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Journal of child science, 2024
Scientific Reports
Mutations in KCNQ2 encoding for voltage-gated K channel subunits underlying the neuronal M-curren... more Mutations in KCNQ2 encoding for voltage-gated K channel subunits underlying the neuronal M-current have been associated with infantile-onset epileptic disorders. The clinical spectrum ranges from self-limited neonatal seizures to epileptic encephalopathy and delayed development. Mutations in KCNQ2 could be either gain- or loss-of-function which require different therapeutic approaches. To better understand genotype–phenotype correlation, more reports of patients and their mutations with elucidated molecular mechanism are needed. We studied 104 patients with infantile-onset pharmacoresistant epilepsy who underwent exome or genome sequencing. Nine patients with neonatal-onset seizures from unrelated families were found to harbor pathogenic or likely pathogenic variants in the KCNQ2 gene. The p.(N258K) was recently reported, and p. (G279D) has never been previously reported. Functional effect of p.(N258K) and p.(G279D) has never been previously studied. The cellular localization study ...
Journal of Child Science
Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis has a very good outcome; however, there a... more Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis has a very good outcome; however, there are few reports in developing countries regarding the outcome of pediatric anti-NMDAR encephalitis. We aimed to report the clinical outcome of pediatric anti-NMDAR encephalitis in the rural area of Thailand. This retrospective cohort study recruited children between the age of 1 month and 15 years with the diagnosis of anti-NMDAR encephalitis admitted at Maharat Nakhon Ratchasima Hospital from 1st May 2015 to 31th March 2020. Baseline characteristics and investigation were recorded. The first-line treatment was intravenous pulse methylprednisolone alone, pulse methylprednisolone plus intravenous immune globulin (IVIG), or IVIG alone. The second-line treatment was monthly intravenous cyclophosphamide or azathioprine. The modified Rankin Scale (MRS) was used for evaluation at 1, 3, 6, 12, 18, and 24 months after receiving first-line treatment to determine clinical outcomes. The factors that...
Journal of the Medical Association of Thailand, Oct 1, 2017
The Japanese Society of Child Neurology, Apr 20, 2017
Journal of Pediatric Epilepsy, 2019
Poor drug adherence can lead to poor seizure control in pediatric epilepsy patients. Patients'... more Poor drug adherence can lead to poor seizure control in pediatric epilepsy patients. Patients' knowledge about drug compliance is the cornerstone to improving drug adherence. In the past, several educational programs have involved multidisciplinary teams, including many specialists, who were recruited to spread and improve awareness about good drug adherence; however, there are few studies conducted in a limited resource country. This paper aims to outline a new program created by our clinicians. The epilepsy alert system (EAS) is an accessible educational program for pediatric epilepsy patients and caregivers, which is suitable for limited resource areas and evaluates the benefit of EAS on drug adherence. The EAS consists of a 20-minute-long educational program, co-led by a pediatric neurologist, a pediatrician, and a pharmacist, using simple tools such as an epilepsy diary and an epilepsy card. Epileptic children aged 1 month to 15 years who visited a pediatric epilepsy clinic...
Clinical Neurology and Neurosurgery, 2018
Insufficient of knowledge of epilepsy causes poor drug adherence and seizure control. Leading us ... more Insufficient of knowledge of epilepsy causes poor drug adherence and seizure control. Leading us to create video animation to educate epilepsy patients and caregivers and evaluate the benefit of this video. Patients and methods: The 8.52-min video animation was created to provide fundamental information regarding diagnosis, treatment and drug usage for pediatric epilepsy patients. The impact of this video animation was evaluated in a randomized controlled trial (RCT) study during June-September 2016. One month to 15 year-old epilepsy patients and caregivers were recruited and randomized into 2 groups; group A: receiving advice from the clinician and watching the video animation, group B: only receiving advice from the clinician. A ten-item questionnaires and drug adherence (Morisky Medication Adherence Scales (MMAS-8)) were used to evaluate before/after watching video/receiving advice and at 3 month-follow up. Results: Two hundreds and fourteen epilepsy patients (126 in group A and 88 in group B) were recruited in the study. Before watching video/receiving advice, the mean scores of questionnaires in group A was lower compare with the group B (group A (6.74) and group B (7.38)) but after the video intervention the score of group A significantly rose to 7.42 (immediate after watching video) and to 7.47 scores at 3 month-follow up, while in group B, no significant differences were observed. The comparison of the MMAS-8 in group A showed a significant improvement of drug adherence than the cases in group B. Conclusion: Video animation as a new method of education for epilepsy patients and caregivers, can improve both their knowledge and the drug adherence.
Journal of Child Science, 2018
Introduction Migraine is the most common primary headache in children which leads to disturbance ... more Introduction Migraine is the most common primary headache in children which leads to disturbance of school performance and impaired quality of life. The prevalence of migraine is different between countries and ethnicities; this study determines the prevalence and precipitating factors of migraine in Thailand. Method This cross-sectional school-based study was conducted in Nakhon Ratchasima. The children aged between 12 and 18 years from four secondary schools were selected by stratified randomization method. The screening questionnaire and directed interview with physical examination were done and migraine was diagnosed based on the criteria of International Classification of Headache Disorders III. The prevalence of migraine was identified and baseline characteristic of disease with precipitating factors was evaluated. Results A total of 2,744 students aged between 12 and 18 years (900 males, 1,844 females) were recruited; mean age was 14.3 ± 1.75 years. Fifty-five students were d...
Journal of Child Science, 2018
Gnathostomiasis is a common parasitic infection in Southeast Asia, involving many organs in infec... more Gnathostomiasis is a common parasitic infection in Southeast Asia, involving many organs in infected human hosts. Common neurological manifestations of Gnathostoma infection include radiculomyelitis, eosinophilic meningitis, and nontraumatic subarachnoid hemorrhage, leading to a high mortality and morbidity. This study first reported transient cerebral vasculopathy, an atypical neurological manifestation, in an 11-year-old Thai girl. The patient was diagnosed with intracerebral and intraventricular hemorrhage, and meningitis with atypical cerebrospinal fluid (CSF) profile. The imaging study of the brain revealed the abnormal white matter lesion and transient cerebral vasculopathy with the cerebral hemorrhage showing a track-like appearance (at the level of the corpus callosum). The serological testing in CSF and serum using the enzyme-linked immunosorbent assay (ELISA) technique was positive for Gnathostoma spinigerum. The patient spontaneously recovered within 3 months without albe...
Brain and Development, 2020
Figure 1: We learn the hatching style from a hand-drawn example (left) and use it to synthesize e... more Figure 1: We learn the hatching style from a hand-drawn example (left) and use it to synthesize example-based hatching illustrations (right).
Journal of child science, 2024
Scientific Reports
Mutations in KCNQ2 encoding for voltage-gated K channel subunits underlying the neuronal M-curren... more Mutations in KCNQ2 encoding for voltage-gated K channel subunits underlying the neuronal M-current have been associated with infantile-onset epileptic disorders. The clinical spectrum ranges from self-limited neonatal seizures to epileptic encephalopathy and delayed development. Mutations in KCNQ2 could be either gain- or loss-of-function which require different therapeutic approaches. To better understand genotype–phenotype correlation, more reports of patients and their mutations with elucidated molecular mechanism are needed. We studied 104 patients with infantile-onset pharmacoresistant epilepsy who underwent exome or genome sequencing. Nine patients with neonatal-onset seizures from unrelated families were found to harbor pathogenic or likely pathogenic variants in the KCNQ2 gene. The p.(N258K) was recently reported, and p. (G279D) has never been previously reported. Functional effect of p.(N258K) and p.(G279D) has never been previously studied. The cellular localization study ...
Journal of Child Science
Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis has a very good outcome; however, there a... more Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis has a very good outcome; however, there are few reports in developing countries regarding the outcome of pediatric anti-NMDAR encephalitis. We aimed to report the clinical outcome of pediatric anti-NMDAR encephalitis in the rural area of Thailand. This retrospective cohort study recruited children between the age of 1 month and 15 years with the diagnosis of anti-NMDAR encephalitis admitted at Maharat Nakhon Ratchasima Hospital from 1st May 2015 to 31th March 2020. Baseline characteristics and investigation were recorded. The first-line treatment was intravenous pulse methylprednisolone alone, pulse methylprednisolone plus intravenous immune globulin (IVIG), or IVIG alone. The second-line treatment was monthly intravenous cyclophosphamide or azathioprine. The modified Rankin Scale (MRS) was used for evaluation at 1, 3, 6, 12, 18, and 24 months after receiving first-line treatment to determine clinical outcomes. The factors that...
Journal of the Medical Association of Thailand, Oct 1, 2017
The Japanese Society of Child Neurology, Apr 20, 2017
Journal of Pediatric Epilepsy, 2019
Poor drug adherence can lead to poor seizure control in pediatric epilepsy patients. Patients'... more Poor drug adherence can lead to poor seizure control in pediatric epilepsy patients. Patients' knowledge about drug compliance is the cornerstone to improving drug adherence. In the past, several educational programs have involved multidisciplinary teams, including many specialists, who were recruited to spread and improve awareness about good drug adherence; however, there are few studies conducted in a limited resource country. This paper aims to outline a new program created by our clinicians. The epilepsy alert system (EAS) is an accessible educational program for pediatric epilepsy patients and caregivers, which is suitable for limited resource areas and evaluates the benefit of EAS on drug adherence. The EAS consists of a 20-minute-long educational program, co-led by a pediatric neurologist, a pediatrician, and a pharmacist, using simple tools such as an epilepsy diary and an epilepsy card. Epileptic children aged 1 month to 15 years who visited a pediatric epilepsy clinic...
Clinical Neurology and Neurosurgery, 2018
Insufficient of knowledge of epilepsy causes poor drug adherence and seizure control. Leading us ... more Insufficient of knowledge of epilepsy causes poor drug adherence and seizure control. Leading us to create video animation to educate epilepsy patients and caregivers and evaluate the benefit of this video. Patients and methods: The 8.52-min video animation was created to provide fundamental information regarding diagnosis, treatment and drug usage for pediatric epilepsy patients. The impact of this video animation was evaluated in a randomized controlled trial (RCT) study during June-September 2016. One month to 15 year-old epilepsy patients and caregivers were recruited and randomized into 2 groups; group A: receiving advice from the clinician and watching the video animation, group B: only receiving advice from the clinician. A ten-item questionnaires and drug adherence (Morisky Medication Adherence Scales (MMAS-8)) were used to evaluate before/after watching video/receiving advice and at 3 month-follow up. Results: Two hundreds and fourteen epilepsy patients (126 in group A and 88 in group B) were recruited in the study. Before watching video/receiving advice, the mean scores of questionnaires in group A was lower compare with the group B (group A (6.74) and group B (7.38)) but after the video intervention the score of group A significantly rose to 7.42 (immediate after watching video) and to 7.47 scores at 3 month-follow up, while in group B, no significant differences were observed. The comparison of the MMAS-8 in group A showed a significant improvement of drug adherence than the cases in group B. Conclusion: Video animation as a new method of education for epilepsy patients and caregivers, can improve both their knowledge and the drug adherence.
Journal of Child Science, 2018
Introduction Migraine is the most common primary headache in children which leads to disturbance ... more Introduction Migraine is the most common primary headache in children which leads to disturbance of school performance and impaired quality of life. The prevalence of migraine is different between countries and ethnicities; this study determines the prevalence and precipitating factors of migraine in Thailand. Method This cross-sectional school-based study was conducted in Nakhon Ratchasima. The children aged between 12 and 18 years from four secondary schools were selected by stratified randomization method. The screening questionnaire and directed interview with physical examination were done and migraine was diagnosed based on the criteria of International Classification of Headache Disorders III. The prevalence of migraine was identified and baseline characteristic of disease with precipitating factors was evaluated. Results A total of 2,744 students aged between 12 and 18 years (900 males, 1,844 females) were recruited; mean age was 14.3 ± 1.75 years. Fifty-five students were d...
Journal of Child Science, 2018
Gnathostomiasis is a common parasitic infection in Southeast Asia, involving many organs in infec... more Gnathostomiasis is a common parasitic infection in Southeast Asia, involving many organs in infected human hosts. Common neurological manifestations of Gnathostoma infection include radiculomyelitis, eosinophilic meningitis, and nontraumatic subarachnoid hemorrhage, leading to a high mortality and morbidity. This study first reported transient cerebral vasculopathy, an atypical neurological manifestation, in an 11-year-old Thai girl. The patient was diagnosed with intracerebral and intraventricular hemorrhage, and meningitis with atypical cerebrospinal fluid (CSF) profile. The imaging study of the brain revealed the abnormal white matter lesion and transient cerebral vasculopathy with the cerebral hemorrhage showing a track-like appearance (at the level of the corpus callosum). The serological testing in CSF and serum using the enzyme-linked immunosorbent assay (ELISA) technique was positive for Gnathostoma spinigerum. The patient spontaneously recovered within 3 months without albe...
Brain and Development, 2020
Figure 1: We learn the hatching style from a hand-drawn example (left) and use it to synthesize e... more Figure 1: We learn the hatching style from a hand-drawn example (left) and use it to synthesize example-based hatching illustrations (right).