FABIEN DEMEESTER - Academia.edu (original) (raw)
Papers by FABIEN DEMEESTER
American Medical Journal, 2011
Problem statement: Nutritional factors appear to be quite important in the pathogenesis and progn... more Problem statement: Nutritional factors appear to be quite important in the pathogenesis and prognosis among patients of Acute Myocardial Infarction (AMI) or Acute Coronary Syndrome (ACS). Increased consumption of proinflammatory foods; such as refined starches and sugar, trans fat, saturated fat and w-6 fatty acids may increase proinflammatory cytokines, oxidative stress and free fatty acids causing endothelial dysfunction. Approach: Columbus foods with low w-6/w-3 ratio of fatty acids, may play a protective role. Many adverse parameters such as higher concentrations of proinflammatory cytokines, transcription factors and adhesion molecules, free radicals and decrease in nitrite levels were shown to be related to the dietary composition and thus may serve as independent predictors of ACS. Diets rich in w-3 fatty acids, vitamins, minerals and antioxidants and low in refined carbohydrates cause decrease in levels of plasma lipid peroxides, antioxidant vitamins, serum Glutamic Oxaloacetate Transaminase (SGOT) and Lactate Dehydrogenase (LDH) cardiac enzymes in patients with ACS. Results: Available evidence indicate that cardioprotective diet can decrease sudden cardiac deaths, total cardiac deaths, non-fatal infractions and total cardiac events among patients receiving such diet compared to standard diet. The existing evidence support that diet rich in w-3 fatty acids, vitamins, minerals and antioxidants with low refined carbohydrates may be beneficial to vascular endothelium and myocardium and thus seems to function as cardioprotective in patients with ACS. Conclusion: The Western foods that lack essential vitamins, minerals and w-3 fatty acids and that are rapidly absorbed should be avoided in patients with ACS. More studies especially in the context of developing countries are required for establishing the vital role of the cardio protective diet.
Biochemical Journal, 1989
Ionic strength strongly influenced the turnover/inactivation ratio in the interaction between bet... more Ionic strength strongly influenced the turnover/inactivation ratio in the interaction between beta-halogenopenicillanates and some class A beta-lactamases. This suggested the stabilization of a highly charged intermediate by solvation. Those data could be interpreted on the basis of a reaction pathway where an episulphonium ion was transiently formed. The various mechanisms proposed for explaining the formation of the dihydrothiazine chromophore are discussed.
Cause and effect of dietary constituents on the genesis of NCD epidemics (CVD, diabetes, etc) in ... more Cause and effect of dietary constituents on the genesis of NCD epidemics (CVD, diabetes, etc) in the Western developed and some developing countries has been diffi-cult to unravel. It appears that inflammation is a key fac-tor and that in its absence total cholesterol may have an apparently neutral effect on arterial tissues and the myo-cardium. The Mediterranean-style diet, combined with physical exercise, resembles a notional Palaeolithic diet of a pre-agricultural era in that the ratio of omega-3/omega-6 unsaturated fatty acids is higher than in most Western diets [1]. Furthermore, evidence suggests that this higher ratio can beneficially change brain function and its inter-action with gut, liver and heart and influence mind-body interactions. This group, in collaboration with others, seek to test the hypothesis, albeit for a 4y longitudinal
Copyright © 2010 R. B. Singh et al. This is an open access article distributed under the Creative... more Copyright © 2010 R. B. Singh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Tsim Tsoum Concept means that humans evolved on a diet in which nature recommends to ingest fatty acids in a balanced ratio (polyunsaturated(P) : saturated(S) = w-6: w-3 = 1: 1)as part of dietary lipid pattern where monounsaturated fatty acids(MUFA) is the major fatty acid(P: M: S = 1: 6: 1) in the background of other dietary factors; antioxidants, vitamins, minerals and fiber as well as physical activity and low mental stress. Several hundred years ago, our diet included natural foods; fruits, vegetables, green vegetables, seeds, eggs and honey. Fish, and wild meat were also available to pre-agricultural humans which shaped modern human genetic nutritional requirement. Cereal grains (refined), and vegetable oils that are rich in w-...
The Tsim Tsoum Concept means that humans evolved on a diet in which nature recommends to ingest f... more The Tsim Tsoum Concept means that humans evolved on a diet in which nature recommends to ingest fatty acids in a balanced ratio (polyunsaturated(P) : saturated(S) = w-6 : w-3 = 1 : 1)as part of dietary lipid pattern where monounsaturated fatty acids(MUFA) is the major fatty acid(P : M : S = 1 : 6 : 1) in the background of other dietary factors; antioxidants, vitamins, minerals and fiber as well as physical activity and low mental stress. Several hundred years ago, our diet included natural foods; fruits, vegetables, green vegetables, seeds, eggs and honey. Fish, and wild meat were also available to pre-agricultural humans which shaped modern human genetic nutritional requirement. Cereal grains (refined), and vegetable oils that are rich in w-6 fatty acids are relatively recent addition to the human diet that represent dramatic departure from those foods to which we are adapted. Excess of linoleic acid, trans fatty acids (TFA), saturated and total fat as well as refined starches and ...
European Heart Journal, 2007
Journal of Nutritional and Environmental Medicine, 2005
The Open Nutraceuticals Journal, 2012
Background: Clinical evidence indicates that insufficient sleep and poor sleep quality appear to ... more Background: Clinical evidence indicates that insufficient sleep and poor sleep quality appear to be common consequences of shift work. These rhythms appear to have independent influence on the function of the endocrine system, circadian brain function and gastrointestinal tract. Insufficient sleep and its poor quality due to shift work interfere with beta cells, leptin and ghrelin functioning, resulting in factors for the development and exacerbation of insulin resistance. Human studies found that insufficient sleep alters the levels of leptin and ghrelin, two hormones involved in the regulation of appetite and body fat. Leptin, released by fat cells, signals the brain to feel satiety. Ghrelin, produced in the stomach, signals hunger. Investigations reported that temporarily sleep-deprived individuals experienced hormonal changes along with greater cravings for sweet and fatty foods. A further reason for their cravings is related to the stress hormone cortisol, which can rise with sleep deprivation and contribute to hunger. In addition to altered hormone levels, people who stay awake longer have more opportunity to eat, and late-night eating often includes high-caloric foods. Weight gain is only one of the many side effects of insufficient sleep, but it can lead to long-term health problems, including diabetes. Although more sleep will not automatically result in weight loss, sufficient sleep and a regular sleep schedule are critical in controlling appetite and promoting a healthy eating pattern. Research on sleep and appetite reveals a consistent link between a lower amount of sleep and a higher body mass index (BMI), a ratio of weight-to-height that indicates overweight. Studies showed those who slept less than eight hours a night were more likely to be overweight. Methods: Internet search and discussion with colleagues. Results: Recent research indicates that disruption of sleep can influence food intake and food and nutrients can influence sleep. There is evidence that high protein and carbohydrates meals can influence moods, attention and concentration among normal adult subjects with respect to age, gender and meal time. Women reported greater sleepiness after two hours of carbohydrate meal as opposed to a protein meal. On the other hand men reported greater calmness after a carbohydrate as opposed to a protein meal. Age of subjects may also influence the response to meals. After a carbohydrate or protein rich breakfast, persons older than 40 years felt more tense and less calm with a protein-rich than carbohydraterich meal. In general older subjects preferred carbohydrate than protein meals. Carbohydrate meals are also reported to impair objective performance; carbohydrate rich foods either in breakfast or lunch have exhibited negative influence on neural response such as impaired objective performance and poor sustained attention. A meal consumed close to bedtime is associated with sleep disturbances. Further, solid foods as well as large meals may cause more sleepiness than liquid foods. Studies have also shown that the larger the meal, the sleepier the person thereafter. In the evening the sleepfacilitating effects of carbohydrates may be beneficial. However, manipulation in the energy content of meals for a single day may cause increase in markedly different levels of insulin without changes in plasma glucose. Conclusions: The findings indicate that food intake can influence sleep and disruption of sleep can cause increased consumption of fast ready-prepared foods which have adverse effects resulting in obesity, diabetes and CVDs.
European Heart Journal, 2007
The history of evolution of human beings indicate that our early diet included natural foods; fru... more The history of evolution of human beings indicate that our early diet included natural foods; fruits, vegetables, green vegetables, seeds, eggs and honey. Fish, and wild meat were also available to preagricultural humans which shaped modern human,s genetic nutritional requirement. Cereal grains (refined), and vegetable oils that are rich in w-6 fatty acids are relatively recent addition to the human diet that represent dramatic departure from those foods to which we are adapted. Early man also had enormous physical activity without any mental stress. The role of fatty acids in the prevention and pathogenesis of cardiovascular diseases(CVD), type 2 diabetes and insulin resistance are well known. Excess of linoleic acid, trans fatty acids (TFA), saturated and total fat as well as refined starches and sugar are proinflammatory. Low dietary monounsaturated fatty acids (MUFA) and n-3 fatty acids and other long chain polyunsarurated fatty acids (LCPUFA) are important in the pathogenesis o...
La presente invention concerne la decouverte qu'un chauffage efficace des oeufs en coquille p... more La presente invention concerne la decouverte qu'un chauffage efficace des oeufs en coquille peut se faire en utilisant des courants de convection d'air a humidite controlee. Le processus a air a humidite controlee decrit ici constitue un moyen puissant et interessant pour prechauffer et/ou pasteuriser, c'est-a-dire prechauffer et conserver, des oeufs en coquille intacts. L'invention concerne egalement des oeufs en coquille pasteurises obtenus selon le procede de l'invention. L'invention concerne en outre des procedes permettant de refroidir les oeufs en coquille et d'en desinfecter la surface en utilisant un air a humidite controlee.
Please cite this article as: Hristova K, Shiue I, Pella D, Singh R, Chaves H, Basu TK, Ozimek L, ... more Please cite this article as: Hristova K, Shiue I, Pella D, Singh R, Chaves H, Basu TK, Ozimek L, Rastogi S, Takahashi T, Wilson D, DeMeester F, Cheema S, Garg M, Buttar H, Milovanovic B, Kumar A, Handjiev S, Cornelissen G, Petrov I, Sofia Declaration On Transition Of Prevention Strategies For Cardiovascular Diseases And Diabetes Mellitus In Developing Countries: A Statement From The International College Of Cardiology And International College Of Nutrition, Nutrition (2014), doi: 10.1016/ j.nut.2013.12.013.
Protein kinase C (PKC) activity has been identified in various strains of the human parasite, Ent... more Protein kinase C (PKC) activity has been identified in various strains of the human parasite, Entamoeba histolyticu. 2. An amoebic protein of mol. wt 78,000 was recognized by polyclonal antibodies raised against the 82,000 mol. wt rat brain protein kinase C. 3. A partially purified PKC preparation from E. histolytica phosphorylated histone I in the presence of calcium, phospholipds and diacylglycerol, and specifically bound tritiated phorbol ester at an apparent K n of 9 nM. 4. A relocalization of the amoebic PKC activity from the cytosol to the membrane fraction was observed when trophozoites were actively phagocytising bacteria. Under these conditions, a labelled phosphoprotein of mol. wt 68,000 was identified. 5. Similar to what was found during macrophage activation, a myristoylated mol. wt 68,000 protein was detected in amoebae grown in the absence of bacteria, but not in amoebae which were active in phagocytosis.
The Open Nutraceuticals Journal, 2009
American Medical Journal, 2011
Problem statement: Nutritional factors appear to be quite important in the pathogenesis and progn... more Problem statement: Nutritional factors appear to be quite important in the pathogenesis and prognosis among patients of Acute Myocardial Infarction (AMI) or Acute Coronary Syndrome (ACS). Increased consumption of proinflammatory foods; such as refined starches and sugar, trans fat, saturated fat and w-6 fatty acids may increase proinflammatory cytokines, oxidative stress and free fatty acids causing endothelial dysfunction. Approach: Columbus foods with low w-6/w-3 ratio of fatty acids, may play a protective role. Many adverse parameters such as higher concentrations of proinflammatory cytokines, transcription factors and adhesion molecules, free radicals and decrease in nitrite levels were shown to be related to the dietary composition and thus may serve as independent predictors of ACS. Diets rich in w-3 fatty acids, vitamins, minerals and antioxidants and low in refined carbohydrates cause decrease in levels of plasma lipid peroxides, antioxidant vitamins, serum Glutamic Oxaloacetate Transaminase (SGOT) and Lactate Dehydrogenase (LDH) cardiac enzymes in patients with ACS. Results: Available evidence indicate that cardioprotective diet can decrease sudden cardiac deaths, total cardiac deaths, non-fatal infractions and total cardiac events among patients receiving such diet compared to standard diet. The existing evidence support that diet rich in w-3 fatty acids, vitamins, minerals and antioxidants with low refined carbohydrates may be beneficial to vascular endothelium and myocardium and thus seems to function as cardioprotective in patients with ACS. Conclusion: The Western foods that lack essential vitamins, minerals and w-3 fatty acids and that are rapidly absorbed should be avoided in patients with ACS. More studies especially in the context of developing countries are required for establishing the vital role of the cardio protective diet.
Biochemical Journal, 1989
Ionic strength strongly influenced the turnover/inactivation ratio in the interaction between bet... more Ionic strength strongly influenced the turnover/inactivation ratio in the interaction between beta-halogenopenicillanates and some class A beta-lactamases. This suggested the stabilization of a highly charged intermediate by solvation. Those data could be interpreted on the basis of a reaction pathway where an episulphonium ion was transiently formed. The various mechanisms proposed for explaining the formation of the dihydrothiazine chromophore are discussed.
Cause and effect of dietary constituents on the genesis of NCD epidemics (CVD, diabetes, etc) in ... more Cause and effect of dietary constituents on the genesis of NCD epidemics (CVD, diabetes, etc) in the Western developed and some developing countries has been diffi-cult to unravel. It appears that inflammation is a key fac-tor and that in its absence total cholesterol may have an apparently neutral effect on arterial tissues and the myo-cardium. The Mediterranean-style diet, combined with physical exercise, resembles a notional Palaeolithic diet of a pre-agricultural era in that the ratio of omega-3/omega-6 unsaturated fatty acids is higher than in most Western diets [1]. Furthermore, evidence suggests that this higher ratio can beneficially change brain function and its inter-action with gut, liver and heart and influence mind-body interactions. This group, in collaboration with others, seek to test the hypothesis, albeit for a 4y longitudinal
Copyright © 2010 R. B. Singh et al. This is an open access article distributed under the Creative... more Copyright © 2010 R. B. Singh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Tsim Tsoum Concept means that humans evolved on a diet in which nature recommends to ingest fatty acids in a balanced ratio (polyunsaturated(P) : saturated(S) = w-6: w-3 = 1: 1)as part of dietary lipid pattern where monounsaturated fatty acids(MUFA) is the major fatty acid(P: M: S = 1: 6: 1) in the background of other dietary factors; antioxidants, vitamins, minerals and fiber as well as physical activity and low mental stress. Several hundred years ago, our diet included natural foods; fruits, vegetables, green vegetables, seeds, eggs and honey. Fish, and wild meat were also available to pre-agricultural humans which shaped modern human genetic nutritional requirement. Cereal grains (refined), and vegetable oils that are rich in w-...
The Tsim Tsoum Concept means that humans evolved on a diet in which nature recommends to ingest f... more The Tsim Tsoum Concept means that humans evolved on a diet in which nature recommends to ingest fatty acids in a balanced ratio (polyunsaturated(P) : saturated(S) = w-6 : w-3 = 1 : 1)as part of dietary lipid pattern where monounsaturated fatty acids(MUFA) is the major fatty acid(P : M : S = 1 : 6 : 1) in the background of other dietary factors; antioxidants, vitamins, minerals and fiber as well as physical activity and low mental stress. Several hundred years ago, our diet included natural foods; fruits, vegetables, green vegetables, seeds, eggs and honey. Fish, and wild meat were also available to pre-agricultural humans which shaped modern human genetic nutritional requirement. Cereal grains (refined), and vegetable oils that are rich in w-6 fatty acids are relatively recent addition to the human diet that represent dramatic departure from those foods to which we are adapted. Excess of linoleic acid, trans fatty acids (TFA), saturated and total fat as well as refined starches and ...
European Heart Journal, 2007
Journal of Nutritional and Environmental Medicine, 2005
The Open Nutraceuticals Journal, 2012
Background: Clinical evidence indicates that insufficient sleep and poor sleep quality appear to ... more Background: Clinical evidence indicates that insufficient sleep and poor sleep quality appear to be common consequences of shift work. These rhythms appear to have independent influence on the function of the endocrine system, circadian brain function and gastrointestinal tract. Insufficient sleep and its poor quality due to shift work interfere with beta cells, leptin and ghrelin functioning, resulting in factors for the development and exacerbation of insulin resistance. Human studies found that insufficient sleep alters the levels of leptin and ghrelin, two hormones involved in the regulation of appetite and body fat. Leptin, released by fat cells, signals the brain to feel satiety. Ghrelin, produced in the stomach, signals hunger. Investigations reported that temporarily sleep-deprived individuals experienced hormonal changes along with greater cravings for sweet and fatty foods. A further reason for their cravings is related to the stress hormone cortisol, which can rise with sleep deprivation and contribute to hunger. In addition to altered hormone levels, people who stay awake longer have more opportunity to eat, and late-night eating often includes high-caloric foods. Weight gain is only one of the many side effects of insufficient sleep, but it can lead to long-term health problems, including diabetes. Although more sleep will not automatically result in weight loss, sufficient sleep and a regular sleep schedule are critical in controlling appetite and promoting a healthy eating pattern. Research on sleep and appetite reveals a consistent link between a lower amount of sleep and a higher body mass index (BMI), a ratio of weight-to-height that indicates overweight. Studies showed those who slept less than eight hours a night were more likely to be overweight. Methods: Internet search and discussion with colleagues. Results: Recent research indicates that disruption of sleep can influence food intake and food and nutrients can influence sleep. There is evidence that high protein and carbohydrates meals can influence moods, attention and concentration among normal adult subjects with respect to age, gender and meal time. Women reported greater sleepiness after two hours of carbohydrate meal as opposed to a protein meal. On the other hand men reported greater calmness after a carbohydrate as opposed to a protein meal. Age of subjects may also influence the response to meals. After a carbohydrate or protein rich breakfast, persons older than 40 years felt more tense and less calm with a protein-rich than carbohydraterich meal. In general older subjects preferred carbohydrate than protein meals. Carbohydrate meals are also reported to impair objective performance; carbohydrate rich foods either in breakfast or lunch have exhibited negative influence on neural response such as impaired objective performance and poor sustained attention. A meal consumed close to bedtime is associated with sleep disturbances. Further, solid foods as well as large meals may cause more sleepiness than liquid foods. Studies have also shown that the larger the meal, the sleepier the person thereafter. In the evening the sleepfacilitating effects of carbohydrates may be beneficial. However, manipulation in the energy content of meals for a single day may cause increase in markedly different levels of insulin without changes in plasma glucose. Conclusions: The findings indicate that food intake can influence sleep and disruption of sleep can cause increased consumption of fast ready-prepared foods which have adverse effects resulting in obesity, diabetes and CVDs.
European Heart Journal, 2007
The history of evolution of human beings indicate that our early diet included natural foods; fru... more The history of evolution of human beings indicate that our early diet included natural foods; fruits, vegetables, green vegetables, seeds, eggs and honey. Fish, and wild meat were also available to preagricultural humans which shaped modern human,s genetic nutritional requirement. Cereal grains (refined), and vegetable oils that are rich in w-6 fatty acids are relatively recent addition to the human diet that represent dramatic departure from those foods to which we are adapted. Early man also had enormous physical activity without any mental stress. The role of fatty acids in the prevention and pathogenesis of cardiovascular diseases(CVD), type 2 diabetes and insulin resistance are well known. Excess of linoleic acid, trans fatty acids (TFA), saturated and total fat as well as refined starches and sugar are proinflammatory. Low dietary monounsaturated fatty acids (MUFA) and n-3 fatty acids and other long chain polyunsarurated fatty acids (LCPUFA) are important in the pathogenesis o...
La presente invention concerne la decouverte qu'un chauffage efficace des oeufs en coquille p... more La presente invention concerne la decouverte qu'un chauffage efficace des oeufs en coquille peut se faire en utilisant des courants de convection d'air a humidite controlee. Le processus a air a humidite controlee decrit ici constitue un moyen puissant et interessant pour prechauffer et/ou pasteuriser, c'est-a-dire prechauffer et conserver, des oeufs en coquille intacts. L'invention concerne egalement des oeufs en coquille pasteurises obtenus selon le procede de l'invention. L'invention concerne en outre des procedes permettant de refroidir les oeufs en coquille et d'en desinfecter la surface en utilisant un air a humidite controlee.
Please cite this article as: Hristova K, Shiue I, Pella D, Singh R, Chaves H, Basu TK, Ozimek L, ... more Please cite this article as: Hristova K, Shiue I, Pella D, Singh R, Chaves H, Basu TK, Ozimek L, Rastogi S, Takahashi T, Wilson D, DeMeester F, Cheema S, Garg M, Buttar H, Milovanovic B, Kumar A, Handjiev S, Cornelissen G, Petrov I, Sofia Declaration On Transition Of Prevention Strategies For Cardiovascular Diseases And Diabetes Mellitus In Developing Countries: A Statement From The International College Of Cardiology And International College Of Nutrition, Nutrition (2014), doi: 10.1016/ j.nut.2013.12.013.
Protein kinase C (PKC) activity has been identified in various strains of the human parasite, Ent... more Protein kinase C (PKC) activity has been identified in various strains of the human parasite, Entamoeba histolyticu. 2. An amoebic protein of mol. wt 78,000 was recognized by polyclonal antibodies raised against the 82,000 mol. wt rat brain protein kinase C. 3. A partially purified PKC preparation from E. histolytica phosphorylated histone I in the presence of calcium, phospholipds and diacylglycerol, and specifically bound tritiated phorbol ester at an apparent K n of 9 nM. 4. A relocalization of the amoebic PKC activity from the cytosol to the membrane fraction was observed when trophozoites were actively phagocytising bacteria. Under these conditions, a labelled phosphoprotein of mol. wt 68,000 was identified. 5. Similar to what was found during macrophage activation, a myristoylated mol. wt 68,000 protein was detected in amoebae grown in the absence of bacteria, but not in amoebae which were active in phagocytosis.
The Open Nutraceuticals Journal, 2009