F. Nataf - Academia.edu (original) (raw)
Papers by F. Nataf
Journal de Radiologie Diagnostique et Interventionnelle, 2014
ABSTRACT Si la description et la définition des caractéristiques morphologiques et architecturale... more ABSTRACT Si la description et la définition des caractéristiques morphologiques et architecturales des troubles vasculaires du système nerveux central (SNC) constituent toujours la première étape d’une analyse IRM, des technologies d’imagerie émergentes offrent de nouvelles informations fonctionnelles permettant de mieux caractériser le risque de rupture des pathologies vasculaires du SNC. Deux principales orientations sont suggérées par de récentes études : l’inflammation de la paroi vasculaire et l’analyse des contraintes physiques du flux sanguin à l’aide d’une imagerie 4D de flux (cisaillement pariétal). Cet article portera plus particulièrement sur l’application radiologique de l’imagerie 4D de flux et de l’imagerie de l’inflammation pour la caractérisation de marqueur pronostique potentiel des pathologies vasculaires du SNC. Nous examinerons les considérations techniques de base de l’angiographie IRM (angio-IRM) de flux 4D, l’imagerie de l’inflammation et nous discuterons de leurs applications dans les troubles vasculaires du SNC : anévrismes, malformations artério-veineuses, fistules artério-veineuses durales. Nous illustrerons leur application potentielle dans la détermination de nouveaux critères individuels pronostiques de risque de rupture des pathologies vasculaires cérébrales.
ECMOR VII - 7th European Conference on the Mathematics of Oil Recovery, 2000
Neuropathology and Applied Neurobiology, 2000
Gynécologie Obstétrique & Fertilité, 2002
Technique. – Almost all prolactinomas are operated through a transsphenoidal route, even in case ... more Technique. – Almost all prolactinomas are operated through a transsphenoidal route, even in case of significant suprasellar extension or intracavernous invasion. Since 1996, we use the only endonasal route which is easier, quicker, less haemorragic and less aggressive than the sublabial one. If the removal of a large macroadenoma cannot be completed (50-70% of cases), a second procedure, ususally transsphenoidal, is
Journal of Neuroradiology, 2007
Cancer/Radiothérapie, 2007
Cancer/Radiothérapie, 2011
Cancer radiothérapie : journal de la Société française de radiothérapie oncologique, 2012
The aim of this article was the study of the successive steps permitting the prescription of dose... more The aim of this article was the study of the successive steps permitting the prescription of dose in stereotactic intracranial radiotherapy, which includes radiosurgery and fractionated stereotactic radiotherapy. The successive steps studied are: the choice of stereotactic intracranial radiotherapy among the therapeutic options, based on curative or palliative treatment intent, then the selection of lesions according to size/volume, pathological type and their number permitting the choice between radiosurgery or fractionated stereotactic radiotherapy, which have the same methodological basis. Clinical experience has determined the level of dose to treat the lesions and limit the irradiation of healthy adjacent tissues and organs at risk structures. The last step is the optimization of the different parameters to obtain a safe compromise between the lesion dose and healthy adjacent structures. Study of dose-volume histograms, coverage indices and 3D imaging permit the optimization of...
Neuro-Chirurgie, 2005
Cerebral oligodendrogliomas represent more than 30% of glial tumors in adults. Mean age at diagno... more Cerebral oligodendrogliomas represent more than 30% of glial tumors in adults. Mean age at diagnosis is 41 for grade A and 45(1/2) for grade B, epilepsy being the main revealing symptom (91.5% of A, 76% of B). Survival at 5, 10 and 15 years is respectively 75.5%, 51% and 22.4% for grade A (median: 136 months), and 45.2%, 31.3% and 0% for grade B (median: 52 months). It is influenced by age at diagnosis: median, before 40 years of age, is 12 years for A and 8(1/2) for B; between 40 and 60, is 12 years for A and 4(1/2) for B; over 60, is 4 years for A and 1(1/2) for B. In children, they represent less than 2.5% of cerebral tumors and include 23% grade A and 77% grade B (48.5% WHO grade II and 51.5% WHO grade III). Mean age at surgical removal is 9.5 +/- 5 years. One third are hemispheric, 2/3 are revealed by epilepsy. A complete surgical removal is performed in 60%. Mean survival is 13 years (154 +/- 20 months), with a mortality at 5 and 10 years of 60% +/- 9%, and a risk of recurrenc...
Neuro-Chirurgie, 2005
Definition of homogeneous tumor groups of oligodendrogliomas or oligo-astrocytomas is a basic con... more Definition of homogeneous tumor groups of oligodendrogliomas or oligo-astrocytomas is a basic condition for an adequate evaluation and comparison of the results of treatments in patients from various institutions. However, increasing discordances are observed in the histological diagnosis of these tumors. The main goal of this study is to assess whether, for retrospective studies, MRI data may serve as a common basis for encompassing asymmetry in diagnosis established according to the WHO or Ste-Anne (SA) classification. This study included 251 adult patients in whom a SA grade A or B oligodendroglioma or oligo-astrocytoma was newly diagnosed at our institution from 1984 to 2003. Routine histological preparations and post-contrast preoperative MRI/CT-scan were simultaneously reviewed in order to assess the impact on survival of the following features: presence or absence of a polymorphous or gemistocytic astrocytic component, of necrosis and of contrast enhancement (CH); endothelial...
Neuro-Chirurgie, 2001
Obliteration is progressive after radiosurgery of cerebral arteriovenous malformations. Thus the ... more Obliteration is progressive after radiosurgery of cerebral arteriovenous malformations. Thus the hemorrhage risk still remains until obliteration. Purposes of this study are to appreciate severity of post-radiosurgery hemorrhages, actuarial risk of hemorrhage and parameters associated with it. and method. Over 705 patients treated, 46 (6.5%) had one or several hemorrhages. Clinical, anatomic, dosimetric parameters and obliteration rates before hemorrhage were studied. Then, actuarial risks per patient and per hemorrhage were calculated. Correlations between parameters and risk were searched by uni and multivariate analysis by drawing hemorrhage-free survival curves (limit-product Kaplan-Meier) and Cox model. Except one pure ventricular hemorrhage causing death of one patient, only parenchymal hemorrhages were associated with morbidity (80% of cases with 45% of permanent deficits). Overall mortality rate by hemorrhage was 6.5%. Overall morbidity rate was 34.8% and 13.6% for permanent...
Neuro-Chirurgie, 2001
Progressive neurological deficits are uncommonly associated with cerebral arteriovenous malformat... more Progressive neurological deficits are uncommonly associated with cerebral arteriovenous malformations. We present 25 cases (3.54%) from our series of 705 patients treated by radiosurgery. Common characteristics were preferentially: large cerebral arteriovenous malformations, arterial steal, arterial recruitment, venous reflux and deep location. After multivariate analysis, only arterial steal was significantly associated with neurological deficits. Course after treatment was variable and correlated with cerebral arteriovenous malformations regression. Different pathophysiologic hypotheses and their therapeutic consequences are discussed.
Neuro-Chirurgie, 2001
The purpose of this study is to analyze the characteristics of epileptic seizures associated with... more The purpose of this study is to analyze the characteristics of epileptic seizures associated with cerebral arteriovenous malformations treated by radiosurgery. Seven hundred and two patients are studied (406 men, 296 women) with a mean age of 33 when radiosurgery was performed. 210 patients had epileptic seizures; those seizures either uniquely revealed the arteriovenous malformation or were associated with other clinical signs. Seizures occurring after an hemorrhage were excluded from the study. We studied the age category upon seizures occurrence, the malformation localization, type of seizure (partial, generalized, or partial secondary generalized), the history related to the epileptic seizures, the clinical topographical correlation, the number of seizures, their duration prior to the radiosurgery, antiepileptic treatment provided, electroence-phalographic characteristics, angiographic characteristics, prior endovascular or surgical treatment, and factors associated with severe ...
Journal of neuroradiology. Journal de neuroradiologie, 2000
We report a case of 54 year old patient harboring a solitary painless mass of the calvarium. Ther... more We report a case of 54 year old patient harboring a solitary painless mass of the calvarium. There was a well-defined biparietal lytic lesion on plain skull radiographics. Computed tomography showed a large hyperdense lesion. This lesion was extraaxial and nearly isointense with gray matter on T1 and T2-weighted MR images, and diffusely enhanced after gadolinium injection. Angiography showed hyperovascularity supplied by middle meningeal and superficial temporal arteries. Imaging study bore some similarities to meningioma. A large extra-axial mass with an important lytic lesion should have led to the diagnosis of plasmocytoma.
Journal de Radiologie Diagnostique et Interventionnelle, 2014
ABSTRACT Si la description et la définition des caractéristiques morphologiques et architecturale... more ABSTRACT Si la description et la définition des caractéristiques morphologiques et architecturales des troubles vasculaires du système nerveux central (SNC) constituent toujours la première étape d’une analyse IRM, des technologies d’imagerie émergentes offrent de nouvelles informations fonctionnelles permettant de mieux caractériser le risque de rupture des pathologies vasculaires du SNC. Deux principales orientations sont suggérées par de récentes études : l’inflammation de la paroi vasculaire et l’analyse des contraintes physiques du flux sanguin à l’aide d’une imagerie 4D de flux (cisaillement pariétal). Cet article portera plus particulièrement sur l’application radiologique de l’imagerie 4D de flux et de l’imagerie de l’inflammation pour la caractérisation de marqueur pronostique potentiel des pathologies vasculaires du SNC. Nous examinerons les considérations techniques de base de l’angiographie IRM (angio-IRM) de flux 4D, l’imagerie de l’inflammation et nous discuterons de leurs applications dans les troubles vasculaires du SNC : anévrismes, malformations artério-veineuses, fistules artério-veineuses durales. Nous illustrerons leur application potentielle dans la détermination de nouveaux critères individuels pronostiques de risque de rupture des pathologies vasculaires cérébrales.
ECMOR VII - 7th European Conference on the Mathematics of Oil Recovery, 2000
Neuropathology and Applied Neurobiology, 2000
Gynécologie Obstétrique & Fertilité, 2002
Technique. – Almost all prolactinomas are operated through a transsphenoidal route, even in case ... more Technique. – Almost all prolactinomas are operated through a transsphenoidal route, even in case of significant suprasellar extension or intracavernous invasion. Since 1996, we use the only endonasal route which is easier, quicker, less haemorragic and less aggressive than the sublabial one. If the removal of a large macroadenoma cannot be completed (50-70% of cases), a second procedure, ususally transsphenoidal, is
Journal of Neuroradiology, 2007
Cancer/Radiothérapie, 2007
Cancer/Radiothérapie, 2011
Cancer radiothérapie : journal de la Société française de radiothérapie oncologique, 2012
The aim of this article was the study of the successive steps permitting the prescription of dose... more The aim of this article was the study of the successive steps permitting the prescription of dose in stereotactic intracranial radiotherapy, which includes radiosurgery and fractionated stereotactic radiotherapy. The successive steps studied are: the choice of stereotactic intracranial radiotherapy among the therapeutic options, based on curative or palliative treatment intent, then the selection of lesions according to size/volume, pathological type and their number permitting the choice between radiosurgery or fractionated stereotactic radiotherapy, which have the same methodological basis. Clinical experience has determined the level of dose to treat the lesions and limit the irradiation of healthy adjacent tissues and organs at risk structures. The last step is the optimization of the different parameters to obtain a safe compromise between the lesion dose and healthy adjacent structures. Study of dose-volume histograms, coverage indices and 3D imaging permit the optimization of...
Neuro-Chirurgie, 2005
Cerebral oligodendrogliomas represent more than 30% of glial tumors in adults. Mean age at diagno... more Cerebral oligodendrogliomas represent more than 30% of glial tumors in adults. Mean age at diagnosis is 41 for grade A and 45(1/2) for grade B, epilepsy being the main revealing symptom (91.5% of A, 76% of B). Survival at 5, 10 and 15 years is respectively 75.5%, 51% and 22.4% for grade A (median: 136 months), and 45.2%, 31.3% and 0% for grade B (median: 52 months). It is influenced by age at diagnosis: median, before 40 years of age, is 12 years for A and 8(1/2) for B; between 40 and 60, is 12 years for A and 4(1/2) for B; over 60, is 4 years for A and 1(1/2) for B. In children, they represent less than 2.5% of cerebral tumors and include 23% grade A and 77% grade B (48.5% WHO grade II and 51.5% WHO grade III). Mean age at surgical removal is 9.5 +/- 5 years. One third are hemispheric, 2/3 are revealed by epilepsy. A complete surgical removal is performed in 60%. Mean survival is 13 years (154 +/- 20 months), with a mortality at 5 and 10 years of 60% +/- 9%, and a risk of recurrenc...
Neuro-Chirurgie, 2005
Definition of homogeneous tumor groups of oligodendrogliomas or oligo-astrocytomas is a basic con... more Definition of homogeneous tumor groups of oligodendrogliomas or oligo-astrocytomas is a basic condition for an adequate evaluation and comparison of the results of treatments in patients from various institutions. However, increasing discordances are observed in the histological diagnosis of these tumors. The main goal of this study is to assess whether, for retrospective studies, MRI data may serve as a common basis for encompassing asymmetry in diagnosis established according to the WHO or Ste-Anne (SA) classification. This study included 251 adult patients in whom a SA grade A or B oligodendroglioma or oligo-astrocytoma was newly diagnosed at our institution from 1984 to 2003. Routine histological preparations and post-contrast preoperative MRI/CT-scan were simultaneously reviewed in order to assess the impact on survival of the following features: presence or absence of a polymorphous or gemistocytic astrocytic component, of necrosis and of contrast enhancement (CH); endothelial...
Neuro-Chirurgie, 2001
Obliteration is progressive after radiosurgery of cerebral arteriovenous malformations. Thus the ... more Obliteration is progressive after radiosurgery of cerebral arteriovenous malformations. Thus the hemorrhage risk still remains until obliteration. Purposes of this study are to appreciate severity of post-radiosurgery hemorrhages, actuarial risk of hemorrhage and parameters associated with it. and method. Over 705 patients treated, 46 (6.5%) had one or several hemorrhages. Clinical, anatomic, dosimetric parameters and obliteration rates before hemorrhage were studied. Then, actuarial risks per patient and per hemorrhage were calculated. Correlations between parameters and risk were searched by uni and multivariate analysis by drawing hemorrhage-free survival curves (limit-product Kaplan-Meier) and Cox model. Except one pure ventricular hemorrhage causing death of one patient, only parenchymal hemorrhages were associated with morbidity (80% of cases with 45% of permanent deficits). Overall mortality rate by hemorrhage was 6.5%. Overall morbidity rate was 34.8% and 13.6% for permanent...
Neuro-Chirurgie, 2001
Progressive neurological deficits are uncommonly associated with cerebral arteriovenous malformat... more Progressive neurological deficits are uncommonly associated with cerebral arteriovenous malformations. We present 25 cases (3.54%) from our series of 705 patients treated by radiosurgery. Common characteristics were preferentially: large cerebral arteriovenous malformations, arterial steal, arterial recruitment, venous reflux and deep location. After multivariate analysis, only arterial steal was significantly associated with neurological deficits. Course after treatment was variable and correlated with cerebral arteriovenous malformations regression. Different pathophysiologic hypotheses and their therapeutic consequences are discussed.
Neuro-Chirurgie, 2001
The purpose of this study is to analyze the characteristics of epileptic seizures associated with... more The purpose of this study is to analyze the characteristics of epileptic seizures associated with cerebral arteriovenous malformations treated by radiosurgery. Seven hundred and two patients are studied (406 men, 296 women) with a mean age of 33 when radiosurgery was performed. 210 patients had epileptic seizures; those seizures either uniquely revealed the arteriovenous malformation or were associated with other clinical signs. Seizures occurring after an hemorrhage were excluded from the study. We studied the age category upon seizures occurrence, the malformation localization, type of seizure (partial, generalized, or partial secondary generalized), the history related to the epileptic seizures, the clinical topographical correlation, the number of seizures, their duration prior to the radiosurgery, antiepileptic treatment provided, electroence-phalographic characteristics, angiographic characteristics, prior endovascular or surgical treatment, and factors associated with severe ...
Journal of neuroradiology. Journal de neuroradiologie, 2000
We report a case of 54 year old patient harboring a solitary painless mass of the calvarium. Ther... more We report a case of 54 year old patient harboring a solitary painless mass of the calvarium. There was a well-defined biparietal lytic lesion on plain skull radiographics. Computed tomography showed a large hyperdense lesion. This lesion was extraaxial and nearly isointense with gray matter on T1 and T2-weighted MR images, and diffusely enhanced after gadolinium injection. Angiography showed hyperovascularity supplied by middle meningeal and superficial temporal arteries. Imaging study bore some similarities to meningioma. A large extra-axial mass with an important lytic lesion should have led to the diagnosis of plasmocytoma.