Felipe Lobato - Academia.edu (original) (raw)
Papers by Felipe Lobato
Revista Neurociências, Jul 1, 2024
Biomedicines, Feb 23, 2024
Journal of Medical Virology
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a coronavirus belonging to the be... more Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a coronavirus belonging to the beta CoV genus, responsible for SARS in humans, which became known as COVID‐19. The emergence of variants of this virus is related to the presence of cases of reinfection, reduced vaccine effectiveness and greater transmission of the virus. Objective: In this study, we evaluated the molecular epidemiology of SARS‐CoV‐2 lineages circulating in the state of Maranhão. This is a cross‐sectional and retrospective epidemiological study of genomic surveillance of SARS‐CoV‐2. The study comprised of 338 genomes sequenced by the Next Generation Sequencing technique on Illumina's Miseq equipment, submitted to Global Initiative on Sharing Avian Influenza Data, 190 (56.2%) are from samples of female and 148 (43.8%) from male patients. Sequencing performed covered samples of patients aged between 1 and 108 years, with emphasis on the age groups from 30 to 39 years with 15.0% of sequenced genomes and...
OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA
Este artigo aborda a presença dos discursos de sustentabilidade na criação do ambiente urbano atr... more Este artigo aborda a presença dos discursos de sustentabilidade na criação do ambiente urbano através do Programa de Aceleração do Crescimento (PAC), especificamente na sua linha de Urbanização de Assentamentos Precários (UAP), que se destina à realocação urbana de famílias em situação de risco socioambiental. Utilizando uma abordagem qualitativa fundamentada no materialismo histórico-dialético, foi conduzido um estudo de caso sobre a intervenção do PAC, a partir do seu Plano de Trabalho Técnico Social (PTTS), nos projetos habitacionais voltados para o deslocamento de famílias que vivem em áreas ambiental e socialmente vulneráveis, na cidade de Belém (PA), mais especificamente na Comunidade Taboquinha, localizada no Distrito de Icoaraci. A análise deste estudo reflete a perspectiva dos envolvidos no processo e a trajetória dos indivíduos durante a transição entre espaços e em seu cotidiano, evidenciando o distanciamento entre a implementação das políticas e a busca pela sustentabili...
Anais do XIV Fórum de Pesquisa e Extensão da Escola de Aplicação da Universidade Federal do Pará
Research, Society and Development
A crise gerada pela pandemia impactou diversos fatores da vida cotidiana das pessoas e promoveu m... more A crise gerada pela pandemia impactou diversos fatores da vida cotidiana das pessoas e promoveu mudanças que propiciaram o aumento do estresse. Esta situação chama atenção para possíveis complicações psiquiátricas, não apenas em pacientes que já foram infectados pelo vírus, mas também em toda a população que precisou lidar com as medidas implementadas pelo governo. Dessa forma, esse estudo baseia-se em avaliar o comprometimento imunológico populacional associado a condições de estresse perante a pandemia da COVID-19. Trata-se de uma revisão integrativa da literatura, com abordagem qualitativa a partir do levantamento de dados nacionais e internacionais das seguintes bases de dados: Medical Literature Analysis and Retrieval System Online (MEDLINE/PubMed), Scientific Eletronic Library Online (SciELO) e Google Scholar. No estudo foi observada a relação do sistema nervoso, imunológico e endócrino, alterando mecanismos nos circuitos imunes neuroendócrino e acarretando danos à saúde pelos...
Hansenologia Internationalis, Oct 18, 2019
![Research paper thumbnail of {"__content__"=>"Hydroalcoholic Extract and Ethyl Acetate Fraction of Leaves Decrease the Inflammatory Response to Subsp. .", "i"=>[{"__content__"=>"Bixa orellana"}, {"__content__"=>"Mycobacterium abscessus"}, {"__content__"=>"massiliense"}]}](https://attachments.academia-assets.com/119577987/thumbnails/1.jpg)
](Evidence-based complementary and alternative medicine : eCAM, 2018
The incidence of infections caused by rapidly growing mycobacteria (RGM), especially subsp. (), i... more The incidence of infections caused by rapidly growing mycobacteria (RGM), especially subsp. (), is increasing worldwide. Severe infections are associated with abscess formation and strong inflammatory response. This study evaluated the antimicrobial and anti-inflammatory activities of a hydroalcoholic extract (BoHE) and ethyl acetate fraction (BoEA) of leaves. Antimicrobial activity was evaluated by broth microdilution to determine the minimum inhibitory (MIC) and the minimum bactericidal (MBC) concentrations. Cytotoxicity was evaluated using erythrocytes and RAW 264.7 cells. Nitric oxide (NO) was assayed in stimulated RAW 264.7 cells, and inflammatory cell migration and acute toxicity were evaluated in a -induced peritonitis mouse model. The compounds present in BoEA were identified by high performance liquid chromatography and mass spectrometry (HPLC-MS). The MIC and MBC values were 2.34 mg/mL and 37.5 mg/mL for BoHE and 0.39 mg/mL and 6.25 mg/mL for BoEA. The extracts did not ind...
Revista de Investigação Biomédica, 2016
O presente estudo de revisão bibliográfica foi realizado entre dezembro de 2014 a maio de 2015, c... more O presente estudo de revisão bibliográfica foi realizado entre dezembro de 2014 a maio de 2015, com abordagem descritiva e qualitativa dos dados, com a utilização de pesquisas em livros, revistas, jornais e artigos científicos na base de dados LILACS, Scielo e PubMed objetivou listar os nomes das plantas medicinais utilizadas no tratamento de doenças reumáticas. No Brasil, muitas pessoas sofrem de doenças reumáticas, as quais compreendem mais de 100 tipos diferentes de distúrbios, afetando, principalmente, as articulações, ossos, músculos esqueléticos, tendões e ligamentos. Os sintomas característicos são a inflamação das articulações, provocando, principalmente, dores lombares e nas pernas. Em geral, os alvos dessa patogenia são os idosos, devido a desgastes nas articulações; porém crianças, jovens e adultos também podem ser afetadas. Na flora medicinal, existem plantas usadas no tratamento do reumatismo, uma alternativa acessível e saudável para aqueles que acreditam na Fitoterapi...
Current Colorectal Cancer Reports, 2017
World journal of surgery, Aug 6, 2017
Abdominal perineal excision (APE) has been associated with a high risk of positive circumferentia... more Abdominal perineal excision (APE) has been associated with a high risk of positive circumferential resection margin (CRM+) and local recurrence rates in the treatment of rectal cancer. An alternative extralevator approach (ELAPE) has been suggested to improve the quality of resection by avoiding coning of the specimen decreasing the risk of tumor perforation and CRM+. The aim of this study is to compare the quality of the resected specimen and postoperative complication rates between ELAPE and "standard" APE. All patients between 1998 and 2014 undergoing abdominal perineal excision for primary or recurrent rectal cancer at a single Institution were reviewed. Between 1998 and 2008, all patients underwent standard APE. In 2009 ELAPE was introduced at our Institution and all patients requiring APE underwent this alternative procedure (ELAPE). The groups were compared according to pathological characteristics, specimen quality (CRM status, perforation and failure to provide th...
Journal of Surgical Research, 2016
Remote ischemic conditioning (RIC) is the most promising surgical approach to mitigate ischemia a... more Remote ischemic conditioning (RIC) is the most promising surgical approach to mitigate ischemia and reperfusion (IR) injury. It consists in performing brief cycles of IR in tissues other than those exposed to ischemia. The underlying mechanisms of the induced protection are barely understood, so we evaluated if RIC works enhancing the antioxidant defense of the liver and kidney before IR injury. Twenty-one Wistar rats were assigned into three groups as follows: sham, same surgical procedure as in the remaining groups was performed, but no RIC was carried out. RIC 10, RIC was performed, and no abdominal organ ischemia was induced. After 10 min of the end of the RIC protocol, the liver and kidney were harvested. RIC 60, similar procedure as performed in RIC 10, but the liver and the kidney were harvested 60 min. RIC consisted of three cycles of 5-min left hind limb ischemia followed by 5-min left hind limb perfusion, lasting 30 min in total. Samples were used to measure tissue total antioxidant capacity. RIC protocol increased both liver (1.064 ± 0.26 mM/L) and kidney (1.310 ± 0.17 mM/L) antioxidant capacity after 10 min when compared with sham (liver, 0.759 ± 0.10 mM/L and kidney, 1.08 ± 0.15 mM/L). Sixty minutes after the RIC protocol, no enhancement on liver (0.687 ± 0.13 mM/L) or kidney (1.09 ± 0.15 mM/L) antioxidant capacity was detected. RIC works through temporary and short-term enhancement of liver and kidney cells antioxidant defenses to avoid the deleterious consequences of a future IR injury.
Journal of Surgical Research, 2014
Remote ischemic perconditioning (rPER) is the newest technique described to mitigate ischemia and... more Remote ischemic perconditioning (rPER) is the newest technique described to mitigate ischemia and reperfusion (IR) injury. Local postconditioning (POS) is also an effective technique for this purpose. It is uncertain if adding local POS to rPER provides superior liver protection, so we tested this hypothesis. Twenty five Wistar rats were assigned into five groups: sham, IR, POS, rPER, and rPER + POS. Animals were subjected to liver ischemia for 60 min. POS consisted of four cycles of 5-min liver perfusion followed by 5-min liver ischemia (40 min total) after the major ischemic period. rPER consisted of four cycles of 5-min hindlimb ischemia followed by 5 min hindlimb perfusion contemporaneously to major liver ischemic period, during its last 40 min. After 2 h, median and left lobes were harvested for malondialdehyde and Trolox equivalent antioxidant capacity (TEAC) measurement, and blood for the measurement of serum transaminases. All tissue conditioning techniques were able to reduce transaminases serum levels, having no differences among them. All tissue conditioning techniques were able to reduce hepatic tissue MDA level; however, only rPER + POS had higher values than SHAM. All tissue conditioning techniques also enhanced TEAC; however, only POS had lower TEAC than SHAM. rPER appears as the most promising technique to avoid IR injury. This technique reduced oxidative stress of cell membranes and lowered transaminases serum level. There was no additive protection when POS and rPER were held together.
Revista Brasileira de Coloproctologia, 2007
O Tailgut Cyst é um remanescente embriológico do intestino posterior, que pode fazer parte da Sín... more O Tailgut Cyst é um remanescente embriológico do intestino posterior, que pode fazer parte da Síndrome de Currarino. Relato do caso: Paciente feminino, 43 anos com lombalgia, retenção urinária e massa retrorretal. História pregressa de ânus ectópico, constipação associada a megacólon congênito. Exames de imagem evidenciando cisto retrorretal comprimindo o sacro, rechaçando as estruturas pélvicas anteriormente e deformidade sacral congênita. Realizada ressecção em bloco da lesão retrorretal, reto, útero e sacro ao nível de S2. Anátomo-patológico evidenciando tailgut cyst. Caracterizamos a paciente como portadora de síndrome de Currarino. Discusão: A síndrome de Currarino é caracterizada pela malformação anorretal, defeito sacral e massa retrorretal. Tem relação com a mutação do gene HLXB9. O tailgut cyst é um remanescente embriológico do intestino posterior, mais comum em mulher adulto jovem (75-90%). O tailgut cyst relacionado à Síndrome de Currarino é uma lesão incomum. A maioria d...
Colorectal Disease, 2011
The aim of this study was to evaluate the outcomes of self-expanding metallic stent (SEMS) placem... more The aim of this study was to evaluate the outcomes of self-expanding metallic stent (SEMS) placement in acute left-sided large-bowel obstruction. From 1997 to 2008, 130 patients [mean 67 (SD 14.7)] underwent SEMS insertion for acute left-sided large-bowel obstruction. One-hundred and one procedures were palliative, and 29 patients underwent stent insertion as a bridge for surgery. The success rate and the outcome were analysed. The chief causes of obstruction were primary (67%) and recurrent (16%) colorectal carcinoma. The success rate was 88% after insertion of the first stent. In nine patients, insertion of a second stent was required. Complications occurred in 20% of the insertions, with migration (10.8%) being the most common. Perforation occurred in two patients and one developed a colovesical fistula. In patients with palliative stenting, 14 (13.9%) required subsequent surgery, with a stoma placed in all except three. Among the 29 patients who underwent SEMS insertion as a bridge to surgery, subsequent surgical resection was performed in 26 patients at a mean interval of 12 days (SD 18.0). Primary anastomosis was performed in 24 patients. The mean survival for those who underwent SEMS insertion as a bridge to surgery was 40 (95% confidence interval: 24-55) months. SEMS placement is safe and effective in relieving acute left-sided colonic obstruction. It allows subsequent definitive surgery on an elective setting and also serves as good palliation for advanced or disseminated disease.
70° Congresso Brasileiro de Coloproctologia
Inflammatory Bowel Diseases, 2022
Background The epidemiology of inflammatory bowel disease (IBD) in developing countries may uncov... more Background The epidemiology of inflammatory bowel disease (IBD) in developing countries may uncover etiopathogenic factors. We investigated IBD prevalence in Brazil by investigating its geographic, spatial, and temporal distribution, and attempted to identify factors associated with its recent increase. Methods A drug prescription database was queried longitudinally to identify patients and verify population distribution and density, race, urbanicity, sanitation, and Human Development Index. Prevalence was calculated using the number of IBD patients and the population estimated during the same decade. Data were matched to indices using linear regression analyses. Results We identified 162 894 IBD patients, 59% with ulcerative colitis (UC) and 41% with Crohn’s disease (CD). The overall prevalence of IBD was 80 per 100 000, with 46 per 100 000 for UC and 36 per 100 000 for CD. Estimated rates adjusted to total population showed that IBD more than triplicated from 2008 to 2017. The dis...
Effect of copaiba oil on correction of abdominal wall defect treated with the use of polypropylen... more Effect of copaiba oil on correction of abdominal wall defect treated with the use of polypropylene/polyglecaprone mesh1
Background: The use of debriding drugs is not common in a situa-tion of acute wound healing, desp... more Background: The use of debriding drugs is not common in a situa-tion of acute wound healing, despite its widespread use in chronic wound healing, with satisfactory results. Collagenase is one of the most used debriding drugs, and its application after a non-stitched skin wound biopsy could lead to a better wound healing outcome and less complication. Methods and Findings: Fifteen Wistar rats were used in this study; four excisional wounds were performed on the dorsum of each animal. Once in a day, collagenase cream was applied in the cranial wounds, while the caudal wounds were washed with isotonic saline. After 7, 14 and 21 postoperative days, 5 animals were randomly chosen for macroscopic and microscopic wound analysis.At the 7th postoperative day: collagenase cream induced greater monocytes invasion, fibroblast invasion, collagen deposit, angiogenesis and reepithelialization. 14th
Revista Neurociências, Jul 1, 2024
Biomedicines, Feb 23, 2024
Journal of Medical Virology
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a coronavirus belonging to the be... more Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a coronavirus belonging to the beta CoV genus, responsible for SARS in humans, which became known as COVID‐19. The emergence of variants of this virus is related to the presence of cases of reinfection, reduced vaccine effectiveness and greater transmission of the virus. Objective: In this study, we evaluated the molecular epidemiology of SARS‐CoV‐2 lineages circulating in the state of Maranhão. This is a cross‐sectional and retrospective epidemiological study of genomic surveillance of SARS‐CoV‐2. The study comprised of 338 genomes sequenced by the Next Generation Sequencing technique on Illumina's Miseq equipment, submitted to Global Initiative on Sharing Avian Influenza Data, 190 (56.2%) are from samples of female and 148 (43.8%) from male patients. Sequencing performed covered samples of patients aged between 1 and 108 years, with emphasis on the age groups from 30 to 39 years with 15.0% of sequenced genomes and...
OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA
Este artigo aborda a presença dos discursos de sustentabilidade na criação do ambiente urbano atr... more Este artigo aborda a presença dos discursos de sustentabilidade na criação do ambiente urbano através do Programa de Aceleração do Crescimento (PAC), especificamente na sua linha de Urbanização de Assentamentos Precários (UAP), que se destina à realocação urbana de famílias em situação de risco socioambiental. Utilizando uma abordagem qualitativa fundamentada no materialismo histórico-dialético, foi conduzido um estudo de caso sobre a intervenção do PAC, a partir do seu Plano de Trabalho Técnico Social (PTTS), nos projetos habitacionais voltados para o deslocamento de famílias que vivem em áreas ambiental e socialmente vulneráveis, na cidade de Belém (PA), mais especificamente na Comunidade Taboquinha, localizada no Distrito de Icoaraci. A análise deste estudo reflete a perspectiva dos envolvidos no processo e a trajetória dos indivíduos durante a transição entre espaços e em seu cotidiano, evidenciando o distanciamento entre a implementação das políticas e a busca pela sustentabili...
Anais do XIV Fórum de Pesquisa e Extensão da Escola de Aplicação da Universidade Federal do Pará
Research, Society and Development
A crise gerada pela pandemia impactou diversos fatores da vida cotidiana das pessoas e promoveu m... more A crise gerada pela pandemia impactou diversos fatores da vida cotidiana das pessoas e promoveu mudanças que propiciaram o aumento do estresse. Esta situação chama atenção para possíveis complicações psiquiátricas, não apenas em pacientes que já foram infectados pelo vírus, mas também em toda a população que precisou lidar com as medidas implementadas pelo governo. Dessa forma, esse estudo baseia-se em avaliar o comprometimento imunológico populacional associado a condições de estresse perante a pandemia da COVID-19. Trata-se de uma revisão integrativa da literatura, com abordagem qualitativa a partir do levantamento de dados nacionais e internacionais das seguintes bases de dados: Medical Literature Analysis and Retrieval System Online (MEDLINE/PubMed), Scientific Eletronic Library Online (SciELO) e Google Scholar. No estudo foi observada a relação do sistema nervoso, imunológico e endócrino, alterando mecanismos nos circuitos imunes neuroendócrino e acarretando danos à saúde pelos...
Hansenologia Internationalis, Oct 18, 2019
Evidence-based complementary and alternative medicine : eCAM, 2018
The incidence of infections caused by rapidly growing mycobacteria (RGM), especially subsp. (), i... more The incidence of infections caused by rapidly growing mycobacteria (RGM), especially subsp. (), is increasing worldwide. Severe infections are associated with abscess formation and strong inflammatory response. This study evaluated the antimicrobial and anti-inflammatory activities of a hydroalcoholic extract (BoHE) and ethyl acetate fraction (BoEA) of leaves. Antimicrobial activity was evaluated by broth microdilution to determine the minimum inhibitory (MIC) and the minimum bactericidal (MBC) concentrations. Cytotoxicity was evaluated using erythrocytes and RAW 264.7 cells. Nitric oxide (NO) was assayed in stimulated RAW 264.7 cells, and inflammatory cell migration and acute toxicity were evaluated in a -induced peritonitis mouse model. The compounds present in BoEA were identified by high performance liquid chromatography and mass spectrometry (HPLC-MS). The MIC and MBC values were 2.34 mg/mL and 37.5 mg/mL for BoHE and 0.39 mg/mL and 6.25 mg/mL for BoEA. The extracts did not ind...
Revista de Investigação Biomédica, 2016
O presente estudo de revisão bibliográfica foi realizado entre dezembro de 2014 a maio de 2015, c... more O presente estudo de revisão bibliográfica foi realizado entre dezembro de 2014 a maio de 2015, com abordagem descritiva e qualitativa dos dados, com a utilização de pesquisas em livros, revistas, jornais e artigos científicos na base de dados LILACS, Scielo e PubMed objetivou listar os nomes das plantas medicinais utilizadas no tratamento de doenças reumáticas. No Brasil, muitas pessoas sofrem de doenças reumáticas, as quais compreendem mais de 100 tipos diferentes de distúrbios, afetando, principalmente, as articulações, ossos, músculos esqueléticos, tendões e ligamentos. Os sintomas característicos são a inflamação das articulações, provocando, principalmente, dores lombares e nas pernas. Em geral, os alvos dessa patogenia são os idosos, devido a desgastes nas articulações; porém crianças, jovens e adultos também podem ser afetadas. Na flora medicinal, existem plantas usadas no tratamento do reumatismo, uma alternativa acessível e saudável para aqueles que acreditam na Fitoterapi...
Current Colorectal Cancer Reports, 2017
World journal of surgery, Aug 6, 2017
Abdominal perineal excision (APE) has been associated with a high risk of positive circumferentia... more Abdominal perineal excision (APE) has been associated with a high risk of positive circumferential resection margin (CRM+) and local recurrence rates in the treatment of rectal cancer. An alternative extralevator approach (ELAPE) has been suggested to improve the quality of resection by avoiding coning of the specimen decreasing the risk of tumor perforation and CRM+. The aim of this study is to compare the quality of the resected specimen and postoperative complication rates between ELAPE and "standard" APE. All patients between 1998 and 2014 undergoing abdominal perineal excision for primary or recurrent rectal cancer at a single Institution were reviewed. Between 1998 and 2008, all patients underwent standard APE. In 2009 ELAPE was introduced at our Institution and all patients requiring APE underwent this alternative procedure (ELAPE). The groups were compared according to pathological characteristics, specimen quality (CRM status, perforation and failure to provide th...
Journal of Surgical Research, 2016
Remote ischemic conditioning (RIC) is the most promising surgical approach to mitigate ischemia a... more Remote ischemic conditioning (RIC) is the most promising surgical approach to mitigate ischemia and reperfusion (IR) injury. It consists in performing brief cycles of IR in tissues other than those exposed to ischemia. The underlying mechanisms of the induced protection are barely understood, so we evaluated if RIC works enhancing the antioxidant defense of the liver and kidney before IR injury. Twenty-one Wistar rats were assigned into three groups as follows: sham, same surgical procedure as in the remaining groups was performed, but no RIC was carried out. RIC 10, RIC was performed, and no abdominal organ ischemia was induced. After 10 min of the end of the RIC protocol, the liver and kidney were harvested. RIC 60, similar procedure as performed in RIC 10, but the liver and the kidney were harvested 60 min. RIC consisted of three cycles of 5-min left hind limb ischemia followed by 5-min left hind limb perfusion, lasting 30 min in total. Samples were used to measure tissue total antioxidant capacity. RIC protocol increased both liver (1.064 ± 0.26 mM/L) and kidney (1.310 ± 0.17 mM/L) antioxidant capacity after 10 min when compared with sham (liver, 0.759 ± 0.10 mM/L and kidney, 1.08 ± 0.15 mM/L). Sixty minutes after the RIC protocol, no enhancement on liver (0.687 ± 0.13 mM/L) or kidney (1.09 ± 0.15 mM/L) antioxidant capacity was detected. RIC works through temporary and short-term enhancement of liver and kidney cells antioxidant defenses to avoid the deleterious consequences of a future IR injury.
Journal of Surgical Research, 2014
Remote ischemic perconditioning (rPER) is the newest technique described to mitigate ischemia and... more Remote ischemic perconditioning (rPER) is the newest technique described to mitigate ischemia and reperfusion (IR) injury. Local postconditioning (POS) is also an effective technique for this purpose. It is uncertain if adding local POS to rPER provides superior liver protection, so we tested this hypothesis. Twenty five Wistar rats were assigned into five groups: sham, IR, POS, rPER, and rPER + POS. Animals were subjected to liver ischemia for 60 min. POS consisted of four cycles of 5-min liver perfusion followed by 5-min liver ischemia (40 min total) after the major ischemic period. rPER consisted of four cycles of 5-min hindlimb ischemia followed by 5 min hindlimb perfusion contemporaneously to major liver ischemic period, during its last 40 min. After 2 h, median and left lobes were harvested for malondialdehyde and Trolox equivalent antioxidant capacity (TEAC) measurement, and blood for the measurement of serum transaminases. All tissue conditioning techniques were able to reduce transaminases serum levels, having no differences among them. All tissue conditioning techniques were able to reduce hepatic tissue MDA level; however, only rPER + POS had higher values than SHAM. All tissue conditioning techniques also enhanced TEAC; however, only POS had lower TEAC than SHAM. rPER appears as the most promising technique to avoid IR injury. This technique reduced oxidative stress of cell membranes and lowered transaminases serum level. There was no additive protection when POS and rPER were held together.
Revista Brasileira de Coloproctologia, 2007
O Tailgut Cyst é um remanescente embriológico do intestino posterior, que pode fazer parte da Sín... more O Tailgut Cyst é um remanescente embriológico do intestino posterior, que pode fazer parte da Síndrome de Currarino. Relato do caso: Paciente feminino, 43 anos com lombalgia, retenção urinária e massa retrorretal. História pregressa de ânus ectópico, constipação associada a megacólon congênito. Exames de imagem evidenciando cisto retrorretal comprimindo o sacro, rechaçando as estruturas pélvicas anteriormente e deformidade sacral congênita. Realizada ressecção em bloco da lesão retrorretal, reto, útero e sacro ao nível de S2. Anátomo-patológico evidenciando tailgut cyst. Caracterizamos a paciente como portadora de síndrome de Currarino. Discusão: A síndrome de Currarino é caracterizada pela malformação anorretal, defeito sacral e massa retrorretal. Tem relação com a mutação do gene HLXB9. O tailgut cyst é um remanescente embriológico do intestino posterior, mais comum em mulher adulto jovem (75-90%). O tailgut cyst relacionado à Síndrome de Currarino é uma lesão incomum. A maioria d...
Colorectal Disease, 2011
The aim of this study was to evaluate the outcomes of self-expanding metallic stent (SEMS) placem... more The aim of this study was to evaluate the outcomes of self-expanding metallic stent (SEMS) placement in acute left-sided large-bowel obstruction. From 1997 to 2008, 130 patients [mean 67 (SD 14.7)] underwent SEMS insertion for acute left-sided large-bowel obstruction. One-hundred and one procedures were palliative, and 29 patients underwent stent insertion as a bridge for surgery. The success rate and the outcome were analysed. The chief causes of obstruction were primary (67%) and recurrent (16%) colorectal carcinoma. The success rate was 88% after insertion of the first stent. In nine patients, insertion of a second stent was required. Complications occurred in 20% of the insertions, with migration (10.8%) being the most common. Perforation occurred in two patients and one developed a colovesical fistula. In patients with palliative stenting, 14 (13.9%) required subsequent surgery, with a stoma placed in all except three. Among the 29 patients who underwent SEMS insertion as a bridge to surgery, subsequent surgical resection was performed in 26 patients at a mean interval of 12 days (SD 18.0). Primary anastomosis was performed in 24 patients. The mean survival for those who underwent SEMS insertion as a bridge to surgery was 40 (95% confidence interval: 24-55) months. SEMS placement is safe and effective in relieving acute left-sided colonic obstruction. It allows subsequent definitive surgery on an elective setting and also serves as good palliation for advanced or disseminated disease.
70° Congresso Brasileiro de Coloproctologia
Inflammatory Bowel Diseases, 2022
Background The epidemiology of inflammatory bowel disease (IBD) in developing countries may uncov... more Background The epidemiology of inflammatory bowel disease (IBD) in developing countries may uncover etiopathogenic factors. We investigated IBD prevalence in Brazil by investigating its geographic, spatial, and temporal distribution, and attempted to identify factors associated with its recent increase. Methods A drug prescription database was queried longitudinally to identify patients and verify population distribution and density, race, urbanicity, sanitation, and Human Development Index. Prevalence was calculated using the number of IBD patients and the population estimated during the same decade. Data were matched to indices using linear regression analyses. Results We identified 162 894 IBD patients, 59% with ulcerative colitis (UC) and 41% with Crohn’s disease (CD). The overall prevalence of IBD was 80 per 100 000, with 46 per 100 000 for UC and 36 per 100 000 for CD. Estimated rates adjusted to total population showed that IBD more than triplicated from 2008 to 2017. The dis...
Effect of copaiba oil on correction of abdominal wall defect treated with the use of polypropylen... more Effect of copaiba oil on correction of abdominal wall defect treated with the use of polypropylene/polyglecaprone mesh1
Background: The use of debriding drugs is not common in a situa-tion of acute wound healing, desp... more Background: The use of debriding drugs is not common in a situa-tion of acute wound healing, despite its widespread use in chronic wound healing, with satisfactory results. Collagenase is one of the most used debriding drugs, and its application after a non-stitched skin wound biopsy could lead to a better wound healing outcome and less complication. Methods and Findings: Fifteen Wistar rats were used in this study; four excisional wounds were performed on the dorsum of each animal. Once in a day, collagenase cream was applied in the cranial wounds, while the caudal wounds were washed with isotonic saline. After 7, 14 and 21 postoperative days, 5 animals were randomly chosen for macroscopic and microscopic wound analysis.At the 7th postoperative day: collagenase cream induced greater monocytes invasion, fibroblast invasion, collagen deposit, angiogenesis and reepithelialization. 14th