Füsun Eyüboğlu - Academia.edu (original) (raw)
Papers by Füsun Eyüboğlu
Tuberkuloz ve toraks, 2003
To discuss diagnosis, risk factors, clinical and radiologic manifestations of invasive pulmonary ... more To discuss diagnosis, risk factors, clinical and radiologic manifestations of invasive pulmonary aspergillosis (IPA) that is accepted as an important mortality factor in organ transplant recipients. We retrospectively evaluated seven IPA cases who were diagnosed among 207 patients that had undergone organ transplantation surgery in our center between 1998-2001. Of seven patients, four was renal and three was liver recipients. Diagnosis was made histopathologically (three post-mortem, one transbronchial lung biopsy) in four patients while culture positivity (sputum and tracheal aspiration material) with clinical and radiological evaluation was the diagnostic criteria for three patients. The most common respiratory symptoms were fever, productive cough and dyspnea. The most common fiberoptic bronchoscopic findings were mucosal fragility, hemorrhage. In one patient plaque formation was found. One liver recipients had been on hemodialysis because of renal insufficiency (serum creatine w...
Turkiye Klinikleri Journal of Immunology Allergy Special Topics, 2009
Türkiye Klinikleri Archives of Lung, 2009
gillus spores which are found widespread in nature. The disease presents with variable clinical p... more gillus spores which are found widespread in nature. The disease presents with variable clinical pictures depending on the patients’ immunity and underlying lung diseases.1 Aspergilloma develops in preexisting cavities. Hypersensitivity pneumonia and allergic bronchopulmonary aspergillosis are seen in atopic patients while invasive pulmonary aspergillosis with high mortality occurs mostly in patients with immuno-
Tuberkuloz ve toraks, 2007
Thrombolytic therapy is the most effective therapy for massive pulmonary embolism (PTE). In this ... more Thrombolytic therapy is the most effective therapy for massive pulmonary embolism (PTE). In this study we evaluated the symptoms, clinical and radiologic features and response to thrombolytic therapy in patients who had massive or submassive PTE. Thrombolytic therapy was administered for a mean period of 3 (1-5) hours to 19 patients with a mean age of 63.7 years who had the diagnosis of PTE based on symptoms which lasted for an average of 72 (2-240) hours and findings of echocardiography, spiral computed tomography (CT) angiography and perfusion scan. The patients to whom heparin infusion and oral anticoagulant treatment were given after thrombolytic therapy were evaluated. Bleeding as a complication was noted in six patients after thrombolytic therapy. Two patients died due to this complication. Control spiral CT angiography was performed to 12 of 15 (80%) patients who were initially diagnosed PTE by spiral CT angiography. While marked regression was noted in 5 (41.7%) patients in ...
Malnutrition is an important problem in patients with chronic obstructive pulmonary disease (COPD... more Malnutrition is an important problem in patients with chronic obstructive pulmonary disease (COPD). It still remains unclear whether malnutrition contributes to poor pulmonary function through a loss of respiratory muscle mass, or if advanced disease and hypoxemia are the causes of weight loss and malnutrition in COPD patients. This study was made to examine the effects of malnutrition on pulmonary function tests (PFTs) in COPD patients. With this purpose 35 stable COPD patients were enrolled in this study. According to their body mass indexes, the subjects were divided in two groups (group 1: cachectic and group 2: non-cachectic). All subjects were performed PFTs, serum tumor necrosis factor-alpha (TNF-alpha) levels, resting energy expenditure (REE), nutrition parameters, and arterial blood gas tension. PFTs were impaired to a greater degree in cachectic than non-cachectic patients. Serum TNF-alpha levels and REE were higher in cachectic patients than in non-cachectic patients. Sig...
Fire-eater's pneumonia is a distinct type of chemical pneumonitis that results from aspiratio... more Fire-eater's pneumonia is a distinct type of chemical pneumonitis that results from aspiration of different types of hydrocarbons. This article describes a case of fire-eater's pneumonia due to accidental aspiration of liquid paraffin. The adolescent patient became febrile the day after the accident. The diagnosis of fire-eater's pneumonia was delayed because aspiration history was not divulged by the patient from the beginning. The most prominent chest X-ray finding was multiple pneumatoceles. He responded well to antibiotics and corticosteroids. Two months after the accident, the lesions had almost completely resolved and only minor scarring was evident. Diagnosis of fire-eater's pneumonia can be difficult, especially if key aspects of related history are not divulged by the patient. Corticosteroid therapy was thought to be beneficial in the rapid recovery of the present case together with broad spectrum antibiotics.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2015
OBJECTIVES Solid-organ transplant recipients can develop chronic hypercoagulation that increases ... more OBJECTIVES Solid-organ transplant recipients can develop chronic hypercoagulation that increases the incidence of pulmonary embolism. Here, we evaluate the frequency of pulmonary embolism in solid-organ transplant recipients during the first 10 years after transplantation and evaluate the risk factors for its development. MATERIALS AND METHODS The medical records of solid-organ transplant recipients who were treated between 2003 and 2013 were retrospectively reviewed. The reviewed data included demographics, type of transplant, comorbidities, procoagulation factors, thromboembolism prophylaxis, and the timing and extent of pulmonary embolism. RESULTS In total, 999 solid-organ transplant recipients are included in this study (661 renal and 338 liver transplant recipients) (male: female ratio = 665:334). Twelve renal (1.2%) and 1 liver transplant recipient (0.3%) were diagnosed with pulmonary embolism. Pulmonary embolism developed 1 year after transplantation in 10 patients: 1 patient...
Journal of Clinical and Analytical Medicine
Abstract: Aim: Bullae and blebs are frequently associated with emphysema, but sometimes occur in ... more Abstract: Aim: Bullae and blebs are frequently associated with emphysema, but sometimes occur in absence of another associated disease. We aimed to find out the location, size of the bullae and/or blebs detected on computed tomography, accompanying radiological ...
OBJECTIVES The purpose of this retrospective study was to determine the rate of occurrence and fe... more OBJECTIVES The purpose of this retrospective study was to determine the rate of occurrence and features of pleural effusion in patients referred to our institution for liver transplant. MATERIALS AND METHODS This study included 135 patients (43 women, 92 men) with a mean age of 40 years (range, 16-66 y). Patient characteristics such as history of pulmonary disease and types of respiratory symptoms were recorded. The chest radiographs of every study patient were examined. RESULTS Of the 135 study patients, 16 (11.9%) had respiratory symptoms upon admission to the hospital, and 49 (36.3%) had abnormalities on their chest radiographs. The most common radiographic abnormality was elevated right hemidiaphragm in 32 patients (23.7%), followed by pleural effusion in 22 (16.2%), atelectasis in 21 (15.5%), hilar enlargement in 18 (13.3%), and elevated left hemidiaphragm in 9 (6.6%). Seventeen of 22 patients (77.3%) had right pleural effusion, 4 (18.2%) had bilateral, and 1 (4.5%) had left pl...
TURKISH JOURNAL OF MEDICAL SCIENCES
Introduction Infectious diseases that increase in incidence and tend to spread geographically wit... more Introduction Infectious diseases that increase in incidence and tend to spread geographically within decades can be defined as emerging infections. Pathogens of these infections appear for the first time or they have existed previously and spread rapidly among the population and new geographical areas. The emergence of novel human pathogens and reemergence of several diseases is of particular concerns of the current century [1]. There is a dominance of zoonotic infections, mostly originating in wildlife, among emerging health threats with a rate of 70%. Pathogens first emerge in themselves and rapidly mutate, which result in a transmission in humans with subsequent dissemination. According to the extent of the transmission, epidemic outbreaks may occur and progress to a pandemic. Diseases that reappear after a significant decline are called as reemerging diseases. Reemergence may occur due to a breakdown in public health measures or the appearance of new strains of organisms [2]. Respiratory infections with epidemic and pandemic potential that cause a global burden have plagued people since the beginning of human history. In this review, the epidemic and pandemic, emerging and reemerging respiratory viruses are summarized in Table. Most emerging viruses come from animals and are zoonotic or vector-borne diseases belonging to the families Orthomyxoviridae, Paramyxoviridae, Picornaviridae, Coronaviridae, Adenoviridae, and Herpesviridae. Community-acquired respiratory viruses are critical pathogens such as influenza, respiratory syncytial virus, adenovirus, parainfluenza virus, human coronavirus, human metapneumovirus, rhinovirus, enterovirus, cause millions of deaths and hospitalizations around all over the world every year [3,4]. In the last century, influenza originated avian, and swine, severe acute respiratory syndrome-coronavirus (SARS-CoV) and the Middle East respiratory syndromecoronavirus (MERS-CoV) were the most damaging respiratory infections for human being all over the world [5]. These emerging viral respiratory infections derived from the animal world [6]. Mutations in the genetic material of RNA viruses accumulate in years and produce new strains of the viruses with new antigenic properties resulting in a transmission in humans [7]. The probability of pandemics with new viruses would be high in the future as this type of mutations will reoccur. The other mechanism of a virus is reassortment which means that the host is infected with 2 different strains of viruses (animal and human viruses) than a new generation of a new virus with mixed genetic materials is developed and causes new pandemics [7]. Bird and swine influenza viruses obtain new gene segments through a reassortment with human strains.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, Nov 1, 2016
Renal transplant is an important treatment option for end-stage renal disease. A successful kidne... more Renal transplant is an important treatment option for end-stage renal disease. A successful kidney transplant improves the quality of life and reduces the mortality risk compared with maintenance dialysis in patients with end-stage renal disease. Several immunologic and nonimmunologic factors are responsible for graft outcomes in renal transplant patients. Our study was performed to evaluate the role of smoking on postoperative pulmonary complications and graft outcomes in renal transplant patients. Our study retrospectively analyzed 1740 patients who had renal transplants between 1987 and 2014 at Baskent University. Patients with smoking data were included in the study. Patient demographic, smoking status, comorbid diseases, postoperative pulmonary complications, graft outcomes, and clinical features were recorded. The relation between postoperative pulmonary complications and risk factors was investigated. Our study included 131 adult renal transplant recipients who had smoking da...
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2015
Heart transplant is the best treatment for end-stage heart failure. Respiratory insufficiency aft... more Heart transplant is the best treatment for end-stage heart failure. Respiratory insufficiency after heart transplant is a potentially serious complication. Pulmonary complications, pulmonary hypertension, allograft failure or rejection, and structural heart defects in the donor heart are among the causes of hypoxemia after transplant. In this study, we evaluated the prevalence of hypoxemia and respiratory insufficiency in patients with orthotopic heart transplant during the early postoperative period. We retrospectively evaluated the medical records of 45 patients who had received orthotopic heart transplant at our center. Clinical and demographic variables and laboratory data were noted. Oxygen saturation values from patients in the first week and the first month after transplant were analyzed. We also documented the cause of respiratory insufficiency and the type of treatment. Mean age was 35.3 ± 15.3 years (range, 12-61 y), with males comprising 32 of 45 patients (71.1%). Two pat...
Balıkesır Health Sciences Journal, 2015
Dünyada 1.1 milyar, Türkiye'de 17 milyon kişi sigara içmektedir. Bu çalışmada hastanemiz sigara b... more Dünyada 1.1 milyar, Türkiye'de 17 milyon kişi sigara içmektedir. Bu çalışmada hastanemiz sigara bırakma polikliniğinin 1 yıllık sonuçları incelendi. YÖNTEMLER: Ekim 2011-Ekim 2012 tarihleri arasında polikliniğimize başvuran 37 hasta ele alındı. Olguların demografik özellikleri, sigara kullanım öyküleri, anamnez, fizik muayene, klinik, radyolojik ve biyokimyasal parametreleri, solunum fonksiyon testleri, Fagerstrom nikotin bağımlılık düzey tespiti ve anksiyete-depresyon durumu değerlendirmesini sağlayan anket form sonuçları kaydedildi. BULGULAR: Olguların 19'u (%51.4) kadın, 18'i (%48.6) erkek ve yaş ortalaması 43.8 yıldı. Sigara kullanımı ort 33.9 paketyıl ve nikotin bağımlılık düzeyleri %70.2 ile yüksek saptandı. Olguların %78.4'ü üniversite mezunu, %67.6'sı evli, %64.9 çocuk sahibi idi, %67.6'sında ek hastalık mevcuttu ve %32.4 olgu daha önce sigara bırakma için profesyonel destek almıştı. Hastalara eğitim ve davranış terapisi ile birlikte %8.1'ine NRT, %40'ına bupropion, %45'ine vareniklin tedavisi verildi. Tedavi süresinde en sık yaşanan sorunlar sigara içme isteği, gerginlik-sinirlilik ve konsantrasyon güçlüğü iken; en sık yan etkiler bulantı, çarpıntı, karıncalanma idi ve 4 hastada yan etkiler nedeniyle tedavi stoplandı. Sigara bırakma oranları; kadın, evli, çocuklu, ek hastalığı olanlarda daha yüksek saptandı ancak fark istatistiksel olarak anlamlı değildi (p>0.05). Başarı oranları; 1. ay sonunda %75.7, 6. ay sonunda %54.1 ve 1. yıl sonunda %54.1 olarak raporlandı. Tedavide başarı oranı; bupropion alanlarda %46.7, vareniklin alanlarda %52.9, NRT alanlarda ise %100 idi. SONUÇ: Sigara kullanımı halen önemli bir halk sağlığı sorunudur ve hastalar sigara bırakma için bilgilendirilmeli, yönlendirilmeli ve profesyonel destek almaları arttırılmalıdır.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2015
Pulmonary hypertension is a common finding in chronic liver disease patients that has prognostic ... more Pulmonary hypertension is a common finding in chronic liver disease patients that has prognostic significance. In this study, we aimed to evaluate the prevalence and severity of pulmonary hypertension in patients undergoing orthotopic liver transplant. We also evaluated pulmonary artery pressure changes after transplant surgery. The records of adult patients with chronic liver disease who underwent orthotopic liver transplant at our center between 2004 and 2015 were retrospectively evaluated. Clinical and demographic variables and laboratory data were noted. Transthoracic Doppler echocardiographic examination reports were obtained. Using continuous-wave Doppler examination, systolic pulmonary artery pressure values were calculated. Pulmonary hypertension was defined as systolic pulmonary artery pressure ≥ 30 mm Hg. Among 208 adult patients who underwent orthotopic liver transplant, 203 who had Doppler echocardiographic examination were enrolled. The mean age of patients was 42.1 ± 1...
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2015
Pulmonary infections are life-threatening complications in heart transplant recipients. Our aim w... more Pulmonary infections are life-threatening complications in heart transplant recipients. Our aim was to evaluate long-term pulmonary infections and the effect of prophylactic antimicrobial strategies on time of occurrence of pulmonary infections in heart transplant recipients. Patients who underwent heart transplantation between 2003 and 2013 at Baskent University were reviewed. Demographic information and data about immunosuppression and infectious episodes were collected. In 82 heart transplant recipients (mean age, 33.85 y; 58 male and 24 female), 13 recipients (15.8%) developed pulmonary infections (mean age, 44.3 y; 9 male and 4 female). There were 12 patients who had dilated cardiomyopathy and 1 patient who had myocarditis before heart transplantation; 12 patients received immunosuppressive therapy in single or combination form. Pulmonary infections developed in the first month (1 patient), from first to third month (6 patients), from third to sixth month (1 patient), and > ...
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2015
Solid-organ transplant recipients can develop chronic hypercoagulation that increases the inciden... more Solid-organ transplant recipients can develop chronic hypercoagulation that increases the incidence of pulmonary embolism. Here, we evaluate the frequency of pulmonary embolism in solid-organ transplant recipients during the first 10 years after transplantation and evaluate the risk factors for its development. The medical records of solid-organ transplant recipients who were treated between 2003 and 2013 were retrospectively reviewed. The reviewed data included demographics, type of transplant, comorbidities, procoagulation factors, thromboembolism prophylaxis, and the timing and extent of pulmonary embolism. In total, 999 solid-organ transplant recipients are included in this study (661 renal and 338 liver transplant recipients) (male: female ratio = 665:334). Twelve renal (1.2%) and 1 liver transplant recipient (0.3%) were diagnosed with pulmonary embolism. Pulmonary embolism developed 1 year after transplantation in 10 patients: 1 patient developed pulmonary embolism < 3 mont...
Tuberkuloz ve toraks, 2003
To discuss diagnosis, risk factors, clinical and radiologic manifestations of invasive pulmonary ... more To discuss diagnosis, risk factors, clinical and radiologic manifestations of invasive pulmonary aspergillosis (IPA) that is accepted as an important mortality factor in organ transplant recipients. We retrospectively evaluated seven IPA cases who were diagnosed among 207 patients that had undergone organ transplantation surgery in our center between 1998-2001. Of seven patients, four was renal and three was liver recipients. Diagnosis was made histopathologically (three post-mortem, one transbronchial lung biopsy) in four patients while culture positivity (sputum and tracheal aspiration material) with clinical and radiological evaluation was the diagnostic criteria for three patients. The most common respiratory symptoms were fever, productive cough and dyspnea. The most common fiberoptic bronchoscopic findings were mucosal fragility, hemorrhage. In one patient plaque formation was found. One liver recipients had been on hemodialysis because of renal insufficiency (serum creatine w...
Turkiye Klinikleri Journal of Immunology Allergy Special Topics, 2009
Türkiye Klinikleri Archives of Lung, 2009
gillus spores which are found widespread in nature. The disease presents with variable clinical p... more gillus spores which are found widespread in nature. The disease presents with variable clinical pictures depending on the patients’ immunity and underlying lung diseases.1 Aspergilloma develops in preexisting cavities. Hypersensitivity pneumonia and allergic bronchopulmonary aspergillosis are seen in atopic patients while invasive pulmonary aspergillosis with high mortality occurs mostly in patients with immuno-
Tuberkuloz ve toraks, 2007
Thrombolytic therapy is the most effective therapy for massive pulmonary embolism (PTE). In this ... more Thrombolytic therapy is the most effective therapy for massive pulmonary embolism (PTE). In this study we evaluated the symptoms, clinical and radiologic features and response to thrombolytic therapy in patients who had massive or submassive PTE. Thrombolytic therapy was administered for a mean period of 3 (1-5) hours to 19 patients with a mean age of 63.7 years who had the diagnosis of PTE based on symptoms which lasted for an average of 72 (2-240) hours and findings of echocardiography, spiral computed tomography (CT) angiography and perfusion scan. The patients to whom heparin infusion and oral anticoagulant treatment were given after thrombolytic therapy were evaluated. Bleeding as a complication was noted in six patients after thrombolytic therapy. Two patients died due to this complication. Control spiral CT angiography was performed to 12 of 15 (80%) patients who were initially diagnosed PTE by spiral CT angiography. While marked regression was noted in 5 (41.7%) patients in ...
Malnutrition is an important problem in patients with chronic obstructive pulmonary disease (COPD... more Malnutrition is an important problem in patients with chronic obstructive pulmonary disease (COPD). It still remains unclear whether malnutrition contributes to poor pulmonary function through a loss of respiratory muscle mass, or if advanced disease and hypoxemia are the causes of weight loss and malnutrition in COPD patients. This study was made to examine the effects of malnutrition on pulmonary function tests (PFTs) in COPD patients. With this purpose 35 stable COPD patients were enrolled in this study. According to their body mass indexes, the subjects were divided in two groups (group 1: cachectic and group 2: non-cachectic). All subjects were performed PFTs, serum tumor necrosis factor-alpha (TNF-alpha) levels, resting energy expenditure (REE), nutrition parameters, and arterial blood gas tension. PFTs were impaired to a greater degree in cachectic than non-cachectic patients. Serum TNF-alpha levels and REE were higher in cachectic patients than in non-cachectic patients. Sig...
Fire-eater's pneumonia is a distinct type of chemical pneumonitis that results from aspiratio... more Fire-eater's pneumonia is a distinct type of chemical pneumonitis that results from aspiration of different types of hydrocarbons. This article describes a case of fire-eater's pneumonia due to accidental aspiration of liquid paraffin. The adolescent patient became febrile the day after the accident. The diagnosis of fire-eater's pneumonia was delayed because aspiration history was not divulged by the patient from the beginning. The most prominent chest X-ray finding was multiple pneumatoceles. He responded well to antibiotics and corticosteroids. Two months after the accident, the lesions had almost completely resolved and only minor scarring was evident. Diagnosis of fire-eater's pneumonia can be difficult, especially if key aspects of related history are not divulged by the patient. Corticosteroid therapy was thought to be beneficial in the rapid recovery of the present case together with broad spectrum antibiotics.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2015
OBJECTIVES Solid-organ transplant recipients can develop chronic hypercoagulation that increases ... more OBJECTIVES Solid-organ transplant recipients can develop chronic hypercoagulation that increases the incidence of pulmonary embolism. Here, we evaluate the frequency of pulmonary embolism in solid-organ transplant recipients during the first 10 years after transplantation and evaluate the risk factors for its development. MATERIALS AND METHODS The medical records of solid-organ transplant recipients who were treated between 2003 and 2013 were retrospectively reviewed. The reviewed data included demographics, type of transplant, comorbidities, procoagulation factors, thromboembolism prophylaxis, and the timing and extent of pulmonary embolism. RESULTS In total, 999 solid-organ transplant recipients are included in this study (661 renal and 338 liver transplant recipients) (male: female ratio = 665:334). Twelve renal (1.2%) and 1 liver transplant recipient (0.3%) were diagnosed with pulmonary embolism. Pulmonary embolism developed 1 year after transplantation in 10 patients: 1 patient...
Journal of Clinical and Analytical Medicine
Abstract: Aim: Bullae and blebs are frequently associated with emphysema, but sometimes occur in ... more Abstract: Aim: Bullae and blebs are frequently associated with emphysema, but sometimes occur in absence of another associated disease. We aimed to find out the location, size of the bullae and/or blebs detected on computed tomography, accompanying radiological ...
OBJECTIVES The purpose of this retrospective study was to determine the rate of occurrence and fe... more OBJECTIVES The purpose of this retrospective study was to determine the rate of occurrence and features of pleural effusion in patients referred to our institution for liver transplant. MATERIALS AND METHODS This study included 135 patients (43 women, 92 men) with a mean age of 40 years (range, 16-66 y). Patient characteristics such as history of pulmonary disease and types of respiratory symptoms were recorded. The chest radiographs of every study patient were examined. RESULTS Of the 135 study patients, 16 (11.9%) had respiratory symptoms upon admission to the hospital, and 49 (36.3%) had abnormalities on their chest radiographs. The most common radiographic abnormality was elevated right hemidiaphragm in 32 patients (23.7%), followed by pleural effusion in 22 (16.2%), atelectasis in 21 (15.5%), hilar enlargement in 18 (13.3%), and elevated left hemidiaphragm in 9 (6.6%). Seventeen of 22 patients (77.3%) had right pleural effusion, 4 (18.2%) had bilateral, and 1 (4.5%) had left pl...
TURKISH JOURNAL OF MEDICAL SCIENCES
Introduction Infectious diseases that increase in incidence and tend to spread geographically wit... more Introduction Infectious diseases that increase in incidence and tend to spread geographically within decades can be defined as emerging infections. Pathogens of these infections appear for the first time or they have existed previously and spread rapidly among the population and new geographical areas. The emergence of novel human pathogens and reemergence of several diseases is of particular concerns of the current century [1]. There is a dominance of zoonotic infections, mostly originating in wildlife, among emerging health threats with a rate of 70%. Pathogens first emerge in themselves and rapidly mutate, which result in a transmission in humans with subsequent dissemination. According to the extent of the transmission, epidemic outbreaks may occur and progress to a pandemic. Diseases that reappear after a significant decline are called as reemerging diseases. Reemergence may occur due to a breakdown in public health measures or the appearance of new strains of organisms [2]. Respiratory infections with epidemic and pandemic potential that cause a global burden have plagued people since the beginning of human history. In this review, the epidemic and pandemic, emerging and reemerging respiratory viruses are summarized in Table. Most emerging viruses come from animals and are zoonotic or vector-borne diseases belonging to the families Orthomyxoviridae, Paramyxoviridae, Picornaviridae, Coronaviridae, Adenoviridae, and Herpesviridae. Community-acquired respiratory viruses are critical pathogens such as influenza, respiratory syncytial virus, adenovirus, parainfluenza virus, human coronavirus, human metapneumovirus, rhinovirus, enterovirus, cause millions of deaths and hospitalizations around all over the world every year [3,4]. In the last century, influenza originated avian, and swine, severe acute respiratory syndrome-coronavirus (SARS-CoV) and the Middle East respiratory syndromecoronavirus (MERS-CoV) were the most damaging respiratory infections for human being all over the world [5]. These emerging viral respiratory infections derived from the animal world [6]. Mutations in the genetic material of RNA viruses accumulate in years and produce new strains of the viruses with new antigenic properties resulting in a transmission in humans [7]. The probability of pandemics with new viruses would be high in the future as this type of mutations will reoccur. The other mechanism of a virus is reassortment which means that the host is infected with 2 different strains of viruses (animal and human viruses) than a new generation of a new virus with mixed genetic materials is developed and causes new pandemics [7]. Bird and swine influenza viruses obtain new gene segments through a reassortment with human strains.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, Nov 1, 2016
Renal transplant is an important treatment option for end-stage renal disease. A successful kidne... more Renal transplant is an important treatment option for end-stage renal disease. A successful kidney transplant improves the quality of life and reduces the mortality risk compared with maintenance dialysis in patients with end-stage renal disease. Several immunologic and nonimmunologic factors are responsible for graft outcomes in renal transplant patients. Our study was performed to evaluate the role of smoking on postoperative pulmonary complications and graft outcomes in renal transplant patients. Our study retrospectively analyzed 1740 patients who had renal transplants between 1987 and 2014 at Baskent University. Patients with smoking data were included in the study. Patient demographic, smoking status, comorbid diseases, postoperative pulmonary complications, graft outcomes, and clinical features were recorded. The relation between postoperative pulmonary complications and risk factors was investigated. Our study included 131 adult renal transplant recipients who had smoking da...
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2015
Heart transplant is the best treatment for end-stage heart failure. Respiratory insufficiency aft... more Heart transplant is the best treatment for end-stage heart failure. Respiratory insufficiency after heart transplant is a potentially serious complication. Pulmonary complications, pulmonary hypertension, allograft failure or rejection, and structural heart defects in the donor heart are among the causes of hypoxemia after transplant. In this study, we evaluated the prevalence of hypoxemia and respiratory insufficiency in patients with orthotopic heart transplant during the early postoperative period. We retrospectively evaluated the medical records of 45 patients who had received orthotopic heart transplant at our center. Clinical and demographic variables and laboratory data were noted. Oxygen saturation values from patients in the first week and the first month after transplant were analyzed. We also documented the cause of respiratory insufficiency and the type of treatment. Mean age was 35.3 ± 15.3 years (range, 12-61 y), with males comprising 32 of 45 patients (71.1%). Two pat...
Balıkesır Health Sciences Journal, 2015
Dünyada 1.1 milyar, Türkiye'de 17 milyon kişi sigara içmektedir. Bu çalışmada hastanemiz sigara b... more Dünyada 1.1 milyar, Türkiye'de 17 milyon kişi sigara içmektedir. Bu çalışmada hastanemiz sigara bırakma polikliniğinin 1 yıllık sonuçları incelendi. YÖNTEMLER: Ekim 2011-Ekim 2012 tarihleri arasında polikliniğimize başvuran 37 hasta ele alındı. Olguların demografik özellikleri, sigara kullanım öyküleri, anamnez, fizik muayene, klinik, radyolojik ve biyokimyasal parametreleri, solunum fonksiyon testleri, Fagerstrom nikotin bağımlılık düzey tespiti ve anksiyete-depresyon durumu değerlendirmesini sağlayan anket form sonuçları kaydedildi. BULGULAR: Olguların 19'u (%51.4) kadın, 18'i (%48.6) erkek ve yaş ortalaması 43.8 yıldı. Sigara kullanımı ort 33.9 paketyıl ve nikotin bağımlılık düzeyleri %70.2 ile yüksek saptandı. Olguların %78.4'ü üniversite mezunu, %67.6'sı evli, %64.9 çocuk sahibi idi, %67.6'sında ek hastalık mevcuttu ve %32.4 olgu daha önce sigara bırakma için profesyonel destek almıştı. Hastalara eğitim ve davranış terapisi ile birlikte %8.1'ine NRT, %40'ına bupropion, %45'ine vareniklin tedavisi verildi. Tedavi süresinde en sık yaşanan sorunlar sigara içme isteği, gerginlik-sinirlilik ve konsantrasyon güçlüğü iken; en sık yan etkiler bulantı, çarpıntı, karıncalanma idi ve 4 hastada yan etkiler nedeniyle tedavi stoplandı. Sigara bırakma oranları; kadın, evli, çocuklu, ek hastalığı olanlarda daha yüksek saptandı ancak fark istatistiksel olarak anlamlı değildi (p>0.05). Başarı oranları; 1. ay sonunda %75.7, 6. ay sonunda %54.1 ve 1. yıl sonunda %54.1 olarak raporlandı. Tedavide başarı oranı; bupropion alanlarda %46.7, vareniklin alanlarda %52.9, NRT alanlarda ise %100 idi. SONUÇ: Sigara kullanımı halen önemli bir halk sağlığı sorunudur ve hastalar sigara bırakma için bilgilendirilmeli, yönlendirilmeli ve profesyonel destek almaları arttırılmalıdır.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2015
Pulmonary hypertension is a common finding in chronic liver disease patients that has prognostic ... more Pulmonary hypertension is a common finding in chronic liver disease patients that has prognostic significance. In this study, we aimed to evaluate the prevalence and severity of pulmonary hypertension in patients undergoing orthotopic liver transplant. We also evaluated pulmonary artery pressure changes after transplant surgery. The records of adult patients with chronic liver disease who underwent orthotopic liver transplant at our center between 2004 and 2015 were retrospectively evaluated. Clinical and demographic variables and laboratory data were noted. Transthoracic Doppler echocardiographic examination reports were obtained. Using continuous-wave Doppler examination, systolic pulmonary artery pressure values were calculated. Pulmonary hypertension was defined as systolic pulmonary artery pressure ≥ 30 mm Hg. Among 208 adult patients who underwent orthotopic liver transplant, 203 who had Doppler echocardiographic examination were enrolled. The mean age of patients was 42.1 ± 1...
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2015
Pulmonary infections are life-threatening complications in heart transplant recipients. Our aim w... more Pulmonary infections are life-threatening complications in heart transplant recipients. Our aim was to evaluate long-term pulmonary infections and the effect of prophylactic antimicrobial strategies on time of occurrence of pulmonary infections in heart transplant recipients. Patients who underwent heart transplantation between 2003 and 2013 at Baskent University were reviewed. Demographic information and data about immunosuppression and infectious episodes were collected. In 82 heart transplant recipients (mean age, 33.85 y; 58 male and 24 female), 13 recipients (15.8%) developed pulmonary infections (mean age, 44.3 y; 9 male and 4 female). There were 12 patients who had dilated cardiomyopathy and 1 patient who had myocarditis before heart transplantation; 12 patients received immunosuppressive therapy in single or combination form. Pulmonary infections developed in the first month (1 patient), from first to third month (6 patients), from third to sixth month (1 patient), and > ...
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2015
Solid-organ transplant recipients can develop chronic hypercoagulation that increases the inciden... more Solid-organ transplant recipients can develop chronic hypercoagulation that increases the incidence of pulmonary embolism. Here, we evaluate the frequency of pulmonary embolism in solid-organ transplant recipients during the first 10 years after transplantation and evaluate the risk factors for its development. The medical records of solid-organ transplant recipients who were treated between 2003 and 2013 were retrospectively reviewed. The reviewed data included demographics, type of transplant, comorbidities, procoagulation factors, thromboembolism prophylaxis, and the timing and extent of pulmonary embolism. In total, 999 solid-organ transplant recipients are included in this study (661 renal and 338 liver transplant recipients) (male: female ratio = 665:334). Twelve renal (1.2%) and 1 liver transplant recipient (0.3%) were diagnosed with pulmonary embolism. Pulmonary embolism developed 1 year after transplantation in 10 patients: 1 patient developed pulmonary embolism < 3 mont...