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Papers by Facundo Sanchez

RESUMEN La presente tesis estudia la incidencia del fideicomiso de retención y reparación de la L... more RESUMEN La presente tesis estudia la incidencia del fideicomiso de retención y reparación de la Ley N° 30737 (FIRR) en el principio de reparación integral del daño, a consecuencia de los casos de corrupción cometidos por el grupo Odebrecht en el Perú. Mediante cuatro capítulos se desarrollaron conceptual y metodológicamente ambas variables de estudio, que junto con la selección y desarrollo de información relevante permitieron demostrar la hipótesis planteada. El capítulo I presenta la realidad problemática, antecedentes y definiciones conceptuales de las variables de estudio, seguida por el capítulo II que contiene el problema de investigación, objetivos, hipótesis, unidades de análisis, técnicas e instrumentos de recolección y análisis de datos y el procedimiento metodológico. Por su parte el capítulo III contiene los resultados obtenidos de la aplicación de instrumentos de análisis en materia legislativa y jurisprudencial de la Corte Suprema de Argentina, Chile, Colombia, Perú y ...

PLOS ONE

Purpose To determine the associations of blindness within rural and urban counties using a regist... more Purpose To determine the associations of blindness within rural and urban counties using a registry of blind persons and geospatial analytics. Methods We used the Oregon Commission for the Blind registry to determine the number of persons who are legally blind, as well as licensure data to determine the density of eye care providers (optometrists and ophthalmologists) within each county of the State of Oregon. We used geospatial statistics, analysis of variance, and logistic regression to determine the explanatory variables associated with blindness within counties. Results We included 8350 individuals who are legally blind within the state of Oregon in the calendar year 2015. The mean observed prevalence of registered blindness was 0.21% and ranged almost 9-fold from 0.04% to 0.58% among counties (p < .001). In univariate models, higher blindness was associated with increasing median age (p = .027), minority race (p < .001), decreased median household income (p < .001), in...

Investigative Ophthalmology & Visual Science, Jun 10, 2020

Investigative Ophthalmology & Visual Science, Jun 21, 2021

Archivos Argentinos de Oftalmología, 2018

Journal of Glaucoma, 2022

PRECIS When compared to cataract surgery in glaucoma patients, trabecular micro-bypass and goniot... more PRECIS When compared to cataract surgery in glaucoma patients, trabecular micro-bypass and goniotomy resulted in a large decrease in the incidence of IOP spikes, a modest effect on IOP, and a minimal effect on medication burden. PURPOSE To compare changes in intraocular pressure (IOP) and ocular hypotensive medications in 3 surgical cohorts: cataract surgery, cataract surgery with trabecular micro-bypass (cataract/trabecular), and cataract surgery with goniotomy (cataract/goniotomy). PARTICIPANTS AND METHODS We included 138 eyes diagnosed with open angle glaucoma: (1) 84 eyes with cataract surgery alone, (2) 25 eyes with cataract/trabecular surgery, and (3) 29 eyes with cataract/goniotomy surgery. We compared the groups for postoperative IOP and the number of ocular hypotensive medications. We adjusted for preoperative IOP, and preoperative and postoperative number of ocular hypotensive medications. We defined an IOP spike as IOP ≥21▒mmHg and 10▒mmHg higher than preoperative on postoperative day 1. RESULTS All 3 surgeries showed a decrease in IOP (P≤0.004) and medication burden (P≤0.001) at 3 and 6 months postoperatively when compared to their own preoperative baselines. When compared to cataract surgery alone, cataract/trabecular and cataract/goniotomy had similar IOP lowering at 1 month postoperatively, and variable results at 3 months and 6 months. The change in ocular hypotensive medications was not statistically different between the surgical groups at any postoperative visit. Cataract/trabecular and cataract/goniotomy decreased IOP on postoperative day 1, and had relative risk reduction of approximately 70% for IOP spikes (P≤0.001 for both). CONCLUSION Trabecular micro-bypass and goniotomy when added to cataract surgery resulted in a large decrease in IOP spikes, a modest effect on IOP, and a minimal effect on medication burden when compared to cataract surgery alone in glaucoma patients.

Investigative Ophthalmology & Visual Science, 2019

Investigative Ophthalmology & Visual Science, 2020

Investigative Ophthalmology & Visual Science, 2018

Current Ophthalmology Reports, 2021

Patient adherence to prescribed medications is critical to prevent progression of glaucoma. This ... more Patient adherence to prescribed medications is critical to prevent progression of glaucoma. This review summarizes recent literature about glaucoma treatment adherence including current strategies to aid in medication administration and opportunities for improvement. Multiple studies have identified poor medication adherence as a major contributor to disease progression in glaucoma. There have been a variety of proposed and investigated techniques to improve adherence including eye drop monitors and reminders, patient education programs, eye drop delivery aids, and alternative medication delivery systems. Many approaches have shown promise in helping to improve medication adherence. A multifaceted and individualized patient treatment strategy is required to face this complex problem.

American Journal of Ophthalmology, 2021

Ophthalmology Glaucoma, 2021

PURPOSE To compare a nose-pivoted drop delivery device (NPDD) against traditional eye drop delive... more PURPOSE To compare a nose-pivoted drop delivery device (NPDD) against traditional eye drop delivery in glaucoma subjects. DESIGN Repeated-measures case series. SUBJECTS Fifty glaucoma subjects (100 eyes) who reported difficulty self-administering eye drops. METHODS We compared eye drop delivery using a NPDD against traditional delivery techniques at baseline (baseline traditional) and after standardized teaching (post-teaching traditional). Subjects used a 1 to 10 scale (10=easiest) to rate the ease of delivery with each technique and completed a satisfaction survey. Two graders used digital video to independently review eye drop delivery and recorded: 1) accurate placement: the eye drop reached the ocular surface; 2) no contact: no bottle tip contact against ocular/periocular surface; 3) number of eye drops dispensed. We defined primary success as accurate placement and no contact; secondary success as primary success with only 1 drop dispensed. MAIN OUTCOME MEASURES We used logistic-transformed GEE regression to compare technique satisfaction, accuracy, no contact, and primary and secondary success. Number of drops dispensed was compared using a Cox model. RESULTS Forty-seven out of the 50 (94%) subjects preferred the NPDD over traditional eye drop delivery. The mean score for ease-of-use was higher for the NPDD (8.9 ± 1.1) than baseline traditional (6.7 ± 2.1, p<0.001) and post-teaching traditional (7.0 ± 2.0, p<0.001). Forty-nine out of the 50 (98%) subjects thought the NPDD was comfortable to use and would recommend the device. The eye drop reached the ocular surface in a similar percentage (>90%) of subjects with each method. The bottle tip contacted fewer eyes with the NPDD (10 eyes) than baseline traditional (33 eyes, p<0.001) and post-teaching traditional (25 eyes, p=0.009). The number of drops dispensed was lower with the NPDD (1.7 ± 1.2) than baseline traditional (2.2 ± 1.6, p=0.017) and post-teaching traditional (2.4 ± 1.8, p=0.006). The NPDD increased primary and secondary success of eye drop delivery (86% and 54%, respectively) compared to baseline traditional (66% [p=0.001] and 28% [p<0.001]) and post-teaching traditional (70% [p=0.005] and 40% [p=0.018]). CONCLUSIONS Eye drop users preferred the NPDD over traditional eye drop delivery. The NPDD improved eye drop delivery success, reduced bottle tip contact, and decreased the number of eye drops wasted.

Clinical Ophthalmology, 2021

Since the first peer-reviewed publication on MicroPulse ® Transscleral Laser Therapy (MP-TLT) in ... more Since the first peer-reviewed publication on MicroPulse ® Transscleral Laser Therapy (MP-TLT) in 2010, authors worldwide have used a wide range of treatment parameter combinations with varying clinical efficacy in terms of the magnitude of intraocular pressure reduction, success rate, durability, and safety profile. This has made it difficult to determine the proper parameters necessary to optimize efficacy and safety, and has made comparison of results from one investigation to another difficult. The first goal of this paper is to explain and highlight the impact of the choices of exposure time and the number of sweeps per hemisphere in terms of "sweep velocity" on energy delivery to the eye. These treatment parameters are underreported in the literature. The second goal is to introduce fluence as a "dose" metric, that combines all the treatment parameters and constants into a single number. Fluence may be a better light-dose metric and a more reliable indicator of clinical outcomes compared to total energy.

Journal of Glaucoma, 2020

The murine stem cell virus (MSCV) promoter exhibits activity in mouse hematopoietic cells and emb... more The murine stem cell virus (MSCV) promoter exhibits activity in mouse hematopoietic cells and embryonic stem cells. We generated transgenic mice that expressed enhanced green fluorescent protein (GFP) under the control of the MSCV promoter. We obtained 12 transgenic founder mice through 2 independent experiments and found that the bodies of 9 of the founder neonates emitted different levels of GFP fluorescence. Flow cytometric analysis of circulating leukocytes revealed that the frequency of GFP-labeled leukocytes among white blood cells ranged from 1.6% to 47.5% across the 12 transgenic mice. The bodies of 9 founder transgenic mice showed various levels of GFP expression. GFP fluorescence was consistently observed in the cerebellum, with faint or almost no fluorescence in other brain regions. In the cerebellum, 10 founders exhibited GFP expression in Purkinje cells at frequencies of 3% to 76%. Of these, 4 mice showed Purkinje cellspecific expression, while 4 and 2 mice expressed GFP in the Bergmann glia and endothelial cells, respectively. The intensity of the GFP fluorescence in the body was relative to the proportion of GFP-positive leukocytes. Moreover, the frequency of the GFP-expressing leukocytes was significantly correlated with the frequency of GFP-expressing Purkinje cells. These results suggest that the MSCV promoter is useful for preferentially expressing a transgene in Purkinje cells. In addition, the proportion of transduced leukocytes in the peripheral circulation reflects the expression level of the transgene in Purkinje cells, which can be used as a way to monitor transgene expression properties in the cerebellum without invasive techniques.