Fatou Sar - Academia.edu (original) (raw)

Papers by Fatou Sar

Bulletin de la Société de pathologie exotique, 2013

Cette étude compare les modifications érythrocytaires entre un groupe de sujets porteurs de trait... more Cette étude compare les modifications érythrocytaires entre un groupe de sujets porteurs de trait drépanocytaire (PTD) et un groupe témoin (sujets avec hémoglobine normale) au cours d'un match de football avec ou sans hydratation. La déformabilité érythrocytaire des sujets a été évaluée par le coefficient de la rigidité érythrocytaire (Tk) qui a été calculé avant et après le match. Nos résultats montrent en condition non hydratée une augmentation significative de la rigidité érythrocytaire chez les PTD à la fin des activités physiques; cependant lorsque ces derniers s'hydrataient ad libitum leur rigidité érythrocytaire diminuait significativement pour atteindre les valeurs des sujets témoins. Ainsi, une hydratation adéquate est recommandée chez les sujets porteurs du trait drépanocytaire pendant et après un exercice physique.

J. Med. Plant …, 2010

1Laboratoire de Physiologie et Explorations fonctionnelles, FMPOS, UCAD, Dakar et Unité Mixte Int... more 1Laboratoire de Physiologie et Explorations fonctionnelles, FMPOS, UCAD, Dakar et Unité Mixte Internationale de Recherches (UMI 3189) 'Environnement, Santé, Sociétés' CNRS-UCAD-CNRST-UNIV.BAMAKO. 2Laboratoire de Physiologie Pharmaceutique, ...

Journal of Physiology and Pharmacology Advances, 2015

Journal of Physiology and Pharmacology Advances, 2015

Treatment failure or tolerance, which rapidly leads to a reduced hemodynamic effects and therapeu... more Treatment failure or tolerance, which rapidly leads to a reduced hemodynamic effects and therapeutic efficacy is the major limitation of long-term use of nitrates, including nitroglycerin (NTG) in the treatment of coronary artery disease. These effects are most often associated with oxidative stress. Thus, in this work, we were interested in the prevention of nitrate tolerance by the antioxidant compounds from Hibiscus sabdariffa L. crude extract, a plant from the Senegalese Pharmacopoeia, rich in polyphenols. Thoracic aorta segments without endothelium were taken from rats and incubated in isolated organ chambers. The vessels were then pre-exposed with the H. sabdariffa polyphenolic extract (HSE, 5.10 -2 g/l) or antioxidants such as N-acetyl cysteine (NAC, 10 -3 M) or vitamin C (VIT C, 10 -2 M), taken as reference. After a 30 min treatment, aortic segments were exposed to NTG (50 M, 1 h) to induce tolerance state before being contracted to adrenaline (10 -8 to 10 -5 M), and then re...

Chronobiology International, 2013

The goal of the present study was to test whether fasting during the holy period of Ramadan may d... more The goal of the present study was to test whether fasting during the holy period of Ramadan may disturb blood rheology in sickle cell trait (SCT) carriers more than in a group of subjects with normal hemoglobin. Twenty African male students participated in the study: 10 SCT carriers and 10 subjects with normal hemoglobin (CONT). Biochemical parameters (plasma glucose and lipids levels), hematocrit, blood viscosity, and urine specific gravity were measured in the two groups on the 14th day of the Ramadan period (Ramadan condition) and 6 wks after the end of Ramadan (baseline condition). All the measurements were performed twice for each experimental day to measure intraday variation: 8:00 and 18:00 h. Plasma glucose level and lipid profile were not significantly different between the two groups. Although Ramadan did not affect the lipid profile, the plasma glucose concentration was lower during the Ramadan period compared with the baseline condition in the two groups. Hematocrit and urine specific gravity did not differ between the two groups and was greater in the evening than in the morning, independently of the condition. SCT carriers had higher blood viscosity than the CONT group. However, whereas blood viscosity remained unchanged through the day in the CONT group, whatever the condition, SCT carriers were characterized by a large increase of blood viscosity in the evening during the Ramadan period, indicating higher risk for microcirculatory blood flow impairments. Specific medical recommendations are needed for SCT carriers engaged in religious fasting.

J. Med. Plant …, 2010

1Laboratoire de Physiologie et Explorations fonctionnelles, FMPOS, UCAD, Dakar et Unité Mixte Int... more 1Laboratoire de Physiologie et Explorations fonctionnelles, FMPOS, UCAD, Dakar et Unité Mixte Internationale de Recherches (UMI 3189) 'Environnement, Santé, Sociétés' CNRS-UCAD-CNRST-UNIV.BAMAKO. 2Laboratoire de Physiologie Pharmaceutique, ...

Journal of Physiology and Pharmacology Advances, 2015

Bulletin de la Société de pathologie exotique, 2013

Cette étude compare les modifications érythrocytaires entre un groupe de sujets porteurs de trait... more Cette étude compare les modifications érythrocytaires entre un groupe de sujets porteurs de trait drépanocytaire (PTD) et un groupe témoin (sujets avec hémoglobine normale) au cours d'un match de football avec ou sans hydratation. La déformabilité érythrocytaire des sujets a été évaluée par le coefficient de la rigidité érythrocytaire (Tk) qui a été calculé avant et après le match. Nos résultats montrent en condition non hydratée une augmentation significative de la rigidité érythrocytaire chez les PTD à la fin des activités physiques; cependant lorsque ces derniers s'hydrataient ad libitum leur rigidité érythrocytaire diminuait significativement pour atteindre les valeurs des sujets témoins. Ainsi, une hydratation adéquate est recommandée chez les sujets porteurs du trait drépanocytaire pendant et après un exercice physique.

J. Med. Plant …, 2010

1Laboratoire de Physiologie et Explorations fonctionnelles, FMPOS, UCAD, Dakar et Unité Mixte Int... more 1Laboratoire de Physiologie et Explorations fonctionnelles, FMPOS, UCAD, Dakar et Unité Mixte Internationale de Recherches (UMI 3189) 'Environnement, Santé, Sociétés' CNRS-UCAD-CNRST-UNIV.BAMAKO. 2Laboratoire de Physiologie Pharmaceutique, ...

Journal of Physiology and Pharmacology Advances, 2015

Journal of Physiology and Pharmacology Advances, 2015

Treatment failure or tolerance, which rapidly leads to a reduced hemodynamic effects and therapeu... more Treatment failure or tolerance, which rapidly leads to a reduced hemodynamic effects and therapeutic efficacy is the major limitation of long-term use of nitrates, including nitroglycerin (NTG) in the treatment of coronary artery disease. These effects are most often associated with oxidative stress. Thus, in this work, we were interested in the prevention of nitrate tolerance by the antioxidant compounds from Hibiscus sabdariffa L. crude extract, a plant from the Senegalese Pharmacopoeia, rich in polyphenols. Thoracic aorta segments without endothelium were taken from rats and incubated in isolated organ chambers. The vessels were then pre-exposed with the H. sabdariffa polyphenolic extract (HSE, 5.10 -2 g/l) or antioxidants such as N-acetyl cysteine (NAC, 10 -3 M) or vitamin C (VIT C, 10 -2 M), taken as reference. After a 30 min treatment, aortic segments were exposed to NTG (50 M, 1 h) to induce tolerance state before being contracted to adrenaline (10 -8 to 10 -5 M), and then re...

Chronobiology International, 2013

The goal of the present study was to test whether fasting during the holy period of Ramadan may d... more The goal of the present study was to test whether fasting during the holy period of Ramadan may disturb blood rheology in sickle cell trait (SCT) carriers more than in a group of subjects with normal hemoglobin. Twenty African male students participated in the study: 10 SCT carriers and 10 subjects with normal hemoglobin (CONT). Biochemical parameters (plasma glucose and lipids levels), hematocrit, blood viscosity, and urine specific gravity were measured in the two groups on the 14th day of the Ramadan period (Ramadan condition) and 6 wks after the end of Ramadan (baseline condition). All the measurements were performed twice for each experimental day to measure intraday variation: 8:00 and 18:00 h. Plasma glucose level and lipid profile were not significantly different between the two groups. Although Ramadan did not affect the lipid profile, the plasma glucose concentration was lower during the Ramadan period compared with the baseline condition in the two groups. Hematocrit and urine specific gravity did not differ between the two groups and was greater in the evening than in the morning, independently of the condition. SCT carriers had higher blood viscosity than the CONT group. However, whereas blood viscosity remained unchanged through the day in the CONT group, whatever the condition, SCT carriers were characterized by a large increase of blood viscosity in the evening during the Ramadan period, indicating higher risk for microcirculatory blood flow impairments. Specific medical recommendations are needed for SCT carriers engaged in religious fasting.

J. Med. Plant …, 2010

1Laboratoire de Physiologie et Explorations fonctionnelles, FMPOS, UCAD, Dakar et Unité Mixte Int... more 1Laboratoire de Physiologie et Explorations fonctionnelles, FMPOS, UCAD, Dakar et Unité Mixte Internationale de Recherches (UMI 3189) 'Environnement, Santé, Sociétés' CNRS-UCAD-CNRST-UNIV.BAMAKO. 2Laboratoire de Physiologie Pharmaceutique, ...

Journal of Physiology and Pharmacology Advances, 2015