Zita Fazakas - Academia.edu (original) (raw)
Papers by Zita Fazakas
Poor diets have proven very detrimental for the maintenance of good health and eating an excessiv... more Poor diets have proven very detrimental for the maintenance of good health and eating an excessive amount of fast food and highly processed meals can harm the general health status of the population. Hence, this work investigates the habits related to eating outside the home and frequency of eating fast food meals in participants from six different countries. A cross-sectional descriptive study was undertaken on a sample of 4,904 adult participants. For the data treatment, basic statistics were complemented with tree classification analysis, using the CRT algorithm. This study concluded that in the sample under study the frequency of eating out of home was in general low, corresponding to four or fewer times per week for 71.9% of the participants, and the consumption of fast food meals was also acceptable, i.e., with a low frequency of up to two times per week in 88.6% of the respondents. The biggest differences were encountered when comparing participants from different age groups, countries or sexes, and not so much for living environment or education level. Tree classification analysis highlighted the relative importance of the considered factors for eating out and fast food meals, being country and age confirmed as the most influential factors. In the evaluated sample the incidence of eating out and fast food meals were low, which is a good indicator to contribute globally for the good health status of the participants involved in the study.
Orvostudományi Értesítö, Dec 1, 2021
Cancer is a common disease that people dread, and most of them fully believe that they will be se... more Cancer is a common disease that people dread, and most of them fully believe that they will be sentenced to death along with the diagnosis. The aim of the present study was to set up a dietary survey and nutritional therapy pattern that can be used in Romania for patients diagnosed with cervical cancer, that will contribute to a better management of the mentioned disease cervical cancer. This diet therapy can help patients to recover easily from cervical cancer, prevent cancer weakening and weight loss, and to fight strenuous medical treatments that can further worsen their overall condition and quality of life. Furthermore, this nutrition intervention can reduce malnutrition outcomes and establishes a diet plan that makes easier for the patients to endure the symptoms and reduces the side effects of multiple cancer treatments. The backbone of our paper was the National Cancer Institute's Nutritional PDQ (Physician Data Query), an american institute that conducts cancer screening and daily information of cancer researchers along with other recent literature sources.
Acta Medica Marisiensis, Sep 1, 2015
Arylsulfatase A (ARSA) is a lysosomal enzyme that plays an important role in catalysis of degrada... more Arylsulfatase A (ARSA) is a lysosomal enzyme that plays an important role in catalysis of degradation of cerebrosidesulphate. The deficiency of this lysosomal enzyme causes an autosomal recessive disorder, called metachromatic leucodystrophy. However, a low ARSA activity can be observed in clinically healthy people, called ARSA pseudodeficiency. In our study we investigated the possible linkage between ARSA activity and sulfatide deficiency causing characteristic aspects of degenerative diseases, such as end stage kidney disease, type 2 Diabetes mellitus, Parkinson syndrome, prostate cancer and HIV (Human Immunodeficiency Virus) infection. We used a spectrophotometric method to determine the activity of ARSA. This method of enzyme dosage is based on a 4 hour long hydrolysis of the ARSA enzyme on 4-nitrocatechol sulfate (p-NCS) substrate. The unit of this measurement is nmol/ml/4h. Our findings show significant values in type 2 diabetes, Parkinson syndrome and chronic kidney disease. The importance of sulfatide in these diseases is well-known, thus presumably the variation of the ARSA's activity might play an important role in the pathophysiology of these diseases, involving a vicious cycle between sulfatide degradation andthese diseases.
Poor diets have proven very detrimental for the maintenance of good health and eating an excessiv... more Poor diets have proven very detrimental for the maintenance of good health and eating an excessive amount of fast food and highly processed meals can harm the general health status of the population. Hence, this work investigates the habits related to eating outside the home and frequency of eating fast food meals in participants from six different countries. A cross-sectional descriptive study was undertaken on a sample of 4,904 adult participants. For the data treatment, basic statistics were complemented with tree classification analysis, using the CRT algorithm. This study concluded that in the sample under study the frequency of eating out of home was in general low, corresponding to four or fewer times per week for 71.9% of the participants, and the consumption of fast food meals was also acceptable, i.e., with a low frequency of up to two times per week in 88.6% of the respondents. The biggest differences were encountered when comparing participants from different age groups, countries or sexes, and not so much for living environment or education level. Tree classification analysis highlighted the relative importance of the considered factors for eating out and fast food meals, being country and age confirmed as the most influential factors. In the evaluated sample the incidence of eating out and fast food meals were low, which is a good indicator to contribute globally for the good health status of the participants involved in the study.
Zenodo (CERN European Organization for Nuclear Research), Mar 2, 2016
Egitania Sciencia
Dietas inadequadas demonstraram ser muito prejudiciais para a manutenção de uma boa saúde, e come... more Dietas inadequadas demonstraram ser muito prejudiciais para a manutenção de uma boa saúde, e comer fast-food em excesso e refeições altamente processadas pode ter um impacto negativo no estado geral de saúde da população. Assim, este trabalho investigou os hábitos relacionados com a alimentação fora de casa e a frequência de refeições rápidas numa amostra oriunda de seis países diferentes. Foi realizado um estudo descritivo transversal numa amostra de 4904 participantes adultos. Para o tratamento dos dados, a análise estatística básica foi complementada com análise de classificação do tipo árvore (Tree), usando o algoritmo CRT. Este estudo permitiu concluir que na amostra em análise a frequência com que os participantes comeram fora de casa foi em geral baixa, correspondendo a quatro ou menos vezes por semana para 71,9% dos participantes, sendo o consumo de fast-food também aceitável, ou seja, com baixa frequência de até duas vezes por semana em 88,6% dos entrevistados. As maiores d...
Life
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Intense oxidative stress, increased glycated hemoglobin and mineral imbalance represent risk fact... more Intense oxidative stress, increased glycated hemoglobin and mineral imbalance represent risk factors for complications in diabetic patients. Cardiovascular complications are most common in these patients, including nephropathy. This study was conducted in 2015 at the Procardia Laboratory in Tîrgu Mureș, Romania on 40 type 2 diabetic adults. Routine biochemical tests were performed on the Konleab 20XTi analyzer (serum glucose, total cholesterol, LDL and HDL cholesterol, triglyceride, creatinine, urea). We also measured serum uric acid, magnesium and calcium concentration by photometric procedures, potassium, sodium and chloride by ion selective electrode, and chromium by atomic absorption spectrometry in a group of patients. Glycated hemoglobin (HbA1c) dosage was made by reflectometry. Urine analysis was performed using the HandUReader equipment. The level of oxidative stress was measured by serum malondialdehyde dosage using the thiobarbituric acid reactive substances method. MDRD (...
JPMA. The Journal of the Pakistan Medical Association, 2019
OBJECTIVE To investigate the perceived importance of information about dietary fibre with regard ... more OBJECTIVE To investigate the perceived importance of information about dietary fibre with regard top opulation socio - demographic characteristics and consumption patterns. METHODS The cross-sectional study was conducted from September to November, 2016, in six different counties and 57 cities across Romania, and was part of a larger project that had nine other countries as well. Data of the Romanian subjects was collected using a validated questionnaire that was disseminated across the 10 countries at the same time. Knowledge about dietary fibre was explored through 10 questions, and the respondents were asked to answer on a 5-point Likert scale varying from 1 (totally disagree) to 5 (totally agree). SPSS 22 was used for data anaylsis. RESULTS Of the 670 subjects, 358 (53.4%) were females, and the overall mean age was 35.81±15.61 years (range: 18-89 years). There were 298 (44.5%) subjects with a university degree, 314(46.9%) had completed high school and 57 (8.5%) had done primary ...
Bevezetés: Az üdítőitalok és élelmiszerek édesítésére használt nagy fruktóz tartalmú kukorica-szi... more Bevezetés: Az üdítőitalok és élelmiszerek édesítésére használt nagy fruktóz tartalmú kukorica-szirup és invertcukor felhasználásának köszönhetően a fruktóz-fogyasztása növekedést mutat.. A nagy mennyiségű fruktóz bevitel komoly szerepet játszik a hypertonia, hasi típusú elhízás, nem alkoholos máj elzsírosodás, dyslipidaemia, inzulin rezisztencia (mely citokinek - TNF-α, transzkripciós faktorok - PPAR-α, ChREBs, X-box-binding protein-1, illetve intracelluláris szignál molekulák - IRS-2, p38-MAPK megváltozott aktivitásának hatására alakul ki.), 2-es típusú diabetes mellitus, illetve ezek különböző variációkban - metabolikus syndromában való kialakulásában. Anyag és módszer: A vizsgálat során a 2015-ben zajló "Survey of Food Intake by Individuals" nevű felmérés során rögzített 250 erdélyi felnőtt adatait használtuk fel, amelyből 100 felnőtt egészséges vegetáriánusnak vallotta magát, 100 felnőtt egészséges mindenevő és 50 felnőtt pedig onkológiai betegnek bizonyult. A Heim Pál Gyermekkórház Gasztroenterológiai osztálya által kiadott fruktóz egyenérték táblázat alapján kiszámítottuk a zöldségek-, gyümölcsök-, gabonafélék fruktóz mennyiségét, amely alapján1 gramm fruktózt tartalmaz 109 g zöldség, 26,83 g gyümölcs és 159,33 g gabonafe. Arányba állítva a zöldségek: gyümölcsök:gabonafélék mennyiségeit fruktózra vonatkozva 4: 1 : 6 arányt kapunk, ami azt jelenti, hogy 4-szer több zöldséget kell elfogyasztani, ahhoz, hogy a szervezet úgyanannyi fruktózhoz jusson, mint gyümölcs esetében. Organizația Mondială a Sănătății javaslata szerint ideális esetben naponta 400 g zöldséget = 400 x 1/109g = 3,66 g fruktózt és 400 g gyümölcsöt = 400 x 1/26,83 = 15 g fruktózt, valamint 800 g gabonafélét = 800 x 1/159,33 = 5 g fruktózt, összesen 23,55 g fruktózt kellene fogyasztani. A kérdőíves felmérés alapján a napi fruktóz adag a felnőtt egészséges vegetáriánusok körében 25 g (az ajánlott adagnak megfelelő), a felnőtt egészséges mindenevőknél 18,6 g (kevesebb az ajánlott adaghoz viszonyítva), míg az onkológiai betegek esetében 37,2 g (magasabb az ajánlott adahoz viszonyítva). Eredmények: A tartós pozitív energiamérleg – amely az onkológiai betegeknél lép fel a tanulmány alapján – előmozdítja a metabolikus szindrómát, fokozva a visceralis zsír felhalmozódását, amely növeli a májba a portalis keringésen keresztül beáramló szabad zsírsavak mennyiségét. A sok fruktózt tartalmazó étrend sokkal közvetlenebbül és gyorsabban vezet a máj zsíros túlterheléséhez a de novo lipogenesis útján. Ennek következménye a májban a TG lerakódás, a VLDL felszaporodása és kiválasztása. A máj TG felhalmozódáshoz kapcsolódik a diacylglycerid koncentrációjának emelkedése, amely aktiválja az nPKC-t (the major isoform of Protein Kinase-C) és megszakítja az inzulin jelzőrendszert. A máj TG, illetve VLDL termelése feltehetően a máj inzulin-rezisztencájához kapcsolódik. Az étrendi fruktóz az étvágyat szabályozó hormonok (főként leptin és ghrelin) kedvezőtlen irányú befolyásolásával megnöveli az energia-bevitelt, így hozzájárul az elhízási járvány gyors terjedéséhez. Fokozott cardiovascularis kockázatot jelent a kialakuló dyslipidaemia mellett a hyperuricaemia és az erek endotheljének működését befolyásoló nitrogénoxid funkciózavara. A fruktóz-indukálta inzulin - rezisztencia lép fel a legtöbb ráktípusnál. Következtetések: A fruktóz-fogyasztás korlátozásának szükségessége indokolt, alapvetően az édesítésre használt fruktóz csökkentésével és nem a természetes fruktóz-források – mint példáula gyümölcsök - fogyasztásának megszorításával
Journal of Hypertension, 2018
Objective: Intracranial atherosclerotic stenosis (ICAS) contributes to nearly 50% of stroke in Ch... more Objective: Intracranial atherosclerotic stenosis (ICAS) contributes to nearly 50% of stroke in China, especially in patients with hypertension. Urine albumin-tocreatinine ratio (ACR) has been related to stroke and other atherosclerotic cardiovascular diseases. However, there is limited information about the effect of ACR on early impairment of cerebral vessels. Hereby we assessed the association between ICAS and ACR in a stroke-free hypertensive population. Design and method: Computed tomography angiography was performed to detect atherosclerotic stenosis of intracranial arteries in 889 hypertension patients. A random spot urine was sampled to evaluate ACR. Logistic regression was carried out to analyze the association of ACR with the presence, extent and lesion number of ICAS. Risk factors which we previously identifi ed were also added in the adjustment to determine whether the association of elevated ACR with ICAS was independent. Results: There were 336 patients (37.8%) with ICAS. Elevated ACR (> = 30 mg/g) was associated with ICAS after adjustment of confounding factors (OR = 1.65, 95% CI: 1.21-2.27). This association remained signifi cant in patients who were male, > = 65 years and without diabetes. Patients with elevated ACR were more prone to develop moderate to severe stenosis (OR = 1.57, 95%CI: 1.16-2.12) and more lesions (OR = 1.58, 95%CI: 1.16-2.15). The association of elevated ACR with ICAS was independent of previously discovered risk factors. Conclusions: Our fi ndings suggested that ACR was associated with asymptomatic ICAS in an aged stroke-free hypertensive population. ACR may serve as a convenient and independent early marker of ICAS in clinical practice.
Journal of Obesity & Eating Disorders, 2017
Research studies showed that consumers' average Dietary Fibres consumption was below the recommen... more Research studies showed that consumers' average Dietary Fibres consumption was below the recommended value and also WHO estimates that the prevalence of obesity increased in the last decade all over the world, data that are a big concern and sustain the need for updated food-based dietary guidelines tuned to each country culture, climate and food sources. We recommend that each country have to implement a rigorous population screening regarding the attitudes, knowledge and practices towards Dietary Fibres sources and to elaborate an efficient strategy for a community intervention program for obesity prevention.
Acta Alimentaria, 2016
Dietary fi bres (DFs) are essential components of the balanced diet. Even though the adequate lev... more Dietary fi bres (DFs) are essential components of the balanced diet. Even though the adequate level of their consumption can be ensured from several natural (e.g. fruit, vegetables, legumes) and 'artifi cial' sources (e.g. functional foods), the consumed levels are below the recommendations. To analyse the Hungarian and Romanian consumers' knowledge level, their perceptions of the health benefi ts associated with fi bre, as well as the recognition of the potential information sources, a survey questionnaire was conducted with the total of 713 consumers. Results showed that the level of knowledge about DFs was not adequate. Internet was found to be widely used and identifi ed as one of the most appropriate information sources to encourage the consumption of DF. It was a favourable result that three-quarter of the respondents was interested in the topic of healthy food consumption; however, just less than half of them took into consideration the label information during their shopping decisions. To increase the consumption of DF and to support the responsibility and conscious consumer decisions steps must to be done (e.g. education of children, pointing out of the sources). For this purpose, modern information technology and communication channels fi tting to the consumers' cultural and personal particularities can be utilized.
Public Health, 2016
Dietary fibre (DF) is one of the components of diet that strongly contributes to health improveme... more Dietary fibre (DF) is one of the components of diet that strongly contributes to health improvements, particularly on the gastrointestinal system. Hence, this work intended to evaluate the relations between some sociodemographic variables such as age, gender, level of education, living environment or country on the levels of knowledge about dietary fibre (KADF), its sources and its effects on human health, using a validated scale. The present study was a cross-sectional study. A methodological study was conducted with 6010 participants, residing in 10 countries from different continents (Europe, America, Africa). The instrument was a questionnaire of self-response, aimed at collecting information on knowledge about food fibres. The instrument was used to validate a scale (KADF) which model was used in the present work to identify the best predictors of knowledge. The statistical tools used were as follows: basic descriptive statistics, decision trees, inferential analysis (t-test for independent samples with Levene test and one-way ANOVA with multiple comparisons post hoc tests). The results showed that the best predictor for the three types of knowledge evaluated (about DF, about its sources and about its effects on human health) was always the country, meaning that the social, cultural and/or political conditions greatly determine the level of knowledge. On the other hand, the tests also showed that statistically significant differences were encountered regarding the three types of knowledge for all sociodemographic variables evaluated: age, gender, level of education, living environment and country. The results showed that to improve the level of knowledge the actions planned should not be delineated in general as to reach all sectors of the populations, and that in addressing different people, different methodologies must be designed so as to provide an effective health education.
Public Health, 2016
Objectives: Because there is scientific evidence that an appropriate intake of dietary fibre shou... more Objectives: Because there is scientific evidence that an appropriate intake of dietary fibre should be part of a healthy diet, given its importance in promoting health, the present study aimed to develop and validate an instrument to evaluate the knowledge of the general population about dietary fibres. Study design: The present study was a cross sectional study. Methods: The methodological study of psychometric validation was conducted with 6010 participants, residing in 10 countries from three continents. The instrument is a questionnaire of self-response, aimed at collecting information on knowledge about food fibres. Exploratory factor analysis (EFA) was chosen as the analysis of the main components using varimax orthogonal rotation and eigenvalues greater than 1. In confirmatory factor analysis by structural equation modelling (SEM) was considered the covariance matrix and adopted the maximum likelihood estimation algorithm for parameter estimation.
Revista Romana de Medicina de Laborator, 2015
Oxidative Stress and Diseases, 2012
Objectives: To estimate the relationship between socio-demographic characteristics of Romanian po... more Objectives: To estimate the relationship between socio-demographic characteristics of Romanian population, and their knowledge towards dietary fiber intake, the information sources preferred and perception of cancer related health risks. Methods: We used a convenient cross-sectional survey, and the data were collected using a validated questionnaire, disseminated online. Six different Romanian counties with 57 cities were selected in 2015, with 670 participants, and we used the SPSS program 22.0 for statistical purpose. Results: The knowledge about dietary fibers intake was low in our sample, also was the ingestion of foods rich in fiber (fruits, vegetables and cereals). Compared to men, women agree significantly more frequent that fibers in appropriate amounts can prevent or treat diseases (U=44607, z=-4.66, p<0.001, r=0.18) and separately related to specific diseases, that fibers can prevent and/or treat cardio-vascular diseases, cholesterol, bowel cancer, breast cancer, consti...
Poor diets have proven very detrimental for the maintenance of good health and eating an excessiv... more Poor diets have proven very detrimental for the maintenance of good health and eating an excessive amount of fast food and highly processed meals can harm the general health status of the population. Hence, this work investigates the habits related to eating outside the home and frequency of eating fast food meals in participants from six different countries. A cross-sectional descriptive study was undertaken on a sample of 4,904 adult participants. For the data treatment, basic statistics were complemented with tree classification analysis, using the CRT algorithm. This study concluded that in the sample under study the frequency of eating out of home was in general low, corresponding to four or fewer times per week for 71.9% of the participants, and the consumption of fast food meals was also acceptable, i.e., with a low frequency of up to two times per week in 88.6% of the respondents. The biggest differences were encountered when comparing participants from different age groups, countries or sexes, and not so much for living environment or education level. Tree classification analysis highlighted the relative importance of the considered factors for eating out and fast food meals, being country and age confirmed as the most influential factors. In the evaluated sample the incidence of eating out and fast food meals were low, which is a good indicator to contribute globally for the good health status of the participants involved in the study.
Orvostudományi Értesítö, Dec 1, 2021
Cancer is a common disease that people dread, and most of them fully believe that they will be se... more Cancer is a common disease that people dread, and most of them fully believe that they will be sentenced to death along with the diagnosis. The aim of the present study was to set up a dietary survey and nutritional therapy pattern that can be used in Romania for patients diagnosed with cervical cancer, that will contribute to a better management of the mentioned disease cervical cancer. This diet therapy can help patients to recover easily from cervical cancer, prevent cancer weakening and weight loss, and to fight strenuous medical treatments that can further worsen their overall condition and quality of life. Furthermore, this nutrition intervention can reduce malnutrition outcomes and establishes a diet plan that makes easier for the patients to endure the symptoms and reduces the side effects of multiple cancer treatments. The backbone of our paper was the National Cancer Institute's Nutritional PDQ (Physician Data Query), an american institute that conducts cancer screening and daily information of cancer researchers along with other recent literature sources.
Acta Medica Marisiensis, Sep 1, 2015
Arylsulfatase A (ARSA) is a lysosomal enzyme that plays an important role in catalysis of degrada... more Arylsulfatase A (ARSA) is a lysosomal enzyme that plays an important role in catalysis of degradation of cerebrosidesulphate. The deficiency of this lysosomal enzyme causes an autosomal recessive disorder, called metachromatic leucodystrophy. However, a low ARSA activity can be observed in clinically healthy people, called ARSA pseudodeficiency. In our study we investigated the possible linkage between ARSA activity and sulfatide deficiency causing characteristic aspects of degenerative diseases, such as end stage kidney disease, type 2 Diabetes mellitus, Parkinson syndrome, prostate cancer and HIV (Human Immunodeficiency Virus) infection. We used a spectrophotometric method to determine the activity of ARSA. This method of enzyme dosage is based on a 4 hour long hydrolysis of the ARSA enzyme on 4-nitrocatechol sulfate (p-NCS) substrate. The unit of this measurement is nmol/ml/4h. Our findings show significant values in type 2 diabetes, Parkinson syndrome and chronic kidney disease. The importance of sulfatide in these diseases is well-known, thus presumably the variation of the ARSA's activity might play an important role in the pathophysiology of these diseases, involving a vicious cycle between sulfatide degradation andthese diseases.
Poor diets have proven very detrimental for the maintenance of good health and eating an excessiv... more Poor diets have proven very detrimental for the maintenance of good health and eating an excessive amount of fast food and highly processed meals can harm the general health status of the population. Hence, this work investigates the habits related to eating outside the home and frequency of eating fast food meals in participants from six different countries. A cross-sectional descriptive study was undertaken on a sample of 4,904 adult participants. For the data treatment, basic statistics were complemented with tree classification analysis, using the CRT algorithm. This study concluded that in the sample under study the frequency of eating out of home was in general low, corresponding to four or fewer times per week for 71.9% of the participants, and the consumption of fast food meals was also acceptable, i.e., with a low frequency of up to two times per week in 88.6% of the respondents. The biggest differences were encountered when comparing participants from different age groups, countries or sexes, and not so much for living environment or education level. Tree classification analysis highlighted the relative importance of the considered factors for eating out and fast food meals, being country and age confirmed as the most influential factors. In the evaluated sample the incidence of eating out and fast food meals were low, which is a good indicator to contribute globally for the good health status of the participants involved in the study.
Zenodo (CERN European Organization for Nuclear Research), Mar 2, 2016
Egitania Sciencia
Dietas inadequadas demonstraram ser muito prejudiciais para a manutenção de uma boa saúde, e come... more Dietas inadequadas demonstraram ser muito prejudiciais para a manutenção de uma boa saúde, e comer fast-food em excesso e refeições altamente processadas pode ter um impacto negativo no estado geral de saúde da população. Assim, este trabalho investigou os hábitos relacionados com a alimentação fora de casa e a frequência de refeições rápidas numa amostra oriunda de seis países diferentes. Foi realizado um estudo descritivo transversal numa amostra de 4904 participantes adultos. Para o tratamento dos dados, a análise estatística básica foi complementada com análise de classificação do tipo árvore (Tree), usando o algoritmo CRT. Este estudo permitiu concluir que na amostra em análise a frequência com que os participantes comeram fora de casa foi em geral baixa, correspondendo a quatro ou menos vezes por semana para 71,9% dos participantes, sendo o consumo de fast-food também aceitável, ou seja, com baixa frequência de até duas vezes por semana em 88,6% dos entrevistados. As maiores d...
Life
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Intense oxidative stress, increased glycated hemoglobin and mineral imbalance represent risk fact... more Intense oxidative stress, increased glycated hemoglobin and mineral imbalance represent risk factors for complications in diabetic patients. Cardiovascular complications are most common in these patients, including nephropathy. This study was conducted in 2015 at the Procardia Laboratory in Tîrgu Mureș, Romania on 40 type 2 diabetic adults. Routine biochemical tests were performed on the Konleab 20XTi analyzer (serum glucose, total cholesterol, LDL and HDL cholesterol, triglyceride, creatinine, urea). We also measured serum uric acid, magnesium and calcium concentration by photometric procedures, potassium, sodium and chloride by ion selective electrode, and chromium by atomic absorption spectrometry in a group of patients. Glycated hemoglobin (HbA1c) dosage was made by reflectometry. Urine analysis was performed using the HandUReader equipment. The level of oxidative stress was measured by serum malondialdehyde dosage using the thiobarbituric acid reactive substances method. MDRD (...
JPMA. The Journal of the Pakistan Medical Association, 2019
OBJECTIVE To investigate the perceived importance of information about dietary fibre with regard ... more OBJECTIVE To investigate the perceived importance of information about dietary fibre with regard top opulation socio - demographic characteristics and consumption patterns. METHODS The cross-sectional study was conducted from September to November, 2016, in six different counties and 57 cities across Romania, and was part of a larger project that had nine other countries as well. Data of the Romanian subjects was collected using a validated questionnaire that was disseminated across the 10 countries at the same time. Knowledge about dietary fibre was explored through 10 questions, and the respondents were asked to answer on a 5-point Likert scale varying from 1 (totally disagree) to 5 (totally agree). SPSS 22 was used for data anaylsis. RESULTS Of the 670 subjects, 358 (53.4%) were females, and the overall mean age was 35.81±15.61 years (range: 18-89 years). There were 298 (44.5%) subjects with a university degree, 314(46.9%) had completed high school and 57 (8.5%) had done primary ...
Bevezetés: Az üdítőitalok és élelmiszerek édesítésére használt nagy fruktóz tartalmú kukorica-szi... more Bevezetés: Az üdítőitalok és élelmiszerek édesítésére használt nagy fruktóz tartalmú kukorica-szirup és invertcukor felhasználásának köszönhetően a fruktóz-fogyasztása növekedést mutat.. A nagy mennyiségű fruktóz bevitel komoly szerepet játszik a hypertonia, hasi típusú elhízás, nem alkoholos máj elzsírosodás, dyslipidaemia, inzulin rezisztencia (mely citokinek - TNF-α, transzkripciós faktorok - PPAR-α, ChREBs, X-box-binding protein-1, illetve intracelluláris szignál molekulák - IRS-2, p38-MAPK megváltozott aktivitásának hatására alakul ki.), 2-es típusú diabetes mellitus, illetve ezek különböző variációkban - metabolikus syndromában való kialakulásában. Anyag és módszer: A vizsgálat során a 2015-ben zajló "Survey of Food Intake by Individuals" nevű felmérés során rögzített 250 erdélyi felnőtt adatait használtuk fel, amelyből 100 felnőtt egészséges vegetáriánusnak vallotta magát, 100 felnőtt egészséges mindenevő és 50 felnőtt pedig onkológiai betegnek bizonyult. A Heim Pál Gyermekkórház Gasztroenterológiai osztálya által kiadott fruktóz egyenérték táblázat alapján kiszámítottuk a zöldségek-, gyümölcsök-, gabonafélék fruktóz mennyiségét, amely alapján1 gramm fruktózt tartalmaz 109 g zöldség, 26,83 g gyümölcs és 159,33 g gabonafe. Arányba állítva a zöldségek: gyümölcsök:gabonafélék mennyiségeit fruktózra vonatkozva 4: 1 : 6 arányt kapunk, ami azt jelenti, hogy 4-szer több zöldséget kell elfogyasztani, ahhoz, hogy a szervezet úgyanannyi fruktózhoz jusson, mint gyümölcs esetében. Organizația Mondială a Sănătății javaslata szerint ideális esetben naponta 400 g zöldséget = 400 x 1/109g = 3,66 g fruktózt és 400 g gyümölcsöt = 400 x 1/26,83 = 15 g fruktózt, valamint 800 g gabonafélét = 800 x 1/159,33 = 5 g fruktózt, összesen 23,55 g fruktózt kellene fogyasztani. A kérdőíves felmérés alapján a napi fruktóz adag a felnőtt egészséges vegetáriánusok körében 25 g (az ajánlott adagnak megfelelő), a felnőtt egészséges mindenevőknél 18,6 g (kevesebb az ajánlott adaghoz viszonyítva), míg az onkológiai betegek esetében 37,2 g (magasabb az ajánlott adahoz viszonyítva). Eredmények: A tartós pozitív energiamérleg – amely az onkológiai betegeknél lép fel a tanulmány alapján – előmozdítja a metabolikus szindrómát, fokozva a visceralis zsír felhalmozódását, amely növeli a májba a portalis keringésen keresztül beáramló szabad zsírsavak mennyiségét. A sok fruktózt tartalmazó étrend sokkal közvetlenebbül és gyorsabban vezet a máj zsíros túlterheléséhez a de novo lipogenesis útján. Ennek következménye a májban a TG lerakódás, a VLDL felszaporodása és kiválasztása. A máj TG felhalmozódáshoz kapcsolódik a diacylglycerid koncentrációjának emelkedése, amely aktiválja az nPKC-t (the major isoform of Protein Kinase-C) és megszakítja az inzulin jelzőrendszert. A máj TG, illetve VLDL termelése feltehetően a máj inzulin-rezisztencájához kapcsolódik. Az étrendi fruktóz az étvágyat szabályozó hormonok (főként leptin és ghrelin) kedvezőtlen irányú befolyásolásával megnöveli az energia-bevitelt, így hozzájárul az elhízási járvány gyors terjedéséhez. Fokozott cardiovascularis kockázatot jelent a kialakuló dyslipidaemia mellett a hyperuricaemia és az erek endotheljének működését befolyásoló nitrogénoxid funkciózavara. A fruktóz-indukálta inzulin - rezisztencia lép fel a legtöbb ráktípusnál. Következtetések: A fruktóz-fogyasztás korlátozásának szükségessége indokolt, alapvetően az édesítésre használt fruktóz csökkentésével és nem a természetes fruktóz-források – mint példáula gyümölcsök - fogyasztásának megszorításával
Journal of Hypertension, 2018
Objective: Intracranial atherosclerotic stenosis (ICAS) contributes to nearly 50% of stroke in Ch... more Objective: Intracranial atherosclerotic stenosis (ICAS) contributes to nearly 50% of stroke in China, especially in patients with hypertension. Urine albumin-tocreatinine ratio (ACR) has been related to stroke and other atherosclerotic cardiovascular diseases. However, there is limited information about the effect of ACR on early impairment of cerebral vessels. Hereby we assessed the association between ICAS and ACR in a stroke-free hypertensive population. Design and method: Computed tomography angiography was performed to detect atherosclerotic stenosis of intracranial arteries in 889 hypertension patients. A random spot urine was sampled to evaluate ACR. Logistic regression was carried out to analyze the association of ACR with the presence, extent and lesion number of ICAS. Risk factors which we previously identifi ed were also added in the adjustment to determine whether the association of elevated ACR with ICAS was independent. Results: There were 336 patients (37.8%) with ICAS. Elevated ACR (> = 30 mg/g) was associated with ICAS after adjustment of confounding factors (OR = 1.65, 95% CI: 1.21-2.27). This association remained signifi cant in patients who were male, > = 65 years and without diabetes. Patients with elevated ACR were more prone to develop moderate to severe stenosis (OR = 1.57, 95%CI: 1.16-2.12) and more lesions (OR = 1.58, 95%CI: 1.16-2.15). The association of elevated ACR with ICAS was independent of previously discovered risk factors. Conclusions: Our fi ndings suggested that ACR was associated with asymptomatic ICAS in an aged stroke-free hypertensive population. ACR may serve as a convenient and independent early marker of ICAS in clinical practice.
Journal of Obesity & Eating Disorders, 2017
Research studies showed that consumers' average Dietary Fibres consumption was below the recommen... more Research studies showed that consumers' average Dietary Fibres consumption was below the recommended value and also WHO estimates that the prevalence of obesity increased in the last decade all over the world, data that are a big concern and sustain the need for updated food-based dietary guidelines tuned to each country culture, climate and food sources. We recommend that each country have to implement a rigorous population screening regarding the attitudes, knowledge and practices towards Dietary Fibres sources and to elaborate an efficient strategy for a community intervention program for obesity prevention.
Acta Alimentaria, 2016
Dietary fi bres (DFs) are essential components of the balanced diet. Even though the adequate lev... more Dietary fi bres (DFs) are essential components of the balanced diet. Even though the adequate level of their consumption can be ensured from several natural (e.g. fruit, vegetables, legumes) and 'artifi cial' sources (e.g. functional foods), the consumed levels are below the recommendations. To analyse the Hungarian and Romanian consumers' knowledge level, their perceptions of the health benefi ts associated with fi bre, as well as the recognition of the potential information sources, a survey questionnaire was conducted with the total of 713 consumers. Results showed that the level of knowledge about DFs was not adequate. Internet was found to be widely used and identifi ed as one of the most appropriate information sources to encourage the consumption of DF. It was a favourable result that three-quarter of the respondents was interested in the topic of healthy food consumption; however, just less than half of them took into consideration the label information during their shopping decisions. To increase the consumption of DF and to support the responsibility and conscious consumer decisions steps must to be done (e.g. education of children, pointing out of the sources). For this purpose, modern information technology and communication channels fi tting to the consumers' cultural and personal particularities can be utilized.
Public Health, 2016
Dietary fibre (DF) is one of the components of diet that strongly contributes to health improveme... more Dietary fibre (DF) is one of the components of diet that strongly contributes to health improvements, particularly on the gastrointestinal system. Hence, this work intended to evaluate the relations between some sociodemographic variables such as age, gender, level of education, living environment or country on the levels of knowledge about dietary fibre (KADF), its sources and its effects on human health, using a validated scale. The present study was a cross-sectional study. A methodological study was conducted with 6010 participants, residing in 10 countries from different continents (Europe, America, Africa). The instrument was a questionnaire of self-response, aimed at collecting information on knowledge about food fibres. The instrument was used to validate a scale (KADF) which model was used in the present work to identify the best predictors of knowledge. The statistical tools used were as follows: basic descriptive statistics, decision trees, inferential analysis (t-test for independent samples with Levene test and one-way ANOVA with multiple comparisons post hoc tests). The results showed that the best predictor for the three types of knowledge evaluated (about DF, about its sources and about its effects on human health) was always the country, meaning that the social, cultural and/or political conditions greatly determine the level of knowledge. On the other hand, the tests also showed that statistically significant differences were encountered regarding the three types of knowledge for all sociodemographic variables evaluated: age, gender, level of education, living environment and country. The results showed that to improve the level of knowledge the actions planned should not be delineated in general as to reach all sectors of the populations, and that in addressing different people, different methodologies must be designed so as to provide an effective health education.
Public Health, 2016
Objectives: Because there is scientific evidence that an appropriate intake of dietary fibre shou... more Objectives: Because there is scientific evidence that an appropriate intake of dietary fibre should be part of a healthy diet, given its importance in promoting health, the present study aimed to develop and validate an instrument to evaluate the knowledge of the general population about dietary fibres. Study design: The present study was a cross sectional study. Methods: The methodological study of psychometric validation was conducted with 6010 participants, residing in 10 countries from three continents. The instrument is a questionnaire of self-response, aimed at collecting information on knowledge about food fibres. Exploratory factor analysis (EFA) was chosen as the analysis of the main components using varimax orthogonal rotation and eigenvalues greater than 1. In confirmatory factor analysis by structural equation modelling (SEM) was considered the covariance matrix and adopted the maximum likelihood estimation algorithm for parameter estimation.
Revista Romana de Medicina de Laborator, 2015
Oxidative Stress and Diseases, 2012
Objectives: To estimate the relationship between socio-demographic characteristics of Romanian po... more Objectives: To estimate the relationship between socio-demographic characteristics of Romanian population, and their knowledge towards dietary fiber intake, the information sources preferred and perception of cancer related health risks. Methods: We used a convenient cross-sectional survey, and the data were collected using a validated questionnaire, disseminated online. Six different Romanian counties with 57 cities were selected in 2015, with 670 participants, and we used the SPSS program 22.0 for statistical purpose. Results: The knowledge about dietary fibers intake was low in our sample, also was the ingestion of foods rich in fiber (fruits, vegetables and cereals). Compared to men, women agree significantly more frequent that fibers in appropriate amounts can prevent or treat diseases (U=44607, z=-4.66, p<0.001, r=0.18) and separately related to specific diseases, that fibers can prevent and/or treat cardio-vascular diseases, cholesterol, bowel cancer, breast cancer, consti...