F. Soriguer - Academia.edu (original) (raw)
Papers by F. Soriguer
European Journal of Clinical Nutrition, 2006
Objective: Few epidemiological studies have examined the relationship of dietary fatty acids, esp... more Objective: Few epidemiological studies have examined the relationship of dietary fatty acids, especially MUFA, with the interrelation between insulin secretion and insulin resistance. We assessed the relation of dietary fatty acids with insulin secretion in a free-living population. Design and setting: This cross-sectional, population-based study was undertaken in Pizarra, a small town in Spain. Subjects and methods: Anthropometrical data were collected for 1226 persons selected randomly from the municipal census, 538 of whom (randomly chosen) were given a prospective, quantitative, 7-day nutritional questionnaire. The fatty acid composition of the serum phospholipids was used as a biological marker of the type of fat consumed. Beta-cell function (bCFI) and insulin-resistance index (IRI) were estimated by the Homeostasis Model Assessment. Results: To determine which factors influence the variability of the bCFI, we analyzed the variance of the bCFI according to sex, the presence of carbohydrate metabolism disorders and the different components of the diet, adjusting the models for age, body mass index (BMI) and IRI. The dietary MUFA and polyunsaturated fatty acids (PUFA) contributed to the variability of the bCFI, whereas only the proportion of serum phospholipid MUFA, but neither the saturated fatty acids nor the PUFA accounted for part of the variability of the bCFI in a multiple regression analysis. Conclusion: The results of this population-based study corroborate the results of other clinical and experimental studies suggesting a favorable relationship of MUFA with b-cell insulin secretion.
The American Journal of Clinical Nutrition, 2003
Background: The family kitchen resembles an uncontrolled laboratory experiment, and some discrepa... more Background: The family kitchen resembles an uncontrolled laboratory experiment, and some discrepancies in the relation between the risk of hypertension and dietary fat may be partly due to the manipulation to which the fats were subjected. Objective: We investigated whether deterioration in the quality of the cooking oils in the family household contributes to the risk of high blood pressure. Design: The study was cross-sectional. Anthropometric measurements were obtained for 1226 persons aged 18-65 y who were selected randomly from the municipal census of Pizarra, Spain. An oral-glucose-tolerance test was given to 1020 of these persons. Samples of the cooking oil being used were taken from the kitchens of a random subset of 538 persons. The concentrations of polar compounds and polymers were used as markers of the deterioration of the oils. The strength of association between variables was measured by calculating the odds ratio from logistic models. Results: Hypertension was strongly associated with obesity and was influenced by sex, diabetes, and age. The presence of excess polar compounds in the cooking oil and the use of sunflower oil were related to the risk of hypertension, whereas the concentration of monounsaturated fatty acids in the serum phospholipids was negatively related to this risk. These associations remained after inclusion in the models of age, sex, obesity, and the presence of carbohydrate metabolism disorder. Conclusions: The risk of hypertension is positively and independently associated with the intake of cooking oil polar compounds and inversely related to blood concentrations of monounsaturated fatty acids.
Diabetes, Oct 14, 2016
Genome-wide association studies (GWAS) have found few common variants that influence fasting meas... more Genome-wide association studies (GWAS) have found few common variants that influence fasting measures of insulin sensitivity. We hypothesized that a GWAS of an integrated assessment of fasting and dynamic measures of insulin sensitivity would detect novel common variants. We performed GWAS of the modified Stumvoll Insulin Sensitivity Index (ISI) within the Meta-Analyses of Glucose and Insulin-related traits Consortium. Discovery was performed in 16,753 individuals, and replication was attempted for the 23 most significant novel loci in 13,354 independent individuals. Association with ISI was tested in models adjusted for age, sex, body mass index (BMI) and in a model ("Model 3") analyzing the combined influence of the genotype effect adjusted for BMI and the interaction effect between the genotype and BMI on ISI. In Model 3, three variants reached genome-wide significance: rs13422522 (NYAP2, P=8.87 ×10(-11)), rs12454712 (BCL2, P=2.7×10(-8)) and rs10506418 (FAM19A2, P=1.9×1...
Revista clinica espanola, 2014
Control glucémico en pacientes con diabetes mellitus tipo 2 en España: ¿Quo vadis? Glucemic contr... more Control glucémico en pacientes con diabetes mellitus tipo 2 en España: ¿Quo vadis? Glucemic control in patients with type 2 diabetes mellitus in Spain: Quo vadis?
Nutrición hospitalaria
To evaluate in a systematic manner, the fat, protein, caloric, and fatty acids contents of 35 spe... more To evaluate in a systematic manner, the fat, protein, caloric, and fatty acids contents of 35 species of fish, seafood and mollusks, usually consumed in Andalucía (Spain). 35 different species, representative of those usually consumed in Andalucía in the course of the four seasons of the year, are studied. In all units of the study, in a portion of the muscle tissue, measurements were taken to evaluate the total fat (extraction by the Folch method and by gravimetry), protein concentration (Kjehldal method), total calories (gas chromatography). A table shows the concentration of fat, protein and different fatty acids found in the studied species. There is a great interspecies variability in the fat concentration and in that of the different fatty acids. In the same way there is a great interspecies seasonal variety for some of those studied. Independently of the season studied, the relative proportion of fatty acids was not independent of the total concentration of fat. From the nutr...
Endocrinología y Nutrición, 2005
Manuscrito recibido el 2-9-2004; aceptado para su publicación el 13-12-2004. 83.188 Soriguer F, e... more Manuscrito recibido el 2-9-2004; aceptado para su publicación el 13-12-2004. 83.188 Soriguer F, et al. Protocolo para el estudio de trastornos debidos a la deficiencia nutricional de yodo
International Journal of Endocrinology, 2012
Objective. To evaluate the association between diabetes mellitus and health-related quality of li... more Objective. To evaluate the association between diabetes mellitus and health-related quality of life (HRQOL) controlled for several sociodemographic and anthropometric variables, in a representative sample of the Spanish population. Methods. A populationbased, cross-sectional, and cluster sampling study, with the entire Spanish population as the target population. Five thousand and forty-seven participants (2162/2885 men/women) answered the HRQOL short form 12-questionnaire (SF-12). The physical (PCS-12) and the mental component summary (MCS-12) scores were assessed. Subjects were divided into four groups according to carbohydrate metabolism status: normal, prediabetes, unknown diabetes (UNKDM), and known diabetes (KDM). Logistic regression analyses were conducted. Results.
European Journal of Epidemiology, 1997
We undertook a systematic evaluation of the lipid, protein, calorie, and fatty acid composition i... more We undertook a systematic evaluation of the lipid, protein, calorie, and fatty acid composition in 35 species of fish, shellfish and molluscs commonly consumed throughout the four seasons of the year in Andalusia, Spain. Using a portion of muscle tissue the following were measured in each study unit: total lipids (extraction using Folch's method and gravimetry), protein concentration (Kjehldal's method), total calories (direct calorimetry), and composition of fatty acids (gas chromatography). The lipid, protein, and different fatty acid concentrations found are presented in table form. There was a high degree of inter-species variability in the concentration of lipids and the various fatty acids. There was also a high degree of intra-species seasonal variability in some cases. The relative proportion of fatty acids was not independent of the total concentration of lipids, independently of the season studied. This systematic study of a large group of species shows that the cataloguing of fish as 'white' or 'blue' depends especially on the time of year they are captured. For example, in spring the mackerel (Scomber scombrus), a fish considered traditionally to be 'blue' (fatty), has the same lipid concentration as the dover sole (Solea vulgaris), commonly considered to be 'white' (little fat), and the sea pike (Merluccius merluccius) has a higher lipid concentration in autumn than the jack mackerel (Trachurus trachurus). Even greater differences existed when the fish were classified according to their richness in n-3 fatty acids. These differences in the total lipid concentration and the composition of fatty acids, as well as the inter-relations between them, may, under certain circumstances, be important for the calculation of dietary calories and nutritional values, and may explain the differences found between the various tables of food composition, as well as the divergent results in epidemiological studies on the association between fish in diets and various diseases, such as diabetes or ischaemic cardiopathy.
Atherosclerosis Supplements, 2007
Atherosclerosis Supplements, 2008
International Journal of Clinical Practice, 2015
Background: Results of studies examining the influence of age on thyroid function and TSH levels,... more Background: Results of studies examining the influence of age on thyroid function and TSH levels, in the absence of thyroid disease, remain controversial. The aim of this study was to determine the course of thyroid function over 11 years in a population with normal thyroid function. Methods: This is a population-based prospective study started in 1995-1997 (first phase), and reassessed 6 (second phase) and 11 years later (third phase). Results: The TSH and FT4 in the third phase were significantly increased (p = 0.001 and p = 0.001, respectively), with the values being higher particularly from the age of 50 years. In those persons with a baseline TSH ≥ 1.2 and < 3 lIU/mL, the OR of having a TSH of 3-5 lIU/ mL in the third phase was 6.10 (p = 0.004). In those with a baseline TSH ≥ 3 and ≤ 5 lIU/mL, the OR of having a TSH of 3-5 lIU/mL in the third phase was 20.8 (p < 0.0001). Similar results were found for FT4. Conclusion: In a population free of clinical thyroid disease, TSH and FT4 values rise over the years. This increase occurs in all age groups, but depends mainly on the basal concentrations of TSH and FT4. What's known Results of studies examining the influence of age on thyroid function and TSH levels, in the absence of thyroid disease, remain controversial. However, most of these studies relating thyroid hormone concentrations with age in persons free of thyroid disease are cross-sectional, which limits the strength of their results. What's new TSH and FT4 values rise over the years in this population-based prospective study, with the values being higher particularly from the age of 50 years. In the absence of any clinical thyroid disorder, and within reference ranges considered normal, the increase in values of TSH and FT4 over time depends not so much on age but more on the baseline values of TSH and FT4. This finding may thus lead to the requirement to reconsider population-based reference values.
Obesity Surgery, 2008
The impact of bariatric surgery on levels of peptide YY (PYY) and ghrelin is still under discussi... more The impact of bariatric surgery on levels of peptide YY (PYY) and ghrelin is still under discussion. We undertook a simultaneous evaluation of the serum changes in PYY and ghrelin depending on the specific type of bariatric surgery. Total PYY and ghrelin were analyzed in 29 healthy persons and in morbidly obese persons undergoing open biliopancreatic diversion (BPD) of Scopinaro (n = 38) or laparoscopic Roux-en-Y gastric bypass (RYGB; n = 13). RYGB resulted in a significantly greater loss of weight and body mass index than BPD. Both RYGB and BPD were associated with a significant increase in PYY, significantly greater for BDP (p = 0.001). Ghrelin rose significantly after RYGB (p = 0.022) but not after BPD. After surgery, PYY correlated positively with weight (r = 0.416, p = 0.009). Ghrelin did not correlate significantly with any of the variables studied. Analysis of variance showed that only the type of surgery contributed significantly to explain the variances in the PYY (p = 0.002) and ghrelin (p = 0.018). BPD results in a greater increase in PYY and a lower weight loss than RYGB. However, only RYGB was associated with a significant increase in ghrelin. The differing weight loss according to the type of bariatric surgery does not seem to be explained by changes arising in PYY and ghrelin.
Nutrition, Metabolism and Cardiovascular Diseases, 2010
Olive oil (OO) is the most representative food of the traditional Mediterranean Diet (MedDiet). I... more Olive oil (OO) is the most representative food of the traditional Mediterranean Diet (MedDiet). Increasing evidence suggests that monounsaturated fatty acids (MUFA) as a nutrient, OO as a food, and the MedDiet as a food pattern are associated with a decreased risk of cardiovascular disease, obesity, metabolic syndrome, type 2 diabetes and hypertension. A MedDiet rich in OO and OO per se has been shown to improve cardiovascular risk factors, such as lipid profiles, blood pressure, postprandial hyperlipidemia, endothelial dysfunction, oxidative stress, and antithrombotic profiles. Some of these beneficial effects can be attributed to the OO minor components. Therefore, the definition of the MedDiet should include OO. Phenolic compounds in OO have shown antioxidant and anti-inflammatory properties, prevent lipoperoxidation, induce favorable changes of lipid profile, improve endothelial function, and disclose antithrombotic properties. Observational studies from Mediterranean cohorts have suggested that dietary MUFA may be protective against age-related cognitive decline and Alzheimer's disease. Recent studies consistently support the concept that the OO-rich MedDiet is compatible with healthier aging and increased longevity. In countries where the population adheres to the MedDiet, such as Spain, Greece and Italy, and OO is the principal source of fat, rates of cancer incidence are lower than in northern European countries. Experimental and human cellular studies have provided new evidence on the potential protective effect of OO on cancer. Furthermore, results of case-control and cohort studies suggest that MUFA intake including OO is associated with a reduction in cancer risk (mainly breast, colorectal and prostate cancers).
elsevier.es
... Aunque en la mayoría de las provincias y comunidades autónomas españolas se ha hecho algún es... more ... Aunque en la mayoría de las provincias y comunidades autónomas españolas se ha hecho algún estudio al respecto, aún quedan al ... sujetos potencialmente estudiados divididos por 30 es el intervalo de muestreo (k). Dentro de cada grupo se elige a un número determinado ...
Journal of Endocrinological Investigation, 2001
The Journal of Clinical Endocrinology & Metabolism, 2008
Background: Transsexual persons afford a very suitable model to study the effect of sex steroids ... more Background: Transsexual persons afford a very suitable model to study the effect of sex steroids on uric acid metabolism. Design: This was a prospective study to evaluate the uric acid levels and fractional excretion of uric acid (FEUA) in a cohort of 69 healthy transsexual persons, 22 male-to-female transsexuals (MFTs) and 47 female-to-male transsexuals (FMTs). The subjects were studied at baseline and 1 and 2 yr after starting cross-sex hormone treatment. Results: The baseline levels of uric acid were higher in the MFT group. Compared with baseline, uric acid levels had fallen significantly after 1 yr of hormone therapy in the MFT group and had risen significantly in the FMT group. The baseline FEUA was greater in the FMT group. After 2 yr of cross-sex hormone therapy, the FEUA had increased in MFTs (P ϭ 0.001) and fallen in FMTs (P ϭ 0.004). In MFTs, the levels of uric acid at 2 yr were lower in those who had received higher doses of estrogens (P ϭ 0.03), and the FEUA was higher (P ϭ 0.04). The FEUA at 2 yr was associated with both the estrogen dose (P ϭ 0.02) and the serum levels of estradiol-17 (P ϭ0.03). In MFTs, a correlation was found after 2 yr of therapy between the homeostasis model assessment of insulin resistance and the serum uric acid (r ϭ 0.59; P ϭ 0.01). Conclusions: Serum levels of uric acid and the FEUA are altered in transsexuals as a result of cross-sex hormone therapy. The results concerning the MFT group support the hypothesis that the lower levels of uric acid in women are due to estrogen-induced increases in FEUA.
International Journal of Clinical Practice, 2014
Retinal vein occlusion (RVO) is the most frequent retinal vascular disease after diabetic retinop... more Retinal vein occlusion (RVO) is the most frequent retinal vascular disease after diabetic retinopathy in which arterial risk factors are much more relevant than venous factors. The objective was to evaluate the role of risk factors in the development of the first episode of RVO. One hundred patients with RVO [mean age 56 years, 42% females and mean body mass index (BMI) 27.5 kg/m(2)] were recruited consecutively from the outpatient clinic of a tertiary hospital in Valencia (Spain). All subjects underwent clinical assessment including anthropometric and blood pressure measurements and laboratory test including homocysteine, antiphospholipid antibodies (aPLAs) and thrombophilia studies. In half of the subjects, a carotid ultrasonography was performed. Three control populations matched by age, sex and BMI from different population-based studies were used to compare the levels and prevalence of arterial risk factors. One cohort of young patients with venous thromboembolic disease was used to compare the venous risk factors. Blood pressure levels and the prevalence of hypertension were significantly higher in the RVO population when compared with those for the general populations. There was also a large proportion of undiagnosed hypertension within the RVO group. Moreover, carotid evaluation revealed that a large proportion of patients with RVO had evidence of subclinical organ damage. In addition, homocysteine levels and prevalence of aPLAs were similar to the results obtained in our cohort of venous thromboembolic disease. The results indicate that hypertension is the key factor in the development of RVO, and that RVO can be the first manifestation of an undiagnosed hypertension. Furthermore, the majority of these patients had evidence of atherosclerotic disease. Among the venous factors, a thrombophilia study does not seem to be useful and only the prevalence of hyperhomocysteinaemia and aPLAs is higher than in the general population.
European Journal of Clinical Nutrition, 2006
Objective: Few epidemiological studies have examined the relationship of dietary fatty acids, esp... more Objective: Few epidemiological studies have examined the relationship of dietary fatty acids, especially MUFA, with the interrelation between insulin secretion and insulin resistance. We assessed the relation of dietary fatty acids with insulin secretion in a free-living population. Design and setting: This cross-sectional, population-based study was undertaken in Pizarra, a small town in Spain. Subjects and methods: Anthropometrical data were collected for 1226 persons selected randomly from the municipal census, 538 of whom (randomly chosen) were given a prospective, quantitative, 7-day nutritional questionnaire. The fatty acid composition of the serum phospholipids was used as a biological marker of the type of fat consumed. Beta-cell function (bCFI) and insulin-resistance index (IRI) were estimated by the Homeostasis Model Assessment. Results: To determine which factors influence the variability of the bCFI, we analyzed the variance of the bCFI according to sex, the presence of carbohydrate metabolism disorders and the different components of the diet, adjusting the models for age, body mass index (BMI) and IRI. The dietary MUFA and polyunsaturated fatty acids (PUFA) contributed to the variability of the bCFI, whereas only the proportion of serum phospholipid MUFA, but neither the saturated fatty acids nor the PUFA accounted for part of the variability of the bCFI in a multiple regression analysis. Conclusion: The results of this population-based study corroborate the results of other clinical and experimental studies suggesting a favorable relationship of MUFA with b-cell insulin secretion.
The American Journal of Clinical Nutrition, 2003
Background: The family kitchen resembles an uncontrolled laboratory experiment, and some discrepa... more Background: The family kitchen resembles an uncontrolled laboratory experiment, and some discrepancies in the relation between the risk of hypertension and dietary fat may be partly due to the manipulation to which the fats were subjected. Objective: We investigated whether deterioration in the quality of the cooking oils in the family household contributes to the risk of high blood pressure. Design: The study was cross-sectional. Anthropometric measurements were obtained for 1226 persons aged 18-65 y who were selected randomly from the municipal census of Pizarra, Spain. An oral-glucose-tolerance test was given to 1020 of these persons. Samples of the cooking oil being used were taken from the kitchens of a random subset of 538 persons. The concentrations of polar compounds and polymers were used as markers of the deterioration of the oils. The strength of association between variables was measured by calculating the odds ratio from logistic models. Results: Hypertension was strongly associated with obesity and was influenced by sex, diabetes, and age. The presence of excess polar compounds in the cooking oil and the use of sunflower oil were related to the risk of hypertension, whereas the concentration of monounsaturated fatty acids in the serum phospholipids was negatively related to this risk. These associations remained after inclusion in the models of age, sex, obesity, and the presence of carbohydrate metabolism disorder. Conclusions: The risk of hypertension is positively and independently associated with the intake of cooking oil polar compounds and inversely related to blood concentrations of monounsaturated fatty acids.
Diabetes, Oct 14, 2016
Genome-wide association studies (GWAS) have found few common variants that influence fasting meas... more Genome-wide association studies (GWAS) have found few common variants that influence fasting measures of insulin sensitivity. We hypothesized that a GWAS of an integrated assessment of fasting and dynamic measures of insulin sensitivity would detect novel common variants. We performed GWAS of the modified Stumvoll Insulin Sensitivity Index (ISI) within the Meta-Analyses of Glucose and Insulin-related traits Consortium. Discovery was performed in 16,753 individuals, and replication was attempted for the 23 most significant novel loci in 13,354 independent individuals. Association with ISI was tested in models adjusted for age, sex, body mass index (BMI) and in a model ("Model 3") analyzing the combined influence of the genotype effect adjusted for BMI and the interaction effect between the genotype and BMI on ISI. In Model 3, three variants reached genome-wide significance: rs13422522 (NYAP2, P=8.87 ×10(-11)), rs12454712 (BCL2, P=2.7×10(-8)) and rs10506418 (FAM19A2, P=1.9×1...
Revista clinica espanola, 2014
Control glucémico en pacientes con diabetes mellitus tipo 2 en España: ¿Quo vadis? Glucemic contr... more Control glucémico en pacientes con diabetes mellitus tipo 2 en España: ¿Quo vadis? Glucemic control in patients with type 2 diabetes mellitus in Spain: Quo vadis?
Nutrición hospitalaria
To evaluate in a systematic manner, the fat, protein, caloric, and fatty acids contents of 35 spe... more To evaluate in a systematic manner, the fat, protein, caloric, and fatty acids contents of 35 species of fish, seafood and mollusks, usually consumed in Andalucía (Spain). 35 different species, representative of those usually consumed in Andalucía in the course of the four seasons of the year, are studied. In all units of the study, in a portion of the muscle tissue, measurements were taken to evaluate the total fat (extraction by the Folch method and by gravimetry), protein concentration (Kjehldal method), total calories (gas chromatography). A table shows the concentration of fat, protein and different fatty acids found in the studied species. There is a great interspecies variability in the fat concentration and in that of the different fatty acids. In the same way there is a great interspecies seasonal variety for some of those studied. Independently of the season studied, the relative proportion of fatty acids was not independent of the total concentration of fat. From the nutr...
Endocrinología y Nutrición, 2005
Manuscrito recibido el 2-9-2004; aceptado para su publicación el 13-12-2004. 83.188 Soriguer F, e... more Manuscrito recibido el 2-9-2004; aceptado para su publicación el 13-12-2004. 83.188 Soriguer F, et al. Protocolo para el estudio de trastornos debidos a la deficiencia nutricional de yodo
International Journal of Endocrinology, 2012
Objective. To evaluate the association between diabetes mellitus and health-related quality of li... more Objective. To evaluate the association between diabetes mellitus and health-related quality of life (HRQOL) controlled for several sociodemographic and anthropometric variables, in a representative sample of the Spanish population. Methods. A populationbased, cross-sectional, and cluster sampling study, with the entire Spanish population as the target population. Five thousand and forty-seven participants (2162/2885 men/women) answered the HRQOL short form 12-questionnaire (SF-12). The physical (PCS-12) and the mental component summary (MCS-12) scores were assessed. Subjects were divided into four groups according to carbohydrate metabolism status: normal, prediabetes, unknown diabetes (UNKDM), and known diabetes (KDM). Logistic regression analyses were conducted. Results.
European Journal of Epidemiology, 1997
We undertook a systematic evaluation of the lipid, protein, calorie, and fatty acid composition i... more We undertook a systematic evaluation of the lipid, protein, calorie, and fatty acid composition in 35 species of fish, shellfish and molluscs commonly consumed throughout the four seasons of the year in Andalusia, Spain. Using a portion of muscle tissue the following were measured in each study unit: total lipids (extraction using Folch&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s method and gravimetry), protein concentration (Kjehldal&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s method), total calories (direct calorimetry), and composition of fatty acids (gas chromatography). The lipid, protein, and different fatty acid concentrations found are presented in table form. There was a high degree of inter-species variability in the concentration of lipids and the various fatty acids. There was also a high degree of intra-species seasonal variability in some cases. The relative proportion of fatty acids was not independent of the total concentration of lipids, independently of the season studied. This systematic study of a large group of species shows that the cataloguing of fish as &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;white&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; or &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;blue&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; depends especially on the time of year they are captured. For example, in spring the mackerel (Scomber scombrus), a fish considered traditionally to be &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;blue&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; (fatty), has the same lipid concentration as the dover sole (Solea vulgaris), commonly considered to be &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;white&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; (little fat), and the sea pike (Merluccius merluccius) has a higher lipid concentration in autumn than the jack mackerel (Trachurus trachurus). Even greater differences existed when the fish were classified according to their richness in n-3 fatty acids. These differences in the total lipid concentration and the composition of fatty acids, as well as the inter-relations between them, may, under certain circumstances, be important for the calculation of dietary calories and nutritional values, and may explain the differences found between the various tables of food composition, as well as the divergent results in epidemiological studies on the association between fish in diets and various diseases, such as diabetes or ischaemic cardiopathy.
Atherosclerosis Supplements, 2007
Atherosclerosis Supplements, 2008
International Journal of Clinical Practice, 2015
Background: Results of studies examining the influence of age on thyroid function and TSH levels,... more Background: Results of studies examining the influence of age on thyroid function and TSH levels, in the absence of thyroid disease, remain controversial. The aim of this study was to determine the course of thyroid function over 11 years in a population with normal thyroid function. Methods: This is a population-based prospective study started in 1995-1997 (first phase), and reassessed 6 (second phase) and 11 years later (third phase). Results: The TSH and FT4 in the third phase were significantly increased (p = 0.001 and p = 0.001, respectively), with the values being higher particularly from the age of 50 years. In those persons with a baseline TSH ≥ 1.2 and < 3 lIU/mL, the OR of having a TSH of 3-5 lIU/ mL in the third phase was 6.10 (p = 0.004). In those with a baseline TSH ≥ 3 and ≤ 5 lIU/mL, the OR of having a TSH of 3-5 lIU/mL in the third phase was 20.8 (p < 0.0001). Similar results were found for FT4. Conclusion: In a population free of clinical thyroid disease, TSH and FT4 values rise over the years. This increase occurs in all age groups, but depends mainly on the basal concentrations of TSH and FT4. What's known Results of studies examining the influence of age on thyroid function and TSH levels, in the absence of thyroid disease, remain controversial. However, most of these studies relating thyroid hormone concentrations with age in persons free of thyroid disease are cross-sectional, which limits the strength of their results. What's new TSH and FT4 values rise over the years in this population-based prospective study, with the values being higher particularly from the age of 50 years. In the absence of any clinical thyroid disorder, and within reference ranges considered normal, the increase in values of TSH and FT4 over time depends not so much on age but more on the baseline values of TSH and FT4. This finding may thus lead to the requirement to reconsider population-based reference values.
Obesity Surgery, 2008
The impact of bariatric surgery on levels of peptide YY (PYY) and ghrelin is still under discussi... more The impact of bariatric surgery on levels of peptide YY (PYY) and ghrelin is still under discussion. We undertook a simultaneous evaluation of the serum changes in PYY and ghrelin depending on the specific type of bariatric surgery. Total PYY and ghrelin were analyzed in 29 healthy persons and in morbidly obese persons undergoing open biliopancreatic diversion (BPD) of Scopinaro (n = 38) or laparoscopic Roux-en-Y gastric bypass (RYGB; n = 13). RYGB resulted in a significantly greater loss of weight and body mass index than BPD. Both RYGB and BPD were associated with a significant increase in PYY, significantly greater for BDP (p = 0.001). Ghrelin rose significantly after RYGB (p = 0.022) but not after BPD. After surgery, PYY correlated positively with weight (r = 0.416, p = 0.009). Ghrelin did not correlate significantly with any of the variables studied. Analysis of variance showed that only the type of surgery contributed significantly to explain the variances in the PYY (p = 0.002) and ghrelin (p = 0.018). BPD results in a greater increase in PYY and a lower weight loss than RYGB. However, only RYGB was associated with a significant increase in ghrelin. The differing weight loss according to the type of bariatric surgery does not seem to be explained by changes arising in PYY and ghrelin.
Nutrition, Metabolism and Cardiovascular Diseases, 2010
Olive oil (OO) is the most representative food of the traditional Mediterranean Diet (MedDiet). I... more Olive oil (OO) is the most representative food of the traditional Mediterranean Diet (MedDiet). Increasing evidence suggests that monounsaturated fatty acids (MUFA) as a nutrient, OO as a food, and the MedDiet as a food pattern are associated with a decreased risk of cardiovascular disease, obesity, metabolic syndrome, type 2 diabetes and hypertension. A MedDiet rich in OO and OO per se has been shown to improve cardiovascular risk factors, such as lipid profiles, blood pressure, postprandial hyperlipidemia, endothelial dysfunction, oxidative stress, and antithrombotic profiles. Some of these beneficial effects can be attributed to the OO minor components. Therefore, the definition of the MedDiet should include OO. Phenolic compounds in OO have shown antioxidant and anti-inflammatory properties, prevent lipoperoxidation, induce favorable changes of lipid profile, improve endothelial function, and disclose antithrombotic properties. Observational studies from Mediterranean cohorts have suggested that dietary MUFA may be protective against age-related cognitive decline and Alzheimer's disease. Recent studies consistently support the concept that the OO-rich MedDiet is compatible with healthier aging and increased longevity. In countries where the population adheres to the MedDiet, such as Spain, Greece and Italy, and OO is the principal source of fat, rates of cancer incidence are lower than in northern European countries. Experimental and human cellular studies have provided new evidence on the potential protective effect of OO on cancer. Furthermore, results of case-control and cohort studies suggest that MUFA intake including OO is associated with a reduction in cancer risk (mainly breast, colorectal and prostate cancers).
elsevier.es
... Aunque en la mayoría de las provincias y comunidades autónomas españolas se ha hecho algún es... more ... Aunque en la mayoría de las provincias y comunidades autónomas españolas se ha hecho algún estudio al respecto, aún quedan al ... sujetos potencialmente estudiados divididos por 30 es el intervalo de muestreo (k). Dentro de cada grupo se elige a un número determinado ...
Journal of Endocrinological Investigation, 2001
The Journal of Clinical Endocrinology & Metabolism, 2008
Background: Transsexual persons afford a very suitable model to study the effect of sex steroids ... more Background: Transsexual persons afford a very suitable model to study the effect of sex steroids on uric acid metabolism. Design: This was a prospective study to evaluate the uric acid levels and fractional excretion of uric acid (FEUA) in a cohort of 69 healthy transsexual persons, 22 male-to-female transsexuals (MFTs) and 47 female-to-male transsexuals (FMTs). The subjects were studied at baseline and 1 and 2 yr after starting cross-sex hormone treatment. Results: The baseline levels of uric acid were higher in the MFT group. Compared with baseline, uric acid levels had fallen significantly after 1 yr of hormone therapy in the MFT group and had risen significantly in the FMT group. The baseline FEUA was greater in the FMT group. After 2 yr of cross-sex hormone therapy, the FEUA had increased in MFTs (P ϭ 0.001) and fallen in FMTs (P ϭ 0.004). In MFTs, the levels of uric acid at 2 yr were lower in those who had received higher doses of estrogens (P ϭ 0.03), and the FEUA was higher (P ϭ 0.04). The FEUA at 2 yr was associated with both the estrogen dose (P ϭ 0.02) and the serum levels of estradiol-17 (P ϭ0.03). In MFTs, a correlation was found after 2 yr of therapy between the homeostasis model assessment of insulin resistance and the serum uric acid (r ϭ 0.59; P ϭ 0.01). Conclusions: Serum levels of uric acid and the FEUA are altered in transsexuals as a result of cross-sex hormone therapy. The results concerning the MFT group support the hypothesis that the lower levels of uric acid in women are due to estrogen-induced increases in FEUA.
International Journal of Clinical Practice, 2014
Retinal vein occlusion (RVO) is the most frequent retinal vascular disease after diabetic retinop... more Retinal vein occlusion (RVO) is the most frequent retinal vascular disease after diabetic retinopathy in which arterial risk factors are much more relevant than venous factors. The objective was to evaluate the role of risk factors in the development of the first episode of RVO. One hundred patients with RVO [mean age 56 years, 42% females and mean body mass index (BMI) 27.5 kg/m(2)] were recruited consecutively from the outpatient clinic of a tertiary hospital in Valencia (Spain). All subjects underwent clinical assessment including anthropometric and blood pressure measurements and laboratory test including homocysteine, antiphospholipid antibodies (aPLAs) and thrombophilia studies. In half of the subjects, a carotid ultrasonography was performed. Three control populations matched by age, sex and BMI from different population-based studies were used to compare the levels and prevalence of arterial risk factors. One cohort of young patients with venous thromboembolic disease was used to compare the venous risk factors. Blood pressure levels and the prevalence of hypertension were significantly higher in the RVO population when compared with those for the general populations. There was also a large proportion of undiagnosed hypertension within the RVO group. Moreover, carotid evaluation revealed that a large proportion of patients with RVO had evidence of subclinical organ damage. In addition, homocysteine levels and prevalence of aPLAs were similar to the results obtained in our cohort of venous thromboembolic disease. The results indicate that hypertension is the key factor in the development of RVO, and that RVO can be the first manifestation of an undiagnosed hypertension. Furthermore, the majority of these patients had evidence of atherosclerotic disease. Among the venous factors, a thrombophilia study does not seem to be useful and only the prevalence of hyperhomocysteinaemia and aPLAs is higher than in the general population.