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Papers by Fernán Gómez-Valenzuela

Cancer research, Mar 22, 2024

Cancers, Dec 21, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Medicina Oral Patologia Oral Y Cirugia Bucal, Dec 31, 2019

Background: Odontogenic tumours are infrequent lesions. Studies on the frequency of odontogenic t... more Background: Odontogenic tumours are infrequent lesions. Studies on the frequency of odontogenic tumours from Latin America are scarce. This work aimed to determine the relative frequency of odontogenic tumours in a Chilean population using the 2022 World Health Organization classification. Material and Methods: This is a case series retrospective study. We reviewed 35,530 samples from 1975 to 2022 from the Oral Pathology Referral Institute and the Pathological Anatomy Service, Faculty of Dentistry, University of Chile. We utilized the 2022 World Health Organization classification for histological typification. Results: According to 2022 World Health Organization classification, 544 odontogenic tumours were confirmed. The most frequent odontogenic tumours were: odontoma (n=241; 44.3%), ameloblastoma (n=109; 20.0%) and cemento-ossifying fibroma (n=71; 13.1%). Benign odontogenic tumours corresponded to 538 cases (98.9%) and malignant tumours were only six cases (1.1%). Conclusions: In our population, odontoma was the most frequent odontogenic tumour followed by ameloblastoma and cemento-ossifying fibroma. Malignant odontogenic tumours were very rare. The results of this study are similar to reports from America, but there are some differences concerning the data from Africa and Asia.

Oral Sessions

Introduction/Background The goal of fertility-sparing treatment (FST) for patients with cervical ... more Introduction/Background The goal of fertility-sparing treatment (FST) for patients with cervical cancer is to achieve comparable oncologic outcomes to those after radical treatment while maximizing reproductive outcomes, which include the ability to conceive and minimizing the risk of preterm birth. Methodology Patients from the international multicentre retrospective FERTISS study, which included women treated with any type of FST, were analysed for information on timing of FST in relation to pregnancy, attempts to conceive, mode of conception, prophylactic procedures to reduce the risk of severe prematurity, rate of pregnancy failure, overall duration of pregnancy and mode of termination. Results Of the 733 patients treated at 44 centres in 13 countries, only half (49.7%) attempted to become pregnant during follow-up (median 72 months). Unsuccessful attempts were

Cancer Research, Jun 15, 2022

Despite growing evidence linking obesity to the development and overall survival of cancer patien... more Despite growing evidence linking obesity to the development and overall survival of cancer patients, the impact of increased body mass index (BMI) on gene expression patterns in gynecologic cancers is unclear. To address this, we herein downloaded RNAseq gene expression data from The Cancer Genome Atlas (TCGA) UCEC (uterine corpus endometrial carcinoma) dataset and matched it with clinical data entries including patient height and weight. We calculated BMI for each patient and used it to stratify patients as normoweight (BMI < 25), overweight (25 ≤ BMI < 30) or obese (BMI ≥ 30). BMI and nutritional status were matched to RNAseq gene expression data. Considering the known differences between endometrioid and serous uterine corpus tumors, analyses were performed separately for endometrioid (n = 356) and serous carcinomas (n = 117). Gene set enrichment analysis (GSEA) was performed between normoweight, overweight and obese patients. GSEA shows that tumors from obese patients display multiple dysregulated Gene Ontology (GO) terms (Biological Process, BP), which also differ between serous and endometrioid tumors. We further explored the impact of obesity on transcriptomic profiles of serous and endometrioid carcinomas by nutritional status independently by differential expression analysis using limma-voom. Significantly up- or downregulated genes were defined as those with logFC ≥ 1.5 at a non-adjusted P-value ≤ 0.01. Despite a clear enrichment or suppression of GO terms as evidenced by GSEA, transcriptomic analyses did not clearly separate patients according to their nutritional status. Therefore, obesity may impact on the dysregulation of biological processes through the cumulative effects of subtle differences in gene expression that, individually, do not seem to play a major role in oncogenesis. These results spotlight the relevance of obesity on the biology of uterine corpus cancers, which impact on the clinical course and treatment response of obese patients is yet to be determined. Funding: This work was supported by CONICYT FONDAP 15130011 (MC, IW), CONICYT-PFCHA/Doctorado Nacional 2019-Folio 21190421 (FG) and FONDECYT 1201083 (MC). Citation Format: Ignacio A. Wichmann, Fernán Gómez, Cristián Salazar, Felipe Suárez, Sumie Kato, Mauricio A. Cuello-Fredes. Distinct biological response of uterine corpus serous and endometrioid carcinomas to obesity may contribute to differences in clinical outcomes [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3361.

Cancers, Feb 10, 2023

Cancer Research, Apr 4, 2023

Our objective was to evaluate the impact of body composition (BC), beyond body mass index (BMI), ... more Our objective was to evaluate the impact of body composition (BC), beyond body mass index (BMI), and lipid metabolism disorders on therapeutic responses and outcomes in high-grade serous ovarian cancer (HGSOC).Methods: 123 and 415 patients with advanced HGSOC from two cohorts (PUC and TCGA) were analyzed. Databases containing clinical/genomic variables were built-up. BC was estimated using the measurement of adiposity (e.g., Whole body Adipose Tissue [WBAT]) and muscle mass (Lumbar muscle area to vertebral body at L4-level, [PLVI]) by CT-scan. A list of 425 genes linked to obesity and lipid metabolism was used to identify clusters using non-negative matrix factorization. GSEA, Gene Ontology, KEGG pathways enrichment, and Ecotyper analyzes were also made. Survival curves and Cox-regression models were also built-up. Results: We identified four BC types and two clusters that, unlike BMI, effectively correlate with survival regardless of achieving optimal debulking or complete response. Mention deserves central sarcopenia, which was associated with worse survival in any condition. So also, that recovering a normal BC and adding medications to correct metabolism disorders (e.g., statins) could have a positive impact on outcomes. Along with this, we showed that micro-environments depleted of immune cells predominate in HGSOC, something more evident in the BC type (High WBAT/Low PLVI) and cluster (Obesity/Lipid Metabolism Type I) with worse prognosis. Conclusions: Here, we demonstrate the relevance of BC and lipid metabolism disorders in determining therapeutic responses and long-term outcomes. Also, the importance of incorporating corrective measures addressing these disorders to obtain better results. (Research supported by Fondecyt 1201083) Citation Format: Mauricio A. Cuello-Fredes, Fernan Gomez, Ignacio Wichmann, Felipe Suarez, Sumie Kato, Jorge Brañes, Elisa Orlandini, Carolina Ibañez. Body composition and metabolic dysfunction really matter for the achievement of better outcomes in high-grade serous ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 922.

Journal of Clinical and Experimental Dentistry, Feb 1, 2023

Revista Española de Patología

International Journal of Molecular Sciences

Muscle and bone are tightly integrated through mechanical and biochemical signals. Osteoclasts ar... more Muscle and bone are tightly integrated through mechanical and biochemical signals. Osteoclasts are cells mostly related to pathological bone loss; however, they also start physiological bone remodeling. Therefore, osteoclast signals released during bone remodeling could improve both bone and skeletal muscle mass. Extracellular ATP is an autocrine/paracrine signaling molecule released by bone and muscle cells. Then, in the present work, it was hypothesized that ATP is a paracrine mediator released by osteoclasts and leads to skeletal muscle protein synthesis. RAW264.7-derived osteoclasts were co-cultured in Transwell® chambers with flexor digitorum brevis (FDB) muscle isolated from adult BalbC mice. The osteoclasts at the upper chamber were mechanically stimulated by controlled culture medium perturbation, resulting in a two-fold increase in protein synthesis in FDB muscle at the lower chamber. Osteoclasts released ATP to the extracellular medium in response to mechanical stimulation...

Frontiers in Oncology

The tumor microenvironment (TME) corresponds to a complex and dynamic interconnection between the... more The tumor microenvironment (TME) corresponds to a complex and dynamic interconnection between the extracellular matrix and malignant cells and their surrounding stroma composed of immune and mesenchymal cells. The TME has constant cellular communication through cytokines that sustain an inflammatory profile, which favors tumor progression, angiogenesis, cell invasion, and metastasis. Although the epithelial-mesenchymal transition (EMT) represents a relevant metastasis-initiating event that promotes an invasive phenotype in malignant epithelial cells, its relationship with the inflammatory profile of the TME is poorly understood. Previous evidence strongly suggests that cyclooxygenase-2 (COX-2) overexpression, a pro-inflammatory enzyme related to chronic unresolved inflammation, is associated with common EMT-signaling pathways. This review article summarizes how COX-2 overexpression, within the context of the TME, orchestrates the EMT process and promotes initial metastatic-related e...

Journal of Oral Pathology & Medicine

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology