FF Fikri - Academia.edu (original) (raw)
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Università degli Studi di Milano - State University of Milan (Italy)
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Papers by FF Fikri
International Journal of Gynecology & Obstetrics, 1971
Effects of progestogens including medroxyprogesterone acetate and norethisterone enanthate on inv... more Effects of progestogens including medroxyprogesterone acetate and norethisterone enanthate on involution of the uterus and the subsequent changes in the endometrium and myometrium are considered. 231 lactating women at the birth control clinics of Ain Shams University were studied. The women were divided into 2 groups: the first 112 women received an injectable contraceptive on the 7th puerperal day. Of these 68 were given norethisterone enanthate 200 mg every 84 days and the rest were given medroxyprogesterone acetate 150 mg (Depo-Provera) every 3 months. Group 2 with 119 women were divided into 2 groups and given either progestogen the first injection at the 6th postpartum week. These progestogens do not affect uterine involution and the duration of lochia was similar to that of controls. The endometrium passed through successive stages of quiesence preatrophy and a trophy and fibrosis. The latter occurred much more rapidly in those starting injection on the 7th postpartum day. The myometrium revealed fibrosis and reduced vascularity. It is remarkable that in all subjects stopping norethisterone enanthate the endometrium regained its cyclic pattern within 2-6 months. After discontinuing Depo-Provera the endometrium required a longer period (5-9 months) to regain activity. It may be delayed even more than 9 months.
Ain Shams medical journal, 1971
79 multiparous volunteers aged 21-40, at the birth control clinics of Ain Shams University in Cai... more 79 multiparous volunteers aged 21-40, at the birth control clinics of Ain Shams University in Cairo, Egypt chose the injection method as their contraceptive choice and were injected with deladroxate (16,17 dihydroxy progesterone acetaphenide 150 mg and 10 mg estradiol enanthate) for a total of 836 cycles. The preparation proved to be 100% effective. Some other results were: 1) the average cycle length decreased under therapy, 2) amount of flow was not affected, 3) breakthrough bleeding occurred in 3-9% of cases, 4) there was a slight increase in incidence of headache, dizziness, and vaginal discharge, 5) liver function did not change, 6) endometrial biopsies and vaginal smears indicated estrogenic effects, 7) there were no corpora lutea in ovarian biopsies but follicles existed in all stages of maturation, and 8) conception occurred within 5-16 months after discontinuation.
BMJ, 1971
Norethisterone ethanate (200 mg every 84 days) and medroxyprogesterone acetate (150 mg every thre... more Norethisterone ethanate (200 mg every 84 days) and medroxyprogesterone acetate (150 mg every three months) were found to be completely effective in fertility control when started in the puerperium. Neither agent had any ill effect on the amount of milk or the duration of lactation. From the third month onward the three-hourly available milk and the infant weight gain per month were statistically higher in treated groups than in controls. Milk proteins showed a slight decrease in most groups, including the controls, owing to the low-protein diet. No important side effect was produced by these agents other than amenorrhoea.
International Journal of Gynecology & Obstetrics, 1971
Effects of progestogens including medroxyprogesterone acetate and norethisterone enanthate on inv... more Effects of progestogens including medroxyprogesterone acetate and norethisterone enanthate on involution of the uterus and the subsequent changes in the endometrium and myometrium are considered. 231 lactating women at the birth control clinics of Ain Shams University were studied. The women were divided into 2 groups: the first 112 women received an injectable contraceptive on the 7th puerperal day. Of these 68 were given norethisterone enanthate 200 mg every 84 days and the rest were given medroxyprogesterone acetate 150 mg (Depo-Provera) every 3 months. Group 2 with 119 women were divided into 2 groups and given either progestogen the first injection at the 6th postpartum week. These progestogens do not affect uterine involution and the duration of lochia was similar to that of controls. The endometrium passed through successive stages of quiesence preatrophy and a trophy and fibrosis. The latter occurred much more rapidly in those starting injection on the 7th postpartum day. The myometrium revealed fibrosis and reduced vascularity. It is remarkable that in all subjects stopping norethisterone enanthate the endometrium regained its cyclic pattern within 2-6 months. After discontinuing Depo-Provera the endometrium required a longer period (5-9 months) to regain activity. It may be delayed even more than 9 months.
Ain Shams medical journal, 1971
79 multiparous volunteers aged 21-40, at the birth control clinics of Ain Shams University in Cai... more 79 multiparous volunteers aged 21-40, at the birth control clinics of Ain Shams University in Cairo, Egypt chose the injection method as their contraceptive choice and were injected with deladroxate (16,17 dihydroxy progesterone acetaphenide 150 mg and 10 mg estradiol enanthate) for a total of 836 cycles. The preparation proved to be 100% effective. Some other results were: 1) the average cycle length decreased under therapy, 2) amount of flow was not affected, 3) breakthrough bleeding occurred in 3-9% of cases, 4) there was a slight increase in incidence of headache, dizziness, and vaginal discharge, 5) liver function did not change, 6) endometrial biopsies and vaginal smears indicated estrogenic effects, 7) there were no corpora lutea in ovarian biopsies but follicles existed in all stages of maturation, and 8) conception occurred within 5-16 months after discontinuation.
BMJ, 1971
Norethisterone ethanate (200 mg every 84 days) and medroxyprogesterone acetate (150 mg every thre... more Norethisterone ethanate (200 mg every 84 days) and medroxyprogesterone acetate (150 mg every three months) were found to be completely effective in fertility control when started in the puerperium. Neither agent had any ill effect on the amount of milk or the duration of lactation. From the third month onward the three-hourly available milk and the infant weight gain per month were statistically higher in treated groups than in controls. Milk proteins showed a slight decrease in most groups, including the controls, owing to the low-protein diet. No important side effect was produced by these agents other than amenorrhoea.