Ferdinand Waldenberger - Academia.edu (original) (raw)

Papers by Ferdinand Waldenberger

Research paper thumbnail of Chirurgie der HI

ABSTRACT Die chirurgische Therapie der HI kann als organerhaltende oder als Herzersatz-Therapie d... more ABSTRACT Die chirurgische Therapie der HI kann als organerhaltende oder als Herzersatz-Therapie durchgeführt werden. Insbesondere bei den organerhaltenden Eingriffen konnten in den vergangenen Jahren durch die Aneurysma- und Mitralklappen-Chirurgie (s. u.), sowie die Hochrisiko-Bypass-Chirurgie und durch elektrostimulatorische Verfahren (siehe Kapitel 5) erhebliche Fortschritte erzielt werden.

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Research paper thumbnail of Evaluation of Natural Substances' Protective Effects Against Oxidative Stress in a Newly Developed Canine Endothelial Cell-Based Assay and in Cell-Free Radical Scavenging Assays

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Research paper thumbnail of Haemodynamic Changes in Patients Undergoing High-Risk PTCA under Protection of Transfemoral Heart-Lung Machine Support with Centrifugal Pumps

International Journal of Artificial Organs, Dec 1, 1998

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Research paper thumbnail of Pre-Clinical Evaluation of a Novel, Pneumatic, Ventricular Assist Device (Medos® HIA-VAD®) under Pathophysiological Conditions

International Journal of Artificial Organs, Jul 1, 1997

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Research paper thumbnail of Efficacy of Sotrovimab (SOT), Molnupiravir (MOL), and Nirmatrelvir/Ritponavir (N/R) and Tolerability of Molnupiravir in Outpatients at High Risk for Severe COVID-19

Viruses

Objective: The main goal of this study was to assess the potential clinical impact of an outpatie... more Objective: The main goal of this study was to assess the potential clinical impact of an outpatient administration of available antivirals including SOT, N/R, and MOL to COVID-19 patients at high risk for disease progression. Methods: We conducted a retrospective analysis on 2606 outpatient individuals with mild to moderate COVID-19 at risk for disease progression, hospitalization, or death. After receiving either SOT (420/2606), MOL (1788/2606), or N/R (398/2606), patients were followed-up with regarding primary (hospitalization rate) and secondary (treatment and side effects) outcomes by phone. Result: A total of 2606 patients were treated at the outpatient clinic (SOT: 420; N/R: 398; MOL: 1788). 3.2% of the SOT patients (1 ICU admission), 0.8% of the MOL patients (2 ICU admissions), and none of the N/R patients were hospitalized. 14.3% of the N/R patients reported strong to severe side effects, exceeding SOT (2.6%) and MOL (5%) patients. A reduction in COVID symptoms after the tr...

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Research paper thumbnail of Cardiac transplantation: current results at the Texas heart institute

Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital, 1984

The first series of cardiac transplants at the Texas Heart Institute began in May of 1968 but was... more The first series of cardiac transplants at the Texas Heart Institute began in May of 1968 but was discontinued because of the complications of infection and rejection. A second series of cardiac transplants was initiated in July of 1982 after the introduction of the immunosuppressant drug, cyclosporine. By August of 1984, 30 patients had undergone orthotopic cardiac transplantation for end-stage cardiac disease. Of the patients in this series, four have died of rejection, two of infectious complications, and one of an unknown cause. The remainder have all returned to Class I New York Heart Association (NYHA) cardiac status. All patients were reviewed in detail for suitability of cardiac transplantation and presented to a cardiac transplant review board. All transplanted patients were functional Class IV. Donor hearts were obtained locally or by long-distance procurement. Ten of the hearts were obtained from an average distance of 250 miles from Houston. Donors ranged in age from 16 ...

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Research paper thumbnail of Coronary sinus endothelin-1 concentrations after cardioplegic cardiac arrest

Coronary artery disease, 1995

Data from animal experiments demonstrate that endothelin-1 is released into the coronary circulat... more Data from animal experiments demonstrate that endothelin-1 is released into the coronary circulation during myocardial ischaemia and reperfusion, indicating that endothelin-1 may contribute to the pathophysiology of ischaemia and reperfusion. The aim of this study was to investigate the release of endothelin-1 into the coronary circulation during reperfusion of the human heart after hypothermic cardioplegic cardiac arrest. Endothelin-1 was measured in arterial, central venous and coronary sinus blood in 19 patients undergoing elective uncomplicated coronary artery bypass grafting before aortic crossclamping and 1, 5, 10 and 20 min after aortic declamping. Endothelin-1 concentrations showed a slight non-significant increase over baseline values 1, 5, 10 and 20 min after aortic declamping. Endothelin-1 concentrations were not significantly higher in coronary sinus blood than in arterial blood at any time point measured, indicating no net release of endothelin-1 by the heart. Our resul...

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Research paper thumbnail of 254 * Evaluation of the Downstream Aorta After Frozen Elephant Trunk Repair for Aortic Dissections in Terms of Diameter and False Lumen Status

Interactive CardioVascular and Thoracic Surgery, 2014

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Research paper thumbnail of Troponin T to diagnose myocardial infarction in bypass surgery

The Lancet, 1991

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Research paper thumbnail of Pre-Clinical Evaluation of a Novel, Pneumatic, Ventricular Assist Device (Medos® HIA-VAD®) under Pathophysiological Conditions

The International Journal of Artificial Organs, 1997

To evaluate a new cardiac assist system, the Medos® HIA-VAD®, we studied the effects of mechanica... more To evaluate a new cardiac assist system, the Medos® HIA-VAD®, we studied the effects of mechanical unloading on regional and global myocardial dysfunction. As a model for the regional temporary contractile dysfunction we chose an anesthetized, open chest preparation in sheep. We occluded the diagonal coronary artery for 15 minutes and reperfused for 90 minutes. Hemodynamic parameters and wall thickening were monitored. Unloading with the 60-ml Medos® HIA-VAD® was performed either during ischemia (group II) or during reperfusion (group III). The recovery of non-uniformity indicated by post-ejection wall thickening was significantly faster (p<0.05) in both groups if compared to the non-assisted group (group I) (all groups n=4). Recovery of systolic wall thickening in the postischemic region in group I was only 76±12%, while it was 103±11% and 92±11% in groups II and III, respectively (p<0.05). In a canine model of global left ventricular failure, we occluded the left anterior de...

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Research paper thumbnail of Evaluation of Natural Substances' Protective Effects Against Oxidative Stress in a Newly Developed Canine Endothelial Cell-Based Assay and in Cell-Free Radical Scavenging Assays

Oxidative stress has been shown to induce damage in a variety of canine and human cardiovascular ... more Oxidative stress has been shown to induce damage in a variety of canine and human cardiovascular cell types, and is implicated in the initiation and progression of various cardiac diseases. Various antioxidant agents used in the management of heart failure appear to confer cardio-protective benefits. In light of growing evidence for the inad

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Research paper thumbnail of Minimal access valve surgery through superior partial sternotomy: a preliminary study

The Journal of heart valve disease, 1996

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Research paper thumbnail of Management of open chest and delayed sternal closure with the vacuum assisted closure system

The Thoracic and Cardiovascular Surgeon, 2008

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Research paper thumbnail of Frozen elephant trunk technique for acute type A aortic dissection

Multimedia manual of cardiothoracic surgery : MMCTS / European Association for Cardio-Thoracic Surgery, 2012

We present a case of a 59-year old male with a Stanford type A aortic dissection (DeBakey type I)... more We present a case of a 59-year old male with a Stanford type A aortic dissection (DeBakey type I) extending from the sinotubular junction to the abdominal aorta. The patient was treated by a combined surgical and endovascular repair (frozen elephant trunk technique) using a specially designed hybrid prosthesis (E-vita open, Jotec GmbH). This onstage hybrid procedure enables simultaneous treatment of the ascending aorta, the aortic arch and the descending aorta.

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Research paper thumbnail of Treatment of complex pathologies of the aortic arch with a new combined surgical and endovascular technique

The Thoracic and Cardiovascular Surgeon, 2008

Aims: We evaluated the application of a new combined surgical and endovascular technique for the ... more Aims: We evaluated the application of a new combined surgical and endovascular technique for the treatment of the aortic arch. The technique is used to treat extensive aortic disease by a single-stage procedure. Surgical outcomes and follow-up data are summarized and analyzed. Methods: Between August 2005 and July 2007, ten patients (54±11,7 years; 8 male, 2 female) with aortic pathologies (7 dissections, 3 aneurysms) underwent replacement of the ascending aorta and the aortic arch, and simultaneous stent graft implantation into the descending aorta. The stent graft was implanted using the E-vita open endoluminal stent graft, employing the technique of circulatory arrest and moderate hypothermia with selective antegrade cerebral perfusion. The stent graft was deployed under visual guidance through the open aortic arch into the true lumen. Results: Intraoperative antegrade stenting of the descending aorta combined with the distal ascending aorta and aortic arch repair was performed successfully in all patients; a survival rate of 100% was achieved. Two patients had a postoperative neurological deficit but recovered almost completely. Seven patients had fully thrombosed perigraft spaces within 11 days, while two patients showed complete obliteration of the false lumen at the three-month control. Conclusion: The combined surgical and endovascular technique described in this report proved feasible for the treatment of extended aortic lesions. It serves as an additional option for aortic repair in a single-stage method and is associated with no elevated risk for the patient.

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Research paper thumbnail of Aortic arch surgery using bilateral antegrade selective cerebral perfusion in combination with near-infrared spectroscopy☆

European Journal of Cardio-Thoracic Surgery, 2010

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Research paper thumbnail of Left ventricular assistance using a catheter-mounted coaxial flow pump (Hemopump) in a canine model of regional myocardial ischaemia

European Heart Journal, 1993

The global and regional effects of left ventricular circulatory assistance were examined in dogs ... more The global and regional effects of left ventricular circulatory assistance were examined in dogs during acute myocardial infarction using a new coaxial flow device (Hemopump). In 12 dogs the left anterior descending coronary artery was occluded for 4 h and subsequently reperfused for 12 h. In six dogs, left ventricular assistance was started 90 min after coronary artery occlusion and maintained for several hours; six control animals received no circulatory support. Survival rate in the animals receiving mechanical support was 100% vs 0% in the control group. The Hemopump reduced left ventricular stroke work up to 80% and maintained blood flows to the brain, kidneys, liver and intestine throughout the experiment. Infarct size, expressed as a percentage of the left ventricle, however, was not modified (12% in supported animals vs 13% in control dogs). Side effects of the coaxial flow pump were thrombocytopaenia, occurring in all six dogs, and haemolysis, which was demonstrated in one animal. It was concluded that the Hemopump provides effective global and regional circulatory support in a canine model of severe cardiogenic shock. However, the value of left ventricular support to modify infarct size could not be demonstrated in this experimental model.

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Research paper thumbnail of Centrifugal Pumps as Left Ventricular Assist for Coronary Revascularization on a Beating Heart

Artificial Organs, 1998

During recent years, coronary bypass surgery has progressed toward minimizing invasiveness. One i... more During recent years, coronary bypass surgery has progressed toward minimizing invasiveness. One important feature of this approach is performing surgery on a beating heart. During the crucial phase of such surgery, the mechanical support of the heart with a left ventricular assist device (LVAD) is a possible option. During the period from October 1, 1994 until June 30, 1997, we employed a centrifugal pump system in 118 cases of coronary artery bypass graft (CABG) procedures with LVAD support (mechanically supported CABG [SUPPCAB]). A total of 179 distal anastomoses with an average of 1.5 +/- 0.5 coronary anastomoses per patient was performed. Three types of pumps were used: 23 BioPump, 87 Isoflow, and 8 Capiox systems. The median time on mechanical support was 44 min (range, 16-116 min). The mean flow rate during support time was 3.5 +/- 0.8 L/min, which results in a calculated flow of 1.7 +/- 0.6 L/min/m2 body surface area (BSA). The average flow was 3.2 +/- 0.8 L/min with the BioPump and 3.7 +/- 0.8 L/min with the Isoflow pump, respectively (p &lt; 0.01). The mean arterial pressure during mechanical support was 75 +/- 12 mm Hg. In 2 patients, the pump system was kept running postoperatively in the ICU. Eight of the patients received operations under resuscitation or in cardiogenic shock. Nine (7.9%) of the patients did not survive the early postoperative phase. For coronary revascularization of the anterolateral and diaphragmatic parts of the heart, the SUPPCAB procedure is feasible with excellent mechanical support of the heart by centrifugal pumps. Especially in high risk cases, this procedure can be recommended.

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Research paper thumbnail of Hybrid Treatment in a Patient With Acute Aortic Syndrome and an Aberrant Right Subclavian Artery

Vascular and Endovascular Surgery

A 57-year-old man was admitted to our department with recent onset of chest pain. Computed tomogr... more A 57-year-old man was admitted to our department with recent onset of chest pain. Computed tomography (CT) scans revealed an acute aortic syndrome manifested by a penetrating atherosclerotic ulcer and contained rupture at the level of origin of an aberrant right subclavian artery. A combined vascular and endovascular approach was selected. The entire arch was rerouted, a reversed bifurcated Dacron prosthesis was placed, and a bypass was created between the right common carotid artery and the lusorian artery, followed by thoracic endovascular aortic repair. The clinical course was uneventful. The CT scan obtained after the procedure revealed regular supra-aortic perfusion and complete exclusion of the complex lesion.

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Research paper thumbnail of Repair of stent graft-induced retrograde type A aortic dissection using the E-vita open prosthesis

European Journal of Cardio-Thoracic Surgery, 2012

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Research paper thumbnail of Chirurgie der HI

ABSTRACT Die chirurgische Therapie der HI kann als organerhaltende oder als Herzersatz-Therapie d... more ABSTRACT Die chirurgische Therapie der HI kann als organerhaltende oder als Herzersatz-Therapie durchgeführt werden. Insbesondere bei den organerhaltenden Eingriffen konnten in den vergangenen Jahren durch die Aneurysma- und Mitralklappen-Chirurgie (s. u.), sowie die Hochrisiko-Bypass-Chirurgie und durch elektrostimulatorische Verfahren (siehe Kapitel 5) erhebliche Fortschritte erzielt werden.

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Research paper thumbnail of Evaluation of Natural Substances' Protective Effects Against Oxidative Stress in a Newly Developed Canine Endothelial Cell-Based Assay and in Cell-Free Radical Scavenging Assays

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Research paper thumbnail of Haemodynamic Changes in Patients Undergoing High-Risk PTCA under Protection of Transfemoral Heart-Lung Machine Support with Centrifugal Pumps

International Journal of Artificial Organs, Dec 1, 1998

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Research paper thumbnail of Pre-Clinical Evaluation of a Novel, Pneumatic, Ventricular Assist Device (Medos® HIA-VAD®) under Pathophysiological Conditions

International Journal of Artificial Organs, Jul 1, 1997

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Research paper thumbnail of Efficacy of Sotrovimab (SOT), Molnupiravir (MOL), and Nirmatrelvir/Ritponavir (N/R) and Tolerability of Molnupiravir in Outpatients at High Risk for Severe COVID-19

Viruses

Objective: The main goal of this study was to assess the potential clinical impact of an outpatie... more Objective: The main goal of this study was to assess the potential clinical impact of an outpatient administration of available antivirals including SOT, N/R, and MOL to COVID-19 patients at high risk for disease progression. Methods: We conducted a retrospective analysis on 2606 outpatient individuals with mild to moderate COVID-19 at risk for disease progression, hospitalization, or death. After receiving either SOT (420/2606), MOL (1788/2606), or N/R (398/2606), patients were followed-up with regarding primary (hospitalization rate) and secondary (treatment and side effects) outcomes by phone. Result: A total of 2606 patients were treated at the outpatient clinic (SOT: 420; N/R: 398; MOL: 1788). 3.2% of the SOT patients (1 ICU admission), 0.8% of the MOL patients (2 ICU admissions), and none of the N/R patients were hospitalized. 14.3% of the N/R patients reported strong to severe side effects, exceeding SOT (2.6%) and MOL (5%) patients. A reduction in COVID symptoms after the tr...

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Research paper thumbnail of Cardiac transplantation: current results at the Texas heart institute

Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital, 1984

The first series of cardiac transplants at the Texas Heart Institute began in May of 1968 but was... more The first series of cardiac transplants at the Texas Heart Institute began in May of 1968 but was discontinued because of the complications of infection and rejection. A second series of cardiac transplants was initiated in July of 1982 after the introduction of the immunosuppressant drug, cyclosporine. By August of 1984, 30 patients had undergone orthotopic cardiac transplantation for end-stage cardiac disease. Of the patients in this series, four have died of rejection, two of infectious complications, and one of an unknown cause. The remainder have all returned to Class I New York Heart Association (NYHA) cardiac status. All patients were reviewed in detail for suitability of cardiac transplantation and presented to a cardiac transplant review board. All transplanted patients were functional Class IV. Donor hearts were obtained locally or by long-distance procurement. Ten of the hearts were obtained from an average distance of 250 miles from Houston. Donors ranged in age from 16 ...

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Research paper thumbnail of Coronary sinus endothelin-1 concentrations after cardioplegic cardiac arrest

Coronary artery disease, 1995

Data from animal experiments demonstrate that endothelin-1 is released into the coronary circulat... more Data from animal experiments demonstrate that endothelin-1 is released into the coronary circulation during myocardial ischaemia and reperfusion, indicating that endothelin-1 may contribute to the pathophysiology of ischaemia and reperfusion. The aim of this study was to investigate the release of endothelin-1 into the coronary circulation during reperfusion of the human heart after hypothermic cardioplegic cardiac arrest. Endothelin-1 was measured in arterial, central venous and coronary sinus blood in 19 patients undergoing elective uncomplicated coronary artery bypass grafting before aortic crossclamping and 1, 5, 10 and 20 min after aortic declamping. Endothelin-1 concentrations showed a slight non-significant increase over baseline values 1, 5, 10 and 20 min after aortic declamping. Endothelin-1 concentrations were not significantly higher in coronary sinus blood than in arterial blood at any time point measured, indicating no net release of endothelin-1 by the heart. Our resul...

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Research paper thumbnail of 254 * Evaluation of the Downstream Aorta After Frozen Elephant Trunk Repair for Aortic Dissections in Terms of Diameter and False Lumen Status

Interactive CardioVascular and Thoracic Surgery, 2014

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Research paper thumbnail of Troponin T to diagnose myocardial infarction in bypass surgery

The Lancet, 1991

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Pre-Clinical Evaluation of a Novel, Pneumatic, Ventricular Assist Device (Medos® HIA-VAD®) under Pathophysiological Conditions

The International Journal of Artificial Organs, 1997

To evaluate a new cardiac assist system, the Medos® HIA-VAD®, we studied the effects of mechanica... more To evaluate a new cardiac assist system, the Medos® HIA-VAD®, we studied the effects of mechanical unloading on regional and global myocardial dysfunction. As a model for the regional temporary contractile dysfunction we chose an anesthetized, open chest preparation in sheep. We occluded the diagonal coronary artery for 15 minutes and reperfused for 90 minutes. Hemodynamic parameters and wall thickening were monitored. Unloading with the 60-ml Medos® HIA-VAD® was performed either during ischemia (group II) or during reperfusion (group III). The recovery of non-uniformity indicated by post-ejection wall thickening was significantly faster (p<0.05) in both groups if compared to the non-assisted group (group I) (all groups n=4). Recovery of systolic wall thickening in the postischemic region in group I was only 76±12%, while it was 103±11% and 92±11% in groups II and III, respectively (p<0.05). In a canine model of global left ventricular failure, we occluded the left anterior de...

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Research paper thumbnail of Evaluation of Natural Substances' Protective Effects Against Oxidative Stress in a Newly Developed Canine Endothelial Cell-Based Assay and in Cell-Free Radical Scavenging Assays

Oxidative stress has been shown to induce damage in a variety of canine and human cardiovascular ... more Oxidative stress has been shown to induce damage in a variety of canine and human cardiovascular cell types, and is implicated in the initiation and progression of various cardiac diseases. Various antioxidant agents used in the management of heart failure appear to confer cardio-protective benefits. In light of growing evidence for the inad

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Research paper thumbnail of Minimal access valve surgery through superior partial sternotomy: a preliminary study

The Journal of heart valve disease, 1996

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Research paper thumbnail of Management of open chest and delayed sternal closure with the vacuum assisted closure system

The Thoracic and Cardiovascular Surgeon, 2008

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Research paper thumbnail of Frozen elephant trunk technique for acute type A aortic dissection

Multimedia manual of cardiothoracic surgery : MMCTS / European Association for Cardio-Thoracic Surgery, 2012

We present a case of a 59-year old male with a Stanford type A aortic dissection (DeBakey type I)... more We present a case of a 59-year old male with a Stanford type A aortic dissection (DeBakey type I) extending from the sinotubular junction to the abdominal aorta. The patient was treated by a combined surgical and endovascular repair (frozen elephant trunk technique) using a specially designed hybrid prosthesis (E-vita open, Jotec GmbH). This onstage hybrid procedure enables simultaneous treatment of the ascending aorta, the aortic arch and the descending aorta.

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Research paper thumbnail of Treatment of complex pathologies of the aortic arch with a new combined surgical and endovascular technique

The Thoracic and Cardiovascular Surgeon, 2008

Aims: We evaluated the application of a new combined surgical and endovascular technique for the ... more Aims: We evaluated the application of a new combined surgical and endovascular technique for the treatment of the aortic arch. The technique is used to treat extensive aortic disease by a single-stage procedure. Surgical outcomes and follow-up data are summarized and analyzed. Methods: Between August 2005 and July 2007, ten patients (54±11,7 years; 8 male, 2 female) with aortic pathologies (7 dissections, 3 aneurysms) underwent replacement of the ascending aorta and the aortic arch, and simultaneous stent graft implantation into the descending aorta. The stent graft was implanted using the E-vita open endoluminal stent graft, employing the technique of circulatory arrest and moderate hypothermia with selective antegrade cerebral perfusion. The stent graft was deployed under visual guidance through the open aortic arch into the true lumen. Results: Intraoperative antegrade stenting of the descending aorta combined with the distal ascending aorta and aortic arch repair was performed successfully in all patients; a survival rate of 100% was achieved. Two patients had a postoperative neurological deficit but recovered almost completely. Seven patients had fully thrombosed perigraft spaces within 11 days, while two patients showed complete obliteration of the false lumen at the three-month control. Conclusion: The combined surgical and endovascular technique described in this report proved feasible for the treatment of extended aortic lesions. It serves as an additional option for aortic repair in a single-stage method and is associated with no elevated risk for the patient.

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Research paper thumbnail of Aortic arch surgery using bilateral antegrade selective cerebral perfusion in combination with near-infrared spectroscopy☆

European Journal of Cardio-Thoracic Surgery, 2010

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Research paper thumbnail of Left ventricular assistance using a catheter-mounted coaxial flow pump (Hemopump) in a canine model of regional myocardial ischaemia

European Heart Journal, 1993

The global and regional effects of left ventricular circulatory assistance were examined in dogs ... more The global and regional effects of left ventricular circulatory assistance were examined in dogs during acute myocardial infarction using a new coaxial flow device (Hemopump). In 12 dogs the left anterior descending coronary artery was occluded for 4 h and subsequently reperfused for 12 h. In six dogs, left ventricular assistance was started 90 min after coronary artery occlusion and maintained for several hours; six control animals received no circulatory support. Survival rate in the animals receiving mechanical support was 100% vs 0% in the control group. The Hemopump reduced left ventricular stroke work up to 80% and maintained blood flows to the brain, kidneys, liver and intestine throughout the experiment. Infarct size, expressed as a percentage of the left ventricle, however, was not modified (12% in supported animals vs 13% in control dogs). Side effects of the coaxial flow pump were thrombocytopaenia, occurring in all six dogs, and haemolysis, which was demonstrated in one animal. It was concluded that the Hemopump provides effective global and regional circulatory support in a canine model of severe cardiogenic shock. However, the value of left ventricular support to modify infarct size could not be demonstrated in this experimental model.

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Research paper thumbnail of Centrifugal Pumps as Left Ventricular Assist for Coronary Revascularization on a Beating Heart

Artificial Organs, 1998

During recent years, coronary bypass surgery has progressed toward minimizing invasiveness. One i... more During recent years, coronary bypass surgery has progressed toward minimizing invasiveness. One important feature of this approach is performing surgery on a beating heart. During the crucial phase of such surgery, the mechanical support of the heart with a left ventricular assist device (LVAD) is a possible option. During the period from October 1, 1994 until June 30, 1997, we employed a centrifugal pump system in 118 cases of coronary artery bypass graft (CABG) procedures with LVAD support (mechanically supported CABG [SUPPCAB]). A total of 179 distal anastomoses with an average of 1.5 +/- 0.5 coronary anastomoses per patient was performed. Three types of pumps were used: 23 BioPump, 87 Isoflow, and 8 Capiox systems. The median time on mechanical support was 44 min (range, 16-116 min). The mean flow rate during support time was 3.5 +/- 0.8 L/min, which results in a calculated flow of 1.7 +/- 0.6 L/min/m2 body surface area (BSA). The average flow was 3.2 +/- 0.8 L/min with the BioPump and 3.7 +/- 0.8 L/min with the Isoflow pump, respectively (p &lt; 0.01). The mean arterial pressure during mechanical support was 75 +/- 12 mm Hg. In 2 patients, the pump system was kept running postoperatively in the ICU. Eight of the patients received operations under resuscitation or in cardiogenic shock. Nine (7.9%) of the patients did not survive the early postoperative phase. For coronary revascularization of the anterolateral and diaphragmatic parts of the heart, the SUPPCAB procedure is feasible with excellent mechanical support of the heart by centrifugal pumps. Especially in high risk cases, this procedure can be recommended.

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Research paper thumbnail of Hybrid Treatment in a Patient With Acute Aortic Syndrome and an Aberrant Right Subclavian Artery

Vascular and Endovascular Surgery

A 57-year-old man was admitted to our department with recent onset of chest pain. Computed tomogr... more A 57-year-old man was admitted to our department with recent onset of chest pain. Computed tomography (CT) scans revealed an acute aortic syndrome manifested by a penetrating atherosclerotic ulcer and contained rupture at the level of origin of an aberrant right subclavian artery. A combined vascular and endovascular approach was selected. The entire arch was rerouted, a reversed bifurcated Dacron prosthesis was placed, and a bypass was created between the right common carotid artery and the lusorian artery, followed by thoracic endovascular aortic repair. The clinical course was uneventful. The CT scan obtained after the procedure revealed regular supra-aortic perfusion and complete exclusion of the complex lesion.

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Research paper thumbnail of Repair of stent graft-induced retrograde type A aortic dissection using the E-vita open prosthesis

European Journal of Cardio-Thoracic Surgery, 2012

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