For-Wey Lung - Academia.edu (original) (raw)

Papers by For-Wey Lung

Research paper thumbnail of Early predictors of poor treatment response in patients with schizophrenia treated with atypical antipsychotics

BMC Psychiatry, Dec 1, 2018

Research paper thumbnail of The association of change in serum cholesterol levels and clinical treatment response in patients with schizophrenia: a prospective, randomized and open-label study

Research paper thumbnail of Outcomes at late childhood of Chinese-speaking preschoolers with developmental language disorders comorbid with behavioral-emotional

DOAJ (DOAJ: Directory of Open Access Journals), 2014

Research paper thumbnail of Adolescent psychotic-like experience in a national birth cohort study

Asian Journal of Psychiatry, Mar 1, 2023

Research paper thumbnail of Religion and the Mediating Role of Alexithymia in the Mental Distress of Healthcare Workers During the Coronavirus Disease 2019 Pandemic in a Psychiatric Hospital in China

Frontiers in Psychiatry, Apr 25, 2022

Research paper thumbnail of Lipids in Health and Disease

Research paper thumbnail of Personality Characteristics, Treatment Satisfaction, and the Adherence of Patients with Chronic Pain

臺灣精神醫學, Mar 1, 2017

目的：人格會影響人們對問題的看法以及問題解決的風格，進而影響他們的求醫行為和結果。本研究的目的是探討慢性疼痛病患雙親依附、人格特質和求醫行為間的關係。方法：共有86 位（82.6% 男性，平均年... more 目的：人格會影響人們對問題的看法以及問題解決的風格，進而影響他們的求醫行為和結果。本研究的目的是探討慢性疼痛病患雙親依附、人格特質和求醫行為間的關係。方法：共有86 位（82.6% 男性，平均年齡30.02 歲）由慢性疼痛門診，排除有精神診斷的病人完成所有的問卷。問卷包含治療滿意度問卷、雙親教養態度量表 (Parental Bonding Inventory) 及艾氏人格問卷 (Eysenck Personality Inventory)。結果：感覺母親顯著的比較關懷的病人比較外向(β = 0.27, p ＜ 0.001)。顯著的比較外向的人比較有可能覺得治療有幫助 (β = 0.33, p ＜ 0.001)，並且對治療感到滿意 (β = 0.36, p ＜ 0.001)，而會顯著的影響他們再次接受治療的意願 (β =0.33, p ＜ 0.001)。覺得治療有幫助是為母親關懷、神經質及願意再接受治療顯著的中介因素 (β= 0.39, p ＜ 0.001)。年紀是重要的影響因素，年紀比較大的人顯著的比較可能覺得治療有幫助(β = 0.26, p ＜ 0.001)，並且顯著的感到滿意 (β = 0.38, p ＜ 0.001)，進而增加他們再次接受治療的意願。性別對求醫行為並沒有顯著的影響。結論：母親依附和人格特質是病人順從性的遠因；病人滿意度或再次願意接受治療的意願是近因。醫師或政策制定者可以使用本研究結果來促進慢性疼痛病患的治療效用及效率。進一步的研究必須瞭解不同族群的順從風格，以建立完整且具理論基礎的治療。

Research paper thumbnail of Adherence Analysis of Couples with Violence Completing Marital Therapy

臺灣精神醫學, Dec 1, 2013

Objectives: This study was intended to study the predictive factors of adherence to and completio... more Objectives: This study was intended to study the predictive factors of adherence to and completion of marital therapy of couples with intimate partner violence. Methods: The participants in this study were 70 couples with husband-initiated aggression against their wives, and who attended a study evaluating the effectiveness of ordinary psychiatric treatment. We analyzed variables such as social status, clinical factors, intimate partner violence, and marital power, to identify the predictive factors of adherence to marital therapy, and the cause-and-effect relation between those variables. Results: The result of the survival analysis showed that wife with higher income (p ＜ 0.05), later age of onset for intimate partner violence, lower frequency of mild violence, and husband with more affection predicted the adherence of couples to marital therapy (p ＜ 0.001). Structural equation modeling further revealed that a husband with more years of education had direct positive effects on a couple's adherence to marital therapy, husband's age had indirect positive effects, and high frequency of mild violence had direct negative effects on the couples' completing marital therapy. In short, husbands who were younger in age, with frequent mild violence, and with lower academic achievement had difficulty adhering to marital therapy. Conclusion: The results of this study can increase our understanding of intimate partner violence, provide intervention strategies for family domestic violence prevention and augment the quality of services.

Research paper thumbnail of Association between Interleukin-10 Gene Promoter Haplotype and Schizophrenia in a Han-Chinese Study

PubMed, Sep 1, 2008

Schizophrenia is a multi-factorial genetic disease, and it is caused by a combination of differen... more Schizophrenia is a multi-factorial genetic disease, and it is caused by a combination of different gene polymorphisms and not individual ones, however, its pathogenesis is still unclear. The purpose of this study was explored the association between the -1082G/A, -819T/C, and -592C/A polymorphisms of interleukin-10 (IL-10) in schizophrenia. A total of 659 schizophrenics were recruited from a teaching hospital, whereas 411 healthy non-schizophrenic individuals were recruited from community in the same geographical area. The -1082G/A, -819T/C and -592C/A polymorphisms were genotyped by using PCR-RFLP, direct sequencing and TaqMan(®) SNP assay. Both maximum likelihood method of UNPHASED program and Bayesian method of PHASE software were utilized for haplotypic analysis. An allelic frequency difference was found between the schizophrenics and community controls at -1082G/A polymorphism of IL-10 promoter (χ(2) =4.678, P=0.031). A haplotype of ACA was observed to be associated with schizophrenia after performing UNPHASED, PHASE and multivariate logistic regression analysis (P<0.001; P=0.001). In addition, the persons who carry haplotype ACA of IL-10 promoter SNPs were estimated for 5.789 fold higher risk to develop schizophrenia than controls. We postulated this haplotype association might due to variant-specific effect on IL-10 gene regulation, which leads to imbalance secretion of Th1/Th2 cytokines. Nevertheless, more detailed mechanism needs to be elucidated in further investigations in order to confirm this hypothesis.

Research paper thumbnail of Apolipoprotein E polymorphism and Alzheimer's disease

PubMed, Apr 1, 2001

We aimed to determine the association and related factors of the apolipoprotein E (ApoE) genotype... more We aimed to determine the association and related factors of the apolipoprotein E (ApoE) genotype and Alzheimer's disease (AD) in Taiwan. We examined ApoE genotypes in 50 Chinese patients with AD and 50 age- and sex-matched controls. The patients met the criteria of probable AD of the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) and AD of the Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM-IV). There were 28 females and 22 males in the case and control groups. The mean age of onset of AD was 72. 62 years. The average interval between onset and research was 3.85 years. The frequency of ApoE epsilon 4 in the AD group was significantly higher than that in the controls (0.13 versus 0.02, p < 0.05). The odds ratio for AD in individuals with at least one ApoE epsilon 4 allele was 6.0 (95% CI 1.34 to 55.3, p < 0.001). The linear trend for AD in proportion to alleles of ApoE epsilon 4 was significant (chi 2 = 8.3, p = 0.004). The risk of ApoE epsilon 4 allele for the late-onset AD patients, males, or those who received less education was higher than that for the early-onset AD patients, females, or those who had received more education. The sensitivity of the epsilon 4 allele was 24%, the specificity 96%, the positive predictive value 86%, and the negative predictive value 56%. Our results supported that the ApoE epsilon 4 allele is related to AD in Taiwan. In addition, sex and education may play important roles in the presence of ApoE epsilon 4 allele. The epsilon 4 allele seemed helpful as an adjunct for diagnostic testing of AD.

Research paper thumbnail of Personality and Alexithymic Disparity in Obsessive-Compulsive Disorder Based on Washing and Checking

Psychiatric Quarterly, Oct 17, 2017

Research paper thumbnail of Anxiety in Predicting Suicide-Related Symptom of Typhoon Disaster Victims: A One-Year Follow-Up Study in Southern Taiwan

Psychiatric Quarterly, Mar 16, 2012

Research paper thumbnail of Personality disparity in chronic regional and widespread pain

Psychiatry Research-neuroimaging, Aug 1, 2017

Research paper thumbnail of The mental health in mothers with autistic children: a case-control study in southern Taiwan

PubMed, Jun 1, 2000

The aim of this study was to investigate the impact of autistic children on the mental health of ... more The aim of this study was to investigate the impact of autistic children on the mental health of their mothers. Autism is a complicated neuropsychiatric disorder. Evidence shows that mothers with autistic children experience greater stress than those having children with other chronic diseases. In this study we have 1) assessed the mental health of mothers with autistic children; 2) determined their prevalence of minor psychiatric morbidity (MPM); 3) classified their MPM; and 4) determined factors related to their mental health. A case-controlled design was used to compare the mental status among mothers having children with either autistic (n = 30), or Down syndrome (n = 11) and with normal children (n = 56). The mean score of the Chinese Health Questionnaire (CHQ) showed no differences between those mothers of case and control groups. Using a 9-point criterion to screen for MPM in the CHQ, more mothers (37%) in the case group had scores > or = 9 compared with the control group (18%). Mothers of the case group had significantly higher for MPM using logistic regression analysis. The educational level was inversely related to the CHQ scores. Mothers with a CHQ score > or = 9, were later diagnosed with either depression (36%) and anxiety (46%); or anxiety and depression (9%). A primary care model for mothers with autistic children should therefore be developed to prevent them from developing mental disorders.

Research paper thumbnail of Personality and emotional response in schizophrenics with persistent auditory hallucination

European Psychiatry, Oct 1, 2009

Research paper thumbnail of Taiwan Birth Cohort Study-Developmental Instrument; 8-Year Old Scale

Research paper thumbnail of To Be Renaming the Term of "Schizophrenia"? The Question of "to Be" or "Not to Be

Research paper thumbnail of Monoamine Oxidase a Polymorphism, Gender, and Smoking as Predictors for Treatment Respose in Olanzapine-treated patients with Schizophrenia

臺灣精神醫學, Dec 1, 2010

Objective: The aim of this study was to explore the treatment effect of olanzapine on the polymor... more Objective: The aim of this study was to explore the treatment effect of olanzapine on the polymorphisms of monoamine oxidase A (MAOA) in schizophrenia. Method: During a 3-month period, 60 patients with schizophrenia were administered olanzapine. Treatment response was assessed by checking for improvement in symptoms as measured on the Positive and Negative Syndrome Scale (PANSS). Results: The short form of MAOA demonstrated a better drug response in the dimension of aggression. Female patients had a better response to olanzapine. Patients who did not smoke had a better response to olanzapine in the dimension of aggression. Conclusion: The results of this study suggest that polymorphisms of MAOA, gender, and cigarette smoking may be three useful response predictors in schizophrenic patients who were treated with olanzapine.

Research paper thumbnail of The Influence of Recruitment Training on Serum Lipid Shifts

Military Medicine, Dec 1, 2004

Research paper thumbnail of Diathesis, Psychopathology, Resilience, and Suicidality

臺灣精神醫學, Sep 1, 2013

Suicide is one of the serious public health problems worldwide. Moreover, suicidal ideation seems... more Suicide is one of the serious public health problems worldwide. Moreover, suicidal ideation seems as a risk factor for attempted and completed suicidal behaviors. It seems that number of different proximal precipitating and distal predisposing risk factors, which include genetic backgrounds, personal characteristics, parental attachment and mental health problems, are associated with increased rates of suicide. The pathway from genes to mental health problems and suicidal behavior are complex and probabilistic. The aim of this overview is to provide a clear protocol for genetics, diathesis, psychopathology, and resilience in suicidal behavior. In this review article, I will assess relevant research articles dealing with direct and deterministic ways from genetic backgrounds, personal characteristics, mental health to suicidality (ideation, plans, attempts and completions) in structural equation modeling. Combining with my own data, I also explored the natural course of the path effect, current effect, and the regression in each contributing factor, using structural equation modeling. I first introduce the concept of stress-diathesis of suicide; then, discuss the relationship between genetics, gene-environment interactions, parental bonding, personality characteristics, and resilience in suicidality. Issues associated with the relationship between genetic backgrounds, parental bonding, personality characteristics and resilience, and its interaction between nature and nurture in suicidality, have not yet settled. But these research findings should improve understanding of the critical ingredients and their differential impact on various at-risk subgroups, and help with effective prevention and intervention in the future.

Research paper thumbnail of Early predictors of poor treatment response in patients with schizophrenia treated with atypical antipsychotics

BMC Psychiatry, Dec 1, 2018

Research paper thumbnail of The association of change in serum cholesterol levels and clinical treatment response in patients with schizophrenia: a prospective, randomized and open-label study

Research paper thumbnail of Outcomes at late childhood of Chinese-speaking preschoolers with developmental language disorders comorbid with behavioral-emotional

DOAJ (DOAJ: Directory of Open Access Journals), 2014

Research paper thumbnail of Adolescent psychotic-like experience in a national birth cohort study

Asian Journal of Psychiatry, Mar 1, 2023

Research paper thumbnail of Religion and the Mediating Role of Alexithymia in the Mental Distress of Healthcare Workers During the Coronavirus Disease 2019 Pandemic in a Psychiatric Hospital in China

Frontiers in Psychiatry, Apr 25, 2022

Research paper thumbnail of Lipids in Health and Disease

Research paper thumbnail of Personality Characteristics, Treatment Satisfaction, and the Adherence of Patients with Chronic Pain

臺灣精神醫學, Mar 1, 2017

目的：人格會影響人們對問題的看法以及問題解決的風格，進而影響他們的求醫行為和結果。本研究的目的是探討慢性疼痛病患雙親依附、人格特質和求醫行為間的關係。方法：共有86 位（82.6% 男性，平均年... more 目的：人格會影響人們對問題的看法以及問題解決的風格，進而影響他們的求醫行為和結果。本研究的目的是探討慢性疼痛病患雙親依附、人格特質和求醫行為間的關係。方法：共有86 位（82.6% 男性，平均年齡30.02 歲）由慢性疼痛門診，排除有精神診斷的病人完成所有的問卷。問卷包含治療滿意度問卷、雙親教養態度量表 (Parental Bonding Inventory) 及艾氏人格問卷 (Eysenck Personality Inventory)。結果：感覺母親顯著的比較關懷的病人比較外向(β = 0.27, p ＜ 0.001)。顯著的比較外向的人比較有可能覺得治療有幫助 (β = 0.33, p ＜ 0.001)，並且對治療感到滿意 (β = 0.36, p ＜ 0.001)，而會顯著的影響他們再次接受治療的意願 (β =0.33, p ＜ 0.001)。覺得治療有幫助是為母親關懷、神經質及願意再接受治療顯著的中介因素 (β= 0.39, p ＜ 0.001)。年紀是重要的影響因素，年紀比較大的人顯著的比較可能覺得治療有幫助(β = 0.26, p ＜ 0.001)，並且顯著的感到滿意 (β = 0.38, p ＜ 0.001)，進而增加他們再次接受治療的意願。性別對求醫行為並沒有顯著的影響。結論：母親依附和人格特質是病人順從性的遠因；病人滿意度或再次願意接受治療的意願是近因。醫師或政策制定者可以使用本研究結果來促進慢性疼痛病患的治療效用及效率。進一步的研究必須瞭解不同族群的順從風格，以建立完整且具理論基礎的治療。

Research paper thumbnail of Adherence Analysis of Couples with Violence Completing Marital Therapy

臺灣精神醫學, Dec 1, 2013

Objectives: This study was intended to study the predictive factors of adherence to and completio... more Objectives: This study was intended to study the predictive factors of adherence to and completion of marital therapy of couples with intimate partner violence. Methods: The participants in this study were 70 couples with husband-initiated aggression against their wives, and who attended a study evaluating the effectiveness of ordinary psychiatric treatment. We analyzed variables such as social status, clinical factors, intimate partner violence, and marital power, to identify the predictive factors of adherence to marital therapy, and the cause-and-effect relation between those variables. Results: The result of the survival analysis showed that wife with higher income (p ＜ 0.05), later age of onset for intimate partner violence, lower frequency of mild violence, and husband with more affection predicted the adherence of couples to marital therapy (p ＜ 0.001). Structural equation modeling further revealed that a husband with more years of education had direct positive effects on a couple's adherence to marital therapy, husband's age had indirect positive effects, and high frequency of mild violence had direct negative effects on the couples' completing marital therapy. In short, husbands who were younger in age, with frequent mild violence, and with lower academic achievement had difficulty adhering to marital therapy. Conclusion: The results of this study can increase our understanding of intimate partner violence, provide intervention strategies for family domestic violence prevention and augment the quality of services.

Research paper thumbnail of Association between Interleukin-10 Gene Promoter Haplotype and Schizophrenia in a Han-Chinese Study

PubMed, Sep 1, 2008

Schizophrenia is a multi-factorial genetic disease, and it is caused by a combination of differen... more Schizophrenia is a multi-factorial genetic disease, and it is caused by a combination of different gene polymorphisms and not individual ones, however, its pathogenesis is still unclear. The purpose of this study was explored the association between the -1082G/A, -819T/C, and -592C/A polymorphisms of interleukin-10 (IL-10) in schizophrenia. A total of 659 schizophrenics were recruited from a teaching hospital, whereas 411 healthy non-schizophrenic individuals were recruited from community in the same geographical area. The -1082G/A, -819T/C and -592C/A polymorphisms were genotyped by using PCR-RFLP, direct sequencing and TaqMan(®) SNP assay. Both maximum likelihood method of UNPHASED program and Bayesian method of PHASE software were utilized for haplotypic analysis. An allelic frequency difference was found between the schizophrenics and community controls at -1082G/A polymorphism of IL-10 promoter (χ(2) =4.678, P=0.031). A haplotype of ACA was observed to be associated with schizophrenia after performing UNPHASED, PHASE and multivariate logistic regression analysis (P<0.001; P=0.001). In addition, the persons who carry haplotype ACA of IL-10 promoter SNPs were estimated for 5.789 fold higher risk to develop schizophrenia than controls. We postulated this haplotype association might due to variant-specific effect on IL-10 gene regulation, which leads to imbalance secretion of Th1/Th2 cytokines. Nevertheless, more detailed mechanism needs to be elucidated in further investigations in order to confirm this hypothesis.

Research paper thumbnail of Apolipoprotein E polymorphism and Alzheimer's disease

PubMed, Apr 1, 2001

We aimed to determine the association and related factors of the apolipoprotein E (ApoE) genotype... more We aimed to determine the association and related factors of the apolipoprotein E (ApoE) genotype and Alzheimer's disease (AD) in Taiwan. We examined ApoE genotypes in 50 Chinese patients with AD and 50 age- and sex-matched controls. The patients met the criteria of probable AD of the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) and AD of the Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM-IV). There were 28 females and 22 males in the case and control groups. The mean age of onset of AD was 72. 62 years. The average interval between onset and research was 3.85 years. The frequency of ApoE epsilon 4 in the AD group was significantly higher than that in the controls (0.13 versus 0.02, p < 0.05). The odds ratio for AD in individuals with at least one ApoE epsilon 4 allele was 6.0 (95% CI 1.34 to 55.3, p < 0.001). The linear trend for AD in proportion to alleles of ApoE epsilon 4 was significant (chi 2 = 8.3, p = 0.004). The risk of ApoE epsilon 4 allele for the late-onset AD patients, males, or those who received less education was higher than that for the early-onset AD patients, females, or those who had received more education. The sensitivity of the epsilon 4 allele was 24%, the specificity 96%, the positive predictive value 86%, and the negative predictive value 56%. Our results supported that the ApoE epsilon 4 allele is related to AD in Taiwan. In addition, sex and education may play important roles in the presence of ApoE epsilon 4 allele. The epsilon 4 allele seemed helpful as an adjunct for diagnostic testing of AD.

Research paper thumbnail of Personality and Alexithymic Disparity in Obsessive-Compulsive Disorder Based on Washing and Checking

Psychiatric Quarterly, Oct 17, 2017

Research paper thumbnail of Anxiety in Predicting Suicide-Related Symptom of Typhoon Disaster Victims: A One-Year Follow-Up Study in Southern Taiwan

Psychiatric Quarterly, Mar 16, 2012

Research paper thumbnail of Personality disparity in chronic regional and widespread pain

Psychiatry Research-neuroimaging, Aug 1, 2017

Research paper thumbnail of The mental health in mothers with autistic children: a case-control study in southern Taiwan

PubMed, Jun 1, 2000

The aim of this study was to investigate the impact of autistic children on the mental health of ... more The aim of this study was to investigate the impact of autistic children on the mental health of their mothers. Autism is a complicated neuropsychiatric disorder. Evidence shows that mothers with autistic children experience greater stress than those having children with other chronic diseases. In this study we have 1) assessed the mental health of mothers with autistic children; 2) determined their prevalence of minor psychiatric morbidity (MPM); 3) classified their MPM; and 4) determined factors related to their mental health. A case-controlled design was used to compare the mental status among mothers having children with either autistic (n = 30), or Down syndrome (n = 11) and with normal children (n = 56). The mean score of the Chinese Health Questionnaire (CHQ) showed no differences between those mothers of case and control groups. Using a 9-point criterion to screen for MPM in the CHQ, more mothers (37%) in the case group had scores > or = 9 compared with the control group (18%). Mothers of the case group had significantly higher for MPM using logistic regression analysis. The educational level was inversely related to the CHQ scores. Mothers with a CHQ score > or = 9, were later diagnosed with either depression (36%) and anxiety (46%); or anxiety and depression (9%). A primary care model for mothers with autistic children should therefore be developed to prevent them from developing mental disorders.

Research paper thumbnail of Personality and emotional response in schizophrenics with persistent auditory hallucination

European Psychiatry, Oct 1, 2009

Research paper thumbnail of Taiwan Birth Cohort Study-Developmental Instrument; 8-Year Old Scale

Research paper thumbnail of To Be Renaming the Term of "Schizophrenia"? The Question of "to Be" or "Not to Be

Research paper thumbnail of Monoamine Oxidase a Polymorphism, Gender, and Smoking as Predictors for Treatment Respose in Olanzapine-treated patients with Schizophrenia

臺灣精神醫學, Dec 1, 2010

Objective: The aim of this study was to explore the treatment effect of olanzapine on the polymor... more Objective: The aim of this study was to explore the treatment effect of olanzapine on the polymorphisms of monoamine oxidase A (MAOA) in schizophrenia. Method: During a 3-month period, 60 patients with schizophrenia were administered olanzapine. Treatment response was assessed by checking for improvement in symptoms as measured on the Positive and Negative Syndrome Scale (PANSS). Results: The short form of MAOA demonstrated a better drug response in the dimension of aggression. Female patients had a better response to olanzapine. Patients who did not smoke had a better response to olanzapine in the dimension of aggression. Conclusion: The results of this study suggest that polymorphisms of MAOA, gender, and cigarette smoking may be three useful response predictors in schizophrenic patients who were treated with olanzapine.

Research paper thumbnail of The Influence of Recruitment Training on Serum Lipid Shifts

Military Medicine, Dec 1, 2004

Research paper thumbnail of Diathesis, Psychopathology, Resilience, and Suicidality

臺灣精神醫學, Sep 1, 2013

Suicide is one of the serious public health problems worldwide. Moreover, suicidal ideation seems... more Suicide is one of the serious public health problems worldwide. Moreover, suicidal ideation seems as a risk factor for attempted and completed suicidal behaviors. It seems that number of different proximal precipitating and distal predisposing risk factors, which include genetic backgrounds, personal characteristics, parental attachment and mental health problems, are associated with increased rates of suicide. The pathway from genes to mental health problems and suicidal behavior are complex and probabilistic. The aim of this overview is to provide a clear protocol for genetics, diathesis, psychopathology, and resilience in suicidal behavior. In this review article, I will assess relevant research articles dealing with direct and deterministic ways from genetic backgrounds, personal characteristics, mental health to suicidality (ideation, plans, attempts and completions) in structural equation modeling. Combining with my own data, I also explored the natural course of the path effect, current effect, and the regression in each contributing factor, using structural equation modeling. I first introduce the concept of stress-diathesis of suicide; then, discuss the relationship between genetics, gene-environment interactions, parental bonding, personality characteristics, and resilience in suicidality. Issues associated with the relationship between genetic backgrounds, parental bonding, personality characteristics and resilience, and its interaction between nature and nurture in suicidality, have not yet settled. But these research findings should improve understanding of the critical ingredients and their differential impact on various at-risk subgroups, and help with effective prevention and intervention in the future.