F. Kaup - Academia.edu (original) (raw)
Papers by F. Kaup
Journal of Medical Primatology, 1994
Following an experimental SIV infection, 11 rhesus monkeys were evaluated to determine the presen... more Following an experimental SIV infection, 11 rhesus monkeys were evaluated to determine the presence of opportunistic infections. Five animals had severe alterations of the hepatobiliary tree, three of which were associated with the presence of numerous Cryptosporidium spp. Subacute to chronic inflammatory changes were observed in the pancreatic ducts of four animals, one without histologic evidence of parasites. In one animal, the inflamed ducts were associated with a chronic interstitial pancreatitis. The rate of Cryptosporidium infection together with hepatic and pancreatic involvement (36%) supports the hypothesis that systemic cryptosporidiosis is the result of a loss of protective mucosal immunity.
Journal of Medical Primatology, 1994
Following an experimental SIV infection, 11 rhesus monkeys were evaluated to determine the presen... more Following an experimental SIV infection, 11 rhesus monkeys were evaluated to determine the presence of opportunistic infections. Five animals had severe alterations of the hepatobiliary tree, three of which were associated with the presence of numerous Cryptosporidium spp. Subacute to chronic inflammatory changes were observed in the pancreatic ducts of four animals, one without histologic evidence of parasites. In one animal, the inflamed ducts were associated with a chronic interstitial pancreatitis. The rate of Cryptosporidium infection together with hepatic and pancreatic involvement (36%) supports the hypothesis that systemic cryptosporidiosis is the result of a loss of protective mucosal immunity.
39th Annual IEEE Conference on Local Computer Networks, 2014
10th International Conference on Network and Service Management (CNSM) and Workshop, 2014
2013 21st IEEE International Conference on Network Protocols (ICNP), 2013
The increased availability and data rates of cellular 3G/4G networks combined with the growing us... more The increased availability and data rates of cellular 3G/4G networks combined with the growing use of mobile applications highly affect the Quality of Experience (QoE) perceived by the end-user. The QoE is affected in two ways: First, the data rates in the networks are low when multiple users simultaneously request content; second, the transmission of data over slow connections consumes a considerable amount of energy compared to faster connections. Both can be avoided by better management of the available resources. This paper proposes a new approach, taking the energy efficiency into account as a key QoE aspect. Based on user mobility models, the available connectivity can be predicted, from which estimates for the energy consumption and expected QoE can be derived. An architecture is sketched, which combines QoE prediction for current and future network connections with energy efficiency on mobile devices.
38th Annual IEEE Conference on Local Computer Networks, 2013
Proceedings of the 6th International Conference on Mobile Computing, Applications and Services, 2014
DTW. Deutsche tierärztliche Wochenschrift, 2002
The term "primates" comprises a varied group of animals, consisting of more than 250 di... more The term "primates" comprises a varied group of animals, consisting of more than 250 different species. The close evolutionary relationship to man resulted in the use of nonhuman primates as subjects of study for scientists from different research fields. In biomedical research the use of primates is restricted to questions which cannot be answered by animals with less developed physiological senses. Primates play an important role in infectious disease research, as many pathogens relevant to humans can be transferred to selected primate species. In the last few decades this applied especially for HIV-infections of man, viral hepatitides, herpesvirus infections and for quite a long time for agents of transmissible spongiform encephalopathies, too. In neurobiology, primates play an outstanding role due to the morphological-structural and functional resemblance of their CNS to that of man. Due to new developments in biomedicine, in particular in the field of gene therapeutic...
Experimental pathology, 1990
Epidemiological study of 340 Golden hamsters and 200 European hamsters bred as laboratory animals... more Epidemiological study of 340 Golden hamsters and 200 European hamsters bred as laboratory animals and necropsied between 1985 and 1989 in our facility (affiliation 2) revealed high incidence of spontaneous cysts. The incidence was in general higher in European (26 to 62%) than Golden hamsters (0 to 15%). The cysts, of different sizes, were localized first of all in the liver, and secondly (in European hamsters only), in the caecum wall. Light microscopic and electron microscopic examinations showed that the cysts are lined by flattened to cuboidal epithelial cells which, on their surface, have microvilli of different lengths and underneath a continuous basement membrane. These examinations lead further to the interpretation of the liver cysts as cystic distensions of the bile ducts. The cysts in the caecum wall could be interpreted as dilatations of the lymphatic vessels. As to the etiology, which remains unclear, several hypotheses are discussed.
Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B, 1983
Zentralblatt für Veterinärmedizin Reihe B, 1983
ABSTRACT ZusammenfassungAus einem extensiv gehaltenem Wassergeflügelbestand konnte ein Virus isol... more ABSTRACT ZusammenfassungAus einem extensiv gehaltenem Wassergeflügelbestand konnte ein Virus isoliert werden, das sich aufgrund seiner physikalisch-chemischen Eigenschaften sowie seiner Morphologie als aviäres Herpesvirus erwies. Die Ergebnisse der Kreuzneutralisationsteste belegen eine serologische Verwandtschaft mit einem bekannten Entenpestvirus, nicht aber mit anderen aviären Herpesviren. Ein Übertragungsversuch auf Flugenten ergab, daß es sich um virulentes Virus handelt.SummaryDuck plague among water birdsFrom an extensively maintained water bird premises a virus was isolated which on the basis of its physico-chemical properties and its morphology was found to be an avian herpes virus. The results of cross-neutralization tests indicated a serological relationship with a known duck plague virus but not with other avian herpes viruses. A transmission attempt with ducks showed that the virus was virulent.RésuméPeste du canard dans un élevage d'oiseaux aquatiquesOn a isolé un virus dans une exploitation extensive d'oiseaux aquatiques. Ce virus s'est révélé être un virus Herpes aviaire sur la base de ses propriétés physico-chimiques et sa morphologie. Les résultats des tests de neutralisation croisée ont correspondu à une parenté sérologique avec un virus connu de la peste du canard, mais pas avec d'autres virus Herpes aviaires. Un essai de transmission sur des canards a révélé qu'il s'agissait d'un virus virulent.ResumenPeste de los ánades en un efectivo de palmípedasDe un efectivo de aves acuáticas, criadas en régimen extensivo, se logró aislar un virus, el cual se reveló como un virus herpético aviar a la vista de sus propiedades físicoquímicas y de sus rasgos morfológicos. Los resultados de las pruebas de neutralización cruzada documentan el parentesco serológico con un virus peste de pato, conocido, mas no con otros virus herpéticos aviares. Un ensayo de transmisión a patos voladores tuvo como resultado el que se trata de un virus virulento.
Journal of Veterinary Medicine, Series B, 2000
Eight monoclonal antibodies (MAbs) were tested for the use in immunogold staining of Sindbis viru... more Eight monoclonal antibodies (MAbs) were tested for the use in immunogold staining of Sindbis virus (SIN) antigen in cultured Baby Hamster kidney (BHK) cells. The antibodies were directed against the capsid (C) protein (5) or against the glycoprotein E1 (3), respectively. Four out of five anti-C MAbs and two out of three anti-E1 Mabs reacted on frozen sections, whereas two of the anti-C antibodies and none of the anti-E1 antibodies reacted on Lowicryl K4M-embedded cells. The MAbs reacting, in particular the anti-C Mabs which react on Lowicryl K4M-sections, will allow further studies of the pathogenesis and replication of alphaviruses on the cellular level. The results also confirm the conformation-dependence of the glycoprotein epitopes.
Veterinary Record, 1995
The clinical findings, and urinary and morphological changes in the urinary bladder were investig... more The clinical findings, and urinary and morphological changes in the urinary bladder were investigated in 25 sows with a urinary tract infection. Eubacterium suis was isolated from 12 of the sows but not from the other 13. The clinical signs did not always correlate with the morphological changes. The only clinical sign indicating the beginning of cystitis appeared to be a significant bacteriuria. Other urinary changes occurred later when the inflammatory processes were more severe. In contrast with cystitis due to other bacteria, infection with E suis frequently resulted in a macrohaematuria and urinary pH values above 8.0. However, the light and electron microscopical findings in the bladder mucosa were similar in the sows with and without cystitis due to E suis. The transformation of goblet cells and the development of mucin cysts were probably due to the local bladder defence mechanisms. More severe lesions were observed with E suis infections, which resulted in changes in the ureterovesical junctions and in ascending renal infection and uraemia.
Diseases of Aquatic Organisms, 1994
Veterinary pathology, 1999
Although Mycobacterium simiae was identified and classified more than three decades ago, only a f... more Although Mycobacterium simiae was identified and classified more than three decades ago, only a few cases are mentioned in the current literature. After experimental simian immunodeficiency virus infection, a 9-year-old female rhesus monkey (Macaca mulatta) developed progressive immunosuppression and gastrointestinal disease very similar to the clinical and pathomorphologic features of Johne's disease, which is caused by M. paratuberculosis. Acid-fast-positive bacteria reacted immunohistochemically with antibodies against M. paratuberculosis and M. bovis but were not useful for differentiation because of a high degree of cross-reactivity. In contrast to immunohistochemistry and histopathology, biochemical methods and cycle sequencing analysis of the 16S ribosomal RNA identified M. simiae as the disease-causing pathogen. This case demonstrates the importance of molecular biological methods for the diagnosis of M. simiae infection in monkeys.
Journal of Medical Primatology, 1994
Following an experimental SIV infection, 11 rhesus monkeys were evaluated to determine the presen... more Following an experimental SIV infection, 11 rhesus monkeys were evaluated to determine the presence of opportunistic infections. Five animals had severe alterations of the hepatobiliary tree, three of which were associated with the presence of numerous Cryptosporidium spp. Subacute to chronic inflammatory changes were observed in the pancreatic ducts of four animals, one without histologic evidence of parasites. In one animal, the inflamed ducts were associated with a chronic interstitial pancreatitis. The rate of Cryptosporidium infection together with hepatic and pancreatic involvement (36%) supports the hypothesis that systemic cryptosporidiosis is the result of a loss of protective mucosal immunity.
Journal of Medical Primatology, 1994
Following an experimental SIV infection, 11 rhesus monkeys were evaluated to determine the presen... more Following an experimental SIV infection, 11 rhesus monkeys were evaluated to determine the presence of opportunistic infections. Five animals had severe alterations of the hepatobiliary tree, three of which were associated with the presence of numerous Cryptosporidium spp. Subacute to chronic inflammatory changes were observed in the pancreatic ducts of four animals, one without histologic evidence of parasites. In one animal, the inflamed ducts were associated with a chronic interstitial pancreatitis. The rate of Cryptosporidium infection together with hepatic and pancreatic involvement (36%) supports the hypothesis that systemic cryptosporidiosis is the result of a loss of protective mucosal immunity.
39th Annual IEEE Conference on Local Computer Networks, 2014
10th International Conference on Network and Service Management (CNSM) and Workshop, 2014
2013 21st IEEE International Conference on Network Protocols (ICNP), 2013
The increased availability and data rates of cellular 3G/4G networks combined with the growing us... more The increased availability and data rates of cellular 3G/4G networks combined with the growing use of mobile applications highly affect the Quality of Experience (QoE) perceived by the end-user. The QoE is affected in two ways: First, the data rates in the networks are low when multiple users simultaneously request content; second, the transmission of data over slow connections consumes a considerable amount of energy compared to faster connections. Both can be avoided by better management of the available resources. This paper proposes a new approach, taking the energy efficiency into account as a key QoE aspect. Based on user mobility models, the available connectivity can be predicted, from which estimates for the energy consumption and expected QoE can be derived. An architecture is sketched, which combines QoE prediction for current and future network connections with energy efficiency on mobile devices.
38th Annual IEEE Conference on Local Computer Networks, 2013
Proceedings of the 6th International Conference on Mobile Computing, Applications and Services, 2014
DTW. Deutsche tierärztliche Wochenschrift, 2002
The term "primates" comprises a varied group of animals, consisting of more than 250 di... more The term "primates" comprises a varied group of animals, consisting of more than 250 different species. The close evolutionary relationship to man resulted in the use of nonhuman primates as subjects of study for scientists from different research fields. In biomedical research the use of primates is restricted to questions which cannot be answered by animals with less developed physiological senses. Primates play an important role in infectious disease research, as many pathogens relevant to humans can be transferred to selected primate species. In the last few decades this applied especially for HIV-infections of man, viral hepatitides, herpesvirus infections and for quite a long time for agents of transmissible spongiform encephalopathies, too. In neurobiology, primates play an outstanding role due to the morphological-structural and functional resemblance of their CNS to that of man. Due to new developments in biomedicine, in particular in the field of gene therapeutic...
Experimental pathology, 1990
Epidemiological study of 340 Golden hamsters and 200 European hamsters bred as laboratory animals... more Epidemiological study of 340 Golden hamsters and 200 European hamsters bred as laboratory animals and necropsied between 1985 and 1989 in our facility (affiliation 2) revealed high incidence of spontaneous cysts. The incidence was in general higher in European (26 to 62%) than Golden hamsters (0 to 15%). The cysts, of different sizes, were localized first of all in the liver, and secondly (in European hamsters only), in the caecum wall. Light microscopic and electron microscopic examinations showed that the cysts are lined by flattened to cuboidal epithelial cells which, on their surface, have microvilli of different lengths and underneath a continuous basement membrane. These examinations lead further to the interpretation of the liver cysts as cystic distensions of the bile ducts. The cysts in the caecum wall could be interpreted as dilatations of the lymphatic vessels. As to the etiology, which remains unclear, several hypotheses are discussed.
Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B, 1983
Zentralblatt für Veterinärmedizin Reihe B, 1983
ABSTRACT ZusammenfassungAus einem extensiv gehaltenem Wassergeflügelbestand konnte ein Virus isol... more ABSTRACT ZusammenfassungAus einem extensiv gehaltenem Wassergeflügelbestand konnte ein Virus isoliert werden, das sich aufgrund seiner physikalisch-chemischen Eigenschaften sowie seiner Morphologie als aviäres Herpesvirus erwies. Die Ergebnisse der Kreuzneutralisationsteste belegen eine serologische Verwandtschaft mit einem bekannten Entenpestvirus, nicht aber mit anderen aviären Herpesviren. Ein Übertragungsversuch auf Flugenten ergab, daß es sich um virulentes Virus handelt.SummaryDuck plague among water birdsFrom an extensively maintained water bird premises a virus was isolated which on the basis of its physico-chemical properties and its morphology was found to be an avian herpes virus. The results of cross-neutralization tests indicated a serological relationship with a known duck plague virus but not with other avian herpes viruses. A transmission attempt with ducks showed that the virus was virulent.RésuméPeste du canard dans un élevage d'oiseaux aquatiquesOn a isolé un virus dans une exploitation extensive d'oiseaux aquatiques. Ce virus s'est révélé être un virus Herpes aviaire sur la base de ses propriétés physico-chimiques et sa morphologie. Les résultats des tests de neutralisation croisée ont correspondu à une parenté sérologique avec un virus connu de la peste du canard, mais pas avec d'autres virus Herpes aviaires. Un essai de transmission sur des canards a révélé qu'il s'agissait d'un virus virulent.ResumenPeste de los ánades en un efectivo de palmípedasDe un efectivo de aves acuáticas, criadas en régimen extensivo, se logró aislar un virus, el cual se reveló como un virus herpético aviar a la vista de sus propiedades físicoquímicas y de sus rasgos morfológicos. Los resultados de las pruebas de neutralización cruzada documentan el parentesco serológico con un virus peste de pato, conocido, mas no con otros virus herpéticos aviares. Un ensayo de transmisión a patos voladores tuvo como resultado el que se trata de un virus virulento.
Journal of Veterinary Medicine, Series B, 2000
Eight monoclonal antibodies (MAbs) were tested for the use in immunogold staining of Sindbis viru... more Eight monoclonal antibodies (MAbs) were tested for the use in immunogold staining of Sindbis virus (SIN) antigen in cultured Baby Hamster kidney (BHK) cells. The antibodies were directed against the capsid (C) protein (5) or against the glycoprotein E1 (3), respectively. Four out of five anti-C MAbs and two out of three anti-E1 Mabs reacted on frozen sections, whereas two of the anti-C antibodies and none of the anti-E1 antibodies reacted on Lowicryl K4M-embedded cells. The MAbs reacting, in particular the anti-C Mabs which react on Lowicryl K4M-sections, will allow further studies of the pathogenesis and replication of alphaviruses on the cellular level. The results also confirm the conformation-dependence of the glycoprotein epitopes.
Veterinary Record, 1995
The clinical findings, and urinary and morphological changes in the urinary bladder were investig... more The clinical findings, and urinary and morphological changes in the urinary bladder were investigated in 25 sows with a urinary tract infection. Eubacterium suis was isolated from 12 of the sows but not from the other 13. The clinical signs did not always correlate with the morphological changes. The only clinical sign indicating the beginning of cystitis appeared to be a significant bacteriuria. Other urinary changes occurred later when the inflammatory processes were more severe. In contrast with cystitis due to other bacteria, infection with E suis frequently resulted in a macrohaematuria and urinary pH values above 8.0. However, the light and electron microscopical findings in the bladder mucosa were similar in the sows with and without cystitis due to E suis. The transformation of goblet cells and the development of mucin cysts were probably due to the local bladder defence mechanisms. More severe lesions were observed with E suis infections, which resulted in changes in the ureterovesical junctions and in ascending renal infection and uraemia.
Diseases of Aquatic Organisms, 1994
Veterinary pathology, 1999
Although Mycobacterium simiae was identified and classified more than three decades ago, only a f... more Although Mycobacterium simiae was identified and classified more than three decades ago, only a few cases are mentioned in the current literature. After experimental simian immunodeficiency virus infection, a 9-year-old female rhesus monkey (Macaca mulatta) developed progressive immunosuppression and gastrointestinal disease very similar to the clinical and pathomorphologic features of Johne's disease, which is caused by M. paratuberculosis. Acid-fast-positive bacteria reacted immunohistochemically with antibodies against M. paratuberculosis and M. bovis but were not useful for differentiation because of a high degree of cross-reactivity. In contrast to immunohistochemistry and histopathology, biochemical methods and cycle sequencing analysis of the 16S ribosomal RNA identified M. simiae as the disease-causing pathogen. This case demonstrates the importance of molecular biological methods for the diagnosis of M. simiae infection in monkeys.