Fatma El-Demerdash - Academia.edu (original) (raw)

Papers by Fatma El-Demerdash

Environmental science and pollution research international, Mar 8, 2024

Pathology Research and Practice, Apr 1, 2023

Journal of future foods, Sep 1, 2023

Frontier Media SA eBooks, 2023

Journal of diabetes & metabolism, Jan 20, 2015

IOP conference series, Nov 1, 2019

The current study was designed to investigate the protective role of Phoenix dactylifera (date pa... more The current study was designed to investigate the protective role of Phoenix dactylifera (date palm) water extract (DPE) against oxidative injury induced by different concentrations of hexavalent chromium (CrVI) in liver and muscles of Tilapia nilotica (Oreochromis niloticus) fish in vitro. Results demonstrated that CrVI caused a significant concentration-dependent inhibition in glutathione S-transferase, superoxide dismutase and catalase activities as well as glutathione content. In addition, inhibition in transaminases and alkaline phosphatase activities were observed. While, thiobarbituric acid reactive substances levels in liver and muscles homogenate were increased. On the other hand, homogenates treated with DPE alone improve the antioxidant status and liver function biomarkers. Moreover, homogenate pretreated with DPE then exposed to CrVI showed marked modulation in lipid peroxidation, enzyme activities and protein content as compared to their respective CrVI treated ones. Conclusively, Phoenix dactylifera might have a potential protective role against CrVI toxicity.

Environmental Toxicology, Jun 6, 2022

Environmental and occupational exposure to chromium compounds, especially hexavalent chromium [Cr... more Environmental and occupational exposure to chromium compounds, especially hexavalent chromium [Cr(VI)], is widely recognized as a potential nephrotoxic in humans and animals. Its toxicity is associated with the overproduction of free radicals, which induces oxidative damage. Echinacea purpurea (L.) Moench is an herbaceous perennial plant rich in phenolic components and frequently used for its medicinal benefits. The current work evaluated the effectiveness of E. purpurea (EP) against oxidative stress and nephrotoxicity induced by potassium dichromate in male rats. Male Wistar rats were divided into four groups: control, E. purpurea (EP; 50 mg/kg; once daily for 3 weeks), hexavalent chromium (Cr(VI); 15 mg/kg; single intraperitoneal dose), and EP + Cr(VI) where rats were pretreated with EP for 3 weeks before receiving CrVI, respectively. Results revealed that rats exposed to Cr(VI) showed a significant increase in PC, TBARS, and H2O2, kidney function biomarkers (Urea, creatinine, and uric acid), lactate dehydrogenase activity (LDH), TNF‐α, IL‐18, nuclear factor kappa B (NFκB), and IGF‐1 (Insulin‐like growth factor‐1) levels as well as a considerable decline in metallothionein (MT), glutathione (GSH) content, enzymatic antioxidants (SOD, CAT, GPx, GR, and GST), alkaline phosphatase (ALP) activities, and protein content. Cr(VI) induced apoptosis in kidney tissues as revealed by upregulation of Bax and caspase 3 and downregulation of Bcl‐2. Furthermore, EP treatment ameliorated the Cr(VI)‐induced histopathological and ultrastructure variations of kidney tissue, which was confirmed by the biochemical and molecular data. It is clear from the results of this study that EP exerts nephroprotective effects by improving the redox state, suppressing inflammatory reaction and cell apoptosis as well as ameliorating the performance of kidney tissue architecture, which is eventually reflected by the improvement of kidney function in rats.

Food Science and Human Wellness, Nov 1, 2023

Journal of Trace Elements in Medicine and Biology, Sep 1, 2021

BACKGROUND Chromium hexavalent (CrVI) is known as a toxic contaminant that induced oxidative stre... more BACKGROUND Chromium hexavalent (CrVI) is known as a toxic contaminant that induced oxidative stress and nephrotoxicity in humans and animals. Rosmarinus officinalis is a perennial herb rich in biologically active constituents that have powerful antioxidant properties. So, the current work evaluated the effectiveness of Rosmarinus officinalis essential oil (REO) against alterations induced by potassium dichromate in the kidney of male rats. METHODS GC-MS analysis, in vitro total phenol contents, and DPPH scavenging activity of REO were estimated. Thirty-five Wistar male rats were categorized into 5 groups. The first group was the control, the second one was orally administered rosemary essential oil (REO; 0.5 mL/kg BW), the third group was injected intraperitoneally with hexavalent chromium (CrVI; 2 mg/kg BW) for 14 days, the fourth group used as the protective group (REO was administrated 30 min before i.p. injection of CrVI) and the fifth group applied as the therapeutic group (rats injected with CrVI 30 min followed by oral administration of REO), respectively. RESULTS Twenty-nine components were detected with high total phenolic contents and high DPPH scavenging activity. Results revealed that CrVI- intoxicated rats showed a valuable increase in oxidative stress profile (TBARS and H2O2) and a notable decline in glutathione (GSH), total protein content, and enzymatic antioxidants (SOD, CAT, GPx, and GST). Furthermore, serum kidney functions biomarkers (urea, creatinine, and uric acid) were increased significantly. Also, the administration of CrVI showed histological and immunohistochemical (PCNA-ir) changes in rat kidney tissue. Otherwise, administration of REO pre or post-treatment with CrVI significantly restored most of the biochemical parameters in addition to improvement in kidney tissue architecture. Moreover, individual intake with REO exhibited an amendment in oxidative stress markers. CONCLUSION Conclusively, REO had a potential antioxidant capacity in ameliorating K2Cr2O7-induced nephrotoxicity, especially in the protection group.

Ain Shams Dental Journal, Jun 1, 2018

The open conference proceedings journal, Aug 4, 2015

The present experiment was carried out to investigate the effectivness of-lipoic acid in allevati... more The present experiment was carried out to investigate the effectivness of-lipoic acid in allevating the toxicity of aluminium phosphide on biochemical parameters, free radicals and enzyme activities in plasma, liver and kidney of male rats. Animals were orally treated with aluminium phosphide,-lipoic acid and their combination for 30 consecutive days. Treatment with aluminium phosphide led to significant decrease in plasma total protein and glucose and increase in transaminases, phosphatases, urea, creatinine and bilirubin. Treatment with aluminium phosphide significantly decreased glutathione S-transferase (GST), catalase (CAT) and reduced glutathione (GSH) in plasma, liver and kidney. While, thiobarbituric acid reactive substances (TBARS; as an index of lipid peroxidation) and superoxide dismutase (SOD) were increased in plasma, liver and kidney of rats treated with aluminium phosphide. Administration of-lipoic acid in combination with aluminium phosphide minimized and alleviated its toxic effects on most of the measured parameters. In conclusion, lipoic acid has beneficial effects and could be able to attenuate aluminium phosphide toxicity.

Frontiers in Pharmacology

Objective: To propose a theoretical formulation of engeletin-nanostructured lipid nanocarriers fo... more Objective: To propose a theoretical formulation of engeletin-nanostructured lipid nanocarriers for improved delivery and increased bioavailability in treating Huntington’s disease (HD).Methods: We conducted a literature review of the pathophysiology of HD and the limitations of currently available medications. We also reviewed the potential therapeutic benefits of engeletin, a flavanol glycoside, in treating HD through the Keap1/nrf2 pathway. We then proposed a theoretical formulation of engeletin-nanostructured lipid nanocarriers for improved delivery across the blood-brain barrier (BBB) and increased bioavailability.Results: HD is an autosomal dominant neurological illness caused by a repetition of the cytosine-adenine-guanine trinucleotide, producing a mutant protein called Huntingtin, which degenerates the brain’s motor and cognitive functions. Excitotoxicity, mitochondrial dysfunction, oxidative stress, elevated concentration of ROS and RNS, neuroinflammation, and protein aggre...

BioMed Research International

Background. Human life quality and expectancy have increased dramatically over the past 5 decades... more Background. Human life quality and expectancy have increased dramatically over the past 5 decades because of improvements in nutrition and antibiotic’s usage fighting against infectious diseases. Yet, it was soon revealed that the microbes adapted to develop resistance to any of the drugs that were used. Recently, there is great concern that commensal bacteria from food and the gastrointestinal tract of humans and animals could act as a reservoir for antibiotic resistance genes. Methodology. This study was intended for evaluating the phenotypic antibiotic resistance/sensitivity profiles of probiotic bacteria from human breast milk and evaluating the inhibitory effect of the probiotic bacteria against both Gram-negative and Gram-positive bacteria. Results. The results point out that some of the isolated bacteria were resistant to diverse antibiotics including gentamycin, imipenem, trimethoprim sulfamethoxazole, and nalidixic acid. Susceptibility profile to certain antibiotics like va...

Egyptian Journal of Histology

BioMed Research International, 2021

Phosphoglycerate mutase 1 (PGAM1) is considered as a novel target for multiple types of cancer dr... more Phosphoglycerate mutase 1 (PGAM1) is considered as a novel target for multiple types of cancer drugs for the upregulation in tumor, cell prefoliation, and cell migration. During aerobic glycolysis, PGAM1 plays a critical role in cancer cell metabolism by catalyzing the conversion of 3-phosphoglycerate (3PG) to 2-phosphoglycerate (2PG). In this computational-based study, the molecular docking approach was used with the best binding active sites of PGAM1 to screen 5,000 Chinese medicinal phytochemical library. The docking results were three ligands with docking score, RMSD-refine, and residues. Docking scores were -16.57, -15.22, and -15.74. RMSD values were 0.87, 2.40, and 0.98, and binding site residues were Arg 191, Arg 191, Arg 116, Arg 90, Arg 10, and Tyr 92. The best compounds were subjected to ADMETsar, ProTox-2 server, and Molinspiration analysis to evaluate the toxicological and drug likeliness potential of such selected compounds. The UCSF-Chimera tool was used to visualize ...

Journal of Chemistry, 2020

Plants of Delphinium are herbal medicine used in the Tibet region with whole grass as a drug, whi... more Plants of Delphinium are herbal medicine used in the Tibet region with whole grass as a drug, which have the effects of analgesic, antibacterial, antipyretic, and anticancer. The main bioactive compounds are alkaloids, flavonoids, and sterols. This review summarized the compounds and pharmacological effects of Delphinium and provides a reference for further research on Delphinium.

Food and Chemical Toxicology

Powder Technology, Jun 1, 2019

sherady, et al., A novel multifunctional sandwiched activated carbon between manganese and tin ox... more sherady, et al., A novel multifunctional sandwiched activated carbon between manganese and tin oxides nanoparticles for removal of divalent metal ions, Powder Technology,

Biomedicine & Pharmacotherapy, Jul 1, 2021

BACKGROUND Cancer is one of the most dreaded diseases characterized by uncontrolled proliferation... more BACKGROUND Cancer is one of the most dreaded diseases characterized by uncontrolled proliferation of abnormal cells that occurs due to impairment of cell division and apoptosis process. Cancer is categorized into several types on the basis of affected organs and breast cancer (BC) is the most predominant cause of mortality among women. Although, several synthetic and semi-synthetic therapies have been developed for the treatment of BC but they exhibit numerous serious adverse effects therefore; pharmacological agents with fewer/no side effects need to be explored. Plants and phytoconstituents perhaps fulfill the aforementioned requirement and could serve as a potential and alternative therapy for BC treatment. The ongoing biomedical research, clinical trials and number of patents granted have further boosted the acceptance of the plants and plant-derived constituents in the effective treatment of BC. PURPOSE OF STUDY Various treatment strategies such as checkpoint inhibitors, targeting micro RNA, apoptotic pathway, BRCA-1 gene, P53 protein, P13K/Akt/mTOR pathway, notch signaling pathway, hedgehog/gli-1 signaling pathway, poly-ADP ribose polymerase inhibitors, mitogen-activated protein kinase inhibitors etc. are available for BC. In addition to these synthetic and semi-synthetic drug therapies, several natural constituents such as alkaloids, sesquiterpenes, polyphenols, flavonoids and diterpenoids from medicinal plants, vegetables and fruits are reported to possess promising anti-cancer activity. The purpose of the present review is to highlight the various signaling pathways through which plants/herbs show the anti-cancer potential especially against the BC. STUDY DESIGN The literature for the present study was collected from various databases such as Pubmed, Scopus, Chemical Abstracts, Medicinal and aromatic plant abstracts, Web of Science etc. The different patent databases were also reviewed for the anti-cancer (BC) potential of the particular herbs/plants and their formulations. RESULT AND CONCLUSION In this review, we have discussed the number of plants along with their patents of different herbal formulations which are being used for the treatment of BC and other types of cancers. We have also delineated the different signaling mechanisms through which they inhibit the growth of BC cells. In nutshell, we can conclude that large numbers of herbs or their extracts are reported for the treatment of BC. But still, there is further need for research in-depth to translate the use of natural products clinically BC treatment.