Eyyüp S A B R I Özden (original) (raw)

Uploads

Papers by Eyyüp S A B R I Özden

Gunumuzde pediyatrik hastalarin havayolu idamesinde kafli, kafsiz endotrakeal tup (ETT) ve Prosea... more Gunumuzde pediyatrik hastalarin havayolu idamesinde kafli, kafsiz endotrakeal tup (ETT) ve Proseal LMA (PLMA) yaygin kullanilmaktadir. Bu calismada 3 farkli yontemi havayolu guvenligi, gastrik insuflasyon ve ekstubasyon sonrasi havayolu komplikasyonlari acisindan karsilastirmayi amacladik. Biz PLMA'nin endotrakeal tuplere alternatif havayolu guvenligi saglayacagi ve havayolu komplikasyonlarinin daha az gorulecegi hipotezinden yola cikarak bu calismayi gerceklestirdik.Calisma Ankara Universitesi Tip Fakultesi Etik Kurulu ve ebeveyn izni alindiktan sonra elektif alt abdominal cerrahi (hipospadias, inmemis testis, inguinal herni) planlanan ASA I-II, 1?24 ay arasi toplam 120 pediyatrik hastada gerceklestirildi. Hastalar kapali zarf yontemiyle 1. Grup PLMA (Grup:P)(n=40), 2. Grup kafli ETT (Grup:KT)(n=40) ve 3. Grup kafsiz ETT (Grup:KST)(n=40) olacak sekilde randomize edildi. Rutin monitorizasyondan sonra sevofluran inhalasyonuyla bilinc kaybini takiben damaryolu acilarak ketamin 0,5 mg/kg, propofol 3 mg/kg ve remifentanil 1 µg/kg uygulandi. LMA ve tup boyutu seciminde Broselow?Luten siniflamasi kullanildi. Entubasyon kalite skorlamasi, entubasyon veya LMA deneme sayisi kaydedildi. Anestezi idamesinde sevofluran kullanildi. Gastrik insuflasyonun tespiti icin epigastrium steteskopla dinlenip nazogastrik sonda takildi. Hastanin ilk 10 soluk alis-verisinde inspiryum ve ekspiryum hacimleri arasindaki fark olan kacak volum ve bu kacak volumun inspiryum hacmine orani olan kacak fraksiyonu kaydedildi. Hastalar ekstubasyon sonrasi postoperatif 1.saate kadar laringospazm, stridor ve krup gibi komplikasyonlarin gelisimi acisindan takip edildi.AbstractToday cuffed and uncuffed endotracheal tube (ETT) and Proseal LMA (Laringeal Mask Airway) (PLMA) are used commonly in the airway maintenance of pediatric patients. In this study, we intended to compare 3 different methods in terms of airway complications after extubation, gastric insufflations and airway safety. We carried out this study by utilizing from this hypothesis that PLMA provides alternative airway safety for endotracheal tubes and hence a decrease is to be seen in airway complications.This study was performed in ASA I-II, between 1-24 months total 120 patients who was planned elective lower abdominal surgery (hypospadias, undescended testis, inguinal hernia) after the consent of Ankara University Medicine Faculty Ethics Committee and parents. Patients were randomized by sealed tender method as follows 1th Group PLMA (Group:P) (n=40), 2nd Group cuffed ETT (Group:KT) (n=40) and 3rd Group ETT without cuff (Group: KST) (n=40). After routine monitorization, through sevoflurane inhalation 0,5 mg/kg ketamine, 3 mg/kg propofol and 1 µg/kg remifentanil were applied by vascular access following loss of consciousness. Broselow-Luten classification was used in selection of LMA and tube size. Intubation quality scoring, intubation and LMA trial score were recorded. In maintenance of anesthesia, sevoflurane was used. For detection of gastric insufflation, after epigastrium listened by stethoscope and then nasogastric catheter was placed. Leak volume which is a difference between the inspiration and expiration volumes in the first 10 breathing and leak fraction which is the proportion of leak volume to the inspiration volume were recorded. After extubation, patients were observed in terms of the development of complications such as laryngospasm, stridor and croup up to 1 hour postoperatively.

Süleyman Demirel Üniversitesi Tıp Fakültesi dergisi, Jun 1, 2017

İnfektif endokardit yüksek morbidite ve mortaliteye sahip klinik bir durumdur ve en çok predispoz... more İnfektif endokardit yüksek morbidite ve mortaliteye sahip klinik bir durumdur ve en çok predispozan faktör altta yatan kapak hastalığıdır. Bu olguda iskemik serebrovasküler olay (SVO) gelişen infektif endokardit hastasında rekürren serebral emboli gelişmesi nedeniyle erken dönem kapak replasmanı yapılmış ve hasta sonrasında sağlıklı olarak taburcu edilmiştir.

Meandros Medical and Dental Journal, Sep 20, 2018

Acute respiratory distress syndrome (ARDS) is an acute, diffuse, inflammatory lung injury that le... more Acute respiratory distress syndrome (ARDS) is an acute, diffuse, inflammatory lung injury that leads to increased pulmonary vascular permeability, increased lung weight, and loss of ventilated tissue. Despite the significant developments in the management of severe ARDS since its definition, it causes more than 40% of the mortalities. The patients who used extracorporeal membrane oxygenation (ECMO) for severe ARDS treatment had lower morbidity and mortality rates. In this case report, a patient with coronary artery disease in whom severe ARDS and septicemia were developed after Candida pneumonia and who was treated with ECMO was presented.

Bosnian Journal of Basic Medical Sciences, Nov 10, 2016

Meandros Medical and Dental Journal, Aug 20, 2020

Akut Solunum Sıkıntısı sendromu (ARDS) pulmoner vasküler geçirgenlikte artış, akciğer ağırlığının... more Akut Solunum Sıkıntısı sendromu (ARDS) pulmoner vasküler geçirgenlikte artış, akciğer ağırlığının artması ve havalanan doku kaybına yol açan akut, yaygın, enflamatuvar bir akciğer hasarıdır. Ağır ARDS, ilk tanımlanmasından bu yana yönetimindeki önemli gelişmelere rağmen, %40'tan fazla mortaliteye neden olmaya devam etmektedir. Ağır ARDS tedavisinde ekstrakorporeal membran oksijenasyonu (ECMO) yapılan hastalar daha düşük morbidite ve mortalite oranlarına sahiptir. Bu olguda koroner arter hastalığı olan Candida pnömonisi sonrası ARDS ve septisemi gelişen hastada ECMO tedavisi uygulanmıştır. Acute Respiratory Distress syndrome (ARDS) is an acute, diffuse, inflammatory lung injury that leads to increased pulmonary vascular permeability, increased lung weight and loss of ventilated tissue. Since the definition of ARDS, more than 40% of the mortalities is caused by it despite the significant developments in the management of severe ARDS. The patients who used extracorporeal membrane oxygenation (ECMO) for severe ARDS treatment had lower morbidity and mortality rates. In this case report, a patient with coronary artery disease in whom severe ARDS and septicemia were developed after Candida pneumonia and was treated with ECMO was presented.

SDÜ Tıp Fakültesi Dergisi

Koronavirüs hastalığı 2019 (COVID-19), yeni tip şiddetli akut solunum yolu sendromu koronavirüsü ... more Koronavirüs hastalığı 2019 (COVID-19), yeni tip şiddetli akut solunum yolu sendromu koronavirüsü 2'nin (SARS-CoV-2) neden olduğu bulaşıcı bir solunum yolu hastalığıdır. Bu virüs tüm dünyada pandemiye yol açmıştır. Hastaneler COVID-19 salgını açısından yüksek riskli ve iyi yönetilmesi gereken kurumların başında gelmektedir. Hastanelerde de en riskli alanlar yoğun bakımlar ve ameliyathanelerdir. Salgının başlamasıyla birlikte cerrahi müdahale gerekli olan tüm hastalar, olası enfekte kabul edilerek hareket edilmelidir. Ameliyathane ekibi (cerrah, hemşire, anestezist ve diğer yardımcı sağlık personeli) olası/kesin tanılı COVID-19 hastaların yönetiminde bulaş önlemlerini acilen hayata geçirmelidir. Özellikle anestezistler havayolu ile hasta ve çalışan güvenliği açısından tecrübeli ve etkin olmaları nedeniyle, COVID-19 ‘un perioperatif yönetiminde lider rol üstlenmektedirler. Bu makalede, olası/kesin tanılı COVID-19 hastalarının ameliyat sürecinde kurumumuzda alınmış olan önlemler ve ...

Süleyman Demirel Üniversitesi Tıp Fakültesi dergisi, Jun 1, 2017

Koruyucu ventilasyon stratejisi, rekruitment manevraları olsun veya olmasın, pozitif ekspirasyon ... more Koruyucu ventilasyon stratejisi, rekruitment manevraları olsun veya olmasın, pozitif ekspirasyon sonu basınç (PEEP) ile düşük Vt'nin (tahmin edilen vücut ağırlığının 4-8 mL / kg aralığında) kullanımını ifade eder. Akut solunum sıkıntısı sendromu (ARDS) olan hastalarda koruyucu ventilasyon en uygun uygulama olarak düşünülmüştür. Ancak genel anestezi uygulanan hastalarda sağlıklı akciğerlerin nasıl havalandırılacağına ilişkin az sayıda insan çalışması yapılmıştır.

Korean Journal of Anesthesiology

Background: Acute kidney injury (AKI) is a serious pathology, causing dysfunction of urination an... more Background: Acute kidney injury (AKI) is a serious pathology, causing dysfunction of urination and concentration due to damage to kidneys, resulting with blood pressure dysregulation and increased toxic metabolites. Dexpanthenol (DEX), a pantothenic acid analog, has anti-inflammatory and anti-apoptotic properties in various tissues. This study aimed to investigate the protective effects of DEX in systemic inflammation induced AKI. Methods: Thirty-two female rats were randomly assigned as control, lipopolysaccharide (LPS), LPS+DEX and DEX groups. LPS (5 mg/kg, single dose on 3 rd day, 6 hours before sacrification) and DEX (500 mg/kg/d for 3 days) were administered intraperitoneally. After sacrification, blood samples and kidney tissues were collected. Hematoxylin-eosin, caspase-3 (Cas-3) and tumor necrosis factor alpha (TNF-α) staining were performed on kidney tissues. Total oxidant status (TOS) and total antioxidant status levels were measured with spectrophotometric method. Aquaporin-2 (AQP-2), silent information regulator gene-1 (SIRT1) and interleukin-6 (IL-6) gene expressions were detected with qRT-PCR. Results: In the histopathological analysis, it was observed that DEX ameliorated histopathological changes. In the LPS group, there was an increase in blood urea nitrogen, creatinine, urea, TOS, oxidative stress index, IL-6, Cas-3, and TNF-α levels compared to the control group, while AQP-2 and SIRT1 levels were decreased. However, treatment with DEX reversed all these changes. Conclusions: In conclusion, DEX was found to be effective in preventing inflammation, oxidative stress, and apoptosis in the kidney through the SIRT1 signaling pathway. Thus, the protective properties of DEX suggest that it may be a potential therapeutic agent for kidney pathologies.

We aimed to compare cuffed and uncuffed endotracheal tubes (ETTs) with ProSealTM laryngeal mask a... more We aimed to compare cuffed and uncuffed endotracheal tubes (ETTs) with ProSealTM laryngeal mask airway (PLMA) in terms of airway security
and extubation, starting out from the hypothesis that PLMA will provide alternative airway safety to the endotracheal tubes, and that airway
complications will be less observed. After obtaining approval from the local Ethics Committee and parental informed consent, 120 pediatric
patients 1-24 months old, American Society of Anesthesiologists physical status I-II, requiring general anesthesia for elective lower abdominal
surgery, were randomized into PLMA (Group P, n = 40), cuffed ETT (Group C, n = 40), and uncuffed ETT (Group UC, n = 40) groups.
The number of intubation or PLMA insertion attempts was recorded. Each patient’s epigastrium was auscultated for gastric insufflation, leak
volumes and air leak fractions (leak volume/inspiratory volume) were recorded. Post-operative adverse events related to airway management
were also followed up during the first post-operative hour. Demographic and surgical data were similar among the groups. There were significantly
fewer airway manipulations in the Group P than in the other groups (p < 0.01), and leak volume and air leak fractions were greater in the
Group UC than in the other two groups (p < 0.01). Laryngospasm was significantly lower in the Group P during extubation and within the first
minute of post-extubation than in the other groups (p < 0.01). Based on this study, PLMA may be a good alternative to cuffed and uncuffed ETTs
for airway management of infants due to the ease of manipulation and lower incidence of laryngospasm

articles by Eyyüp S A B R I Özden

Bosnian Journal of Basic Medical Sciences, 2016

We aimed to compare cuffed and uncuffed endotracheal tubes (ETTs) with ProSealTM laryngeal mask a... more We aimed to compare cuffed and uncuffed endotracheal tubes (ETTs) with ProSealTM laryngeal mask airway (PLMA) in terms of airway security and extubation, starting out from the hypothesis that PLMA will provide alternative airway safety to the endotracheal tubes, and that airway complications will be less observed. After obtaining approval from the local Ethics Committee and parental informed consent, 120 pediatric patients 1-24 months old, American Society of Anesthesiologists physical status I-II, requiring general anesthesia for elective lower abdominal surgery, were randomized into PLMA (Group P, n = 40), cuffed ETT (Group C, n = 40), and uncuffed ETT (Group UC, n = 40) groups. The number of intubation or PLMA insertion attempts was recorded. Each patient's epigastrium was auscultated for gastric insufflation, leak volumes and air leak fractions (leak volume/inspiratory volume) were recorded. Post-operative adverse events related to airway management were also followed up during the first post-operative hour. Demographic and surgical data were similar among the groups. There were significantly fewer airway manipulations in the Group P than in the other groups (p < 0.01), and leak volume and air leak fractions were greater in the Group UC than in the other two groups (p < 0.01). Laryngospasm was significantly lower in the Group P during extubation and within the first minute of post-extubation than in the other groups (p < 0.01). Based on this study, PLMA may be a good alternative to cuffed and uncuffed ETTs for airway management of infants due to the ease of manipulation and lower incidence of laryngospasm.

Süleyman Demirel Üniversitesi Tıp Fakültesi dergisi, Jun 1, 2017

Meandros Medical and Dental Journal, Sep 20, 2018

Bosnian Journal of Basic Medical Sciences, Nov 10, 2016

Meandros Medical and Dental Journal, Aug 20, 2020

SDÜ Tıp Fakültesi Dergisi

Süleyman Demirel Üniversitesi Tıp Fakültesi dergisi, Jun 1, 2017

Korean Journal of Anesthesiology

Bosnian Journal of Basic Medical Sciences, 2016

We aimed to compare cuffed and uncuffed endotracheal tubes (ETTs) with ProSealTM laryngeal mask a... more We aimed to compare cuffed and uncuffed endotracheal tubes (ETTs) with ProSealTM laryngeal mask airway (PLMA) in terms of airway security and extubation, starting out from the hypothesis that PLMA will provide alternative airway safety to the endotracheal tubes, and that airway complications will be less observed. After obtaining approval from the local Ethics Committee and parental informed consent, 120 pediatric patients 1-24 months old, American Society of Anesthesiologists physical status I-II, requiring general anesthesia for elective lower abdominal surgery, were randomized into PLMA (Group P, n = 40), cuffed ETT (Group C, n = 40), and uncuffed ETT (Group UC, n = 40) groups. The number of intubation or PLMA insertion attempts was recorded. Each patient's epigastrium was auscultated for gastric insufflation, leak volumes and air leak fractions (leak volume/inspiratory volume) were recorded. Post-operative adverse events related to airway management were also followed up during the first post-operative hour. Demographic and surgical data were similar among the groups. There were significantly fewer airway manipulations in the Group P than in the other groups (p < 0.01), and leak volume and air leak fractions were greater in the Group UC than in the other two groups (p < 0.01). Laryngospasm was significantly lower in the Group P during extubation and within the first minute of post-extubation than in the other groups (p < 0.01). Based on this study, PLMA may be a good alternative to cuffed and uncuffed ETTs for airway management of infants due to the ease of manipulation and lower incidence of laryngospasm.