Francesca Del Bene - Academia.edu (original) (raw)

Francesca Del Bene

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Papers by Francesca Del Bene

Research paper thumbnail of PA401, A Novel Decoy CXCL8- Based Biologic Therapeutic Reduces Lung Inflammation Induced By LPS As Well As Plasma Inflammatory Markers In Mice

C31. REGULATION OF LUNG INFLAMMATION, 2012

Research paper thumbnail of PK / PD analysis of trazodone and gabapentin in neuropathic pain rodent models: Translational PK‐PD modeling from nonclinical to clinical development

Clinical and Translational Science

Research paper thumbnail of A Minimal Model of Tumor Growth Inhibition in Combination Regimens Under the Hypothesis of No Interaction Between Drugs

IEEE Transactions on Biomedical Engineering, 2012

Research paper thumbnail of A4S: A user-friendly graphical tool for pharmacokinetic and pharmacodynamic (PK/PD) simulation

Computer Methods and Programs in Biomedicine, 2013

Effective communication of PK/PD principles and results in a biomedical research environment rema... more Effective communication of PK/PD principles and results in a biomedical research environment remains a significant challenge which can result in lack of buy-in and engagement from scientists outside the modeling and simulation communities. In our view, one of the barriers in this area is a lack of user-friendly tools which allow "non experts" to use PK/PD models without the need to develop technical skills and expertise in advanced mathematical principles and specialist software. The costs of commercial software may also prevent large-scale distribution. One attempt to address this issue internally in our research organizations has resulted in the development of the A4S ("Accelera for Sandwich") software, which is a simple-to-use, menu-drive Matlab-based PK/PD simulator targeted at biomedical researchers with little PK/PD experience.

Research paper thumbnail of Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents

Research paper thumbnail of Testing additivity of anticancer agents in pre-clinical studies: A PK/PD modelling approach

European Journal of Cancer, Oct 1, 2009

Research paper thumbnail of PA401, A Novel Decoy CXCL8- Based Biologic Therapeutic Reduces Lung Inflammation Induced By LPS As Well As Plasma Inflammatory Markers In Mice

C31. REGULATION OF LUNG INFLAMMATION, 2012

Research paper thumbnail of PK / PD analysis of trazodone and gabapentin in neuropathic pain rodent models: Translational PK‐PD modeling from nonclinical to clinical development

Clinical and Translational Science

Research paper thumbnail of A Minimal Model of Tumor Growth Inhibition in Combination Regimens Under the Hypothesis of No Interaction Between Drugs

IEEE Transactions on Biomedical Engineering, 2012

Research paper thumbnail of A4S: A user-friendly graphical tool for pharmacokinetic and pharmacodynamic (PK/PD) simulation

Computer Methods and Programs in Biomedicine, 2013

Effective communication of PK/PD principles and results in a biomedical research environment rema... more Effective communication of PK/PD principles and results in a biomedical research environment remains a significant challenge which can result in lack of buy-in and engagement from scientists outside the modeling and simulation communities. In our view, one of the barriers in this area is a lack of user-friendly tools which allow "non experts" to use PK/PD models without the need to develop technical skills and expertise in advanced mathematical principles and specialist software. The costs of commercial software may also prevent large-scale distribution. One attempt to address this issue internally in our research organizations has resulted in the development of the A4S ("Accelera for Sandwich") software, which is a simple-to-use, menu-drive Matlab-based PK/PD simulator targeted at biomedical researchers with little PK/PD experience.

Research paper thumbnail of Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents

Research paper thumbnail of Testing additivity of anticancer agents in pre-clinical studies: A PK/PD modelling approach

European Journal of Cancer, Oct 1, 2009

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