Federica Lince - Academia.edu (original) (raw)
Papers by Federica Lince
Journal of Colloid and Interface Science, Jun 1, 2008
In this work turbulent precipitation through solvent displacement for the production of poly-epsi... more In this work turbulent precipitation through solvent displacement for the production of poly-epsilon-caprolactone (PCL) nanoparticles is investigated; two different PCL molecular weights have been employed, using acetone and water as solvent and anti-solvent, respectively. The main important thermodynamic and kinetic parameters, such as solubility and interfacial tension of PCL in water-acetone mixtures, are determined and the effect of the process operating conditions on the final particle size distribution is also investigated. Particles produced under different conditions into a Confined Impinging Jets Reactor (CIJR) were characterized by Dynamic Light Scattering, Zeta potential measurements and Scanning Electronic Microscopy. Results clearly show the strong effect of mixing on the particle size distribution and how mixing must be controlled in order to obtain a product with particular characteristics. Eventually the measured thermodynamic and kinetic parameters are used to interpret the obtained experimental data.
Chemical Engineering and Processing, Apr 1, 2011
Active and passive mixers, including a considerable variety of micro-devices, are nowadays widely... more Active and passive mixers, including a considerable variety of micro-devices, are nowadays widely used for the production of nanoparticles. Polymer nanoparticles for controlled drug delivery applications are investigated in this work with two specific objectives. The first one is to experimentally quantify the efficiency of confined impinging jets reactors and Tee-mixers in the production of nanoparticles constituted by two polymers:
Chemical engineering research & design, Nov 1, 2011
AIChE Annual Meeting, 2007
Federica Lince 1 , Daniele Marchisio 1 , Anna Jawor-Baczynska 2 , Jan Sefcik 2 , and Antonello Ba... more Federica Lince 1 , Daniele Marchisio 1 , Anna Jawor-Baczynska 2 , Jan Sefcik 2 , and Antonello Barresi 1 . (1) Scienza dei Materiali e Ingegneria Chimica, Politecnico di Torino, C.so Duca degli Abruzzi 24, Torino ... 1] Soppimath, KS; Aminabhavi, TM; Kulkarni, AR; Rudzinski, WE, J ...
Journal of Pharmaceutical Sciences, Jun 1, 2011
In this work, the biodegradable copolymer poly(methoxypolyethyleneglycolcyanoacrylate-co-hexadecy... more In this work, the biodegradable copolymer poly(methoxypolyethyleneglycolcyanoacrylate-co-hexadecylcyanoacrylate) is used to prepare nanoparticles via solvent displacement in a confined impinging jets reactor (CIJR). For comparison, nanoparticles constituted by the homopolymer counterpart are also investigated. The CIJR is a small passive mixer in which very fast turbulent mixing of the solvent (i.e., acetone and tetrahydrofuran) and of the antisolvent (i.e., water) solutions occurs under controlled conditions. The effect of the initial copolymer concentration, solvent type, antisolvent-to-solvent ratio, and mixing rate inside the mixer on the final nanoparticle size distribution, surface properties, and morphology is investigated from the experimental point of view. The effect of some of these parameters is studied by means of a computational fluid dynamics (CFD) model, capable of quantifying the mixing conditions inside the CIJR. Results show that the CIJR can be profitably used for producing nanoparticles with controlled characteristics, that there is a clear correlation between the mixing rate calculated by CFD and the mean nanoparticle size, and therefore that CFD can be used to design, optimize, and scale-up these processes.
Federica Lince 1 , Daniele Marchisio 1 , Anna Jawor-Baczynska 2 , Jan Sefcik 2 , and Antonello Ba... more Federica Lince 1 , Daniele Marchisio 1 , Anna Jawor-Baczynska 2 , Jan Sefcik 2 , and Antonello Barresi 1 . (1) Scienza dei Materiali e Ingegneria Chimica, Politecnico di Torino, C.so Duca degli Abruzzi 24, Torino ... 1] Soppimath, KS; Aminabhavi, TM; Kulkarni, AR; Rudzinski, WE, J ...
Colloidal suspensions of engineered nanoparticles have been studied in recent years for waste wat... more Colloidal suspensions of engineered nanoparticles have been studied in recent years for waste water and in-situ groundwater remediation. Zero-valent iron micro- and nano-particles represent a promising technology for groundwater remediation. Due to their large surface area, reactivity and mobility, iron micro- and nano-particles are extremely effective in contaminants degradation, allowing source treatment, as they can be injected directly in the subsurface in the form of viscous dispersions, characterized by complex rheological properties. Assessing the mobility of iron-based colloids is a key issue for field applications of these materials. In this work, co-funded by European Union project AQUAREHAB (FP7 - Grant Agreement Nr. 226565), micro- and macro-scale modelling approaches are proposed to determine the key factors that control the mobility of iron suspensions, and to simulate their transport at both laboratory and field scale. A micro-scale model can improve knowledge of pore...
Zero-valent iron micro- and nano-particles represent a promising technology for groundwater remed... more Zero-valent iron micro- and nano-particles represent a promising technology for groundwater remediation. Due to their large surface area, reactivity and mobility, iron micro- and nano-particles are extremely effective in contaminants degradation, allowing source treatment, as they can be injected directly in the subsurface in the form of aqueous dispersions. Some promising results have shown that some mobility limitations of iron particles, due to aggregation, can be overtaken by modification of the suspensions using biodegradable hydrocolloids, namely guar gum and xanthan gum, thus forming non-Newtonian fluids. The design of a remediation project is thus strictly connected to the determination of the radius of influence of an injection well (ROI). This can be estimated using a macro-scale modelling approach, able to predict particle transport and accounting for particle-particle and particle-grain interactions. The aim of this work (co-funded by European Union project AQUAREHAB (FP...
The use of viscous, shear thinning fluids (eg. guar gum and xanthan gum solutions) has been recen... more The use of viscous, shear thinning fluids (eg. guar gum and xanthan gum solutions) has been recently proposed to improve colloidal stability of micro- and nanoscale zerovalent iron particles (MZVI and NZVI) for groundwater remediation. When modelling the colloidal transport of such suspensions, the rheological, non-Newtonian properties of the shear thinning carrier fluid are to be incorporated into the model, in order to correctly simulate pressure drops and viscosity of the suspension. For small flow rates, typical of laboratory column tests, the extended Darcy law is known to be applicable also to non Newtonian fluids. However, when field injection is considered, high Reynolds numbers are encountered close to the injection point, and linear flow cannot be assumed. The Darcy-Forchheimer law is known to be applicable for Newtonian flow and for simple models of shear thinning fluids (power law). However, this is not demonstrated for other, more realistic, shear thinning rheological m...
The solvent displacement method involves three main steps to obtain nanoparticles: dissolution of... more The solvent displacement method involves three main steps to obtain nanoparticles: dissolution of both the polymer and the drug into a solvent, mixing of the obtained solution with the anti-solvent, and elimination of the solvent through evaporation. 1 Mixing leads to rapid diffusion of the solvent into the anti-solvent and spontaneous particle formation. Particle formation is extremely rapid and therefore mixing must be very fast: for this reason special efficient continuous mixers must be used, such as Confined Impinging Jets Reactors (CIJR), 2,3 in which two solutions of solvent and anti-solvent are mixed in a very small volume in the center of a mixing chamber, where owing to collision and impingement of the two jets, turbulent kinetic energy is generated and then quickly dissipated. This reactor generally leads to high mixing efficiencies, which allows production of very small particles. In this work poly(methoxypolyethyleneglycol cyanoacrylate-co-hexadecyl cyanoacrylate) (P(Me...
Porous media are ubiquitous in chemical engineering. They are involved in many separation process... more Porous media are ubiquitous in chemical engineering. They are involved in many separation processes (e.g., filtration, chromatography) and they play an important role in numerous chemically reacting systems such as in catalysis and in remediation of contaminated aquifers. Very often the fluids involved are characterized by very diverse rheological properties, ranging from classical Newtonian to non-Newtonian behaviors. Although the final applications are very different from each other and are typically characterized by very different features there are some common issues that despite the huge amount of experimental data still need to be addressed. These are generally related to the need of describing the porous medium at the macro-scale as a continuum defined in terms of a set of parameters that quantify its flow properties (e.g., porosity, permeability) and its particle transport characteristics (e.g., collection efficiency). This work (co-funded by European Union project AQUAREHAB...
Journal of Colloid and Interface Science, Jun 1, 2008
In this work turbulent precipitation through solvent displacement for the production of poly-epsi... more In this work turbulent precipitation through solvent displacement for the production of poly-epsilon-caprolactone (PCL) nanoparticles is investigated; two different PCL molecular weights have been employed, using acetone and water as solvent and anti-solvent, respectively. The main important thermodynamic and kinetic parameters, such as solubility and interfacial tension of PCL in water-acetone mixtures, are determined and the effect of the process operating conditions on the final particle size distribution is also investigated. Particles produced under different conditions into a Confined Impinging Jets Reactor (CIJR) were characterized by Dynamic Light Scattering, Zeta potential measurements and Scanning Electronic Microscopy. Results clearly show the strong effect of mixing on the particle size distribution and how mixing must be controlled in order to obtain a product with particular characteristics. Eventually the measured thermodynamic and kinetic parameters are used to interpret the obtained experimental data.
Chemical Engineering and Processing, Apr 1, 2011
Active and passive mixers, including a considerable variety of micro-devices, are nowadays widely... more Active and passive mixers, including a considerable variety of micro-devices, are nowadays widely used for the production of nanoparticles. Polymer nanoparticles for controlled drug delivery applications are investigated in this work with two specific objectives. The first one is to experimentally quantify the efficiency of confined impinging jets reactors and Tee-mixers in the production of nanoparticles constituted by two polymers:
Chemical engineering research & design, Nov 1, 2011
AIChE Annual Meeting, 2007
Federica Lince 1 , Daniele Marchisio 1 , Anna Jawor-Baczynska 2 , Jan Sefcik 2 , and Antonello Ba... more Federica Lince 1 , Daniele Marchisio 1 , Anna Jawor-Baczynska 2 , Jan Sefcik 2 , and Antonello Barresi 1 . (1) Scienza dei Materiali e Ingegneria Chimica, Politecnico di Torino, C.so Duca degli Abruzzi 24, Torino ... 1] Soppimath, KS; Aminabhavi, TM; Kulkarni, AR; Rudzinski, WE, J ...
Journal of Pharmaceutical Sciences, Jun 1, 2011
In this work, the biodegradable copolymer poly(methoxypolyethyleneglycolcyanoacrylate-co-hexadecy... more In this work, the biodegradable copolymer poly(methoxypolyethyleneglycolcyanoacrylate-co-hexadecylcyanoacrylate) is used to prepare nanoparticles via solvent displacement in a confined impinging jets reactor (CIJR). For comparison, nanoparticles constituted by the homopolymer counterpart are also investigated. The CIJR is a small passive mixer in which very fast turbulent mixing of the solvent (i.e., acetone and tetrahydrofuran) and of the antisolvent (i.e., water) solutions occurs under controlled conditions. The effect of the initial copolymer concentration, solvent type, antisolvent-to-solvent ratio, and mixing rate inside the mixer on the final nanoparticle size distribution, surface properties, and morphology is investigated from the experimental point of view. The effect of some of these parameters is studied by means of a computational fluid dynamics (CFD) model, capable of quantifying the mixing conditions inside the CIJR. Results show that the CIJR can be profitably used for producing nanoparticles with controlled characteristics, that there is a clear correlation between the mixing rate calculated by CFD and the mean nanoparticle size, and therefore that CFD can be used to design, optimize, and scale-up these processes.
Federica Lince 1 , Daniele Marchisio 1 , Anna Jawor-Baczynska 2 , Jan Sefcik 2 , and Antonello Ba... more Federica Lince 1 , Daniele Marchisio 1 , Anna Jawor-Baczynska 2 , Jan Sefcik 2 , and Antonello Barresi 1 . (1) Scienza dei Materiali e Ingegneria Chimica, Politecnico di Torino, C.so Duca degli Abruzzi 24, Torino ... 1] Soppimath, KS; Aminabhavi, TM; Kulkarni, AR; Rudzinski, WE, J ...
Colloidal suspensions of engineered nanoparticles have been studied in recent years for waste wat... more Colloidal suspensions of engineered nanoparticles have been studied in recent years for waste water and in-situ groundwater remediation. Zero-valent iron micro- and nano-particles represent a promising technology for groundwater remediation. Due to their large surface area, reactivity and mobility, iron micro- and nano-particles are extremely effective in contaminants degradation, allowing source treatment, as they can be injected directly in the subsurface in the form of viscous dispersions, characterized by complex rheological properties. Assessing the mobility of iron-based colloids is a key issue for field applications of these materials. In this work, co-funded by European Union project AQUAREHAB (FP7 - Grant Agreement Nr. 226565), micro- and macro-scale modelling approaches are proposed to determine the key factors that control the mobility of iron suspensions, and to simulate their transport at both laboratory and field scale. A micro-scale model can improve knowledge of pore...
Zero-valent iron micro- and nano-particles represent a promising technology for groundwater remed... more Zero-valent iron micro- and nano-particles represent a promising technology for groundwater remediation. Due to their large surface area, reactivity and mobility, iron micro- and nano-particles are extremely effective in contaminants degradation, allowing source treatment, as they can be injected directly in the subsurface in the form of aqueous dispersions. Some promising results have shown that some mobility limitations of iron particles, due to aggregation, can be overtaken by modification of the suspensions using biodegradable hydrocolloids, namely guar gum and xanthan gum, thus forming non-Newtonian fluids. The design of a remediation project is thus strictly connected to the determination of the radius of influence of an injection well (ROI). This can be estimated using a macro-scale modelling approach, able to predict particle transport and accounting for particle-particle and particle-grain interactions. The aim of this work (co-funded by European Union project AQUAREHAB (FP...
The use of viscous, shear thinning fluids (eg. guar gum and xanthan gum solutions) has been recen... more The use of viscous, shear thinning fluids (eg. guar gum and xanthan gum solutions) has been recently proposed to improve colloidal stability of micro- and nanoscale zerovalent iron particles (MZVI and NZVI) for groundwater remediation. When modelling the colloidal transport of such suspensions, the rheological, non-Newtonian properties of the shear thinning carrier fluid are to be incorporated into the model, in order to correctly simulate pressure drops and viscosity of the suspension. For small flow rates, typical of laboratory column tests, the extended Darcy law is known to be applicable also to non Newtonian fluids. However, when field injection is considered, high Reynolds numbers are encountered close to the injection point, and linear flow cannot be assumed. The Darcy-Forchheimer law is known to be applicable for Newtonian flow and for simple models of shear thinning fluids (power law). However, this is not demonstrated for other, more realistic, shear thinning rheological m...
The solvent displacement method involves three main steps to obtain nanoparticles: dissolution of... more The solvent displacement method involves three main steps to obtain nanoparticles: dissolution of both the polymer and the drug into a solvent, mixing of the obtained solution with the anti-solvent, and elimination of the solvent through evaporation. 1 Mixing leads to rapid diffusion of the solvent into the anti-solvent and spontaneous particle formation. Particle formation is extremely rapid and therefore mixing must be very fast: for this reason special efficient continuous mixers must be used, such as Confined Impinging Jets Reactors (CIJR), 2,3 in which two solutions of solvent and anti-solvent are mixed in a very small volume in the center of a mixing chamber, where owing to collision and impingement of the two jets, turbulent kinetic energy is generated and then quickly dissipated. This reactor generally leads to high mixing efficiencies, which allows production of very small particles. In this work poly(methoxypolyethyleneglycol cyanoacrylate-co-hexadecyl cyanoacrylate) (P(Me...
Porous media are ubiquitous in chemical engineering. They are involved in many separation process... more Porous media are ubiquitous in chemical engineering. They are involved in many separation processes (e.g., filtration, chromatography) and they play an important role in numerous chemically reacting systems such as in catalysis and in remediation of contaminated aquifers. Very often the fluids involved are characterized by very diverse rheological properties, ranging from classical Newtonian to non-Newtonian behaviors. Although the final applications are very different from each other and are typically characterized by very different features there are some common issues that despite the huge amount of experimental data still need to be addressed. These are generally related to the need of describing the porous medium at the macro-scale as a continuum defined in terms of a set of parameters that quantify its flow properties (e.g., porosity, permeability) and its particle transport characteristics (e.g., collection efficiency). This work (co-funded by European Union project AQUAREHAB...