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Papers by Femke Buisman-pijlman

Research paper thumbnail of Physical but not emotional stress induces a delay in behavioural coping responses in rats

Behavioural brain research, Jan 15, 2002

Physical stress (PS) and emotional stress (ES) have opposite long-term effects on open field beha... more Physical stress (PS) and emotional stress (ES) have opposite long-term effects on open field behaviour. PS consisted of a repeated mild foot shock treatment, which the ES animals witnessed. PS caused a long-term decrease in locomotor activity and exploration behaviours and increased immobility. ES induced an increase in locomotor activity. These changes in open field behaviour could be the result of several factors such as increased anxiety, a shift in coping strategy or simply a change in locomotor activity. To investigate the effect of the PS and ES treatment on these separate factors, the following behavioural tests were performed: defensive withdrawal, shock prod bury, large open field and social interaction. PS animals initially showed immobility in the shock prod bury test and the large open field, while the differences measured over the entire test period were small or not present. PS did not induce differences in the defensive withdrawal and the social interaction tests. ES ...

Research paper thumbnail of Tops, M., Buisman-Pijlman, F.T.A., & Carter, C.S. (2012). Oxytocin and attachment facilitate a shift from seeking novelty to recognizing and preferring familiarity: The key to increasing resilience? In Martha Kent, Mary C. Davis, John W. Reich (Eds.), The Resilience Handbook: Approaches to Stress...

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Research paper thumbnail of Toll-like receptor 4: innate immune regulator of neuroimmune and neuroendocrine interactions in stress and major depressive disorder

Frontiers in neuroscience, 2014

Major depressive disorder (MDD) poses one of the highest disease burdens worldwide. Yet, current ... more Major depressive disorder (MDD) poses one of the highest disease burdens worldwide. Yet, current treatments targeting serotonergic and noradrenaline reuptake systems are insufficient to provide long-term relief from depressive symptoms in most patients, indicating the need for new treatment targets. Having the ability to influence behavior similar to depressive symptoms, as well as communicate with neuronal and neuroendocrine systems, the innate immune system is a strong candidate for MDD treatments. Given the complex nature of immune signaling, the main question becomes: What is the role of the innate immune system in MDD? The current review presents evidence that toll-like receptor 4 (TLR4), via driving both peripheral and central immune responses, can interact with serotonergic neurotransmission and cause neuroendocrine disturbances, thus integrating with widely observed hallmarks of MDD. Additionally, through describing the multi-directional communication between immune, neural ...

Research paper thumbnail of Early Social Environment Affects the Endogenous Oxytocin System: A Review and Future Directions

Frontiers in Endocrinology, 2015

Endogenous oxytocin plays an important role in a wide range of human functions including birth, m... more Endogenous oxytocin plays an important role in a wide range of human functions including birth, milk ejection during lactation, and facilitation of social interaction. There is increasing evidence that both variations in the oxytocin receptor (OXTR) and concentrations of oxytocin are associated with differences in these functions. The causes for the differences that have been observed in tonic and stimulated oxytocin release remain unclear. Previous reviews have suggested that across the life course, these differences may be due to individual factors, e.g., genetic variation (of the OXTR), age or sex, or be the result of early environmental influences, such as social experiences, stress, or trauma partly by inducing epigenetic changes. This review has three aims. First, we briefly discuss the endogenous oxytocin system, including physiology, development, individual differences, and function. Second, current models describing the relationship between the early life environment and the development of the oxytocin system in humans and animals are discussed. Finally, we describe research designs that can be used to investigate the effects of the early environment on the oxytocin system, identifying specific areas of research that need further attention.

Research paper thumbnail of Oxytocin treatment in pediatric populations

Frontiers in behavioral neuroscience, 2014

The role of endogenous oxytocin as neuromodulator of birth, lactation and social behaviors is wel... more The role of endogenous oxytocin as neuromodulator of birth, lactation and social behaviors is well-recognized. Moreover, the use of oxytocin as a facilitator of social and other behaviors is becoming more and more accepted. Many positive effects have been attributed to intranasal oxytocin administration in animals and humans; with current research highlighting encouraging advances in its potential for use in mental health disorders. The new frontier will be investigating the effective use of oxytocin in pediatric populations. Limited animal data is available on this. Large-scale human studies focusing on autism are currently under way, but many other possibilities seem to lie in the future. However, we need to know more about the risks and effects of repeated use on the developing brain and body. This paper will provide an overview of the current understanding of the role of endogenous oxytocin and its related neuropeptide systems in influencing behaviors, in particular attachment, ...

Research paper thumbnail of Guest editorial. The role of oxytocin in positive affect and drug-related reward

Pharmacology, biochemistry, and behavior, 2014

Research paper thumbnail of Cortisol-induced increases of plasma oxytocin levels predict decreased immediate free recall of unpleasant words

Frontiers in psychiatry, 2012

Cortisol and oxytocin have been shown to interact in both the regulation of stress responses and ... more Cortisol and oxytocin have been shown to interact in both the regulation of stress responses and in memory function. In the present study we administered cortisol to 35 healthy female subjects in a within-subject double-blind placebo-controlled design, while measuring oxytocin levels, adrenocorticotropic hormone (ACTH) levels, and free recall of pleasant and of unpleasant words. We found that cortisol administration suppressed ACTH levels and (1) induced a decrease in oxytocin associated with ACTH suppression and (2) an increase in oxytocin that was independent from ACTH suppression. This cortisol-induced increase in plasma oxytocin was associated with a selective decrease in immediate free recall of unpleasant words from primacy positions. The present results add to evidence that cortisol-induced increases in oxytocin could mediate some of the effects of stress and cortisol on memory, and possibly play a role in the regulation of the hypothalamo-pituitary-adrenal stress response. T...

Research paper thumbnail of Disconnected and extremely Insensitive Parenting (DIP)

Research paper thumbnail of Oxytocin treatment in paediatric populations

Research paper thumbnail of New online international master of science in addiction studies: a joined effort to improve learning and access to training

Research paper thumbnail of Applying the Research Skill Development (Level IV) framework for marking matrices in multidisciplinary research

Research paper thumbnail of The development of an assessment matrix to promote student learning in postgraduate multidisciplinary research projects

Research paper thumbnail of Policy Versus Evidence: Cost-Effectiveness of Opioid Agonist Maintenance Treatments (Oamts) for Opioid Dependence and Implications for Clinical Practice

Research paper thumbnail of Alcohol, Drug Use and Intoxication in the Workplace: Prevalence and Patterns

Research paper thumbnail of Tool Based Assessment and Management Triage to Reduce Opioid Misuse in Chronic Cancer Pain

Research paper thumbnail of Challenging Student Attitudes to Daily Clinical Practice in an Online Environment: Experiences from an International Postgraduate Course

Research paper thumbnail of Oxytocin and attachment facilitate a shift from seeking novelty to recognizing and preferring familiarity: The key to increasing resilience?

Research paper thumbnail of Physical but not emotional stress induces a delay in behavioural coping responses in rats

Behavioural brain research, Jan 15, 2002

Physical stress (PS) and emotional stress (ES) have opposite long-term effects on open field beha... more Physical stress (PS) and emotional stress (ES) have opposite long-term effects on open field behaviour. PS consisted of a repeated mild foot shock treatment, which the ES animals witnessed. PS caused a long-term decrease in locomotor activity and exploration behaviours and increased immobility. ES induced an increase in locomotor activity. These changes in open field behaviour could be the result of several factors such as increased anxiety, a shift in coping strategy or simply a change in locomotor activity. To investigate the effect of the PS and ES treatment on these separate factors, the following behavioural tests were performed: defensive withdrawal, shock prod bury, large open field and social interaction. PS animals initially showed immobility in the shock prod bury test and the large open field, while the differences measured over the entire test period were small or not present. PS did not induce differences in the defensive withdrawal and the social interaction tests. ES ...

Research paper thumbnail of Tops, M., Buisman-Pijlman, F.T.A., & Carter, C.S. (2012). Oxytocin and attachment facilitate a shift from seeking novelty to recognizing and preferring familiarity: The key to increasing resilience? In Martha Kent, Mary C. Davis, John W. Reich (Eds.), The Resilience Handbook: Approaches to Stress...

Research paper thumbnail of Fig 2A

Research paper thumbnail of Fig 2B

Research paper thumbnail of Fig 1

Research paper thumbnail of Toll-like receptor 4: innate immune regulator of neuroimmune and neuroendocrine interactions in stress and major depressive disorder

Frontiers in neuroscience, 2014

Major depressive disorder (MDD) poses one of the highest disease burdens worldwide. Yet, current ... more Major depressive disorder (MDD) poses one of the highest disease burdens worldwide. Yet, current treatments targeting serotonergic and noradrenaline reuptake systems are insufficient to provide long-term relief from depressive symptoms in most patients, indicating the need for new treatment targets. Having the ability to influence behavior similar to depressive symptoms, as well as communicate with neuronal and neuroendocrine systems, the innate immune system is a strong candidate for MDD treatments. Given the complex nature of immune signaling, the main question becomes: What is the role of the innate immune system in MDD? The current review presents evidence that toll-like receptor 4 (TLR4), via driving both peripheral and central immune responses, can interact with serotonergic neurotransmission and cause neuroendocrine disturbances, thus integrating with widely observed hallmarks of MDD. Additionally, through describing the multi-directional communication between immune, neural ...

Research paper thumbnail of Early Social Environment Affects the Endogenous Oxytocin System: A Review and Future Directions

Frontiers in Endocrinology, 2015

Endogenous oxytocin plays an important role in a wide range of human functions including birth, m... more Endogenous oxytocin plays an important role in a wide range of human functions including birth, milk ejection during lactation, and facilitation of social interaction. There is increasing evidence that both variations in the oxytocin receptor (OXTR) and concentrations of oxytocin are associated with differences in these functions. The causes for the differences that have been observed in tonic and stimulated oxytocin release remain unclear. Previous reviews have suggested that across the life course, these differences may be due to individual factors, e.g., genetic variation (of the OXTR), age or sex, or be the result of early environmental influences, such as social experiences, stress, or trauma partly by inducing epigenetic changes. This review has three aims. First, we briefly discuss the endogenous oxytocin system, including physiology, development, individual differences, and function. Second, current models describing the relationship between the early life environment and the development of the oxytocin system in humans and animals are discussed. Finally, we describe research designs that can be used to investigate the effects of the early environment on the oxytocin system, identifying specific areas of research that need further attention.

Research paper thumbnail of Oxytocin treatment in pediatric populations

Frontiers in behavioral neuroscience, 2014

The role of endogenous oxytocin as neuromodulator of birth, lactation and social behaviors is wel... more The role of endogenous oxytocin as neuromodulator of birth, lactation and social behaviors is well-recognized. Moreover, the use of oxytocin as a facilitator of social and other behaviors is becoming more and more accepted. Many positive effects have been attributed to intranasal oxytocin administration in animals and humans; with current research highlighting encouraging advances in its potential for use in mental health disorders. The new frontier will be investigating the effective use of oxytocin in pediatric populations. Limited animal data is available on this. Large-scale human studies focusing on autism are currently under way, but many other possibilities seem to lie in the future. However, we need to know more about the risks and effects of repeated use on the developing brain and body. This paper will provide an overview of the current understanding of the role of endogenous oxytocin and its related neuropeptide systems in influencing behaviors, in particular attachment, ...

Research paper thumbnail of Guest editorial. The role of oxytocin in positive affect and drug-related reward

Pharmacology, biochemistry, and behavior, 2014

Research paper thumbnail of Cortisol-induced increases of plasma oxytocin levels predict decreased immediate free recall of unpleasant words

Frontiers in psychiatry, 2012

Cortisol and oxytocin have been shown to interact in both the regulation of stress responses and ... more Cortisol and oxytocin have been shown to interact in both the regulation of stress responses and in memory function. In the present study we administered cortisol to 35 healthy female subjects in a within-subject double-blind placebo-controlled design, while measuring oxytocin levels, adrenocorticotropic hormone (ACTH) levels, and free recall of pleasant and of unpleasant words. We found that cortisol administration suppressed ACTH levels and (1) induced a decrease in oxytocin associated with ACTH suppression and (2) an increase in oxytocin that was independent from ACTH suppression. This cortisol-induced increase in plasma oxytocin was associated with a selective decrease in immediate free recall of unpleasant words from primacy positions. The present results add to evidence that cortisol-induced increases in oxytocin could mediate some of the effects of stress and cortisol on memory, and possibly play a role in the regulation of the hypothalamo-pituitary-adrenal stress response. T...

Research paper thumbnail of Disconnected and extremely Insensitive Parenting (DIP)

Research paper thumbnail of Oxytocin treatment in paediatric populations

Research paper thumbnail of New online international master of science in addiction studies: a joined effort to improve learning and access to training

Research paper thumbnail of Applying the Research Skill Development (Level IV) framework for marking matrices in multidisciplinary research

Research paper thumbnail of The development of an assessment matrix to promote student learning in postgraduate multidisciplinary research projects

Research paper thumbnail of Policy Versus Evidence: Cost-Effectiveness of Opioid Agonist Maintenance Treatments (Oamts) for Opioid Dependence and Implications for Clinical Practice

Research paper thumbnail of Alcohol, Drug Use and Intoxication in the Workplace: Prevalence and Patterns

Research paper thumbnail of Tool Based Assessment and Management Triage to Reduce Opioid Misuse in Chronic Cancer Pain

Research paper thumbnail of Challenging Student Attitudes to Daily Clinical Practice in an Online Environment: Experiences from an International Postgraduate Course

Research paper thumbnail of Oxytocin and attachment facilitate a shift from seeking novelty to recognizing and preferring familiarity: The key to increasing resilience?