Feleke Tilahun - Academia.edu (original) (raw)

Papers by Feleke Tilahun

Journal of the American Academy of Dermatology, 2007

Case report: A 15-year-old white male patient came to the Sanitary Dermatology Department of the ... more Case report: A 15-year-old white male patient came to the Sanitary Dermatology Department of the Instituto de Dermatologia Prof. Rubem David Azulay, in Rio de Janeiro, Brazil; complaining about a lesion on his penis and worsening of general symptoms. Two months after unsafe sex, he developed a punctiform lesion on his penis that rapidly grew to a non-painful ulceration, fever, maculo-papular erithematous rash with small generalized lymphadenomegaly and a sore throat. His lues serology title was 1:256, with a positive TPHA and negative anti-HIV 1 and 2. He was treated with benzathine penicilline (4.8 million units IM) with remission of the fever, rash and lymphadenomegaly after 9 days, except for a bilateral inguinal lymphadenopathy.

PLOS Neglected Tropical Diseases

Background Cutaneous leishmaniasis (CL) is generally caused by Leishmania aethiopica in Ethiopia,... more Background Cutaneous leishmaniasis (CL) is generally caused by Leishmania aethiopica in Ethiopia, and is relatively hard to treat. Sodium stibogluconate (SSG) is the only routinely and widely available antileishmanial treatment, and can be used systemically for severe lesions and locally for smaller lesions. There is limited data on the effectiveness of intralesional (IL) SSG for localized CL in Ethiopia and therefore good data is necessary to improve our understanding of the effectiveness of the treatment. Methodology/Principal findings A pragmatic (before and after Quazi experimental) study was done to assess the effectiveness of intralesional SSG among localized CL patients at Boru Meda general hospital, Northeast Ethiopia. Patients who were assigned to intralesional SSG by the treating physician were eligible for this study. Study subjects were recruited between January and August 2021. Infiltration of intralesional SSG was given weekly to a maximum of six doses. However, when a...

Trichology and Cosmetology – Open Journal, 2017

Introduction: Irrational use of topical corticosteroid (TC) is quite common in Ethiopia due to th... more Introduction: Irrational use of topical corticosteroid (TC) is quite common in Ethiopia due to the unrestricted availability and use of topical steroids (TS) not only by general public but also by physicians and chemists. This practice is highly prevalent and sought after, owing to the quick relief of symptoms in different dermatological conditions and its nature of enhancing beauty for a certain period. Objective: This study aims to evaluate and analyze the prevalence of misuse of topical steroids, causes behind the misuse and consequences after the use of topical steroids among females in a dermatology outpatient department (OPD) at Ayder Referral Hospital, Ethiopia. Materials and Methods: A cross-sectional observational questionnaire based study was conducted from April to August 2015. Patients were questioned and assessed for misuse of topical steroids in terms of indication, dose, frequency, duration, effects after use and source of recommendation of topical steroids among fema...

PLoS Neglected Tropical Diseases, 2021

Background Cutaneous leishmaniasis (CL) in Ethiopia, caused by Leishmania aethiopica, is often se... more Background Cutaneous leishmaniasis (CL) in Ethiopia, caused by Leishmania aethiopica, is often severe and hard to treat compared to CL caused by other species elsewhere. Miltefosine is the only oral anti-leishmanial drug, with a favorable side-effect profile compared to routinely available sodium stibogluconate (SSG), but evidence about its use for L. aethiopica is lacking. Methodology and principal findings In an observational cohort study, treatment outcomes, safety and adherence among CL patients who required systemic treatment and received miltefosine for 28 days in Boru Meda Hospital and University of Gondar Hospital were studied. Patient cure was defined as 100% flattening for non-ulcerated lesions and 100% flattening and 100% re-epithelization for ulcerated lesions. Outcomes were documented for day 28, 90 and 180, both per site, and pooled, adjusting for site as a fixed effect with effect coding. Among 94 included patients (32 in Gondar, 62 in Boru Meda), median lesion durati...

Introduction; Cutaneous leishmaniasis is a neglected tropical disease strongly associated with po... more Introduction; Cutaneous leishmaniasis is a neglected tropical disease strongly associated with poverty with an adverse health effects over the poorest populations of the world. The disease is endemic in 88 countries, 72 of them are developing countries including Ethiopia. It has been estimated that 12million people are infected and 350 million people are at risk with the annual incidence of new cases is estimated between 1.5-2million. Ethiopia has seen new outbreaks in areas previously not known to be endemic often with co-infection by the human immunodeficiency virus with rates reaching 5.6% of the cases and other associated risk factors. As best of my knowledge similar study was not conducted specifically in Mekelle even though other study conducted to the whole region, Tigray. Thus, this preliminary study concerns to determine the magnitude and associated factors of cutaneous leishmaniasis in Mekelle city.Objectives; To assess the prevalence and associated factors of cutaneous leishmaniasis on patients who visit dermatology out patient department in Ayder referral hospital, Mekelle, Tigray, Northern Ethiopia. Methods and subjects; Institutional based cross sectional study was conducted on 478 study population from Ayder referral hospital by using systematic random sampling technique. Data entry and analysis was conducted by using SPSS v-20. The association between different variables in relation to the outcome variable was measured by odds ratio with 95% confidence interval. All variables with P<0.05 in the bivariate analysis were included in the multivariate model, accepting P ≤0.05 as the inclusion level for the independent variables. Result; Prevalence of cutaneouse leishmaniasis in this study was nearly six percent (5.6%) with 99% response rate. Sex [AOR 2.1(95% CI); (0.15, 0.79)], income source being farmer [AOR 2.1(95% CI); (0.00.0.248)], location of the home near to both farm and gorge [AOR 10.1 (95% CI); (0.00, 0.574)] and presence of the hyrax [AOR 1.1(95% CI); (0.00, 0.60)] were statistically significant to the presence of cutaneouse leishmaniasis in Mekelle city. Conclusion The overall prevalence of cutaneouse leishmaniasis in the study area was relatively high (5.6%) having a statistical significant association with sex, income source (farmer), location of the residence near to farm land and gorge and the presence of hyrax. Thus, a continuous health education and awareness creation about the disease, factors and preventive methods of cutaneouse should be sought.

Journal of the American Academy of Dermatology, 2007

Case report: A 15-year-old white male patient came to the Sanitary Dermatology Department of the ... more Case report: A 15-year-old white male patient came to the Sanitary Dermatology Department of the Instituto de Dermatologia Prof. Rubem David Azulay, in Rio de Janeiro, Brazil; complaining about a lesion on his penis and worsening of general symptoms. Two months after unsafe sex, he developed a punctiform lesion on his penis that rapidly grew to a non-painful ulceration, fever, maculo-papular erithematous rash with small generalized lymphadenomegaly and a sore throat. His lues serology title was 1:256, with a positive TPHA and negative anti-HIV 1 and 2. He was treated with benzathine penicilline (4.8 million units IM) with remission of the fever, rash and lymphadenomegaly after 9 days, except for a bilateral inguinal lymphadenopathy.

PLOS Neglected Tropical Diseases

Background Cutaneous leishmaniasis (CL) is generally caused by Leishmania aethiopica in Ethiopia,... more Background Cutaneous leishmaniasis (CL) is generally caused by Leishmania aethiopica in Ethiopia, and is relatively hard to treat. Sodium stibogluconate (SSG) is the only routinely and widely available antileishmanial treatment, and can be used systemically for severe lesions and locally for smaller lesions. There is limited data on the effectiveness of intralesional (IL) SSG for localized CL in Ethiopia and therefore good data is necessary to improve our understanding of the effectiveness of the treatment. Methodology/Principal findings A pragmatic (before and after Quazi experimental) study was done to assess the effectiveness of intralesional SSG among localized CL patients at Boru Meda general hospital, Northeast Ethiopia. Patients who were assigned to intralesional SSG by the treating physician were eligible for this study. Study subjects were recruited between January and August 2021. Infiltration of intralesional SSG was given weekly to a maximum of six doses. However, when a...

Trichology and Cosmetology – Open Journal, 2017

Introduction: Irrational use of topical corticosteroid (TC) is quite common in Ethiopia due to th... more Introduction: Irrational use of topical corticosteroid (TC) is quite common in Ethiopia due to the unrestricted availability and use of topical steroids (TS) not only by general public but also by physicians and chemists. This practice is highly prevalent and sought after, owing to the quick relief of symptoms in different dermatological conditions and its nature of enhancing beauty for a certain period. Objective: This study aims to evaluate and analyze the prevalence of misuse of topical steroids, causes behind the misuse and consequences after the use of topical steroids among females in a dermatology outpatient department (OPD) at Ayder Referral Hospital, Ethiopia. Materials and Methods: A cross-sectional observational questionnaire based study was conducted from April to August 2015. Patients were questioned and assessed for misuse of topical steroids in terms of indication, dose, frequency, duration, effects after use and source of recommendation of topical steroids among fema...

PLoS Neglected Tropical Diseases, 2021

Background Cutaneous leishmaniasis (CL) in Ethiopia, caused by Leishmania aethiopica, is often se... more Background Cutaneous leishmaniasis (CL) in Ethiopia, caused by Leishmania aethiopica, is often severe and hard to treat compared to CL caused by other species elsewhere. Miltefosine is the only oral anti-leishmanial drug, with a favorable side-effect profile compared to routinely available sodium stibogluconate (SSG), but evidence about its use for L. aethiopica is lacking. Methodology and principal findings In an observational cohort study, treatment outcomes, safety and adherence among CL patients who required systemic treatment and received miltefosine for 28 days in Boru Meda Hospital and University of Gondar Hospital were studied. Patient cure was defined as 100% flattening for non-ulcerated lesions and 100% flattening and 100% re-epithelization for ulcerated lesions. Outcomes were documented for day 28, 90 and 180, both per site, and pooled, adjusting for site as a fixed effect with effect coding. Among 94 included patients (32 in Gondar, 62 in Boru Meda), median lesion durati...

Introduction; Cutaneous leishmaniasis is a neglected tropical disease strongly associated with po... more Introduction; Cutaneous leishmaniasis is a neglected tropical disease strongly associated with poverty with an adverse health effects over the poorest populations of the world. The disease is endemic in 88 countries, 72 of them are developing countries including Ethiopia. It has been estimated that 12million people are infected and 350 million people are at risk with the annual incidence of new cases is estimated between 1.5-2million. Ethiopia has seen new outbreaks in areas previously not known to be endemic often with co-infection by the human immunodeficiency virus with rates reaching 5.6% of the cases and other associated risk factors. As best of my knowledge similar study was not conducted specifically in Mekelle even though other study conducted to the whole region, Tigray. Thus, this preliminary study concerns to determine the magnitude and associated factors of cutaneous leishmaniasis in Mekelle city.Objectives; To assess the prevalence and associated factors of cutaneous leishmaniasis on patients who visit dermatology out patient department in Ayder referral hospital, Mekelle, Tigray, Northern Ethiopia. Methods and subjects; Institutional based cross sectional study was conducted on 478 study population from Ayder referral hospital by using systematic random sampling technique. Data entry and analysis was conducted by using SPSS v-20. The association between different variables in relation to the outcome variable was measured by odds ratio with 95% confidence interval. All variables with P<0.05 in the bivariate analysis were included in the multivariate model, accepting P ≤0.05 as the inclusion level for the independent variables. Result; Prevalence of cutaneouse leishmaniasis in this study was nearly six percent (5.6%) with 99% response rate. Sex [AOR 2.1(95% CI); (0.15, 0.79)], income source being farmer [AOR 2.1(95% CI); (0.00.0.248)], location of the home near to both farm and gorge [AOR 10.1 (95% CI); (0.00, 0.574)] and presence of the hyrax [AOR 1.1(95% CI); (0.00, 0.60)] were statistically significant to the presence of cutaneouse leishmaniasis in Mekelle city. Conclusion The overall prevalence of cutaneouse leishmaniasis in the study area was relatively high (5.6%) having a statistical significant association with sex, income source (farmer), location of the residence near to farm land and gorge and the presence of hyrax. Thus, a continuous health education and awareness creation about the disease, factors and preventive methods of cutaneouse should be sought.