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Research paper thumbnail of The Effect of Low FODMAP Diet with and without Gluten on Irritable Bowel Syndrome: A Double Blind, Placebo Controlled Randomized Clinical Trial

Clinical Nutrition ESPEN, 2021

BACKGROUND & AIM Although the effects of low fermentable oligosaccharide, disaccharide, monos... more BACKGROUND & AIM Although the effects of low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol (FODMAP) diet on amelioration of irritable bowel syndrome (IBS) symptoms have been reported previously, it has not yet been elucidated whether the gluten of wheat and barley induces the symptoms or only their fructans lead to aggravation of the symptoms. The aim of this study was to assess the effect of low FODMAPs diet with vs. without gluten on clinical symptoms in IBS patients. METHODS In this double-blind, placebo-controlled randomized trial, forty nine IBS patients were randomly assigned to placebo and/or intervention group. Patients in the intervention group received 5 gr/day of gluten powder with low FODMAP diet, while placebo group received 5 gr of rice flour as placebo, with low FODMAP diet. Quality of life (QoL) and IBS-SSS (symptom severity score) were measured before and after the intervention using a valid QoL questionnaire and a standard visual analog scale, respectively. RESULTS Significant improvements were observed in total scores of IBS-SSS (-32% vs. - 49%), abdominal pain intensity (-45% vs. -52%), and frequency (-26 vs. -46%), abdominal distension (-29% vs. -63%), Interference with community function (-14% vs. -45%) and quality of life (+23 vs. +32%) in both gluten and placebo groups respectively (P < 0.05). Only 5 patients in the gluten-containing diet reported exacerbation of their symptoms. CONCLUSION Exacerbation of IBS symptoms after wheat and barley consumption is due to their fructan, and not related to their gluten content in most of the patients. CLINICAL TRIAL REGISTRATION NO IRCT20100524004010N29.

Research paper thumbnail of Glutamine Supplementation Enhances the Effects of a Low FODMAP Diet in Irritable Bowel Syndrome Management

Frontiers in Nutrition, 2021

Background and Aims: Although irritable bowel syndrome is one of the most common gastrointestinal... more Background and Aims: Although irritable bowel syndrome is one of the most common gastrointestinal disorders presented to gastroenterologists, therapeutic strategies are not yet well-established. Accordingly, we conducted a randomized, double-blind, placebo-controlled, clinical trial to evaluate the possible superiority of adding glutamine supplement to low fermentable oligo- di- monosaccharides and polyols (FODMAP) diet in patients with irritable bowel syndrome (IBS).Methods: Eligible adults were randomized to receive a low FODMAP diet either with glutamine (15 g/day) or a placebo for 6 weeks. The primary endpoint was a significant reduction in IBS-symptom severity score (IBS-SSS). Secondary endpoints were changes in IBS symptoms, stool frequency, consistency, and quality of life.Results: The study group enrolled 50 patients, among which 22 participants from each group completed the study protocol. The glutamine group had significant changes in total IBS-severity score, dissatisfact...

Research paper thumbnail of The effect of Cumin on anthropometric measurements: A systematic review of randomized controlled clinical trials

Background Obesity and overweight are known as risk factors of cardiovascular diseases, hypertens... more Background Obesity and overweight are known as risk factors of cardiovascular diseases, hypertension, diabetes mellitus, osteoarthritis, and some cancers leading to increased morbidity and mortality. Cuminum cyminum L. is one of the medicinal plants belonging to the Apiaceae family. The native regions for this plant are India, Iran, the Mediterranean region, and Egypt. Cumin contains essential fatty acids and volatile oils, phenolic compounds, flavonoids, and terpenes. Cumin could be used as an anti-oxidant, anti-inflammatory, diuretic, anti-dyspepsia, and anti-obesity agent. Therefore, this systematic review was conducted to evaluate the efficacy of cumin on weight, BMI, waist circumference, and waist-hip ratio. Methods PubMed, Scopus, ISI, science direct, and Google Scholar databases were searched for April 2020. Twelve studies were included for this systematic review. Results Cumin can modulate anthropometric indices in the obese and overweight population by activating some enzym...

Research paper thumbnail of The Effect of Low FODMAP Diet with and without Gluten on Irritable Bowel Syndrome: A Double Blind, Placebo Controlled Randomized Clinical Trial

Clinical Nutrition ESPEN, 2021

BACKGROUND & AIM Although the effects of low fermentable oligosaccharide, disaccharide, monos... more BACKGROUND & AIM Although the effects of low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol (FODMAP) diet on amelioration of irritable bowel syndrome (IBS) symptoms have been reported previously, it has not yet been elucidated whether the gluten of wheat and barley induces the symptoms or only their fructans lead to aggravation of the symptoms. The aim of this study was to assess the effect of low FODMAPs diet with vs. without gluten on clinical symptoms in IBS patients. METHODS In this double-blind, placebo-controlled randomized trial, forty nine IBS patients were randomly assigned to placebo and/or intervention group. Patients in the intervention group received 5 gr/day of gluten powder with low FODMAP diet, while placebo group received 5 gr of rice flour as placebo, with low FODMAP diet. Quality of life (QoL) and IBS-SSS (symptom severity score) were measured before and after the intervention using a valid QoL questionnaire and a standard visual analog scale, respectively. RESULTS Significant improvements were observed in total scores of IBS-SSS (-32% vs. - 49%), abdominal pain intensity (-45% vs. -52%), and frequency (-26 vs. -46%), abdominal distension (-29% vs. -63%), Interference with community function (-14% vs. -45%) and quality of life (+23 vs. +32%) in both gluten and placebo groups respectively (P < 0.05). Only 5 patients in the gluten-containing diet reported exacerbation of their symptoms. CONCLUSION Exacerbation of IBS symptoms after wheat and barley consumption is due to their fructan, and not related to their gluten content in most of the patients. CLINICAL TRIAL REGISTRATION NO IRCT20100524004010N29.

Research paper thumbnail of Glutamine Supplementation Enhances the Effects of a Low FODMAP Diet in Irritable Bowel Syndrome Management

Frontiers in Nutrition, 2021

Background and Aims: Although irritable bowel syndrome is one of the most common gastrointestinal... more Background and Aims: Although irritable bowel syndrome is one of the most common gastrointestinal disorders presented to gastroenterologists, therapeutic strategies are not yet well-established. Accordingly, we conducted a randomized, double-blind, placebo-controlled, clinical trial to evaluate the possible superiority of adding glutamine supplement to low fermentable oligo- di- monosaccharides and polyols (FODMAP) diet in patients with irritable bowel syndrome (IBS).Methods: Eligible adults were randomized to receive a low FODMAP diet either with glutamine (15 g/day) or a placebo for 6 weeks. The primary endpoint was a significant reduction in IBS-symptom severity score (IBS-SSS). Secondary endpoints were changes in IBS symptoms, stool frequency, consistency, and quality of life.Results: The study group enrolled 50 patients, among which 22 participants from each group completed the study protocol. The glutamine group had significant changes in total IBS-severity score, dissatisfact...

Research paper thumbnail of The effect of Cumin on anthropometric measurements: A systematic review of randomized controlled clinical trials

Background Obesity and overweight are known as risk factors of cardiovascular diseases, hypertens... more Background Obesity and overweight are known as risk factors of cardiovascular diseases, hypertension, diabetes mellitus, osteoarthritis, and some cancers leading to increased morbidity and mortality. Cuminum cyminum L. is one of the medicinal plants belonging to the Apiaceae family. The native regions for this plant are India, Iran, the Mediterranean region, and Egypt. Cumin contains essential fatty acids and volatile oils, phenolic compounds, flavonoids, and terpenes. Cumin could be used as an anti-oxidant, anti-inflammatory, diuretic, anti-dyspepsia, and anti-obesity agent. Therefore, this systematic review was conducted to evaluate the efficacy of cumin on weight, BMI, waist circumference, and waist-hip ratio. Methods PubMed, Scopus, ISI, science direct, and Google Scholar databases were searched for April 2020. Twelve studies were included for this systematic review. Results Cumin can modulate anthropometric indices in the obese and overweight population by activating some enzym...