on block and counterstaining were omitted. Sections (40nm) were thinner than usual and generated highly contrasted images. General appearance of the cells remains similar to that of conventional TEM. New features were however revealed. The matrix of the pancreatic granules displays heterogeneity with partitions that may correspond to the inner-segregation of their secretory proteins. Mitochondria revealed the presence of the ATP synthase granules along their cristea. The nuclear dense chromatin displayed a honeycomb organization while distinct beads, nucleosomes, aligned along thin threads were seen in the dispersed chromatin. Nuclear pore protein complexes revealed their globular nature. The intercalated disks in cardiac muscle displayed their fine structural organization. These features correlate well with data described or predicted by cell and molecular biology. These new aspects are not revealed when thicker and conventionally osmicated tissue sections were examined by LVTEM, indicating that major masking effects are associated with standard TEM techniques. Immunogold was adapted to LVTEM further enhancing its potential in cell biology.

Research paper thumbnail of Perspectives on low voltage transmission electron microscopy as applied to cell biology

Microscopy Research and Technique, 2014

Low voltage transmission electron microscopy (LVTEM) with accelerating voltages as low as 5 kV wa... more Low voltage transmission electron microscopy (LVTEM) with accelerating voltages as low as 5 kV was applied to cell biology. To take advantage of the increased contrast given by LVTEM, tissue preparation was modified omitting all heavy metals such as osmium, uranium, and lead from the fixation, on block staining and counterstaining. Nonstained ultra-thin tissue sections (40 nm thick) generated highly contrasted images. While the aspect of the cells remains similar to that obtained by conventional TEM, some new substructures were revealed. The pancreatic acinar cells granules present a heterogeneous matrix with partitions corresponding to segregation of their different secretory proteins. Microvilli display their core of microfilaments anchored to the dense top membrane. Mitochondria revealed the presence of distinct particles along their cristea membranes that may correspond to the ATP synthase complexes or oxysomes. The dense nuclear chromatin displays a honey-comb appearance while distinct beads aligned along thin threads were seen in the dispersed chromatin. These new features revealed by LVTEM correlate with structures described or predicted through other approaches. Masking effects due to thickness of the tissue sections and to the presence of heavy metals must have prevented their observation by conventional TEM. Furthermore, the immunogold was adapted to LVTEM revealing nuclear lamin-A at the edge of the dense chromatin ribbons. Combining cytochemistry with LVTEM brings additional advantages to this new approach in cell biology.

Research paper thumbnail of Pressure-assisted reactive synthesis of titanium aluminides from dense 50Al50Ti elemental powder blends

Metallurgical and Materials Transactions A-physical Metallurgy and Materials Science, 1996

In the present research, dense γ-TiAl based intermetallic samples were fabricated by reactive syn... more In the present research, dense γ-TiAl based intermetallic samples were fabricated by reactive synthesis of fully dense elemental 50 at. pct Al-50 at. pct Ti powder blends. Two different processing routes were attempted: thermal explosion under pressure (combustion consolidation) and reactive hot pressing. In both approaches, relatively low processing or preheating temperatures (900 °C) were used. The entire procedure of thermal explosion under pressure could be performed in open air without noticeable oxidation damage to the final product. The application of a moderate external pressure (≤250 MPa) during synthesis was shown to be enough to accommodate the negative volume change associated with TiAl formation from the elemental components and, thereby, to ensure full density of the final product. Microstructure and phase composition of the materials obtained were characterized employing X-ray diffraction and scanning electron microscopy with energy dispersive analysis. It was found that at elevated temperatures(e.g., 900 °C), the equiatomic 50Al-50Ti alloy lies beyond the homogeneity range of the y-TiAl phase in the Ti-Al binary and contains, in addition to γ-TiAl, Al-rich Ti3Al. Mechanical properties of the materials synthesized were evaluated in compression tests at different temperatures and by microhardness measurements. Due to its very fine microstructure, the Ti-Al material synthesizedvia reactive hot pressing exhibited superplastic behavior at temperatures as low as 800 °C.

Research paper thumbnail of Compartmentalization of Pancreatic Secretory Zymogen Granules as Revealed by Low-Voltage Transmission Electron Microscopy

Journal of Histochemistry & Cytochemistry, 2011

Research paper thumbnail of The challenges of adding natural graphite into castables

An original approach to the carbon incorporation into castable was developed in CIREP. It employs... more An original approach to the carbon incorporation into castable was developed in CIREP. It employs micropellets containing flake graphite with fillers and further enhanced by a surface treatment. The application of pellets significantly improves the rheology, compared with other sources of graphite, and subsequently allows introducing relatively high amounts of carbon into castables. The corrosion resistance of carbon containing castables with the pellets, mainly the low slag penetration, is comparable to carbon-containing brick. The thermomechanical properties, especially the hot strength, as well as the parameters characterizing the thermal shock resistance, can be significantly modified by using Si-metal as an antioxidant and the strength-enhancing additive. All of those positive effects make the pellets certainly an attractive and promising source of carbon for this type of applications.

Research paper thumbnail of Effects of Andalusite Grain Size on Microstructure and Mechanical Properties of Low Cement Alumina-Based Castables

Canadian Metallurgical Quarterly, 2003

Abstract Three high alumina-based, low cement castables each containing a 15% addition of andalus... more Abstract Three high alumina-based, low cement castables each containing a 15% addition of andalusite of different grain size were compared to a similar castable containing micro-silica (3.7%) and no andalusite. All castables were fired at 1450 °C for 12 hours. High temperature mechanical properties of the castables were measured employing a wedge splitting test (WST). While the castable with the micro-silica addition exhibited superior strength properties, both strength and work-of-fracture values at high temperature improved in castables containing ultra fine andalusite powder. Microstructural factors leading to the observed differences in properties are discussed.

Research paper thumbnail of Application of Cathodoluminescence Technique in Light Microscopy to Crystallisation Study of Mold Fluxes

Microscopy and Microanalysis, 2002

Research paper thumbnail of Role of Melatonin in Curtailing Oxidative Stress during COVID-19

Medicine and clinical science, Dec 30, 2021

Several studies carried out during the ongoing COVID-19 pandemic revealed that oxidation stress i... more Several studies carried out during the ongoing COVID-19 pandemic revealed that oxidation stress is a major factor in the disease development, particularly in its severe complications, such as ALI and ARDS. It has been hypothesized that the well-known natural hormone melatonin may play a significant role in countering oxidative stress and consequently easing the progression of COVID-19. The present review summarizes available information on the contribution of oxidation stress during the pathogenesis of COVID-19 and several other diseases, and the rationale of their possible treatment with melatonin. This research direction will further expand our knowledge about melatonin beyond its role as the regulator of the circadian rhythm, and towards its application as an efficient adjuvant treatment for various diseases, including COVID-19 infection.

Research paper thumbnail of Phase Recognition in AlN-Ti System by Energy Dispersive Spectroscopy and Electron Backscatter Diffraction

Mikrochimica Acta, 2000

The combination of energy dispersive spectroscopy (EDS) and electron backscatter diffraction (EBS... more The combination of energy dispersive spectroscopy (EDS) and electron backscatter diffraction (EBSD) techniques in scanning electron microscope was employed to characterize the reacted interface between Ti matrix and AlN particles. Due to the high localization of EDS and EBSD, representative measurements of chemical composition and reliable determination of the crystal structure were possible for each phase in the reaction zone with complex morphology. The TiN 1Àx (cubic, NaCl type), Ti 3 AlN (cubic, perovskite type) and Ti-rich Ti 3 Al (hexagonal, Ni 3 Sn type) phases were identi®ed in the reaction zone after annealing at 1100 C. EDSEBSD combination is an ef®cient tool for phase analysis at the interface in reactive multicomponent systems.

Research paper thumbnail of Low Voltage Transmission Electron Microscopy in Cell Biology

Progress in Histochemistry and Cytochemistry, 2015

Low voltage transmission electron microscopy (LVTEM) was employed to examine biological tissues w... more Low voltage transmission electron microscopy (LVTEM) was employed to examine biological tissues with accelerating voltages as low as 5kV. Tissue preparation was modified to take advantage of the low-voltage techniques. Treatments with heavy metals, such as post-fixation with osmium tetroxide, on block and counterstaining were omitted. Sections (40nm) were thinner than usual and generated highly contrasted images. General appearance of the cells remains similar to that of conventional TEM. New features were however revealed. The matrix of the pancreatic granules displays heterogeneity with partitions that may correspond to the inner-segregation of their secretory proteins. Mitochondria revealed the presence of the ATP synthase granules along their cristea. The nuclear dense chromatin displayed a honeycomb organization while distinct beads, nucleosomes, aligned along thin threads were seen in the dispersed chromatin. Nuclear pore protein complexes revealed their globular nature. The intercalated disks in cardiac muscle displayed their fine structural organization. These features correlate well with data described or predicted by cell and molecular biology. These new aspects are not revealed when thicker and conventionally osmicated tissue sections were examined by LVTEM, indicating that major masking effects are associated with standard TEM techniques. Immunogold was adapted to LVTEM further enhancing its potential in cell biology.

Research paper thumbnail of Perspectives on low voltage transmission electron microscopy as applied to cell biology

Microscopy Research and Technique, 2014

Low voltage transmission electron microscopy (LVTEM) with accelerating voltages as low as 5 kV wa... more Low voltage transmission electron microscopy (LVTEM) with accelerating voltages as low as 5 kV was applied to cell biology. To take advantage of the increased contrast given by LVTEM, tissue preparation was modified omitting all heavy metals such as osmium, uranium, and lead from the fixation, on block staining and counterstaining. Nonstained ultra-thin tissue sections (40 nm thick) generated highly contrasted images. While the aspect of the cells remains similar to that obtained by conventional TEM, some new substructures were revealed. The pancreatic acinar cells granules present a heterogeneous matrix with partitions corresponding to segregation of their different secretory proteins. Microvilli display their core of microfilaments anchored to the dense top membrane. Mitochondria revealed the presence of distinct particles along their cristea membranes that may correspond to the ATP synthase complexes or oxysomes. The dense nuclear chromatin displays a honey-comb appearance while distinct beads aligned along thin threads were seen in the dispersed chromatin. These new features revealed by LVTEM correlate with structures described or predicted through other approaches. Masking effects due to thickness of the tissue sections and to the presence of heavy metals must have prevented their observation by conventional TEM. Furthermore, the immunogold was adapted to LVTEM revealing nuclear lamin-A at the edge of the dense chromatin ribbons. Combining cytochemistry with LVTEM brings additional advantages to this new approach in cell biology.

Research paper thumbnail of Pressure-assisted reactive synthesis of titanium aluminides from dense 50Al50Ti elemental powder blends

Metallurgical and Materials Transactions A-physical Metallurgy and Materials Science, 1996

In the present research, dense γ-TiAl based intermetallic samples were fabricated by reactive syn... more In the present research, dense γ-TiAl based intermetallic samples were fabricated by reactive synthesis of fully dense elemental 50 at. pct Al-50 at. pct Ti powder blends. Two different processing routes were attempted: thermal explosion under pressure (combustion consolidation) and reactive hot pressing. In both approaches, relatively low processing or preheating temperatures (900 °C) were used. The entire procedure of thermal explosion under pressure could be performed in open air without noticeable oxidation damage to the final product. The application of a moderate external pressure (≤250 MPa) during synthesis was shown to be enough to accommodate the negative volume change associated with TiAl formation from the elemental components and, thereby, to ensure full density of the final product. Microstructure and phase composition of the materials obtained were characterized employing X-ray diffraction and scanning electron microscopy with energy dispersive analysis. It was found that at elevated temperatures(e.g., 900 °C), the equiatomic 50Al-50Ti alloy lies beyond the homogeneity range of the y-TiAl phase in the Ti-Al binary and contains, in addition to γ-TiAl, Al-rich Ti3Al. Mechanical properties of the materials synthesized were evaluated in compression tests at different temperatures and by microhardness measurements. Due to its very fine microstructure, the Ti-Al material synthesizedvia reactive hot pressing exhibited superplastic behavior at temperatures as low as 800 °C.

Research paper thumbnail of Compartmentalization of Pancreatic Secretory Zymogen Granules as Revealed by Low-Voltage Transmission Electron Microscopy

Journal of Histochemistry & Cytochemistry, 2011